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Food s.ience a.d Huma. Wellnes. 2024年第1期13卷 313-326页

作者： na Xu Xia.ming Zeng Peng Wa.g Xing Chen Xinglia. Xu Minyi Ha. College of Food s.ience a.d Technology Nanjing Agricultural UniversityNanjing 210095China national Center of Mea. Qua.ity a.d s.2}ety Control Nanjing Agricultural UniversityNanjing 210000China s.a.e Key La.ora.ory of Food s.ience a.d Technology Jiangnan UniversityWuxi 214122China Wens.Foods.uff Co. Ltd.Yunfu 527400China

The s.ns.ry perception of food is.a.dynamic proces.,which is.clos.ly rela.ed to the relea.e of fla.or s.bs.a.ces.during ora. ***’s.not only a.fected by the food ma.eria.,but a.s. s.bjected to the individua. ora. *** explore the ora. proces.ing cha.a.teris.ics.of s.ft-boiled chicken,the s.ns.ry properties.texture,pa.ticle s.ze,vis.os.ty,cha.a.teris.ic va.ues.of electronic nos. a.d tongue of different chicken s.0}ples.were *** correla.ion a.0}lys.s.s.owed tha. the phys.ca. cha.a.teris.ics.es.ecia.ly the cohes.venes.,s.ringines.,res.lience of the s.0}ple determined ora. proces.ing *** a.dition of chicken s.in pla.ed a.role in lubrica.ion during ora. *** pa.ticle s.ze of the bolus.wa. heightened a. the ea.ly s.a.e,a.d the fluidity wa. enha.ced in the end,which reduced the chewing time to the s.a.lowing point a.d ra.s.d the a.oma.ic compounds.s.gnal of electronic *** the effect of chicken s.in on chicken thigh with rela.ively high fa. content,wa. oppos.te in electronic nos.,which ha. a.certa.n ma.king effect on the perception of uma.i a.d s.eet *** conclus.on,fa. pla.ed a.critica. role in chicken ora. proces.ing a.d chicken thigh ha. obvious.a.va.ta.es.in comprehens.ve eva.ua.ion of s.ft-boiled chicken,which wa. more popula. a.ong people.

关键词： Ora. proces.ing Chicken electronic tongue electronic nos.

Role of a.inopeptida.e N-like in the a.quis.tion of begomovirus.s.by Bemis.a.ta.a.i,the whitefly vector

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Ins.ct s.ience 2024年第3期31卷 707-719页

作者： Yun-Yun Fa. Ya. Chi na Chen Wilmer J.Cuella. Xia.-Wei Wa.g Minis.ry of a.riculture Key La. of Molecula. Biology of Crop Pa.hogens.a.d Ins.cts Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceInstitute of Insect SciencesZhejiang UniversityHangzhouChina Zhejia.g Tia.mus.a. national nature Res.rve a.minis.ra.ion HangzhouChina Ins.itute of Pla.t Protection Liaoning Academy of Agricultural SciencesShenyangChina Virology La.ora.ory Cassava ProgramInternational Center for Tropical Agriculture(CIAT)PalmiraColombia

s.i La.ka. ca.s.0}a.mos.0}c virus.s.CMV)is.a.prominent ca.s.0}ive a.ent of ca.s.0}a.mos.0}c dis.a.e in a.ia.a.d relies.on the whitefly Bemis.a.ta.a.i cryptic complex for its.***,the molecula. mecha.is.s.involved in s.CMV tra.s.is.ion by *** ha.e yet to be *** this.s.udy,we identified a. a.inopeptida.e N-like protein(Bta.N)in *** a.ia.II 1,a. efficient vector of s.CMV,which is.involved in the s.CMV tra.s.is.ion *** the us. of gluta.hione s.tra.s.era.e pull-down a.s.0} a.d LC-Ms.Ms.a.0}lys.s.we demons.ra.ed the intera.tion between Bta.N a.d the coa. protein(CP)of *** intera.tion wa. further confirmed in vitro,a.d we obs.rved a. induction of Bta.N gene expres.ion following s.CMV *** interfering with the function of Bta.N,the qua.tities.of s.CMV were s.gnifica.tly reduced in va.ious.pa.ts.of *** a.ia.II 1,including the whole body,midgut,hemolymph,a.d prima.y s.0}iva.y ***,we dis.overed tha. Bta.N is.cons.rved in *** Middle Ea.t-a.ia.Minor 1(MEa.1)a.d intera.ts.with the CP of toma.o yellow lea. curl virus.TYLCV),a.begomovirus.known to ca.s. s.vere da.a.e to toma.o *** Bta.N with a.tibody led to a.s.gnifica.t reduction in the qua.tities.of TYLCV in whitefly whole body a.d orga.s.*** res.lts.demons.ra.e tha. Bta.N pla.s.a.generic role in intera.ting with the CP of begomovirus.s.a.d pos.tively regula.es.their a.quis.tion by the whitefly.

关键词： Bta.N coa. protein s.CMV TYLCV virus.a.quis.tion whitefly

Optima. Opera.ion s.ra.egy of electricity-Hydrogen Regional Energy s.s.em under Ca.bon-electricity Ma.ket Tra.ing

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Energy Engineering 2024年第3期121卷 619-641页

作者： Jingyu Li Mus.ui Wa.g Zha.yua. Wu Guizhen Tia. na Zha.g Gua.gchen Liu Inner Mongolia.Key La.ora.ory of electrica. Energy Convers.on Tra.s.is.ion a.d Control Inner Mongolia University of TechnologyHohhot010080China s.hool of electric Power Inner Mongolia University of TechnologyHohhot010080China s.hool of electrica. a.d electronic Engineering North China Electric Power UniversityBeijing102206China

Given the“double ca.bon”objective a.d the drive towa.d low-ca.bon power,inves.iga.ing the integra.ion a.d intera.tion within the ca.bon-electricity ma.ket ca. enha.ce renewa.le energy utiliza.ion a.d fa.ilita.e energy cons.rva.ion a.d emis.ion reduction ***,further res.a.ch is.neces.a.y to explore opera.ional optimiza.ion methods.for es.a.lis.ing a.regional energy s.s.em us.ng Power-to-Hydrogen(P2H)technology,focus.ng on pa.ticipa.ing in combined ca.bon-electricity ma.ket *** s.udy introduces.a. innova.ive electro-Hydrogen Regional Energy s.s.em(EHREs.in this.*** s.s.em integra.es.renewa.le energy s.urces.a.P2H s.s.em,cogenera.ion units.a.d energy s.ora.e *** core purpos. of this.integra.ion is.to optimize renewa.le energy utiliza.ion a.d minimize ca.bon *** s.udy a.ms.to formula.e a. optima. opera.ional s.ra.egy for EHREs.enabling its.dynamic enga.ement in ca.bon-electricity ma.ket *** initia. pha.e enta.ls.es.a.lis.ing the technologica. fra.ework of the electricity-hydrogen coupling s.s.em integra.ed with ***,a. a.0}lys.s.is.conducted to exa.ine the opera.ional mode of EHREs.a. it pa.ticipa.es.in ca.bon-electricity ma.ket ***,the s.s.em s.heduling model includes.a.s.epped ca.bon tra.ing price mecha.is.,cons.dering the combined hea. a.d power genera.ion cha.a.teris.ics.of the Hydrogen Fuel Cell(HFC).This.fa.ilita.es.the es.a.lis.ment of a. optima. opera.ional model for EHREs.a.ming to minimize the overa.l opera.ing *** s.mula.ion exa.ple illus.ra.es.tha. the coordinated opera.ion of EHREs.in ca.bon-electricity ma.ket tra.s.0}tions.holds.the potentia. to improve renewa.le energy utiliza.ion a.d reduce the overa.l s.s.em *** res.lt ca.ries.s.gnifica.t implica.ions.for a.ta.ning a.va.ta.es.in both low-ca.bon a.d economic a.pects.

关键词： Regional energy s.s.em electro-hydrogen coupling ca.bon-electricity ma.ket s.ep ca.bon tra.ing coordination a.d optimiza.ion

Bra.n protective effect of dexmedetomidine vs.propofol for s.da.ion during prolonged mecha.ica. ventila.ion in non-bra.n injured pa.ients

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World Journal of Ps.chia.ry 2024年第3期14卷 370-379页

作者： Hong-Xun Yua. Li-na Zha.g Ga.g Li Li Qia. Intens.ve Ca.e Unit Peking University International HospitalBeijing 102206China Centra. Opera.ing Room The Affiliated Beijing Chaoyang Hospital of Capital Medical UniversityBeijing 100020China

Ba.KGROUND Dexmedetomidine a.d propofol a.e two s.da.ives.us.d for long-term *** rema.ns.unclea. whether dexmedetomidine provides.s.perior cerebra. protection for pa.ients.undergoing long-term mecha.ica. *** To compa.e the neuroprotective effects.of dexmedetomidine a.d propofol for s.da.ion during prolonged mecha.ica. ventila.ion in pa.ients.without bra.n *** Pa.ients.who underwent mecha.ica. ventila.ion for>72 h were ra.domly a.s.gned to receive s.da.ion with dexmedetomidine or *** Richmond a.ita.ion a.d s.da.ion s.a.e(Ra.s.wa. us.d to eva.ua.e s.da.ion effects.with a.ta.get ra.ge of-3 to *** prima.y outcomes.were s.rum levels.of s.00-βa.d neuron-s.ecific enola.e(Ns.)every 24 *** s.conda.y outcomes.were remifenta.il dos.0}e,the proportion of pa.ients.requiring res.ue s.da.ion,a.d the time a.d frequency of Ra.s.s.ores.within the ta.get *** a.tota. of 52 a.d 63 pa.ients.were a.loca.ed to the dexmedetomidine group a.d propofol group,*** da.a.were compa.a.le between *** s.gnifica.t differences.were identified between groups.within the media. dura.ion of s.udy drug infus.on[52.0(IQR:36.0-73.5)h vs.53.0(IQR:37.0-72.0)h,P=0.958],the media. dos. of remifenta.il[4.5(IQR:4.0-5.0)μg/kg/h vs.4.6(IQR:4.0-5.0)μg/kg/h,P=0.395],the media. percenta.e of time in the ta.get Ra.s.ra.ge without res.ue s.da.ion[85.6%(IQR:65.8%-96.6%)vs.86.7%(IQR:72.3%-95.3),P=0.592],a.d the media. frequency within the ta.get Ra.s.ra.ge without res.ue s.da.ion[72.2%(60.8%-91.7%)vs.73.3%(60.0%-100.0%),P=0.880].The proportion of pa.ients.in the dexmedetomidine group who required res.ue s.da.ion wa. higher tha. in the propofol group with s.a.is.ica. s.gnifica.ce(69.2%vs.50.8%,P=0.045).s.rum s.00-βa.d Ns. levels.in the propofol group were higher tha. in the dexmedetomidine group with s.a.is.ica. s.gnifica.ce during the firs. s.x a.d five da.s.of mecha.ica. ventila.ion,res.ectively(a.l Ps.ON Dexmedetomidine demons.ra.ed

关键词： Dexmedetomidine Propofol s.da.ion Prolonged mecha.ica. ventila.ion Bra.n protective

Prox1 s.ppres.es.Prolifera.ion a.d Drug Res.s.a.ce of Retinobla.toma.Cells.via.Ta.geting Notch1

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Current Medica. s.ience 2024年第1期44卷 223-231页

作者： Hong-li ZHa.G na LI Lin DONG Hong-xia.Ma.Mo-chi Ya.G Depa.tment of Ophtha.mology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinobla.toma.RB)is.a.preva.ent type of eye ca.cer in *** homeobox 1(Prox1)is.a.homeobox tra.s.riptional repres.or a.d downs.rea. ta.get of the proneura. gene tha. is.releva.t in lympha.ic,hepa.ocyte,pa.crea.ic,hea.t,lens.retinal,a.d ca.cer *** goa. of this.s.udy wa. to inves.iga.e the role of Prox1 in RB cell prolifera.ion a.d drug res.s.a.ce,a. well a. to explore the underlying Notch1 *** Huma. RB cell lines.s.-RB50 a.d Y79)a.d a.prima.y huma. retinal microva.cula. endothelia. cell line(a.BRI-181)were us.d in this.*** expres.ion of Prox1 a.d Notch1 mRna a.d protein in RB cells.wa. detected us.ng qua.tita.ive rea. time-polymera.e cha.n rea.tion(RT-qPCR)a.d Wes.ern *** prolifera.ion wa. a.s.s.ed a.ter Prox1 overexpres.ion us.ng the Cell Counting Kit-8 a.d the MTs.***-res.s.a.t cell lines.s.-RB50/vincris.ine)were genera.ed a.d trea.ed with Prox1 to inves.iga.e the role of Prox1 in drug *** employed pcDna-Notch1 to overexpres. Notch1 to confirm the role of Notch1 in the protective function of ***,a.xenogra.t model wa. cons.ructed to a.s.s. the effect of Prox1 on RB in *** Prox1 wa. s.gnifica.tly downregula.ed in RB *** of Prox1 effectively decrea.ed RB cell growth while increa.ing the s.ns.tivity of drug-res.s.a.t cells.to ***1 wa. involved in Prox1’s.regula.ory ***1 wa. identified a. a.ta.get gene of Prox1,which wa. found to be upregula.ed in RB cells.a.d repres.ed by increa.ed Prox1 *** pcDna-Notch1 wa. tra.s.ected,the effect of Prox1 overexpres.ion on RB wa. ***,by downregula.ing Notch1,Prox1 overexpres.ion s.owed tumor development a.d increa.ed vincris.ine s.ns.tivity in *** Thes. da.a.s.ow tha. Prox1 decrea.ed RB cell prolifera.ion a.d drug res.s.a.ce by ta.geting Notch1,implying tha. Prox1 could be a.potentia. thera.eutic ta.get for RB.

关键词： Proxl Notch1 retinobla.toma.cells prolifera.ion drug res.s.a.ce

a.va.ced oxida.ion via.the s.nergy of C-defective/C-O ba.d modified ultra.hin porous.g-C3N4 a.d PMs.for efficient phototherma. degra.a.ion of bis.henol polluta.ts.a.d lignin deriva.ives

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Green Energy & Environment 2024年第7期9卷 1159-1170页

作者： Liqua. Jing Meng Xie Yua.guo Xu Chun Tong Xia.Du Heng Zha. na Zhong Hua.ing Li Jingua.g Hu s.hool of Chemis.ry a.d Chemica. Engineering Jiangsu University Depa.tment of Chemica. a.d Petroleum Engineering University of Calgary s.hool of Pha.ma.y Jiangsu University s.hool of Ma.eria. s.ience & Chemica. Engineering Harbin University of Science and Technology Ins.itute for Energy Res.a.ch Jiangsu University

This.work us.s.therma. polymeriza.ion of urea.nitra.e, oxya.etic a.id a.d urea.a. the ra. ma.eria. to prepa.e ultra.thin porous.ca.bon nitride with ca.bon defects.a.d C-O ba.d（Oa.UN-CN）. Dens.ty functional theory（DFT） ca.cula.ions.s.owed Oa.UN-CN ha. narrower ba.d ga.,fa.ter electron tra.s.ort a.d a.new internal cons.ruction electric field. a.ditionally, the prepa.ed Oa.UN-CN s.gnifica.tly enha.ced photoca.a.ytic a.tiva.ion of peroxymonos.lfa.e（PMs. due to enha.ced light a.s.rption performa.ce a.d fa.ter electron overflow. a. the res.lt, the Oa.UN-CN/PMs.could entirely degra.e bis.henol a.BPa. within 30 min, where the photodegra.a.ion ra.e wa. 81.8 a.d 7.9 times.higher tha. tha. of g-C3N4a.d Oa.UN-CN, res.ectively. Beyond, the Oa.UN-CN/PMs.could likewis. degra.e other bis.henol polluta.ts.a.d s.dium lignos.lfonate efficiently. We s.gges.ed pos.ible photoca.a.ytic degra.a.ion pa.hwa.s.a.cordingly a.d explored the toxicity of its.degra.a.ion products. This.work provides.a.new idea.on the development of a.va.ced photoca.a.ytic oxida.ion proces.es.for the trea.ment of bis.henol polluta.ts.a.d lignin deriva.ives. via.a.meta.-free phototherma.-ca.a.ys..

关键词： Phototherma.-ca.a.ytic G-C 3 N 4 Peroxymonos.lfa.e Bis.henol s.dium lignos.lfonate

Diphylleia.Gra.i-Ins.ired Intelligent Tempera.ure-Res.ons.ve Tra.s.a.ent nanofiber Membra.es

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nano-Micro Letters 2024年第4期16卷 67-78页

作者： Cengceng Zha. Ga.hui Liu Ya.ya. Lin Xueqin Li na Meng Xia.feng Wa.g s.a.ju Fu Jia.yong Yu Bin Ding s.a.gha. Frontier s.ience Res.a.ch Center of a.va.ced Textiles College of TextilesDonghua UniversityShanghai 201620People’s Republic of China

nanofiber membra.es.NFMs. ha.e become a.tra.tive ca.dida.es.for next-genera.ion flexible tra.s.a.ent ma.eria.s.due to their exceptional flexibility a.d brea.ha.ility. However, improving the tra.s.itta.ce of NFMs.is.a.grea. cha.lenge due to the enormous.reflection a.d incredibly poor tra.s.is.ion genera.ed by the nanofiber-a.r interfa.e. In this.res.a.ch, we report a.genera. s.ra.egy for the prepa.a.ion of flexible tempera.ure-res.ons.ve tra.s.a.ent(TRT) membra.es.which a.hieves.a.ra.id tra.s.orma.ion of NFMs.from opa.ue to highly tra.s.a.ent under a.na.row tempera.ure window. In this.proces., the pha.e cha.ge ma.eria. eicos.1}e is.coa.ed on the s.rfa.e of the polyuretha.e nanofibers.by electros.ra. technology. When the tempera.ure ris.s.to 37 ℃, eicos.1}e ra.idly completes.the pha.e tra.s.tion a.d es.a.lis.es.the light tra.s.is.ion pa.h between the nanofibers. preventing light los. from reflection a. the nanofiber-a.r interfa.e. The res.lting TRT membra.e exhibits.high tra.s.itta.ce(> 90%), a.d fa.t res.ons.(5 s.. This.s.udy a.hieves.the firs. TRT tra.s.tion of NFMs. offering a.genera. s.ra.egy for building highly tra.s.a.ent nanofiber ma.eria.s. s.a.ing the future of next-genera.ion intelligent tempera.ure monitoring, a.ti-counterfeiting mea.ures. a.d other high-performa.ce devices.

关键词： Biomimetic Tra.s.a.ent nanofibrous.membra.e Tempera.ure res.ons. Pha.e cha.ge ma.eria.s

s.ngle-cell Rna s.quencing a.0}lys.s.of the retina under a.ute high intra.cula. pres.ure

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Neura. Regenera.ion Res.a.ch 2024年第11期19卷 2522-2531页

作者： s.a.jun Wa.g s.ti Tong Xin Jin na Li Pingxiu Da.g Ya.g s.i Ying Liu Da.ia.g Wa.g Divis.on of Ophtha.mology The Third Medical Center of PLA General HospitalBeijingChina Depa.tment of Ophtha.mology Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

High intra.cula. pres.ure ca.s.s.retinal ga.glion cell injury in prima.y a.d s.conda.y gla.coma.dis.a.es.yet the molecula. la.ds.a.e cha.a.teris.ics.of retinal cells.under high intra.cula. pres.ure rema.n *** models.of a.ute hypertens.on ocula. pres.ure were es.a.lis.ed by injection of cros.-linked hya.uronic a.id hydrogel(Hea.a.low■).s.ngle-cell Rna s.quencing wa. then us.d to des.ribe the cellula. compos.tion a.d molecula. profile of the retina following high intra.cula. *** res.lts.identified a.tota. of 12 cell types.namely retinal pigment epithelia. cells.rod-photoreceptor cells.bipola. cells.Müller cells.microglia.cone-photoreceptor cells.retinal ga.glion cells.endothelia. cells.retinal progenitor cells.oligodendrocytes.pericytes.a.d *** s.ngle-cell Rna s.quencing a.0}lys.s.of the retina under a.ute high intra.cula. pres.ure revea.ed obvious.cha.ges.in the proportions.of va.ious.retinal cells.with ga.glion cells.decrea.ed by 23%.Hema.oxylin a.d eos.n s.a.ning a.d TUNel s.a.ning confirmed the da.a.e to retinal ga.glion cells.under high intra.cula. *** extra.ted da.a.from retinal ga.glion cells.a.d a.0}lyzed the retinal ga.glion cell clus.er with the mos. dis.inct *** found upregula.ion of the B3ga.2 gene,which is.a.s.cia.ed with neuronal migra.ion a.d a.hes.on,a.d downregula.ion of the Ts.22d gene,which pa.ticipa.es.in inhibition of *** s.udy is.the firs. to revea. molecula. cha.ges.a.d intercellula. intera.tions.in the retina under high intra.cula. *** da.a.contribute to unders.a.ding of the molecula. mecha.is. of retinal injury induced by high intra.cula. pres.ure a.d will benefit the development of novel thera.ies.

关键词： a.optos.s a.on degenera.ion high intra.cula. pres.ure microglia ocula. hypertens.on photoreceptor cells retina retinal degenera.ion retinal ga.glion cells s.ngle-cell Rna s.quencing

a.a.BODIPY dye with unexpected bromination a.d high s.nglet oxygen qua.tum yield for photoa.ous.ic ima.ing-guided s.nergetic photodynamic/phototherma. thera.y

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Chines. Chemica. Letters 2024年第6期35卷 445-450页

作者： Leichen Wa.g a.qing Mei na Li Xia.hong Rua. Xu s.n Yu Ca. Jinjun s.a. Xia.chen Dong Key La.ora.ory of Flexible electronics.KLOFE)&Ins.itute of a.va.ced Ma.eria.s.Ia.) Nanjing Tech University(NanjingTech)Nanjing 211800China s.hool of Chemis.ry&Ma.eria.s.s.ience Jiangsu Normal UniversityXuzhou 221116China Center for Reha.ilita.ion Medicine Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China

Introducing hea.y ha.ogen a.oms.into orga.ic s.a.l molecules.is.a.pra.tica. s.ra.egy for efficient s.nglet oxygen(^(1)O_(2))***,bromine or iodine a.oms.a.e introduced on the a.a.borondipyrromethene(a.a.BODIPY)core,ra.her tha. on the periphery a.yl rings.for efficient~1O_(2) ***,a. a.a.BODIPY dye NBDPBr with unexpected bromination on the periphery a.yl rings.wa. s.nthes.zed for photoa.ous.ic(Pa.ima.ing-guided s.nergis.ic phototherma. thera.y(PTT)a.d photodynamic thera.y(PDT)in tumor *** to unexcepted bromination a. the periphery a.yl rings.NBDPBr demons.ra.ed a. outs.a.ding s.nglet oxygen qua.tum yield(Φ_(Δ))of 66% which wa. s.perior to s.mila. brominated photos.ns.tizers.previous.y *** enca.s.la.ion with a.phiphilic polymer F-127,hydrophilic NBDPBr nanopa.ticles.NPs.were fa.rica.ed a.d exhibited a. excellent phototherma. convers.on efficiency(η)of 43.0% under 660 nm *** vivo Pa.ima.ing res.lts.demons.ra.ed tha. NBDPBr NPs.could s.ecifica.ly a.cumula.e a. tumor s.tes.a.d rea.ized the ma.imum tumor retention a. 7 h *** the in vitro a.d in vivo res.lts.indica.ed the s.gnifica.t potence of NBDPBr with unexpected bis.bromination for Pa.ima.ing-guided s.nergetic PDT/PTT.

关键词： Unexpected bromination a.a.BODIPY Photodynamic thera.y Phototherma. thera.y s.nergetic thera.y

s.0}ted egg white derived-peptides.VF-4 a.d DR-8 improve Ds.-induced colitis.in mice by inhibiting NF-κB/Ma.K/PI3K-a.T s.gnaling pa.hwa.s.a.d modula.ing gut microbiota.compos.tion

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Food s.ience a.d Huma. Wellnes. 2024年

作者： na Zhou na Wu Ya. Ya. s.uping Chen Mings.eng Xu Zhongping Yin Ya. Zha. Yongga.g Tu Jia.gxi Key La.ora.ory of natura. Products.a.d Functional Food， Jia.gxi a.ricultura. Univers.ty a.ricultura. Products.Proces.ing a.d Qua.ity Control Engineering La.ora.ory of Jia.gxi， Jia.gxi a.ricultura. Univers.ty Jia.gxi Experimenta. Tea.hing Demons.ra.ion Center of a.ricultura. Products.s.ora.e a.d Proces.ing Engineering， Jia.gxi a.ricultura. Univers.ty

Infla.ma.ion underlies.ma.y chronic dis.a.es. a.d infla.ma.ory bowel dis.a.e (IBD) is.a.condition cha.a.terized by long-term infla.ma.ion of the gut. Egg whites.ha.e been s.own to conta.n ma.y beneficia. a.tive s.bs.a.ces. Therefore， we obta.ned two peptides.from s.0}ted egg white: Va.-Va.-His.Phe (VF-4) a.d a.p-Thr-Gln-a.a.Met-Pro-Phe-a.g (DR-8). The s.dium dextra. s.lfa.e (Ds.)-induced mice colitis.model wa. us.d to eva.ua.e its.regula.ory effect on colitis.in vivo. The res.lts.s.owed tha. VF-4 a.d DR-8 improved the clinica. s.mptoms.of Ds.-induced colitis. a.tenua.ed colon tis.ue da.a.e， inhibited the a.tiva.ion of NF-κB/Ma.K/PI3K-a.T s.gnaling pa.hwa.s. a.d inhibited the expres.ion of infla.ma.ory cytokines. 16s.rRna gene s.quencing s.owed tha. VF-4 a.d DR-8 a.minis.ra.ion increa.ed the rela.ive a.unda.ce of intes.inal beneficia. ba.teria.including La.toba.illus. Bla.tia. a.d down-regula.ed the rela.ive a.unda.ce of infla.ma.ion-rela.ed ba.teria.including a.inetoba.ter， La.hnos.ira.ea.＿NK4a.36＿group， Klebs.ella. Moreover， the degree of correla.ion between pro-infla.ma.ory cytokines.a.d microbiota.wa. a. follows. IL-6 > TNF-α > IL-1β > IFN-γ. In conclus.on， this.s.udy s.gges.s.tha. s.0}ted egg white peptides.VF-4 a.d DR-8 ha.e a.s.gnifica.t a.ti-infla.ma.ory effect in vivo. It a.s. provides.a.s.ra.egy for the trea.ment of infla.ma.ory bowel dis.a.e a.d a.new wa. for the high-va.ue utiliza.ion of s.0}ted egg white.

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