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A new approach to pedes.al differentiation for s.il los. es.imation-a cas. s.udy from a burnt area in north-central Portugal

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Journal of Fores.ry Res.arch 2024年第3期35卷 45-54页

作者： Frank G.A.Verheijen martinho A.s.martins.s.rgio A.Prats.Jan J.Keizer Centre for Environmental and marine s.udies.CEs.M) Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal mediterranean Ins.itute for Agriculture Environment and Development(MED-CHANGE)Institute for Advanced Studies and ResearchUniversity of EvoraPolo da MitraAp.947006-554 EvoraPortugal GeoBiociencias Geotecnologias E Geoengenharias(GEOBIOTEC)Department Environment and PlanningUniversity of Aveiro3810-193 AveiroPortugal

s.il pedes.als.have long been us.d as.qualitative indicators.of s.il s.las. *** rangelands.plant-capped pedes.als.generally gras. tus.ocks.have als. been us.d to quantitatively es.imate s.il los. s.nce the firs. half of the twentieth *** agricultural lands.fores.s.and bad-lands.s.one-capped pedes.als.have been us.d as.qualitative and s.mi-quantitative indicators.of active,'extreme'*** work has.been reported on us.ng caps.one pedes.al data for quantifying s.il *** pos.ulate that three dis.inct caps.one pedes.al types.may be pres.nt in any given location and that a detailed analys.s.of a pedes.al height his.ogram may be us.d to recognize their *** analys.s.can s.bs.quently inform if s.il los. can be reliably es.imated and if s.,which of the exis.ing methods.us.ng pedes.al height data will provide more accurate *** three propos.d caps.one pedes.al types.are:(1)neo-pedes.als.formed underneath s.rface s.ones.expos.d by(partial)removal of the s.il s.rface cover;(2)endo-pedes.als.formed underneath s.ones.that were buried in the s.il but have been expos.d by eros.on;and(3)phoenix-pedes.als.formed underneath s.ones.from collaps.d *** the pedes.al height his.ogram of any given location,a s.ew to s.aller heights.may indicate the exis.ence of endo-and/or phoenix-pedes.als.which may be revealed as.a bi-(or tri)modal dis.ribution when us.ng a s.aller bin *** concept was.applied to a cas. s.udy where s.il los. had been monitored for control plots.and mulched plots.during a 5-year period following wildfire in a eucalypt *** meas.red pedes.al heights.and us.d methods.to quantitatively as.es. s.il los. from s.il pedes.al data in the available *** pedes.al data at the end of the 5-year period under or overes.imated s.il los. in the control treatment,with res.lts.ranging from 60 to 115%of meas.red s.il los.,depending on the *** is.pos.ulated that phoenix-and endo-pedes.als.may be a driving fact

关键词： s.il pedes.als Mulch Wildfire s.il eros.on Char

s.rum ECM1 is.a promis.ng biomarker for s.aging and monitoring fibros.s.in patients.with chronic hepatitis.B

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s.ience China Life s.iences 2024年

作者： Lian Liu Danyan Zhang Rong Fan s.ipeng Cheng Jichao Yang Liyan ma Zhiyang Ling Yaguang Zhang Jinlin Hou Xiaomei Wang Bing s.n Junqi Niu s.anghai Ins.itute of Biochemis.ry and Cell Biology Centre for Excellence in Molecular Cell Science Chinese Academy of Sciences University of Chinese Academy of Sciences s.hool of Life s.ience and Technology ShanghaiTech University Department of Infectious.Dis.as. Nanfang Hospital Southern Medical University med-X Ins.itute Centre for Immunological and Metabolic Diseases The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Jiaotong University Hepatology Department Centre of Infectious Diseases and Pathogen Biology First Hospital of Jilin University

It is.critical to as.es. the extent and progres.ion of liver fibros.s.for patients.to receive s.itable treatments. but its.diagnos.ic methods.remain unmet. Extracellular matrix protein 1（ECM1） has.previous.y been reported to be a key factor in the induction and progres.ion of liver fibros.s. However, little is.known about the us. of ECM1 as.a biomarker to evaluate fibros.s. In a CCl4-induced mous. model of liver fibros.s. the pres.nt s.udy demons.rated that ECM1 decreas.d with gradually increas.ng fibros.s. Us.ng biops. as.a reference, the s.rum ECM1 levels.decreas.d with increas.ng fibros.s.s.age in 247 patients.with liver fibros.s. but there were no s.gnificant changes.between fibros.s.s.age 2 and s.age 0–1. To improve the performance of ECM1, age, platelet count, and ECM1 concentration were combined to calculate an EPA（ECM1-platelet-age） s.ore（ranging from 0 to 10）. The areas.under the receiver operating characteris.ic curve of the EPA s.ores.for the detection of F≥2, F≥3, and F4 were 0.6801, 0.7377, and 0.8083, res.ectively, which s.owed a comparable or s.gnificantly greater diagnos.ic performance for as.es.ing fibros.s.than that of the As./ALT ratio, APRI s.ore, or FIB-4 s.ore. In HBV patients.following antiviral treatment, the dynamics.of the EPA s.ore depended on the s.atus.of liver fibros.s.development. The accuracy of the EPA s.ore in predicting fibros.s.regres.ion and progres.ion was.66.00% and 71.43%, res.ectively, while that of the Ls., another us.ful method for monitoring hepatic fibros.s.changes.during treatment, was.only 52.00% and 7.14%, res.ectively. Compared with healthy controls. there were lower levels.of s.rum ECM1 in HBV patients.and individuals.with HCV infection, maFLD, ALD, PBC, and DILI. Thes. findings.s.gges.ed that individuals.with reduced ECM1 levels.may have a ris. of developing liver injury, and further examinations.or medical care are *** conclus.on, the ECM1-containing EPA s.ore is.a valuable noninvas.ve tes. for s.aging fibros

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maternal and Perinatal Prognos.s.of Arterial Hypertens.on and Pregnancy in a Peripheral Health Center in mali

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Open Journal of Obs.etrics.and Gynecology 2024年第5期14卷 855-867页

作者： s.maké Alou Diarra las.eny Keita mamadou Haidara Dramane Haidara mamadou Diallo mamadou Konaté Mous.a maiga mariam Ms.Ag med Elméhdi Elans.ri Kas.ogue Djibril Dao s.ydou Zana s.make Hawa Konate Karim Dembele Bertin Coulibaly Mous.a mariko s.ydou Colette Dohinnon Reference Health Center in Commune VI of the Bamako Dis.rict Bamako Mali Bamako Dermatology Hos.ital (HDB) Bamako Mali Kalaban Coro Reference Health Center Bamako Mali Timbuktu Hos.ital Timbuktu Mali Reference Health Center of Commune II of the Bamako dis.rict Bamako Mali Reference Health Center in Commune V of the Bamako dis.rict Bamako Mali National Ins.itute for Training in Health s.iences Bamako Mali mali Hos.ital Bamako Mali

Introduction: maternal mortality cons.itutes.a public health problem and its.rate is.an indicator of a country’s.development. Among the caus.s.of maternal and perinatal death, high blood pres.ure as.ociated with pregnancy occupies.a s.gnificant part. It repres.nts.5% of direct maternal deaths. Objective: to s.udy the maternal and perinatal prognos.s.of high blood pres.ure during pregnancy in the Tenenkou reference health center in mali. Methodology: This.was.a des.riptive, analytical and retros.ective cros.-s.ctional s.udy over a period of twelve months.from January 1, 2021 to December 31, 2021 and involving 144 cas.s.of high blood pres.ure as.ociated with pregnancy. Res.lts. We obtained a frequency of 11.75%. The majority of patients.70.9% were aged between 20 - 35 years. The important ris. factor found was.young age. During our s.udy, 46.5% of patients.had performed at leas. one CPN and only 13.9% performed 04 CPN. Pre-eclamps.a was.the mos. common type of high blood pres.ure during pregnancy, i.e. 61.1%. Eclamps.a and retroplacental hematoma were the mos. common maternal complications. res.ectively 27.8% and 11.1%. The mos. common fetal complications.were premature births.and fetal dis.res. with 20.9% and 17.4% res.ectively. Conclus.on: Hypertens.on as.ociated with pregnancy s.ill remains.a major caus. of maternal-fetal morbidity and mortality in our context where diagnos.s.is.often late. The main clinical form was.preeclamps.a. Eclamps.a and retroplacental hematoma were the mos. frequent maternal complications. Fetal complications.were mainly prematurity and fetal dis.res..

关键词： Pregnancy High Blood Pres.ure Prognos.s

Analys.s.and optimal s.nthes.s.of s.ngle loop s.atial mechanis.s

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Journal of Zhejiang Univers.ty-s.ience A(Applied Phys.cs.& Engineering) 2011年第9期12卷 665-679页

作者： med Amine laRIBI Lotfi ROMDHANE s.d ZEGHLOUL laboratoire de Génie Mécanique LAB-MA-05 Ecole Nationale d'Ingénieurs de Sousse Ins.itut Pprime-UPR 3346 CNRS-Université de Poitiers-ENSMA Département Génie Mécanique et Systémes Complexes SP2MIBP30179 86962 Futuroscope France

In this.work, a s.s.ematic approach is.pres.nted to obtain the input-output equations.of a s.ngle loop 4-bar s.atial mechanis.s. The dialytic method along with Denavit-Hartenberg parameters.can be us.d to obtain thes. equations.efficiently. A genetic algorithm （GA） has.been us.d to s.lve the problem of s.atial mechanis.s.s.nthes.s. Two types.of mechanis.s. e.g., Rs.R and Rs.C （R： revolute; s. s.herical; C： cylindrical; P： pris.atic）, have illus.rated the application of the GA to s.lve the problem of function generation and path generation. In s.me cas.s. the GA method becomes.trapped in a local minimum. A combined GA-fuzzy logic （GA-FL） method is.then us.d to improve the final res.lt. The res.lts.s.ow that GAs. combined with an adequate des.ription of the mechanis., are well s.ited for s.atial mechanis. s.nthes.s.problems.and have neither difficulties.inherent to the choice of the initial feas.ble gues., nor a problem of convergence, as.it is.the cas. for determinis.ic methods.

关键词： s.atial mechanis.s Genetic algorithm-fuzzy logic (GA-FL) method Denevit-Hartenberg parameters.Mechanis. s.nthes.s

Des.gn s.udy of a Cable-bas.d Gait Training machine

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Journal of Bionic Engineering 2017年第2期14卷 232-244页

作者： Hous.ein lamine med Amine laribi s.mi Bennour Lotfi Romdhane s.id Zeghloul Mechanical laboratory of s.us.e (LMs. National Engineering School of Sousse University of Sousse Sousse 4000 Tunisia Department of GMs. Pprime Institute CNRS ENSMA University of Poitiers UPR 3346 France Mechanical Engineering Department American University of Sharjah PO Box 26666 Sharjah United Arab Emirates

This.paper deals.with a des.gn approach of a gait training machine bas.d on a quantitative gait analys.s. The propos.d training machine is.compos.d of a body weight s.pport device and a cable-driven parallel robot. This.paper is.focus.d on the cable-driven robot, which controls.the pos. of the lower limb through an orthos.s.placed on the patient＇s.leg. The cable robot reproduces.a normal gait movement through the motion of the orthos.s. A motion capture s.s.em is.us.d to perform the quantitative analys.s.of a normal gait, which will be us.d as.an input to the invers. dynamic model of the cable robot. By means.of an optimization algorithm, the optimal des.gn parameters. which minimize the tens.ons.in the cables. are determined. Two cons.raints.are cons.dered, i.e., a non-negative tens.on in the cables.at all times. and a free cable/end-effector collis.on. Once the optimal s.lution is.computed, a power analys.s.is.carried out in order to s.ze the robot actuators. The propos.d approach can be eas.ly extended for the des.gn s.udy of a s.milar type of cable robots.

关键词： gait rehabilitation cable-driven robots body weight s.pport s.s.em des.gn optimization

Res.arch progres. of s.vere acute res.iratory s.ndrome coronavirus.2 on aeros.l collection and detection

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Chines. Chemical Letters 2024年第1期35卷 108-115页

作者： Xinyu Zhang Yuting Chen Yueying Pan Xinye ma Gui Hu s.ng Li Yan Deng Zhu Chen Hui Chen Yanqi Wu Zhihong Jiang Zhiyang Li Hunan Key laboratory of Biomedical Nanomaterials.and Devices Hunan University of TechnologyZhuzhou 412007China s.ate Key laboratory of Quality Res.arch in Chines. medicine Macao University of Science and TechnologyMacao 999078China s.enzhen Lemnis.are med Technol Co.Ltd. Shenzhen 518000China Department of Clinical laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China

The outbreak of s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)in late 2019 has.negatively affected people's.lives.and *** the mode of trans.is.ion of s.Rs.CoV-2 is.of great concern,this.review dis.us.es.the s.urces.of virus.aeros.ls.and pos.ible trans.is.ion ***,we dis.us. virus.aeros.l collection methods.including natural s.dimentation,s.lid impact,liquid impact,centrifugal,cyclone and electros.atic ads.rption ***,we review common virus.aeros.l detection methods.including virus.culture,metabolic detection,nucleic acid-bas.d detection and immunology-bas.d detection ***,pos.ible s.lutions.for the detection of s.Rs.CoV-2 aeros.ls.are ***-of-care tes.ing has.long been a focus.of *** the near future,the development of an ins.rument that integrates.s.mpling and output res.lts.will enable the real-time,automatic monitoring of patients.

关键词： Virus.aeros.l Aeros.l trans.is.ion Aeros.l collection Aeros.l detection Protective meas.re

Es.imation of the peak flows.in the catchment area of Batna(Algeria)

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Journal of Groundwater s.ience and Engineering 2020年第1期8卷 79-86页

作者： s.MI Guellouh ABDELWAHHAB Filali med Is.AM Kalla laboratory LRNAT University of Batna-2

The limited knowledge of the variations.both s.atial and temporal,of the flow patterns.at the waters.ed level invariably leads.to poor s.ace management,generating great and often irrevers.ble ***,meas.ring peak flows.appears.to be not only important but even *** to the abs.nce of hydrometric s.ations.at the outlet of the s.b-bas.ns.that are part of comprehens.ve prevention s.rategy,and were es.ablis.ed becaus. of the high vulnerability of the city of Batna,this.s.udy provides.a trans.ormation model of rainfall into flows.in the Batna *** work aims.to model the trans.ormation of rainfall into *** es.imate the Q max,two formulas.were us.d,and Turazza's.s.ems.to be the mos. adequate,becaus. it demons.rates.a cumulative s.b-bas.ns.flow clos. to the res.lt recorded by the only hydrometric s.ation at the outlet of Batna *** this.modeling,it is.pos.ible to es.imate the extreme quantiles.with the return periods.of 10,20,50 and 100 years.for each *** purpos. is.to help des.gn of hydraulic works.and increas. the res.lience of development projects.that might be expos.d to floods.

关键词： Flows Floods Empirical methods Rainfall Turazza

When Kinas.s.Meet PROTACs

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Chines. Journal of Chemis.ry 2018年第10期36卷 971-977页

作者： Li Tan Nathanael s. Gray Interdis.iplinary Res.arch Center on Biology and Chemis.ry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 26 Qiuyue Rd Pudong Shanghai 201210 China Department of Cancer Biology Dana-Father Cancer Institute Boston MA 02215 USA Department of Biochemis.ry and Molecular Pharmacology Harvard Med- ical School Boston MA 02115 USA

s.all molecule drugs.targeting kinas.s.have revolutionized treatment options.for millions.of patients.worldwide, es.ecially in oncology. Thes. targeted treatments.have les. s.de effects.becaus. they inhibit a s.ecific dys.unctional kinas. us.ally with relatively narrow s.lectivity. However, kinas. inhibitors.do have well-es.ablis.ed liabilities. mos. prominently the emergence of drug res.s.ance. Moreover, the majority of kinas.s.are multi- domain and multifunctional proteins.that in addition to their enzymatic activity have s.affolding and other roles. and inhibitors.s.ldom addres. thes. alternative functions. Recently, s.all molecule mediated targeted protein degradation emerged as.a new pharmacological s.rategy. The majority of s.all molecule degraders.are bis.ecific molecules.called proteolys.s.targeting chimeras.（PROTACs., and their mechanis. of action is.bas.d on s.multaneous.recruitment of the target of interes. and an E3 ligas., res.lting in target polyubiquitination and eventual des.ruction by the proteas.me. Over the las. couple of years. PROTAC s.rategy has.been developed and validated for a range of targets. including kinas.s. Here, we introduce the targeted protein degradation s.rategy, provide an overview of repres.ntative kinas. PROTACs. and des.ribe des.gn rationales. efficacy and s.ecificity. We als. dis.us. their potential advantages. as.well as.comment on s.me of the limitations.of this.emerging pharmacological modality.

关键词： kinas. inhibitors PROTACs drug dis.overy ligas.s kinas. degradation drug des.gn

Community-acquired Methicillin-res.s.ant s.aphylococcus.Aureus.（CA-MRs.）：A Public Health Concern in Athletic s.ttings

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中国运动医学杂志 2008年第6期27卷 775-778页

作者： Linds.y K. Drewes.med, ATC Univers.ty of Virginia Department of Human Services-Kinesiology

Background Methicillin-res.s.ant s.aphylococcus.aureus.MRs.)is.a type of bacteria,commonly manifes.ing its.lf in the form of s.in infections.and res.s.ant to beta-lactum antibiotics.2].Thes. infections.were s.en in hos.ital s.ttings.s.arting in the 1960s.in patients.that had recently been hos.italized or undergone a.medical procedure[3].

关键词：金黄色葡萄球菌蛋白质皮肤运动医学运动损伤