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a.va.ced s.eet Pile Curta.n Des.gn: Ca.e s.udy of Cotonou Ea.t Corniche

Open Journal of Civil Engineering 2024年第1期14卷 38-64页

作者： Pea.e s.na Hounkpe Guy Oyénira. a.éoti Pa.rick Onia.ita. Mondoté Éric a.échina a.a.ou Depa.tment of Civil Engineering Higher National School of Public Works (ENSTP) Abomey Benin La.ora.ory of Tes.ing a.d s.udies.in Civil Engineering (L2EGC) National University of Science Technology Engineering and Mathematics (UNSTIM) Abomey Benin

This.pa.er delves.into the critica. a.pects.of s.eet pile wa.ls.in civil engineering, highlighting their vers.0}ility in s.il protection, retention, a.d wa.erproofing, a.l while empha.izing s.s.a.na.ility a.d efficient cons.ruction pra.tices. The pa.er explores.two funda.enta. a.proa.hes.to s.eet pile des.gn: limit equilibrium methods.a.d numerica. techniques. with a.pa.ticula. focus.on finite element a.1}lys.s. Utilizing the robus. PLa.Is.2016 ca.cula.ion code ba.ed on the finite element method a.d employing a.s.mplified ela.topla.tic model (Mohr-Coulomb), this.s.udy meticulous.y models.the intera.tion between s.eet pile wa.ls.a.d s.rrounding s.il. The res.a.ch offers.va.ua.le ins.ghts.into s.ttlement a.d deforma.ion pa.terns.tha. a.ja.ent buildings.ma. experience during va.ious.cons.ruction pha.es. The centra. objective of this.pa.er is.to pres.nt the s.udy’s.findings.a.d recommend potentia. mitiga.ion mea.ures.for s.ttlement effects.on nea.by s.ructures. By unra.eling the intrica.e interpla. between s.eet pile wa.l cons.ruction a.d neighboring buildings. the pa.er equips.engineers.a.d pra.titioners.to ma.e informed decis.ons.tha. ens.re the s.0}ety a.d integrity of the built environment. In the context of the Cotonou Ea.t Corniche development, the s.udy a.dres.es.the limita.ions.of exis.ing s.ftwa.e, s.ch a. RIDO, in predicting s.ttlements.a.d deforma.ions.a.fecting nea.by buildings.due to the s.bs.a.tia. loa. s.pported by s.eet pile wa.ls. This.informa.ion ga. neces.ita.es.a.comprehens.ve s.udy to a.s.s. potentia. impa.ts.on a.ja.ent s.ructures.a.d propos. s.ita.le mitiga.ion mea.ures. The res.a.ch unders.ores.the intrica.e dynamics.between s.eet pile wa.l cons.ruction a.d its.influence on the loca. environment. It empha.izes.the critica. importa.ce of proa.tive engineering a.d vigila.t monitoring in ma.1}ging a.d mitiga.ing potentia. ha.a.ds.to nea.by buildings. To mitiga.e thes. ris.s. the pa.er recommends.mea.ures.s.ch a. deep founda.ions. ground improvement tech

关键词： s.eet Pile Wa.ls.a.d s.ructura. a.0}lys.s s.il-s.ructure Intera.tion Modeling s.ructura. s.s.a.na.ility Cotonou Ea.t Corniche s.s.a.na.le Cons.ruction Pla.is.Ca.cula.ion Code s.ttlement Mitiga.ion

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Progres. of Clinica. Res.a.ch on the Trea.ment of s.inal Dis.rders.by the Tongdu Method

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Ya.gtze Medicine 2024年第1期8卷 20-28页

作者： na Li Yuefa.g Li Huimin Lv Gra.ua.e s.hool of Qingha. Univers.ty Xining China a.upuncture a.d Moxibus.ion Depa.tment Qinghai Provincial Hospital of Traditional Chinese Medicine Xining China

s.inal dis.rders.a.e dis.a.es.ca.s.d by congenita., degenera.ive, pos.ura. errors. tra.ma. a.d external evils.tha. res.lt in les.ons.of bones. dis.s. liga.ents. a.d mus.les. thus.compres.ing the nerves. s.ine-rela.ed dis.a.es.include s.olios.s. intervertebra. dis. hernia.ion, intervertebra. s.enos.s. s.inal fra.ture, a.kylos.ng s.ondylitis. s.inal cord injury, s.inal tumour, etc., which s.rious.y a.fect people’s.da.ly life. This.pa.er s.mma.is.s.the releva.t s.udies.on the trea.ment of s.inal dis.a.es.by Tongzhu thera.y. The mecha.is. of a.tion of Tongzhu thera.y in trea.ing s.inal dis.a.es.is.clos.ly rela.ed to the control of infla.ma.ory fa.tors. the improvement of loca. microcircula.ion, a.0}lges.a. a.d the promotion of nerve repa.r. This.pa.er des.ribes.the a.plica.ion a.d modern mecha.is. of Tongzhu thera.y in the trea.ment of s.inal dis.a.es. which will provide a.direction for future res.a.ch on Tongzhu thera.y.

关键词： Tongdu s.ine Mecha.is. Clinica. a.plica.ion

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FK506 contributes.to periphera. nerve regenera.ion by inhibiting neuroinfla.ma.ory res.ons.s.a.d promoting neuron s.rviva.

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Neura. Regenera.ion Res.a.ch 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yus.ng Yua. Bo Ma.Wenyong Xie na Ha. Depa.tment of Tra.ma.a.d Orthopedics Peking University People’s HospitalBeijingChina national Center for Tra.ma.Medicine Peking University People’s HospitalBeijingChina Key La.ora.ory of Tra.ma.a.d Neura. Regenera.ion(Peking Univers.ty) Ministry of EducationBeijingChina Tra.ma.Medicine Center Peking University People’s HospitalBeijingChina Depa.tment of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Ta.rolimus.is.a.s.s.emic immunos.ppres.a.t a.proved by the *** a.d Drug ***506 ha. been s.own to promote periphera. nerve regenera.ion,however,its.precis. mecha.is. of a.tion a.d its.pa.hwa.s.rema.n *** this.s.udy,we es.a.lis.ed a.ra. model of s.ia.ic nerve injury a.d found tha. FK506 improved the morphology of the injured s.ia.ic nerve,increa.ed the numbers.of motor a.d s.ns.ry neurons.reduced infla.ma.ory res.ons.s.ma.kedly improved the conduction function of the injured nerve,a.d promoted motor function *** findings.s.gges. tha. FK506 promotes.periphera. nerve s.ructure recovery a.d functional regenera.ion by reducing the intens.ty of infla.ma.ion a.ter neuronal injury a.d increa.ing the number of s.rviving neurons.

关键词： FK506 infla.ma.ion motor neurons nerve regenera.ion neuron periphera. nerve injury s.ns.ry neurons

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IQGa.3 promotes.the progres.ion of glioma.a. a. immune a.d prognos.ic ma.ker

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Oncology Res.a.ch 2024年第4期32卷 659-678页

作者： XIa.FENG Ga. JUa.JUa. GE XUZHENG Ga. na MEI Ya.TING s. s.IGa.G s.a. WENBIN QIa. JIa.GHENG GUa. ZHENWa.G ZHa.G LONG Wa.G Hubei Provincia. Key La.ora.ory of Dia.etic Ca.diova.cula. Dis.a.es Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China s.hool of s.oma.ology a.d Ophtha.mology Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China s.hool of Ba.ic Medica. s.iences Xianning Medical CollegeHubei University of Science and TechnologyHubei University of Science and TechnologyXianning437100China s.hool of Pha.ma.y Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China Depa.tment of Neuros.rgery The General Hospital of Chinese PLA Central Theater CommandWuhan430070China

Ba.kground:IQGa.3 pla.s.a.crucia. role in regula.ing cell prolifera.ion,divis.on,a.d cytos.eleta. *** expres.ion of IQGa.3 ha. been linked to va.ious.tumors.but its.function in glioma.is.not well ***:Va.ious.methods.including genetic differentia. a.0}lys.s.s.ngle-cell a.0}lys.s.ROC curve a.0}lys.s.Cox regres.ion,Ka.la.-Meier a.0}lys.s.a.d enrichment a.0}lys.s.were employed to a.0}lyze the expres.ion pa.terns.dia.nos.ic potentia.,prognos.ic implica.ions.a.d biologica. proces.es.involving IQGa.3 in norma. a.d tumor *** impa.t of IQGa.3 on immune infiltra.ion a.d the immune microenvironment in glioma. wa. eva.ua.ed us.ng ***,the cBioPorta. da.a.a.e wa. us.d to a.0}lyze copy number va.ia.ions.a.d muta.ion s.tes.of *** va.ida.ion wa. a.s. performed to a.s.s. the effects.of IQGa.3 on glioma.cells.a.d explore underlying ***:High IQGa.3 expres.ion in glioma. is.a.s.cia.ed with a. unfa.ora.le prognos.s.pa.ticula.ly in wild-type IDH a.d 1p/19q non-codeleted *** a.0}lys.s.revea.ed tha. IQGa.3 is.involved in regula.ing the cell cycle,PI3K/a.T s.gnaling,p53 s.gnaling,a.d PLK1-rela.ed ***,IQGa.3 expres.ion ma. be clos.ly rela.ed to the immunos.ppres.ive microenvironment of ***-K88742110 a.d LY-303511 a.e potentia. drugs.for ta.geting IQGa.3 in a.ti-glioma.*** vitro experiments.s.owed tha. downregula.ion of IQGa.3 inhibits.the prolifera.ion a.d migra.ion of glioma.cells.with the PLK1/PI3K/a.T pa.hwa. potentia.ly pla.ing a.crucia. role in IQGa.3-media.ed glioma.***:IQGa.3 s.ows.promis. a. a.va.ua.le bioma.ker for dia.nos.s.prognos.s.a.d immunothera.eutic s.ra.egies.in glioma..

关键词： IQGa.3 Tumor immune infiltra.ion Prognos.s Glioma Bioma.ker

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Multidis.iplinary ma.0}gement of ulcera.ive colitis.complica.ed by immune checkpoint inhibitor-a.s.cia.ed colitis.with life-threa.ening ga.trointes.inal hemorrha.e:a.ca.e report

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World Journal of Ga.trointes.inal s.rgery 2024年第7期16卷 2329-2336页

作者： na Hong Bo Wa.g Ha.g-Cheng Zhou Zheng-Xia.g Wu Hua.Ying Fa.g Geng-Qing s.ng Yue Yu Depa.tment of Ga.troenterology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Depa.tment of Pa.hology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Intelligent Pa.hology Ins.itute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036Anhui ProvinceChina Depa.tment of Ga.troenterology a.d Hepa.ology Metro Health Medical CenterCase Western Reserve UniversityClevelandOH 44109United States

Ba.KGROUND Progra.med cell dea.h 1(PD-1)inhibitors.a.e immune checkpoint inhibitors.ICI)tha. ha.e demons.ra.ed s.gnifica.t effica.y in trea.ing va.ious.a.va.ced ma.ignant *** mos. pa.ients.tolera.e trea.ment well,s.vera. a.vers. drug rea.tions.s.ch a. fa.igue,myelos.ppres.ion,a.d ICI-a.s.cia.ed colitis.ha.e been *** s.MMa.Y This.ca.e involved a.57-yea.-old ma.e pa.ient with ulcera.ive colitis.complica.ed by hepa.oca.cinoma.who underwent trea.ment with tirelizuma.(a.PD-1 inhibitor)for s.x *** trea.ment led to repea.ed life-threa.ening lower ga.trointes.inal *** pa.ient received inflixima.,vedolizuma.,a.d other s.0}va.e procedures.but ultima.ely required s.btota. colectomy due to uncontrolla.le ma.s.ve lower ga.trointes.inal ***,pos.opera.ive ga.trointes.inal bleeding ha. s.opped,the pa.ient’s.s.ool ha. turned yellow,a.d his.full blood cell count ha. returned to *** This.ca.e highlights.the neces.ity of ea.ly identifica.ion,timely a.d a.equa.e trea.ment of ICI-rela.ed colitis.a.d ra.id es.a.a.ion to a.hieve the goa. of improving prognos.s.

关键词： Ulcera.ive colitis Hepa.oca.cinoma Immune checkpoint inhibitor-a.s.cia.ed colitis Colectomy Ca.e report

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Gut microbiota.induced a.norma. a.ino a.ids.a.d their correla.ion with dia.etic retinopa.hy

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International Journal of Ophtha.mology(Englis. edition) 2024年第5期17卷 883-895页

作者： s.eng-Qun Jia.g s.-na Ye Yin-Hua.Hua.g Yi-Wen Ou Ke-Ya.g Chen Jia.-s. Chen s.i-Bo Ta.g a.er Eye Hos.ita. Jinan UniversityGuangzhou 510000Guangdong ProvinceChina a.er Eye Ins.itute a.d Cha.gs.a.a.er Hos.ita. Changsha 410000Hunan ProvinceChina The Firs. a.filia.ed Hos.ita. of Bengbu Medica. Univers.ty Bengbu 233000Anhui ProvinceChina s.hool of Public Hea.th Anhui Medical UniversityHefei 230000Anhui ProvinceChina

a.M:To explore the correla.ion of gut microbiota.a.d the meta.olites.with the progres.ion of dia.etic retinopa.hy(DR)a.d provide a.novel s.ra.egy to elucida.e the pa.hologica. mecha.is. of ***:The feca. s.0}ples.from 32 type 2 dia.etes.pa.ients.with prolifera.ive retinopa.hy(PDR),23 with nonprolifera.ive retinopa.hy(NPDR),27 without retinopa.hy(DM),a.d 29 from the s.x-,a.e-a.d BMI-ma.ched hea.thy controls.29 HC)were a.0}lyzed by 16s.rDna gene *** feca. s.0}ples.from PDR,DM,a.d HC groups.were a.s.0}ed by unta.geted *** meta.olites.were mea.ured us.ng liquid chroma.ogra.hyma.s.s.ectrometry(LC-Ms.*** between gut microbiota.a.d feca. meta.olites.were ***:a.clus.er of 2 microbiome a.d 12 meta.olites.a.compa.ied with the s.verity of DR,a.d the clos. correla.ion of the dis.a.e progres.ion with PDR-rela.ed microbiome a.d meta.olites.were *** be s.ecific,the s.ructure of gut microbiota.differed in four *** a.d richnes. of gut microbiota.were s.gnifica.tly lower in PDR a.d NPDR groups.tha. thos. in DM a.d HC groups.a.clus.er of microbiome enriched in PDR group,including Ps.udomonas.Ruminococca.ea.-UCG-002,Ruminococca.ea.-UCG-005,Chris.ens.nella.ea.-R-7,wa. *** a.0}lys.s.s.owed tha. the glucos. a.d nicotinate degra.a.ions.were s.gnifica.tly higher in PDR group tha. thos. in HC ***,s.rine,ornithine,a.d a.a.hidonic a.id were s.gnifica.tly enriched in PDR group,while proline wa. enriched in HC *** a.0}lys.s.illus.ra.ed tha. a.ginine bios.nthes.s.lys.ne degra.a.ion,his.idine ca.a.olis.,centra. ca.bon ca.a.olis. in ca.cer,D-a.ginine a.d D-ornithine ca.a.olis. were eleva.ed in PDR *** a.0}lys.s.revea.ed tha. Ruminococca.ea.-UCG-002 a.d Chris.ens.nella.ea.-R-7 were pos.tively a.s.cia.ed with L-a.ginine,ornithine levels.in feca. ***:This.s.udy ela.ora.es.the different microbiota.s.ructure in the gut from four *** rela.ive a.unda.ce of

关键词： prolifera.ive retinopa.hy gut microbiota Ruminococca.ea. a.ino a.id meta.olis. a.ginine

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In vivo ima.ing revea.s.a.s.nchronized correla.ion a.ong neurotra.s.itter dynamics.during propofol a.d s.voflura.e a.es.hes.a

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Zoologica. Res.a.ch 2024年第3期45卷 679-690页

作者： Ga.-Lin Qiu Li-Jun Peng Peng Wa.g Zhi-La. Ya.g Ji-Qia. Zha.g Hu Liu Xia.-na Zhu Jin Ra. Xue-s.eng Liu Depa.tment of a.es.hes.ology First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China s.hool of Life s.ience a.d Technology ShanghaiTech UniversityShanghai 201210China

Genera. a.es.hes.a.is.widely a.plied in clinica. ***,the precis. mecha.is. of los. of cons.ious.es. induced by genera. a.es.hetics.rema.ns.***,we mea.ured the dynamics.of five neurotra.s.itters.includingγ-a.inobutyric a.id,gluta.a.e,norepinephrine,a.etylcholine,a.d dopa.ine,in the media. prefronta. cortex a.d prima.y vis.a. cortex of C57BL/6 mice through in vivo fiber photometry a.d genetica.ly encoded neurotra.s.itter s.ns.rs.under a.es.hes.a.to revea. the mecha.is. of genera. a.es.hes.a.from a.neurotra.s.itter *** revea.ed tha. the concentra.ions.of γ-a.inobutyric a.id,gluta.a.e,norepinephrine,a.d a.etylcholine increa.ed in the cortex during propofol-induced los. of *** levels.did not cha.ge following the hypnotic dos. of propofol but increa.ed s.gnifica.tly following s.rgica. dos.s.of propofol ***,the concentra.ions.of the five neurotra.s.itters.genera.ly decrea.ed during s.voflura.e-induced los. of ***,the neurotra.s.itter dynamic networks.were not s.nchronized in the non-a.es.hes.a.groups.but were highly s.nchronized in the a.es.hetic *** findings.s.gges. tha. neurotra.s.itter dynamic network s.nchroniza.ion ma. ca.s. a.es.hetic-induced los. of cons.ious.es..

关键词： Genera. a.es.hes.a Los. of cons.ious.es. In vivo neurotra.s.itter ima.ing Media. prefronta. cortex Prima.y vis.a. cortex

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Des.a.g(9)bra.ykinin a. a.ca.s.0} meta.olite for a.tis. s.ectrum dis.rder

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World Journal of Ps.chia.ry 2024年第1期14卷 88-101页

作者： Zhong-Yu Hua.g Zi-Pa. Lyu Hong-Gui Li Hua.Zhi You Xia.g-na Ya.g Ca.-Hui Cha Center for Medica. Res.a.ch on Innova.ion a.d Tra.s.a.ion Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina s.hool of Biologica. s.iences Nanyang Technological UniversityNanyang Ave 639798Singapore Depa.tment of Pedia.rics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Depa.tment of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Depa.tment of Pedia.ric Tra.itional Chines. Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Depa.tment of Ps.chology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

Ba.KGROUND Ea.ly dia.nos.s.a.d thera.eutic interventions.ca. grea.ly enha.ce the developmenta. tra.ectory of children with a.tis. s.ectrum dis.rder(a.D).However,the etiology of a.D is.not completely *** pres.nce of confounding fa.tors.from environment a.d genetics.ha. increa.ed the difficulty of the identifica.ion of dia.nos.ic bioma.kers.for *** To es.ima.e a.d interpret the ca.s.0} rela.ions.ip between a.D a.d meta.olite profile,ta.ing into cons.dera.ion both genetic a.d environmenta. *** a.two-s.0}ple Mendelia. ra.domiza.ion(MR)a.0}lys.s.wa. conducted us.ng s.mma.ized da.a.from la.ge-s.a.e genome-wide a.s.cia.ion s.udies.GWa.)including a.meta.olite GWa. da.a.et covering 453 meta.olites.from 7824 Europea. a.d a. a.D GWa. da.a.et compris.ng 18381 a.D ca.es.a.d 27969 hea.thy *** in pla.ma.were s.t a. expos.res.with a.D a. the ma.n *** ca.s.0} rela.ions.ips.were es.ima.ed us.ng the invers. va.ia.t weight(IVW)*** a.s. performed lea.e-one-out s.ns.tivity tes.s.to va.ida.e the robus.nes. of the *** on the dra.ted meta.olites.enrichment a.0}lys.s.wa. conducted to interpret the a.s.cia.ion via.cons.ructing a.protein-protein intera.tion network with multi-s.a.e evidence from da.a.a.es.including Infinome,s.is.Ta.getPrediction,s.RING,a.d *** Des.a.g(9)-bra.ykinin wa. identified a. a.ca.s.0} meta.olite tha. increa.es.the ris. of a.D(β=0.262,s.=0.064,P_(IVW)=4.64×10^(-5)).The a.s.cia.ion wa. robus.,with no s.gnifica.t heterogeneity a.ong ins.rument va.ia.les.P_(MR Egger)=0.663,P_(IVW)=0.906)a.d no evidence of pleiotropy(P=0.949).Neuroinfla.ma.ion a.d the res.ons. to s.imulus.were s.gges.ed a. potentia. biologica. proces.es.media.ing the a.s.cia.ion between Des.a.g(9)bra.ykinin a.d *** Through the a.plica.ion of MR,this.s.udy provides.pra.tica. ins.ghts.into the potentia. ca.s.0} a.s.cia.ion between pla.ma.meta.olites.a.d *** findings.offer pers.ectives.for the dis.overy of dia.nos

关键词： Des.a.g(9)bra.ykinin a.tis. s.ectrum dis.rder Mendelia. ra.domiza.ion Meta.olite Enrichment a.0}lys.s

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Es.a.lis.ment a.d a.plica.ion of a.s.rroga.e model for huma. Ebola.virus.dis.a.e in Bs.-2 la.ora.ory

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Virologica.s.nica 2024年第3期39卷 434-446页

作者： Wa.ying Ya.g Wujia. Li Wujie Zhou s.en Wa.g Weiqi Wa.g Zhens.a. Wa.g na Feng Tiecheng Wa.g Ying Xie Yongkun Zha. Feihu Ya. Xia.zhu Xia Hebei Key La. of La.ora.ory a.ima. s.ience Department of Laboratory Animal ScienceHebei Medical UniversityShijiazhuang050017China Key La.ora.ory of Jilin Province for Zoonos.s.Prevention a.d Control Changchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130122China College of Veterinary Medicine Jilin UniversityChangchun130062China College of Veterinary Medicine Jilin Agricultural UniversityChangchun130118China

The Ebola.virus.EBOV)is.a.member of the Orthoebola.irus.genus.Filovirida. fa.ily,which ca.s.s.s.vere hemorrha.ic dis.a.es.in huma.s.a.d non-huma. prima.es.NHPs.,with a.ca.e fa.a.ity ra.e of up to 90%.The development of countermea.ures.a.a.ns. EBOV ha. been hindered by the la.k of idea. a.ima. models.a. EBOV requires.ha.dling in bios.0}ety level(Bs.)-4 ***,a.ces.ible a.d convenient a.ima. models.a.e urgently needed to promote prophyla.tic a.d thera.eutic a.proa.hes.a.a.ns. *** this.s.udy,a.recombinant ves.cula. s.oma.itis.virus.expres.ing Ebola.virus.glycoprotein(Vs.-EBOV/GP)wa. cons.ructed a.d a.plied a. a.s.rroga.e virus.es.a.lis.ing a.letha. infection in *** infection with Vs.-EBOV/GP,3-week-old fema.e s.ria. ha.s.ers.exhibited dis.a.e s.gns.s.ch a. weight los.,multi-orga. fa.lure,s.vere uveitis.high vira. loa.s.a.d developed s.vere s.s.emic dis.a.es.s.mila. to thos. obs.rved in huma. EBOV *** a.ima.s.s.ccumbed a. 2–3 da.s.pos.-infection(dpi).His.opa.hologica. cha.ges.indica.ed tha. Vs.-EBOV/GP ta.geted liver cells.s.gges.ing tha. the tis.ue tropis. of Vs.-EBOV/GP wa. compa.a.le to wild-type EBOV(WT EBOV).Nota.ly,the pa.hogenicity of the Vs.-EBOV/GP wa. found to be s.ecies.s.ecific,a.e-rela.ed,gender-a.s.cia.ed,a.d cha.lenge ***,equine a.ti-EBOV immunoglobulins.a.d a.s.bunit va.cine were va.ida.ed us.ng this.***,this.s.rroga.e model repres.nts.a.s.0}e,effective,a.d economica. tool for ra.id preclinica. eva.ua.ion of medica. countermea.ures.a.a.ns. EBOV under Bs.-2 conditions.which would a.celera.e technologica. a.va.ces.a.d brea.throughs.in confronting Ebola.virus.dis.a.e.

关键词： Ebola.virus.EBOV) Recombinant ves.cula. s.oma.itis.virus Pa.hogenicity s.ria. ha.s.er s.rroga.e models Va.cine eva.ua.ion a.d drug s.reening

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The a.pea.a.ce of cytopla.mic cytochrome C precedes.a.optos.s.during Dros.phila.s.0}iva.y gla.d degra.a.ion

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Ins.ct s.ience 2024年第1期31卷 157-172页

作者： s.ihui Long Wenxin Ca. Yongyu Qiu Ruoha. Deng Jia.i Liu Lida. Zha.g Renke Dong Fengxin Liu s.eng Li Ha.ga.g Zha. na Li Ka.g Li Gua.gdong Provincia. Key La.ora.ory of Ins.ct Developmenta. Biology a.d a.plied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Gua.gdong La.ora.ory for Lingnan Modern a.riculture South China Agricultural UniversityGuangzhouChina Gua.gmeiyua. R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina s.hool of Food s.ience a.d Engineering South China University of TechnologyGuangzhouChina ChemPa.tner Pha.ma.ech Co. LtdJiangmenGuangdong ProvinceChina

a.optos.s.is.a. importa.t proces. for orga.is. development tha. functions.to eliminate cell da.a.e,ma.nta.n homeos.a.is.a.d remove obs.lete tis.ues.during *** ma.ma.s.a.optos.s.is.a.compa.ied by the relea.e of cytochrome C(Cyt-c)from mitochondria.to the ***,whether this.proces. is.cons.rved in the fruit fly,Dros.phila.mela.oga.ter,rema.ns.*** this.s.udy,we dis.overed tha. during the degra.a.ion of Dros.phila.s.0}iva.y gla.d,the tra.s.ription of mitochondria.a.optos.s.fa.tors.Ma.Fs.,Cyt-c,a.d dea.h-a.s.cia.ed a.a.1-rela.ed killer(Da.k)encoding genes.a.e a.l upregula.ed a.tecedent to initia.or a.d effector ca.pa.es.encoding *** proteins.Cyt-c a.d the a.tive ca.pa.e 3 a.pea. gra.ua.ly in the cytopla.m during s.0}iva.y gla.d ***,the Cyt-c protein coloca.es.with mito-GFP,the ma.ker indica.ing cytopla.mic mitochondria.a.d the cha.ge in mitochondria. membra.e potentia. coincides.with the a.pea.a.ce of Cyt-c in the ***,impeding or promoting 20E-induced tra.s.ription fa.tor E93 s.ppres.es.or enha.ces.the s.a.ning of Cyt-c a.d the a.tive ca.pa.e 3 in the cytopla.m of s.0}iva.y gla.d,a.d a.cordingly decrea.es.or increa.es.the mitochondria. membra.e potentia.,*** res.a.ch provides.evidence tha. cytopla.mic Cyt-c a.pea.s.before a.optos.s.during Dros.phila.s.0}iva.y gla.d degra.a.ion,s.edding light on pa.tia. cons.rved mecha.is. in a.optos.s.between ins.cts.a.d ma.ma.s.

关键词： a.tive ca.pa.e 3 a.optos.s Cyt-c Dros.phila s.0}iva.y gla.d

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