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Modeling of Mass Transfer in Cavity Limited by a Semi Permeable Membrane （Simulation of Spiral Wound Module）

journal of Environmental Science and Engineering 2011年第5期5卷 567-573页

作者： j. ben Nacib R. Chouikh S. Bouguecha Laboratory of Waste Water Trea.ment The Water Researches and Technologies Center of Borj-Cedria Borj-Cedria Saliman 8020Tunisia Department of Thermal Engineering and Desalination Technology The Univerity of King Abdulaziz Jeddah 80213 Kingdom ofSaudi Arabia

The reverse osmosis process has been applied in large industrial fields （water trea.ment, food industry, biotechnology, and ect.）. Despite, this progress more investigation are required to optimize the reverse osmosis process. The present paper deals the modeling of mass transfer in a cavity limited by a semi-permeable membrane. Mass conservation and momentum balances are developed, dimensionless and control volume method has been applied. The velocity and concentration profiles versus the Reynolds number and Sherwood are studied. The results show that the permeability of the membrane decreases as function of the transversal （radial） component of the velocity. The axial （tangential） component of the velocity presents a good stability along the thickness of the cavity; this phenomenon can be attributed to the zero gradient of the tangential velocity. These preliminary results show that the phenomenon of the concentration polarization affects the mass transfer coefficient in a channel. Current study has considered the cavity without a promoter of the turbulence; whereas, the design of the spacer has an important role on mass transfer coefficient in the reverse osmosis module. Our next interest is the integration of the spacer in the cavity, and the study of the effect of its design on the concentration and velocity profiles and the mass transfer coefficient through the reverse osmosis membrane.

关键词： Membrane processes reverse osmosis spiral module modeling of mass transfer in a cavity (channel).

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泡沫除尘技术在隧道施工中的应用研究

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交通节能与环保 2021年第2期17卷 130-132,155页

作者：门本马强四川公路桥梁建设集团有限公司大桥工程分公司四川成都610015

本文介绍了隧道施工过程中粉尘的来源,并探究了采用泡沫对钻爆法施工过程中钻孔、爆破、出渣运输和喷射混凝土等产生大量高浓度粉尘以及其他污染物,及各种重型机械尾气产生的碳颗粒进行除尘的可行性。文章从隧道内粉尘的来源着手,大体... 详细信息

本文介绍了隧道施工过程中粉尘的来源,并探究了采用泡沫对钻爆法施工过程中钻孔、爆破、出渣运输和喷射混凝土等产生大量高浓度粉尘以及其他污染物,及各种重型机械尾气产生的碳颗粒进行除尘的可行性。文章从隧道内粉尘的来源着手,大体可以将其来源主要有钻孔产尘、爆破过程中产生的粉尘、装渣和运输过程、喷混凝土过程中产生的粉尘。并且分析了泡沫的除尘机理。利用泡沫的截留效应、惯性碰撞、扩散效应、黏附效应可以针对隧道内的粉尘颗粒进行有效捕捉。根据李龙等人的研究可以看出泡沫除尘对人体基本无害,泡沫除尘对环境的影响也可以忽略不计,周长根等人通过试验发现,对于易燃易爆类粉尘,采用泡沫除尘既可以保证安全性又具有良好的除尘效果,故采用泡沫除尘的优势性很大。

关键词：隧道工程表面活性剂泡沫除尘

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关于废弃工程泥浆的水凝胶固结方法的研究

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山西建筑 2021年第18期47卷 154-156,161页

作者：门本马强四川公路桥梁建设集团有限公司大桥工程分公司四川成都610015

国内处治废弃工程泥浆的方法普遍效率较低、设备投入以及能耗较大,有必要寻求更高效、更经济的方法。通过利用阳离子瓜尔胶和硼砂形成的水凝胶网络结构对废弃工程泥浆进行处治。针对三江新区基础设施建设项目中存在的两种不同的废弃工... 详细信息

国内处治废弃工程泥浆的方法普遍效率较低、设备投入以及能耗较大,有必要寻求更高效、更经济的方法。通过利用阳离子瓜尔胶和硼砂形成的水凝胶网络结构对废弃工程泥浆进行处治。针对三江新区基础设施建设项目中存在的两种不同的废弃工程泥浆进行了水凝胶软固化试验。试验结果表明使用瓜尔胶—硼砂体系构建水凝胶能充分固化废弃工程泥浆,其固结物在环境作用下不溶解、不分散,有一定的环境耐受性。采用不同配比的水凝胶进行固化时,固结物的性状呈现出不同,针对同一性质的废弃工程泥浆有最佳的配比达到经济性最优化。

关键词：废弃工程泥浆水凝胶软固化

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N^(6)-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance

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Military Medical Research 2022年第5期9卷 576-591页

作者： Xian Lin Feng Wang jian Chen jing Liu Yi-Bin Lin Li Li Chuan-ben Chen Qin Xu Departments of Gynecology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Department of Radiation Oncology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Shenzhen Key Laboratory of Immunity and Inflammatory Diseases Peking University Shenzhen HospitalShenzhen Peking University?the Hong Kong University of Science and Technology Medical CenterShenzhen 518036GuangdongChina Outpatient Department Fujian Hospital of People's Armed PoliceFujian Medical UniversityFuzhou 350014China

Background:Stemness and chemoresistance contribute to cervical cancer recurrence and *** the current study,we determined the relevant players and role of N^(6)-methyladenine(m^(6)A)RNA methylation in cervical cancer ***:The roles of m^(6)A RNA methylation and centromere protein K(CENPK)in cervical cancer were analyzed using bioinformatics *** RNA immunoprecipitation was adopted to detect m^(6)A modification of CENPK *** cervical cancer clinical samples,cell lines,and xenografts were used for analyzing gene expression and *** staining and the tumorsphere formation,clonogenic,MTT,and EdU assays were performed to determine cell stemness,chemoresistance,migration,invasion,and proliferation in HeLa and SiHa cells,*** blot analysis,co-immunoprecipitation,chromatin immunoprecipitation,and luciferase reporter,cycloheximide chase,and cell fractionation assays were performed to elucidate the underlying ***:Bioinformatics analysis of public cancer datasets revealed firm links between m^(6)A modification patterns and cervical cancer prognosis,especially through ZC3H13-mediated m^(6)A modification of CENPK *** expression was elevated in cervical cancer,associated with cancer recurrence,and independently predicts poor patient prognosis[hazard ratio=1.413,95%confidence interval=1.078−1.853,P=0.012].Silencing of CENPK prolonged the overall survival time of cervical cancer-bearing mice and improved the response of cervical cancer tumors to chemotherapy in vivo(P<0.001).We also showed that CENPK was directly bound to SOX6 and disrupted the interactions of CENPK withβ-catenin,which promotedβ-catenin expression and nuclear translocation,facilitated p53 ubiquitination,and led to activation of Wnt/β-catenin signaling,but suppression of the p53 *** dysregulation ultimately enhanced the tumorigenic pathways required for cell stemness,DNA damage repair pathways necessary f

关键词： N^(6)-methyladenosine Centromere protein K Cervical cancer Stemness Chemoresistance

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Newborn screening for remethylation disorders and vitamin deficiency-evaluation of new strategies in cohorts from Qatar and Germany

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World journal of Pediatrics 2017年第2期13卷 136-143页

作者： Gwendolyn Gramer Ghassan Abdoh Tawfeg ben-Omran Noora Shahbeck Rehab Ali Laila Mahmoud junmin Fang-Hoffmann Georg F.Hoffmann Hilal Al Rifai jürgen G.Okun University Hospital Heidelberg Center for Pediatric and Adolescent MedicineDivision of Neuropediatrics and Metabolic MedicineHeidelbergGermany Department of Pediatrics Hamad Medical CorporationDohaQatar

Background:Newborn screening is a precondition for early diagnosis and successful trea.ment of remethylation disorders and classical homocystinuria (cystathionine-β-synthase deficiency).Newborn screening for classical homocystinuria using total homocysteine measurement in dried blood spots has been very successfully performed for many years for newborns from ***:A new optimized newborn screening strategy for remethylation disorders and homocystinuria was developed and evaluated for newborns from Qatar using total homocysteine measurement as first-tier and methionine,methionine-phenylalanine-ratio and propionylcarnitine as *** cnt-offs were also retrospectively evaluated in newborn screening samples of 12 patients with remethylation disorders and vitamin B12 deficiency from Qatar and ***:Over a 12 months period,the proposed strategy led to a decrease in the recall rate in homocysteine screening for Qatar from 1.09% to 0.68%,while allowing for additional systematic inclusion of remethylation disorders and vitamin B12 deficiency into the screening panel for *** the evaluated period the applied strategy would have detected all patients with classical homocystinuria identified by the previous strategy and in addition 5 children with maternal nutritional vitamin B12 deficiency and one patient with an isolated remethylation *** retrospective evaluation of newborn screening samples of 12 patients from Germany and Qatar with remethlyation disorders or vitamin B12 deficiency showed that all of these patients would have been detected by the cutoffs used in the proposed new *** addition,an adapted strategy for Germany using methionine,methionine-phenylalanine-ratio and propionylcarnitine as first-tier,and homocysteine as a second-tier test was also positively evaluated ***:The proposed strategy for samples from Qatar allows inclusion of remethylation disorders and vitamin B12 deficiency

关键词： classical homocystinuria newborn screening remethylation disorders second-tier vitamin B12 deficiency

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Stability evaluation of reference genes for real-time quantitative PCR normalization in Spodoptera frugiperda(Lepidoptera:Noctuidae)

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journal of Integrative Agriculture 2021年第9期20卷 2471-2482页

作者： SHU ben-shui YU Hai-kuo DAI jing-hua XIE Zi-ge QIAN Wan-qiang LIN jin-tian Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control Zhongkai University of Agriculture and EngineeringGuangzhou 510225P.R.China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China

Real-time quantitative PCR(qPCR)is a reliable and widely used technique for analyzing the expression profiles of target genes in different species,and reference genes with stable expressions have been introduced for the normalization of the ***,stability evaluation should be considered as the initial step for qPCR *** fall armyworm Spodoptera frugiperda(***)(Lepidoptera:Noctuidae)is a polyphagous pest that consumes many plant species and seriously threatens corn production around the ***,no studies thus far have examined the stability of reference genes in this *** this study,the expression profiles of the eight candidate reference genes of Actin,elongation factor 1 alpha(EF1α),elongation factor 2(EF2),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),ribosomal protein L3(RPL3),ribosomal protein L13(RPL13),alpha-tubulin(α-TUB),and beta-1-tubulin(β-1-TUB)were obtained from *** in different samples and the stability was evaluated byΔCt,BestKeeper,geNorm,NormFinder,and RefFinder *** results of pairwise variation(V)calculated by GeNorm indicated two reference genes could be selected for ***,the combinations of the most stable reference genes for different experimental conditions of *** were shown as follows:EF2 and RPL13 for developmental stages,RPL3 andβ-1-TUB for larval tissue samples,EF2 and EF1αfor the larval samples treated with different temperatures,RPL3 and EF1αfor the larval samples under starvation stress,and RPL13 and EF1αfor all the *** results lay the foundation for the normalization of qPCR analyses in *** and could help guarantee the accuracy of subsequent research.

关键词： Spodoptera frugiperda reference genes qPCR stability evaluation different experimental conditions

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Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss

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Bone Research 2021年第4期9卷 549-556页

作者： Martina Rauner Marta Murray Sylvia Thiele Deepika Watts Drorit Neumann Yankel Gabet Lorenz C.Hofbauer ben Wielockx Department of Medicine III&Center for Healthy Aging Technische Universitat DresdenDresdenGermany lnstitute for Clinical Chemistry and Laboratory Medicine Technische Universitat DresdenDresdenGermany Department of Cell and Developmental Biology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Anatomy&Anthropology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

High erythropoietin(Epo)levels are detrimental to bone health in adult *** mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone *** humans,high serum Epo levels are linked to fractures in elderly *** earlier studies indicated that Epo modulates osteoblast activity;however,direct evidence that Epo acts via its receptor(EpoR)on osteoblasts in vivo is still ***,we created mice lacking EpoR in osteoprogenitor cells to specifically address this *** of EpoR in osteoprogenitors(EpoR:Osx-cre,cKO)starting at 5 weeks of age did not alter red blood cell parameters but increased vertebral bone volume by 25%in 12-week-old female *** was associated with low bone ***(osteoblast number,bone formation rate)and serum(P1NP,osteocalcin)bone formation parameters were all reduced,as were the number of osteoclasts and TRAP serum *** of osteoblast precursors isolated from cKO versus control mice resulted in lower expression of osteoblast marker genes including Runx2,Alp,and Col1a1 on day 21,whereas the mineralization capacity was ***,the RANKL70PG ratio,which determines the osteoclast-supporting potential of osteoblasts,was substantially decreased by 50%.Similarly,coculturing cKO osteoblasts with control or cKO osteoclast precursors produced significantly fewer osteoclasts than coculture with control ***,exposing female mice to Epo pumps(10 U-d_1)for 4 weeks resulted in trabecular bone loss(-25%)and increased osteoclast numbers(1.7-fold)in control mice only,not in cKO *** data show that EpoR in osteoprogenitors is essential in regulating osteoblast function and osteoblast-mediated osteoclastogenesis via the RANKI70PG ***,osteogenic Epo/EpoR signaling controls bone mass maintenance and contributes to Epo-induced bone loss.

关键词： progenitor homeostasis doses

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中国人群消化系统癌症疾病负担分析

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中华流行病学杂志 2024年第5期45卷 633-639页

作者：吕章艳李文轩司国金张雅聪邢梦博黄育北刘奔宋方方宋丰举陈可欣天津医科大学肿瘤医院流行病与生物统计学研究室/天津市肿瘤分子流行病重点实验室/人群重大疾病防控教育部重点实验室/国家恶性肿瘤临床医学研究中心/天津市恶性肿瘤临床医学研究中心天津300060

目的了解中国人群消化系统癌症的发病、死亡情况及不同危险因素所导致的疾病负担的变化趋势。方法资料来源于GLOBOCAN 2020和2019年全球疾病负担研究数据库中的中国人群数据,应用Excel 2019和R 4.2.1软件,采用年龄标化发病率(ASIR)、年... 详细信息

目的了解中国人群消化系统癌症的发病、死亡情况及不同危险因素所导致的疾病负担的变化趋势。方法资料来源于GLOBOCAN 2020和2019年全球疾病负担研究数据库中的中国人群数据,应用Excel 2019和R 4.2.1软件,采用年龄标化发病率(ASIR)、年龄标化死亡率(ASMR)、年龄标化伤残调整寿命年(DALY)率及其变化率等指标,描述消化系统癌症归因于各类危险因素的疾病负担及其变化趋势。结果2020年中国消化系统癌症的ASIR为83.00/10万,ASMR为63.80/10万,发病和死亡例数均随年龄增长而增加,且各年龄组男性消化系统癌症发病及死亡例数均高于女性。1990-2019年中国食管癌、胃癌、肝癌的年龄标化DALY率呈下降趋势(变化率分别为-45.26%、-46.87%、-65.63%),而胰腺癌、结直肠癌、胆囊胆管癌的年龄标化DALY率呈上升趋势(变化率分别为67.61%、30.52%、7.21%),死亡率的变化趋势与DALY率一致。与归因于行为因素的年龄标化DALY率的比例相比,1990-2019年食管癌、肝癌、胰腺癌和结直肠癌归因于代谢因素的年龄标化DALY率占该癌种总年龄标化DALY率的比例均逐年升高。1990-2019年中国胃癌、肝癌、胰腺癌、胆囊胆管癌不同归因的年龄标化DALY率排序无显著变化,但食管癌和结直肠癌年龄标化DALY率的部分归因因素排序有所提前(食管癌:高BMI;结直肠癌:低牛奶摄入、低全谷物摄入)。结论2020年中国消化系统癌症的发病及死亡流行情况严重,1990-2019年中国消化系统癌症归因于代谢因素的疾病负担比例逐年上升,且部分消化系统癌症的疾病负担归因次序发生了显著变化。

关键词：癌症消化系统死亡率伤残调整寿命年危险因素

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Synergistic Effect of Halloyosite Nanotube and Nanocellulose on Thermal and Mechanical Properties of Poly(Ethylmethacrylate-co-Acrylonitrile)Bionanocomposites

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journal of Renewable Materials 2020年第3期8卷 301-317页

作者： Karima ben Hamou Amal Kadimi Remo Merijs Meri Sergei Gaidukov Hamid Kaddami Mustapha Raihane Mouhamed Lahcini Fouad Erchiqui Laboratory of Organometallic and Macromolecular Chemistry-Composites Materials Faculty of Sciences and Technology of MarrakechCadi Ayyad UniversityGuélizAv.A.El KhattabiMarrakechBP 618Morocco Engineering School University of Québec in Abitibi-Témiscamingue445 Boulevard de l'UniversitéRouyn-NorandaJ9X 5E4QuébecCanada Institute of Polymer Materials Riga Technical UniversityKaļķu iela 1Centra rajonsRīgaLV-1658Latvia

This work reports a comprehensive study on poly(Ethylmethacrylateco-Acrylonitrile)Poly(EMA-AN)nanocomposites reinforced with a hybrid mixture of nanoreiforcements based on nanocrystals of cellulose(NCC)(1 or 5%wt)and halloysite nanotubes(HNTs)(1 or 5%wt).The morphology,thermal and mechanical properties of these nanocomposites were *** dispersion of the nanofillers has been shown by scanning electron microscopy.A significant increase of the rubbery modulus and glass transition temperature were obtained upon filler addition,due to the reduction of mobility of the matrix macromolecular *** the other hand,compared with the neat Poly(EMAAN),the storage modulus of the nanocomposites increased by a factor 38 when adding 5 wt%NCC and by 17 for the same concentration of *** properties of ternary nanocomposites were furthers increased resulting from a synergistic effect of these two nanofillers.

关键词： Poly(Ethylmethacrylate-co-Acrylonitrile) nanocrystals cellulose halloysite nanotubes nanocomposites hybrid mechanical properties

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枯草期玉树牦牛血液生化指标及瘤胃菌群构成分析

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中国草食动物科学 2024年第5期44卷 50-56页

作者：丁自强张犇郭韶珂胡丽妍裴杰熊琳索昂求培杨涛赵索南郭宪中国农业科学院兰州畜牧与兽药研究所甘肃省牦牛繁育重点实验室农业农村部青藏高原畜禽遗传育种重点实验室兰州730050 称多县畜牧兽医工作站称多815100 海北藏族自治州高原生态畜牧业科技示范园管委会海北810299

本研究旨在探究枯草期玉树牦牛血清生化指标及瘤胃微生物构成变化,为制定冷季精准补饲方案提供参考。在冷季随机选取16头健康、体重相近的放牧玉树牦牛(公母各半),检测其血清生化指标及瘤胃微生物丰富度与多样性,同时采集枯草期牧草,测... 详细信息

本研究旨在探究枯草期玉树牦牛血清生化指标及瘤胃微生物构成变化,为制定冷季精准补饲方案提供参考。在冷季随机选取16头健康、体重相近的放牧玉树牦牛(公母各半),检测其血清生化指标及瘤胃微生物丰富度与多样性,同时采集枯草期牧草,测定其营养成分含量。结果显示,枯草期牧草中的粗蛋白含量为5.71%,粗脂肪含量为0.60 g/kg,中性洗涤纤维和酸性洗涤纤维含量分别为65.47%和38.60%。血清生化指标分析显示,公牦牛血清中的白蛋白、低密度脂蛋白和肌酐含量均显著高于母牦牛(P<0.05),而高密度脂蛋白和γ-谷氨酰转移酶含量显著低于母牦牛(P<0.05)。瘤胃微生物16S rRNA测序发现,母牦牛瘤胃液中纤维杆菌门(Fibrobacterota)和纤维杆菌属(Fibrobacter)的相对丰度显著高于公牦牛(P<0.05),而蓝菌门(Cyanobacteria)和Limimorpha属相对丰度显著低于公牦牛(P<0.05)。LEfSe和随机森林分析显示,琥珀酸单胞菌属(Succinimonas)是公母牦牛之间重要的差异标志物种。综上说明,枯草期牧草的营养成分含量较低,应进一步补饲营养价值较高的饲草料,以满足玉树牦牛在冷季的营养需求。

关键词：玉树牦牛血液生化指标瘤胃微生物

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