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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol na j.jay Liu Young-ju Kim Wangyun Won department of Chemical and Biological Engineering Korea University department of Chemical Engineering (Integrated process) Kyung Hee University department of Chemical Engineering and Materials Science Ewha Womans University department of Chemical Engineering Pukyong National University Resources Engineering Plant Research department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（Lcas）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLlaR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： carbon capture and utilization

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da silva Madeleen jansen van Rensburg Anine Crous Heidi Abrahamse laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 j/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Game changer:How janus kinase inhibitors are reshaping the landscape of ulcerative colitis mana

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World journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio M caballero-Mateos Guillermo Arturo cañadas-de la Fuente department of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain department of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancements in the treatment landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of janus kinase(jAK)-signal transducer and activator of transcription *** novel agents offer a paradigm shift in UC management by targeting key signaling pathways involved in inflammatory *** approved jAK inhibitors(jAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to modulate immune responses and gene expression,potentially revolutionizing the treatment algorithm for *** trials have demonstrated the efficacy of jAKis in inducing and maintaining remission,presenting viable options for patients who have failed conventional ***-world data support the use of jAKis not only as first-line treatments but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of jAKis have broadened the possibilities in the management strategies of UC,offering timely relief for patients with active disease and facilitating personalized treatment *** safety concerns,including cardiovascular risks and infections,ongoing research and post-marketing surveillance will continue to refine our understanding of the risk-benefit profile of jAKis in UC management.

关键词： Ulcerative colitis janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD Program in pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate Program in pathological Anatomy(PPGAP/UFRj) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro Susana Monteiro Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

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Analysis and Modeling of Slope Stability in the Three-Gorges Dam Reservoir (China)——The case of Huangtupo landslide

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journal of Mountain Science 2011年第2期8卷 166-175页

作者： R.COjEAN Y.j.ca Centre de Géosciences Mines-ParisTech Paris France Changjiang Institute of Survey Planning Design & Research CWRC Wuhan China

The water level in the Three Gorges Dam reservoir is expected to change between the elevations of 145 m and 175 m, as a function of the flood control implementation and the intensity of the annual flood. As a matter of fact, the hydraulical and mechanical loadings, related to the water level modifications, will result in alterations in the slope stability conditions. The town of Badong (Hubei), of 20 000 inhabitants, is one of the towns which was submerged by the impoundment of the reservoir. As a consequence, the new town of Badong was constructed on a nearby site which appeared to be partly an unstable site. A part of this site corresponds to an old landslide, the Huangtupo landslide, the base of which had to be submerged by the water of the reservoir. The analysis of the Huangtupo landslide, taking into account various events scenarios, drainage and reinforcement measures and monitoring devices, allows to illustrate the general process implemented all along the reservoir in order to mitigate the landslide hazard.

关键词： Three Gorges Dam landslide Modelling

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Seamount chains and hotspot tracks:Superficially similar,deeply different

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Geoscience Frontiers 2023年第6期14卷 307-326页

作者： Edgardo cañón-Tapia División de Ciencias de la Tierra CICESE.Carretera Ensenada-Tijuana#3985Ensenada Baja CaliforniaCP 22860Mexico

Nearly 80%of the seafloor extension has not been covered by high-resolution bathymetry,impeding direct observation of ***,lists of seamount location and height at a global scale have been produced using different *** this work four of such databases(publicly available)are compared with each other to assess their *** identify large differences among databases that could have exerted strong influences on models of seamount production and associated geodynamic *** those differences,it is shown that all databases allow the identification of seamount lines both along the present-day Mid Ocean Ridge(MOR)system and on intraplate ***,those seamount lines do not coincide with the so-called hotspot tracks that commonly were defined by selectively focusing attention on the larger *** of all the databases also shows that distinction based only on seamount size between seamounts produced at Mid-Ocean Ridge(MOR)environments from those associated with mantle-plum fed-hotspot activity has been ***,combined with the fact that most seamount lines defined by the available databases can be traced back to past locations of MOR indicates that most of the present-day intraplate linear arrays of seamounts,which include some large seamounts,were not produced by the action of underlying mantle anomalies envisaged in the form of mantle *** evidence presented here calls for a reassessment of the form in which volcanic and tectonic activities are conceptually related to each other.

关键词： Seamount origin Chains of seamounts Spatial distribution of volcanism Intraplate volcanism Mid Ocean Ridge volcanism

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Authigenic titanite in weathered basalts: Implications for paleoatmospheric reconstructions

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Geoscience Frontiers 2020年第6期11卷 2183-2196页

作者： Alexey A.Novoselov Dailto silva carlos Roberto de souza Filho Institute of Applied Economic Geology Universidad de ConcepcionConcepcionChile Institute of Geosciences University of CampinasCampinasSPBrazil

The stability of titanite is sensitive to temperature and partial pressure of *** finding of authigenic titanite grains in weathering regolith formed on parana basalts,Brazil,under tropical climatic conditions,reveals the thermodynamically-driven conversion from calcite to titanite at elevated ambient *** unusual nowadays,this phase transition provides important implications for the understanding of silicate weathering in earlier geological *** types of secondary titanites were identified in the weathering profile of the study *** tiny grains of 10 μm are forming in the microscopic voids in the ***,large fractures filled with Fe-rich clay minerals contain bigger specimens of up to 170μ*** titanites of second type often coexist with chalcedony and *** carbonate minerals were found in the weathering *** sphene can be discriminated from other titanite types by its strong positive Eu anomaly,increased Al2 O3 content and low content of trace *** specific chemical composition and reactive transport modeling link this secondary mineral with dissolution of *** titanite precipitation is controlled by slow diffusion in poorly-aerated,highly-alkaline pore *** subaerial weathering of basaltic rocks provides a significant reservoir for atmospheric ***,the deposition of carbonate minerals is thermodynamically avoided at the stability field of *** demonstrate a complex feedback between CO2 and soil *** rise in pCO2 triggers the precipitation of calcite in the weathering regolith,but the greenhouse effect increasing the temperature can cease carbonate *** titanites were found in several paleosols and at least a part of them can be of weathering origin.

关键词： Titanite Sphene calcite paleosols Weathering paleoclimates

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基于计算机视觉的藏式古建筑石砌体壁画墙裂缝生长变形监测

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工程力学 2025年第1期42卷 129-142页

作者：杨娜王烁汪德佳北京交通大学土木建筑工程学院北京100044

对单一背景下裂缝的定期检测研究已取得一定成果，但对复杂背景下裂缝预防性长期生长变形监测的研究尚处于起步阶段。该文综合古建筑壁画墙变形微量和不宜扰动的特点，基于计算机视觉研究了传统图像分割处理技术和裂缝图像智能语义分割... 详细信息

对单一背景下裂缝的定期检测研究已取得一定成果，但对复杂背景下裂缝预防性长期生长变形监测的研究尚处于起步阶段。该文综合古建筑壁画墙变形微量和不宜扰动的特点，基于计算机视觉研究了传统图像分割处理技术和裂缝图像智能语义分割神经网络模型，建立了一套非接触式、预防性生长变形监测系统。为降低壁画墙裂缝特有的彩绘壁画、环境光照及噪声等干扰，有效地将裂缝从复杂背景中分离出来，在传统阈值分割算法系统中，通过SIFT特征匹配和单应性矩阵的求解，解决图像视角差异问题，通过对比不同滤波算法，选择更适用于壁画墙裂缝分割的双边滤波算法与阈值分割相结合的监测算法;在智能语义分割系统中，采用多层卷积、采样和拼接等操作，去除多余特征，重构裂缝高级语义特征图，选择多步优化策略改进原U-Net模型网络架构，提升模型测试平均准确率至0.9899。监测12天典型藏式古建筑石砌体壁画墙裂缝，提取裂缝轮廓及裂缝骨架线等相关特征参数作为关键指标定量描述裂缝生长变化信息，发现：传统阈值分割算法二维特征指标(如裂缝面积、密度、宽度)的变异系数COV值处于4.50%~6.52%，改进的U-Net模型将传统方案中数据波动最大的裂缝面积COV由6.52%降至3.53%，提高了监测系统对壁画色彩、光照和阴影干扰的鲁棒性;系统中两类算法分别处理了不同视角下的同一裂缝的12张图像，输出的数据具备均匀一致性，COV不超过7%，证明了该监测系统为壁画墙裂缝的生长变形提供实时无损监测的技术可行性。

关键词：藏式古建筑壁画墙裂缝阈值分割算法神经网络模型特征参数

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