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neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： maria.ne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin CXCR4

SYNTHESIS OF SOLUBLE POLY(3,4-dIHYdROXY-o-TOLYLEne):REdOX POLYMER

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Chinese Journal of Polymer Science 2006年第1期24卷 41-46页

作者： Sad Moulay Fatima M'zyène Laboratoire de Chimie-Physique Moléculaire et macromoléculaire Faculté des Sciences de l'Ingénieur département de Chimie Industrielle Université de BlidaRoute de SoumèaB.P.270Blida 09000Algeria. Laboratoire de Chimie-Physique Moléculaire et macromoléculaire Faculté des Sciences de l'Ingénieur département de Chimie Industrielle Université de BlidaRoute de SoumaB.P.270Blida 09000Algeria.

Conventional chloromethylation, paraformaldehyde/hydrogen chloride in acetic acid medium, was applied to 1,2- dimethoxybenzene. Chloroform-soluble poly（3,4-dimethoxy-o-tolylene） was obta.ned with an intrinsic viscosity of 0.034 dL g^-1. The polymer was evaluated as a condensation redox polymer precursor formed by a Friedel-Crafts reaction. Cleavage of the methoxy groups present in this polymer resulted in poly（3,4-dihydroxy-o-tolylene） which manifested a great air-oxidation resistance. The redox property of the latter polymer was found to be 1017 mV by potentiometric titration with 0.05 N ceric ammonium nitrate at 25℃. This midpotential was compared to that of catechol, a monomeric analogue, under the same titration conditions.

关键词： Poly(3,4-dimethoxy-o-tolylene) Poly(3,4-dihydroxy-o-tolylene) Redox polymer.

Innate and adaptive immune responses toward nanomedicines

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Acta Pharmaceutica Sinica B 2021年第4期11卷 852-870页

作者： Iara maíra de Oliveira Viana Sabrina Roussel Joan defrêne Eliana martins Lima Frédéric Barabé Nicolas Bertrand Laboratory of Pharmaceutical Technology(FarmaTec) Federal University of GoiásGoiás 74605-220Brazil Faculty of Pharmacy UniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada department of Medicine Faculty of MedicineUniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada

Since the commercialization of the frst liposomes used for drug delivery,doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological *** work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more *** nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond *** parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented *** rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune *** review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions.

关键词： Cancer immunotherapy mRNA vaccine Complement activation macrophage In vivo clearance Anti-PEG antibody Nanoparticle mRNA-1273 BNT162b2 Immunology

Impact du traitement carcinologique sur le fonctionnement sexuel et l’image du corps des patientes tunisiennes en rémission d’un cancer du sein localiséImpact of Cancer Treatment on Sexual Functioning and Body Image of Tunisian Patients in Remission from Localized Breast Cancer

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Psycho-Oncologie 2024年第3期18卷 241-248页

作者： Nada Charfi Nour Regaieg Ines Ayadi Najeh Smaoui Rim Feki Imen Gassara Sana Omri Lobna Zouari Jihène Ben Thabet manel maâlej Bouali Afef Khanfir Mohamed maâlej Service de psychiatrie C CHU Hedi ChakerSfax3000Tunisie Service de carcinologie médicale CHU Habib BourguibaSfax3029Tunisie Facultéde médecine de Sfax Universitéde SfaxSfax3029Tunisie

The diagnosis and the management of breast cancer(BC)affect in a complex way women’s sexual lives and touch the symbol of femininity,which is very important in the constitution of the body *** objectives were to assess the sexual functioning and the body image of patients in remission of localized BC,to determine the links between these two parameters,and to study their relationship with the therapeutic *** conducted a cross-sectional,descriptive,and analytical study in the medical oncology and radiotherapy departments of Habib Bourguiba University Hospital Center in Sfax(Tunisia),between February and August *** were assessed based on a clinical information sheet and two psychometric scales exploring sexual functioning and body image:Female Sexual Function Index(FSFI)and Body Image Scale(BIS).The sample comprised 74 patients with a mean age of 51.55 *** were treated by conservative or radical surgery(44.6%and 55.4%,respectively),chemotherapy(87.8%),hormone therapy(79.7%),targeted therapies(36.5%),and radiotherapy(97.3%).A rate of 51.4%of women had sexual dysfunction(Sd),87.8%had hypoactive sexual desire and 36.5%had body image *** body image disorder was significantly associated with dS(p=0.001).The total FSFI score(p=0.001)as well as the subscores of desire(p=0.005),arousal(p=0.003),orgasm(p=0.002),satisfaction(pd pain(0.03)were significantly lower in patients with body image *** presence of a Sd was not associated with any therapeutic *** contrast,the presence of body image disorder was significantly associated with the radical type of surgery(p=0.003)and chemotherapy(p=0.001).Our results showed a relatively high frequency of Sd and body image disorder in women in remission from *** two parameters seem to be closely linked,and this link would be mainta.ned by mastectomy and chemotherapy,which appear to be therapeutic modalities incriminated in the disturbance of body *** the importan

关键词： Breast cancer sexual dysfunction body image Female Sexual Function Index Body Image Scale

Combining two-photon lithography with laser ablation of sacrificial layers:A route to isolated 3d ma.netic nanostructures

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Nano Research 2023年第1期16卷 1441-1447页

作者： Arjen van den Berg Mylène Caruel matthew Hunt Sam Ladak School of Physics and Astronomy Cardiff UniversityCardiffCF243AAUK Institut National des Sciences Appliquées(INSA)of Toulouse 35 Avenue de Rangueil31400 ToulouseFrance

Three-dimensional(3d)nanostructured functional materials are important systems allowing new means for intricate control of electroma.netic properties.A key problem is realising a 3d printing methodology on the nanoscale that can yield a range of functional *** this article,it is shown that two-photon lithography,when combined with laser ablation of sacrificial layers,can be used to realise such a vision and produce 3d functional nanomaterials of complex ***-of-principle is first shown by fabricating planar ma.netic nanowires raised above the substrate that exhibit controlled domain wall injection and ***,3d artificial spin-ice(3dASI)structures are fabricated,whose complex switching can be probed using optical *** show that by careful analysis of the ma.neto-optical Kerr effect signal and by comparison with microma.netic simulations,depth dependent switching information can be obta.ned from the 3dASI *** work paves the way for new materials,which exploit additional physics provided by non-trivial 3d geometries.

关键词： three-dimensional(3d)nanoma.netism 3d lithography 3d artificial spin ice sacrificial layers ma.neto-optical Kerr effect

des entreprises pour stimuler la prospérité commune Cha.ne de solidarité reposant sur le principe d'une redistribution en cascade,la prospérité atteint désormais,les régions les plus reculées

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中国与非洲（法文版） 2022年第3期14卷 22-23页

作者： ma LI 不详

Effect of Soluble Components From Plant Aggregates on the Setting of the Lime-Based Binder

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Journal of Renewable materials 2019年第9期7卷 903-913页

作者： Lepeng Wang Hélène Lenormand Hafida Zmamou Nathalie Leblanc UniLaSalle Transformations&Agro-Resources Research UnitVAM²IN(EA 7519 UniLaSalle-Universitéd’Artois)3 rue du Tronquet76130 Mont-Saint-AignanFrance

Plant aggregate-based building materials are a viable solution for reducing greenhouse gas emissions and providing good thermal and acoustic *** this study,the investigated lightweight mortars require a hydraulic *** and on-site empirical observations about plant aggregate-based materials indicate a delay in setting time and a decrease in the mechanical performances of concretes based on plant *** natural origin of plant-aggregates causes a lot of variability in their *** studies have shown that the incompatibility between plant aggregates and cement is mainly caused by the dissolved and decomposed components of plant aggregates in alkaline ***,no research on the specific impact of each component on the setting time of lime-based binder *** this work,the impact of some soluble compounds(e.g.,sucrose,glucose,fructose,pectin)on the setting reaction of the lime matrix was studied using Vicat test,thermogravimetric analysis(TGA)and FT-IR *** results showed that carbohydrates such as glucose and sucrose not only affect the setting time but also have a long-term impact on the carbonation of *** measure of the setting time by Vicat test appears as a possible indicator to predict the compatibility between the matrix and plant aggregates.

关键词： Plant aggregates setting time lime-based binder carbohydrates hydration

Research of inverse mathematical model to high-speed trains

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Journal of Central South University 2014年第1期21卷 428-438页

作者：朱涛肖守讷马卫华阳光武 Traction Power National Key Laboratory Southwest Jiaotong University

Operation safety and stability of the train mainly depend on the interaction between the wheel and *** of wheel/rail contact force is important for vehicle control systems that aim to enhance vehicle stability and passenger *** wheel/rail contact forces of high-speed train are very difficult to measure directly,a.new estimation process for wheel/rail contact forces was introduced in this *** on the state space equation,dynamic programming methods and the Bellman principle of optimality,the main theoretical derivation of the inversion mathematical model was *** new method overcomes the wea.ness of large fluctuations which exist in current inverse ***-speed vehicle was chosen as the research object,accelerations of axle box as input conditions,10 degrees of freedom vertical vibration model and 17 degrees of freedom lateral vibration model were established,*** 250 km/h,the vertical and lateral wheel/rail forces were *** the time domain and frequency domain,the comparison of the results between inverse and SIMPACK models were *** results show that the inverse mathematical model has high precision for inversing the wheel/rail contact forces of an operation high-speed vehicle.

关键词： load inversion high-speed vehicle wheel/rail contact force derailment index

The Sav-AQ Project:Study of Obstacles and Levers Related to the Use of a Website dedicated to Breast Cancer Patients;the Example of the Nouvelle-Aquita.ne Region

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Psycho-Oncologie 2023年第3期17卷 159-166页

作者： Valérie Berger Hélène Hoarau Florence Saillour Unitéde Recherche et d’Innovation et Soins et en Sciences Huma.nes(URISH) CHU de BordeauxBordeaux33000France Laboratoire Culture et diffusion des Savoirs(CedS) Universitéde BordeauxBordeaux33000France Pôle santépublique Méthodes d’évaluation en santé(UMES) CHU BordeauxBordeaux33000France ISPEd Centre INSERM U1219Bordeaux Population Health–UnitéPHARes FUniversity de BordeauxBordeaux33000France

The development of digital platforms is transforming caregiver-patient interactions and the dissemination of *** information from the Internet has become a habit for many patients and must be considered by ***,understanding the use of digital tools by patients is a public health *** Sav-AQ study aims to understand patterns of use by women with breast cancer and the role of health ***-AQ is an exploratory feasibility study with a mixed design,exploring patient and healthcare experience before and after the integration of a specific website into their care *** research is based on the digital platform“My Breast Cancer network”,which was built by and for patients with breast cancer.A group of 30 breast cancer patients and six healthcare professionals using the platform were *** results show that for all users,the activity on the website decreases over *** the beginning of the course,patients were more assiduous,which can be expla.ned by the search for elements related to an unknown care *** results also show that technical skills to use the platform are necessary for patients and must be accompanied by a health *** is of interest to devise a larger study to assessing the impact of such a platform on patient healthcare uptake and health skills development.

关键词： Breast cancer knowledge transfer interdisciplinarity digital health

LidAR Is Effective in Characterizing Vine Growth and detecting Associated Genetic Loci

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Plant Phenomics 2023年第4期5卷 836-851页

作者： Elsa Chedid Komlan Avia Vincent dumas Lionel Ley Nicolas Reibel Gisèle Butterlin maxime Soma Raul Lopez-Lozano Frédéric Baret didier Merdinoglu Éric duchêne INRAE University of StrasbourgUMR SVQV28rue de Herrlisheim68000 ColmarFrance INRAE UEAV28rue de Herrlisheim68000 ColmarFrance INRAE Aix-Marseille UniversitéUMR RECOVER3275 Route de Cézanne13182 Aix-en-ProvenceFrance INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l'aérodrome84914 AvignonFrance

The strong societal demand to reduce pesticide use and adaptation to climate change challenges the capacities of phenotyping new varieties in the ***-throughput phenotyping is a way to obtain meaningful and reliable information on hundreds of genotypes in a limited *** evaluated traits related to growth in 209 genotypes from an interspecific grapevine biparental cross,between IJ119,a local genitor,and divona,both in summer and in winter,using several methods:fresh pruning wood weight,exposed leaf area calculated from digital images,leaf chlorophyll concentration,and LidAR-derived apparent *** high-density genetic information obta.ned by the genotyping by sequencing technology(GBS),we detected 6 regions of the grapevine genome[quantitative trait loci(QTL)]associated with the variations of the traits in the *** detection of statistically significant QTLs,as well as correlations(R^(2))with traditional methods above 0.46,shows that LidAR technology is effective in characterizing the growth features of the *** calculated with LidAR-derived total canopy and pruning wood volumes were high,above 0.66,and stable between growing *** variables provided genetic models explaining up to 47%of the phenotypic variance,which were better than models obta.ned with the exposed leaf area estimated from images and the destructive pruning weight *** results highlight the relevance of LidAR-derived traits for characterizing genetically induced differences in grapevine growth and open new perspectives for high-throughput phenotyping of grapevines in the vineyard.

关键词： LidAR traits hundreds