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Zircon U-Pb dating and geochemical study of the Xianggou granite in the Ma'anqiao gold deposit and its relationship with gold mineralization

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Science China Earth Sciences 2010年第2期53卷 220-240页

作者： LEE ben State Key Laboratory of Continental Dynamics Department of GeologyNorthwest University

Single zircon LA-ICP-MS U-Pb dating and lithogeochemical studies have been performed on the Xianggou monzonitic granitic porphyry outcropped in the Ma’anqiao gold deposit.A weighted average U-Pb age of 242.0±0.8 Ma for Xianggou monzonitic porphyry has been *** corresponds with the conclusions of previous studies indicating a syn-orogenic age (242±21 Ma) of the Qinling Orogenic Belt,suggesting that the formation of the Xianggou granite should be associated with the collisional event of the North China Plate and the Yangtze Plate in the Indosinian *** Xianggou granite is characterized by the high silicon and alkali of high K calc-alkaline series *** is rich in Al (Al2O3=14.49%-15.61%) and Sr (457.10-630.82 ppm),poor in Y (fractionated REE *** geochemical characteristics suggest the Xianggou granite can be classified as C-type adakitic *** initial Sr isotope ratios for the Xianggou granite vary from 0.70642 to 0.70668,εNd(t) values from -4.54 to -3.98,and TDM values from 1152 Ma to 1220 *** low εNd(t) and ISr and high TDM values,as well as Na2O/K2O ratios of the Xianggou granite are close to 1 (Na2O/K2O=0.95-1.10),indicating that it is not an I-type adakite formed by partial melting of the subducting oceanic crust,nor adakitic rock formed by melting of the underplated basaltic lower crust,but the product of partial melting of the nonunderplated basaltic thickened lower *** from the Xianggou pluton have a homogeneous Hf isotopic composition with negative εHf(t) values (between -9.7 and -5.9,with an average of -6.9),indicating that the rock-forming materials were mostly extracted from the ancient crust,not from the depleted *** Xianggou monzonitic granitic porphyry is rich in LILE and LREE and depleted in HSFE,HREE and Y;the composition of trace element and REE are similar to those

关键词： zircon U-Pb dating Xianggou monzonitic granitic porphyry Carlin type and Carlin-like type gold deposits petrologenic and metallogenic dynamic background

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Cysteine proteases as therapeutic targets:does selectivity matter? A systematic review of calpain and cathepsin inhibitors

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Acta Pharmaceutica Sinica B 2015年第6期5卷 506-519页

作者： Marton Siklos Manel ben Aissa Gregory R.j.Thatcher Department of Medicinal Chemistry and Pharmacognosy University of Illinois College of Pharmacy

Cysteine proteases continue to provide validated targets for trea.ment of human *** neurodegenerative disorders,multiple cysteine proteases provide targets for enzyme inhibitors,notably caspases,calpains,and *** reactive,active-site cysteine provides specificity for many inhibitor designs over other families of proteases,such as aspartate and serine;however,a)inhibitor strategies often use covalent enzyme modification,and b)obtaining selectivity within families of cysteine proteases and their isozymes is *** review provides a general update on strategies for cysteine protease inhibitor design and a focus on cathepsin B and calpain 1 as drug targets for neurodegenerative disorders;the latter focus providing an interesting query for the contemporary assumptions that irreversible,covalent protein modification and low selectivity are anathema to therapeutic safety and efficacy.

关键词： Cysteine protease Calpain Cathepsin Enzyme inhibitors Neurodegeneration Alzheimer’s disease

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“固-激-增-强-育”式《药物化学》教学创新探索与实践

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云南化工 2024年第2期51卷 162-166页

作者：门吉英王立敏赵林秀中北大学化学与化工学院国家级实验教学示范中心山西太原030054

基于传统教学中以教师为中心的不足,进行了药物化学课程创新改革。坚持“两性一度”课程建设标准,采用卡片学习固基础、案例分析激兴趣、任务驱动增水平、科教融合强工科、课程思政育新人的创新教学方法,并进行合理地课程评价。实践结... 详细信息

基于传统教学中以教师为中心的不足,进行了药物化学课程创新改革。坚持“两性一度”课程建设标准,采用卡片学习固基础、案例分析激兴趣、任务驱动增水平、科教融合强工科、课程思政育新人的创新教学方法,并进行合理地课程评价。实践结果表明,创新性教学方法能够培养具有创新能力、问题解决能力以及能够完成具有挑战高难度任务的有担当的制药专业人才。

关键词：创新教学案例分析任务驱动科教融合课程思政

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Regulation of HMGB1 release by infl ammasomes

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Protein & Cell 2013年第3期4卷 163-167页

作者： ben Lu Haichao Wang Ulf Andersson Kevin j.Tracey Laboratory of Biomedical Science Feinstein Institute for Medical Research350 Community DriveManhassetNY 11030USA The Elmezzi Graduate School of Molecular Medicine North Shore-LIJ Health system350 Community DriveManhassetNY 11030USA Department of Emergency Medicine North Shore University HospitalManhassetNY 11030USA Department of Women’s and Children’s Health Karolinska InstitutetS-17677 StockholmSweden

High mobility group box 1(HMGB1)is an evolutionarily conserved non-histone chromatin-binding *** infection or injury,activated immune cells and damaged cells release HMGB1 into the extracellular space,where HMGB1 functions as a proinflammatory mediator and contributes importantly to the pathogenesis of inflammatory *** studies reveal that infl ammasomes,intracellular protein complexes,critically regulate HMGB1 release from activated immune cells in response to a variety of exogenous and endogenous danger *** stranded RNA dependent kinase(PKR),an intracellular danger-sensing molecule,physically interacts with inflammasome components and is important for infl ammasome activation and HMGB1 ***,these studies not only unravel novel mechanisms of HMGB1 release during infl ammation,but also provide potential therapeutic targets to treat HMGB1-related infl ammatory diseases.

关键词： HMGB1 infl ammasome PKR

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Ureteroscopy with Holmium: YAG Laser—A Initial Study in the Urology Department of the Pr Bocar Sidy Sall University Hospital of Kati

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Open journal of Urology 2024年第4期14卷 207-216页

作者： Amadou Kassogue Idrissa Sissoko Daouda Sangare Moussa Salifou Diallo Hamed Sylla Mahamadou Traore Boureima Coulibaly Salia Coulibaly Modibo Diakite Modibo Togola Fadima Tall Ilias Guindo ben Naoum Kamel Mamadou Lamine Diakite Urology Department University Hospital of Pr Bocar Sidy Sall Kati Mali Radiology Department University Hospital of Pr Bocar Sidy Sall Kati Mali Anesthesy and Reanimation Department University Hospital of Pr Bocar Sidy Sall Kati Mali Urology Department University Hospital Nimes France Urology Department University Hospital of Point G Bamako Mali

Introduction: Ureteroscopy is a minimally invasive endoscopic surgery which provides access to the ureter, pyelon and calyceal cavities via the urethra and the bladder. Laser ureteroscopy uses the laser as an energy source to treat the stone and eliminate it naturally. Minimally invasive endoscopic methods are struggling to become popular in sub-Saharan African countries, especially for the upper urinary tract. The objective of our work was to report the results of our first laser ureteroscopy experience in the department. Materials and Methods: This was a prospective and descriptive study running from December 1, 2023 to February 19, 2024. Included in our study was any case of upper urinary tract stone operated by Laser ureteroscopy. The characteristics of the lithiasis were determined by CT scan. Sterilization of urine was verified by carrying out a cytobacteriological examination of urine. Ureteral lithiasis was approached by semi-rigid ureteroscopy. Renal lithiasis was immediately addressed by flexible ureteroscopy. Ureteroscopy was coupled with a Holmium YAG laser. A double j ureteral catheter was placed after the operation. A 230 µm laser fiber was used in each case with a generator with a power of 35 watts (Storz Calculase III type). An access sheath was used in all cases of flexible ureteroscopy. The parameters studied were: sociodemographic characteristics, lithiasis (site, size, number, density, topography), type of anesthesia, duration of laser use, duration of intervention, postoperative outcomes. Data entry and analysis were carried out using the software (Word 2016 and SPSS). Result: We collected 30 cases of laser ureteroscopy. The average age was 37 years with extremes of 9 and 79 years. The male gender was more represented. The most common age group was 24-39 years old. Renal colic was the most frequent reason for admission, 12 patients (40%). On physical examination, lumbar tenderness was present in 47% (14 patients). ECBU was positive in 4 patients

关键词： Ureteroscopy Semi-Rigid Flexible Holmium YAG Laser

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以煤矸石为原料制备土壤改良剂的综合实验设计

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当代化工研究 2024年第2期 134-136页

作者：朱晓波门子湄李望马名杰河南理工大学化学化工学院河南454000

本文设计了利用微生物处理煤矸石制备土壤改良剂的大学化学综合实验项目,为煤矸石的绿色资源化利用提供了新途径。本实验项目涵盖了以煤矸石为原料,选育微生物并进行特征分析,微生物作用煤矸石制备土壤改良剂等知识点。本实验项目具有... 详细信息

本文设计了利用微生物处理煤矸石制备土壤改良剂的大学化学综合实验项目,为煤矸石的绿色资源化利用提供了新途径。本实验项目涵盖了以煤矸石为原料,选育微生物并进行特征分析,微生物作用煤矸石制备土壤改良剂等知识点。本实验项目具有符合国家环保政策、源于实际、操作方便、有利于拓宽学生科研视野、创新能力和社会意识的特点。

关键词：综合实验土壤改良剂煤矸石微生物

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Inductively coupled plasma emission spectroscopic and flame photometric analysis of goat epididymal fluid

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Asian journal of Andrology 2000年第4期2卷 288-292页

作者： Meenakshi Gaur Vikas Pruthi Ramasare Prasad ben M.j.Pereira Reproductive Biology Laboratory Dept. of Bioscience and Biotechnology University of Roorkee Roorkee-247 667 U. P. IndiaReproductive Biology Laboratory Dept. of Bioscience and Biotechnology University of Roorkee Roorkee-247 667 U. P. IndiaReproductive Biology Laboratory Dept. of Bioscience and Biotechnology University of Roorkee Roorkee-247 667 U. P. IndiaReproductive Biology Laboratory Dept. of Bioscience and Biotechnology University of Roorkee Roorkee-247 667 U. P. India

Aim: The elemental composition of the epididymal luminal fluid (ELF) in adult goat ( Capra indica) was investigat-ed. Methods: ELF was collected by micropuncture from twelve sites along the epididymal duct. The elementalcontents was analyzed with inductively coupled plasma (ICP) emission spectroscopy, a microanalytical technique thatcan simultaneously measure many elements in minute volumes of sample. The Na and K concentrations were determinedby flame photometry. Results: ICP spectroscopy showed the presence of copper, calcium, nickel, iron, magne-sium, chromium, titanium and zinc in ELF, with fluctuating levels at different sites along the length of the ***, cobalt, lead and manganese were not fotmd. The Na^+ / K^+ ratio was seen to be higher at the initial seg-ments of the epididymis and lower at the distal. Conclusion: It is proposed that the observed characteristic distribu-tion of elements in ELF may have far reaching implications in sperm maturation and storage known to occur in the epi-didymis. (Asian j Androl 2000 Dec; 2: 288-292)

关键词： goat epididymis epididymal luminal fluid elements spectroscopy flame photometry

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First-principles calculations to investigate structural,electronic,magnetic,optical and thermodynamic properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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journal of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.Masrour M.Hamedoun j.Kharbach A.Rezzouk A.Hourmatallah N.benzakour K.Bouslykhane Laboratory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this paper,we analyzed the physical characteristics of the ternary alloys RE_(2)Rh_(3)Ge(RE=Pr and Sm)using the first principles calculation based on functional density theory integrated in the Wien2k *** calculated formation energies of Pr_(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge are−5.3827 and−5.2782 eV/atom,respectively,showing that these alloys may exist *** results of the band structure and density of states indicate that all of the compounds tested are magnetic metals,and their magnetism is mostly related to the contribution of Pr and Sm *** total magnetic moments of Pr_(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge are 4.07245 and 11.16161μB/f.u,*** parameters such as heat capacity at constant pressure,entropy,Debye temperature,lattice volume,compressibility coefficients,and Grüneisen parameter alloys were calculated using the Gibbs algorithm and studied in depth over a large temperature range of 0-900 *** Debye temperature increases with increasing pressure and decreases with decreasing ***,the Debye temperatures calculated at p=0 GPa and T=300 K are equal to be 342 and 322 K for Pr_(2)Rh_(3)Ge and Sm_(2)Rh_(3)Ge,*** optical characteristics such as the real and imaginary portions of the dielectric function,the absorption coefficient,the energy-loss function,and the refractive index were investigated and discussed in more depth.

关键词： Magnetic metals Functional density theory Density of states Magnetic moment Optical and thermodynamic properties Rare earths

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考虑曲率与加工变形的薄壁叶片测点规划与补偿方法

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机械设计与研究 2024年第2期40卷 126-131页

作者：虞奔项四通叶佩青宁波大学机械工程与力学学院浙江宁波315211 清华大学机械工程系北京100084

薄壁叶片易发生加工变形,传统的在机检测测点规划未考虑加工变形,导致测点不能准确反映加工情况。为此,提出了综合考虑叶片曲率特征与加工变形的分区域测点规划与镜像补偿方法。首先,对叶片进行截面划分,确定截面数与截面线位置;预测叶... 详细信息

薄壁叶片易发生加工变形,传统的在机检测测点规划未考虑加工变形,导致测点不能准确反映加工情况。为此,提出了综合考虑叶片曲率特征与加工变形的分区域测点规划与镜像补偿方法。首先,对叶片进行截面划分,确定截面数与截面线位置;预测叶片的加工变形,并根据变形大小对截面线进行区域划分。然后,根据各区域的曲率和加工变形设置对应的弦偏差值和测点数,并利用弦公差法确定各区域测点,综合提取各区域测点并进行实验验证。最后,利用镜像补偿法来提高叶片加工精度。实验结果显示,与传统的弦公差法相比,本方法可在测点总数减少18.8%的前提下,使得叶片整体拟合的最大偏差减小37.5%,平均偏差减少16.3%,补偿后叶片的整体偏差减小了65.2%。本方法符合叶片曲率特征的分布,且与加工变形分布相匹配,有效提高了叶片在机检测的效率和加工精度。

关键词：薄壁叶片在机检测测点规划加工变形

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基于GAMLSS的非一致性设计洪水研究——以云南省盘龙河龙潭寨水文站为例

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水文 2024年第3期44卷 8-15,40页

作者：余航杨茂灵李新华付奔云南农业大学水利学院云南昆明650201 昭通市水利水电勘测设计研究院云南昭通657099 云南兴电集团有限公司云南文山663000 云南省水文水资源局云南昆明650101

气候变化和人类活动等因素使洪水序列的一致性遭到破坏,因此推求非一致性条件下的设计洪水具有重要的理论和实践价值。以云南省盘龙河龙潭寨水文站为例,采用实测、模拟和预测的降水和洪水数据,基于GAMLSS模型和等可靠度方法计算一致性... 详细信息

气候变化和人类活动等因素使洪水序列的一致性遭到破坏,因此推求非一致性条件下的设计洪水具有重要的理论和实践价值。以云南省盘龙河龙潭寨水文站为例,采用实测、模拟和预测的降水和洪水数据,基于GAMLSS模型和等可靠度方法计算一致性以及以时间、降水为协变量的非一致性的设计洪水。结果表明:(1)以降水为协变量的非一致性概率模型好于以时间为协变量的非一致性和一致性的概率模型,其不仅能够模拟洪水序列的趋势,还能够反映洪水的波动变化。(2)龙潭寨水文站的一致性的设计洪水为269~423 m^(3)/s,总体大于非一致性的设计洪水(182~432 m^(3)/s)。(3)以降水为协变量的设计洪水更为合理。研究结果可为洪水灾害防治和水利工程设计等提供参考依据。

关键词：云南盘龙河非一致性设计洪水 GAMLSS

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