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How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility

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Hepatobiliary Surgery and Nutrition 2021年第1期10卷 1-8页

作者： Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson Department of Clinical Science Intervention and TechnologyDivision of SurgeryKarolinska InstituteKarolinska University HospitalStockholmSweden Department of Surgery and Clinical and Experimental Medicine Linköping UniversityLinköpingSweden Department of Hepato-Pancreato-Biliary Surgery Oslo University HospitalOsloNorway Department of Surgical Gastroenterology and Transplantation RigshospitaletUniversity of CopenhagenDenmark Department of Radiology and Nuclear Medicin RikshospitaletOslo University HospitalOsloNorway Department of Radiology RigshospitaletUniversity of CopenhagenCopenhagenDenmark Department of Surgery Skane University HospitalLundSweden

Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is *** aim of this study was to compare successful resection rates(RR)with upfront ALPPS *** with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ***:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day ***:A total of 189 patients were *** RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on *** sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) liver surgery colorectal liver metastases(CRLM) portal vein embolization(PVE)

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Evidence that chronic hypoxia causes reversible impairment on male fertility

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Asian Journal of Andrology 2008年第4期10卷 602-606页

作者： Vittore Verratti Francesco Berardinelli Camillo Di Giulio Gerardo Bosco Marisa Cacchio Mario Pellicciotta Michele nicolai Stefano Martinotti Raffaele Tenaglia Department of Medicine and Aging Science University of Chieti Chieti 66013 Italy Department of Basic and Applied Medical Sciences University of Chieti Chieti 66013 Italy Biostatistical Office Regina Elena Institute Rome 00144 Italy Laboratorio di Patologia Clinica H University of Chieti Chieti 66013 Italy

Aim： To evaluate the effect of chronic hypoxia on human spermatogenic parameters and their recovery time. Methods： Seminological parameters of six male healthy mountain trekkers were evaluated in normoxia at sea level. After 26 days exposure to altitude （ranging from 2 000 m to 5 600 m, Karakorum Expedition） the same parameters were again evaluated after returning to sea level. These parameters were once again evaluated after 1 month and then again after 6 months. Results： Sperm count was found to be lower immediately after returning to sea level （P = 0.0004） and again after a month （P = 0.0008）. Normal levels were reached after 6 months. Spermatic motility （%） shows no reduction immediately after returning to sea level （P = 0.0583）, whereas after 1 month this reduction was significant （P = 0.0066）. After 6 months there was a recovery to pre-hypoxic exposure values. Abnormal or immature spermatozoa （%） increased immediately after returning to sea level （P = 0.0067） and then again after 1 month （P = 0.0004）. After 6 months there was a complete recovery to initial values. The total number of motile sperm in the ejaculate was found to be lower immediately after returning to sea level （P = 0.0024） and then again after 1 month （P = 0.0021）. After 6 months there was a recovery to pre-hypoxic exposure values. Conclusion： Chronic hypoxia induces a state of oligospermia and the normalization of such seminological parameters at the restoration of previous normoxic conditions after 6 months indicate the influence of oxygen supply in physiological mechanisms of spermatogenesis and male fertility.

关键词： male fertility hypoxia seminological parameters high altitude

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Clinical outcome after orbital floor fracture reduction with special regard to patient's satisfaction

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Chinese Journal of Traumatology 2019年第3期22卷 155-160页

作者： Stefan Hartwig Marie-Christine Nissen Jan Oliver Voss Christian Doll nicolai Adolphs Max Heiland Jan Dirk Raguse Department for Oral and Maxillofacial and Facial Plastic Surgery Johannes Wesling Hospital MindenUniversity Hospital of the Ruhr University BochumGermany Charite-Universitatsmedizin Berlin Corporate Member of Freie Universitat BerlinHumboldt-Universitat zu Berlinand Berlin Institute of HealthDepartment of Oral and Maxillofacial SurgeryGermany

Purpose: Primary reconstruction via transconjunctival approach is a standardized treatment option for orbital floor fractures. The aim of this study was to compare the findings of specific ophthalmologic assessment with the patient's complaints after fracture reduction. Methods: A retrospective medical chart analysis was performed on patients who had undergone transconjunctival orbital floor fracture reduction for fracture therapy with resorbable foil (ethisorb sheet or polydioxanone foil). A follow-up assessment including ophthalmological evaluation regarding visual acuity (eye chart projector), binocular visual field screening (Bagolini striated glasses test) and diplopia (cover test, Hess screen test) was conducted. Additionally, a questionnaire was performed to assess patients' satisfaction. Results: A total of 53 patients with a mean follow-up of 23 months (ranging from 11 to 72) after surgical therapy were included. Diplopia was present preoperatively in 23 (43.4%) and reduced in follow-up examination (n = 12, 22.6%). Limitations in ocular motility reduced from 37.7% to 7.5%. The questionnaire about the patient's satisfaction revealed excellent outcomes in relation to the functional and esthetical parameters. Conclusion: Transconjunctival approach is a safe approach for orbital fracture therapy. Postoperative diplopia is nearly never perceptible for the individual and differs to pathologic findings in the ophthalmic assessment.

关键词： Orbital floor fractures Blow out fractures Transconjunctival approach Clinical outcome

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Endoscopic hemostasis makes the difference:Angiographic treatment in patients with lower gastrointestinal bleeding

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World Journal of Gastrointestinal Endoscopy 2021年第7期13卷 221-232页

作者： David John Werner Till Baar Ralf Kiesslich nicolai Wenzel Nael Abusalim Achim Tresch Johannes Wilhelm Rey Radiologie Rhein-Nahe Krankenhaus am St.MarienwörthBad Kreuznach 55543RLPGermany Department of Radiology Helios Dr.Horst-Schmidt-ClinicGermanyWiesbaden 65199HessenGermany Institute for Medical Statistics and Computational Biology Faculty of MedicineUniversity of CologneGermanyCologne 50923NRWGermany Department of Internal Medicine II Helios Dr.Horst-Schmidt-ClinicWiesbadenGermanyWiesbaden 65199HessenGermany Department of Diagnostic and Interventional Radiology Medical Center HanauGermanyHanau 63450HessenGermany CECAD University of CologneGermanyCologne 50923NRWGermany Center for Data and Simulation Science University of CologneGermanyCologne 50923NRWGermany Department of Gastroenterology and Endoscopy Medical Center OsnabrueckGermanyOsnabrueck 49076NiedersachsenGermany

BACKGROUND The large majority of gastrointestinal bleedings subside on their own or after endoscopic ***,a small number of these may pose a challenge in terms of therapy because the patients develop hemodynamic instability,and endoscopy does not achieve adequate *** radiology supplemented with catheter angiography(CA)and transarterial embolization have gained importance in recent *** To evaluate clinical predictors for angiography in patients with lower gastrointestinal bleeding(LGIB).METHODS We compared two groups of patients in a retrospective *** group had been treated for more than 10 years with CA for LGIB(n=41).The control group had undergone non-endoscopic or endoscopic treatment for two years and been registered in a bleeding registry(n=92).The differences between the two groups were analyzed using decision trees with the goal of defining clear rules for optimal *** Patients in the CA group had a higher shock index,a higher Glasgow-Blatchford bleeding score(GBS),lower serum hemoglobin levels,and more rarely achieved hemostasis in primary *** patients needed more transfusions,had longer hospital stays,and had to undergo subsequent surgery more frequently(P<0.001).CONCLUSION Endoscopic hemostasis proved to be the crucial difference between the two patient *** endoscopic hemostasis,along with GBS and the number of transfusions,would permit a stratification of *** prospective confirmation of the present findings,the use of decision trees would permit the identification of patients at risk for subsequent diagnosis and treatment based on interventional radiology.

关键词： Lower gastrointestinal bleeding Endoscopy Angiography Embolization Computed tomography angiography Intervention

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论德国应用科学大学的发展前景

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应用型高等教育研究 2019年第4期4卷 59-64页

作者： nicolai Müller-Bromley 陈颖(翻译) 奥斯纳布吕克应用科学大学德国奥斯纳布吕克49076

德国应用科学大学自50年前成立以来,已在教学和科研领域成功地奠定了自己的地位,并与行业产业界和社会建立了良好的合作关系。现在面临的最大挑战是,在与传统的综合大学呈趋同发展的形势下,如何进一步突出自己本身的特质,实现特色发展... 详细信息

德国应用科学大学自50年前成立以来,已在教学和科研领域成功地奠定了自己的地位,并与行业产业界和社会建立了良好的合作关系。现在面临的最大挑战是,在与传统的综合大学呈趋同发展的形势下,如何进一步突出自己本身的特质,实现特色发展。应用科学大学迫切需要更多研究资源,特别是要建立有基本资助保障的科研人员队伍、获得独立的博士学位授予权和为教授岗位创设更有吸引力的工作条件。

关键词：德国应用科学大学特色发展挑战

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Unmasking lower gastrointestinal bleeding under administration of norepinephrine

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World Journal of Radiology 2022年第12期14卷 375-383页

作者： David John Werner nicolai Wenzel Nael Abusalim Ralf Kiesslich Till Baar Achim Tresch Johannes Wilhelm Rey Department of Radiology Helios Dr.Horst-Schmidt-ClinicWiesbaden 65199HessenGermany Radiologie Rhein-Nahe Krankenhaus St.MarienwörthBad Kreuznach 55543Rheinland-PfalzGermany Department of Diagnostic and Interventional Radiology Medical Center HanauHanau 63450HessenGermany Department of Internal Medicine II Helios Dr.Horst-Schmidt-ClinicWiesbaden 65199HessenGermany Institute for Medical Statistics and Computational Biology Faculty of MedicineUniversity of CologneCologne 50923Nordrhein-WestfalenGermany Department of Gastroenterology and Endoscopy Medical Center OsnabrueckOsnabrueck 49076NiedersachsenGermany

BACKGROUND Bleeding in the gastrointestinal tract is common and transarterial embolization enables the clinician to control gastrointestinal *** extravasation is a prerequisite for successful *** angiography is helpful in the detection of elusive *** We performed a retrospective analysis of angiographic treatment in patients with lower gastrointestinal hemorrhage and initially negative angiographies,as well as the role of norepinephrine(NE)in unmasking *** We analyzed 41 patients with lower gastrointestinal bleeding after angiography who had undergone treatment over a period of 10 *** patients had a positive shock index and needed intensive *** In three of four patients,angiography disclosed the site of bleeding when NE was used during the procedure for hemodynamic *** We suggest that angiography performed after the administration of NE in unstable patients with gastrointestinal bleeding and an initially negative angiography has the potential to unmask bleeding sites for successful ***,this statement must be confirmed in prospective studies.

关键词： Lower gastrointestinal bleeding Endoscopy Provocative angiography Norepinephrine Radiology Gastrointestinal bleeding

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Magnetic configuration effects on the edge heat flux in the limiter plasma on W7-X measured using the infrared camera and the combined probe

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Plasma Science and Technology 2018年第5期20卷 18-22页

作者： P DREWS H NIEMANN J COSFELD Y GAO J GEIGER O GRULKE M HENKEL D HOSCHEN K HOLLFELD C KILLER A KRAMER-FLECKEN Y LIANG S LIU D nicolai O NEUBAUER M RACK B SCHWEER G SATHEESWARAN L RUDISCHHAUSER N SANDRI N WANG the W7-X Team Forschungszentrum Jtilich GmbH Institut fur Energie-und Klimaforschung PlasmaphysikPartner of the Trilateral Euregio Cluster(TEC)D-52425 JulichGermany Max-Planck-Institut fur Plasmaphysik GreifswaldGermany Forschungszentrum Jtilich GmbH Central Institute for EngineeringElectronics and Analytics/Engineering and Technology(ZEA-1)D-52425 JulichGermany JARA-HPC Germany School of Electrical and Electronic Engineering Huazhong University of Science and TechnologyWuhan 430074People's Republic of China

Controlling the heat and particle fluxes in the plasma edge and on the plasma facing components is important for the safe and effective operation of every magnetically confined fusion *** was attempted on Wendelstein 7-X in the first operational campaign,with the modification of the magnetic configuration by use of the trim coils and tuning the field coil currents,commonly named iota ***,the heat loads on the five limiters are ***,they differ between each limiter and are non-uniform,due to the（relatively small） error fields caused by the misalignment of *** is therefore necessary to study the influence of the configuration changes on the transport of heat and particles in the plasma edge caused by the application of error fields and the change of the magnetic *** this paper the upstream measurements conducted with the combined probe are compared to the downstream measurements with the DIAS infrared camera on the limiter.

关键词： Wendelstein 7-X W7-X plasma edge heat flux limiter

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费欣油画

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丛书名：环球美术家视点系列

2004年

作者：（俄）尼古拉·费欣（nicolai Fechin）绘

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为什么储存药品时必须对环境进行监测?

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流程工业 2022年第7期 52-54页

作者： nicolai Denzel Stefan Prothmann Testo SE&Co.KGaA

药品和医疗器械关乎着人们的健康与生命安全——所以它们从研发到交付的全流程都必须保证万无一失。对此,Testo的数据记录器和不同报警级别的系统可以识别出生产环境的异常,为制药企业保证药品质量提供帮助。与许多其他种类的产品相比,... 详细信息

药品和医疗器械关乎着人们的健康与生命安全——所以它们从研发到交付的全流程都必须保证万无一失。对此,Testo的数据记录器和不同报警级别的系统可以识别出生产环境的异常,为制药企业保证药品质量提供帮助。与许多其他种类的产品相比,医药产品的部分效果受限甚至完全失效并不会立即引起人们的注意。因此“取出-打开-检查-无法使用-送回”这个原则对于药品以及部分医疗器械来说是行不通的。

关键词：制药企业医疗器械数据记录器药品质量完全失效全流程万无一失生命安全

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从“构造”角度解读北欧家具设计

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装饰 2020年第1期 46-57页

作者：朱婕 [丹麦]尼古拉·德·吉尔北京林业大学丹麦皇家建筑艺术设计学院

本文源自丹麦皇家建筑艺术设计学院尼古拉·德·吉尔(nicolai de Gier)教授主编的Chair’s Tectonic一书,笔者作为该书中文版的译者,在深入理解了该论著对于构造概念的阐述后,凝炼撰写了本文,即有关如何从"构造"的角度更深入地理解北欧... 详细信息

本文源自丹麦皇家建筑艺术设计学院尼古拉·德·吉尔(nicolai de Gier)教授主编的Chair’s Tectonic一书,笔者作为该书中文版的译者,在深入理解了该论著对于构造概念的阐述后,凝炼撰写了本文,即有关如何从"构造"的角度更深入地理解北欧家具设计中对于形式、材料、技术三者紧密连接、深刻系统的设计观。本文以最典型的家具类型——椅子为例,从构造的基本释意开始阐述,对椅子的造型、材质、连接方式进行了类型学的归类、分析和概括,带领读者从构造和美学的角度重新审视北欧经典坐具设计作品,从而获得更为系统的设计观。

关键词：构造材料类型学造型连接方式

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