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中山大学学报(医学科学版) 2000年第4期21卷 322-323页

作者： ChengDanFong,BDs,ma,DDs,PHD DivisionofEndodontics!schoolofDentalandOralsurgery ColumbiaUniversity NewYork NY U.s.A. DivisionofEndodontics!schoolofDentalandOralsurgery ColumbiaUniversity NewYork NY U.s.A. DivisionofEndodontics!schoolofDentalandOralsurgery ColumbiaUniversity NewYork N

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Temporal Behaviour of a Corner separation in a Radial Vaned Diffuser of a Centrifugal Compressor Operating near surge

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Journal of Thermal science 2013年第6期22卷 555-564页

作者： A.marsan I.Trébinjac s.Coste G.Leroy Laboratoire de Mécanique des Fluides et d'Acoustique UMR CNRS 5509 cole Centrale de Lyon Turbomeca Safran group

The temporal behaviour of a flow separation in the hub-suction side comer of a transonic diffuser is studied thanks to unsteady numerical simulations based on the phase-lagged approach. The validity of the numerical re- sults is confn＇med by comparison with experimental unsteady pressure measurements. An analysis of the instan- taneous skin-friction pattern and particles trajectories is presented. It highlights the topology of the separation and its temporal behaviour. The major result is that, despite of a highly time-dependent core flow, the separation is found to be a ＂fixed unsteady separation＂ characterized by a fixed location of the main saddle of the separation but an extent of the stall region modulated by the pressure waves induced by the impeller-diffuser interaction.

关键词： Corner separation Radial Vaned Diffuser Centrifugal Compressor surge

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实验性癫痫及电针抗痫时大鼠海马内胆囊收缩素基因表达的变化

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针刺研究 1996年第2期21卷 62-66页

作者：杨茹王布尔程介士上海医科大学医学神经生物学国家重点实验室上海200032

采用原位杂交，NorthernBlot及计算机图像处理技术，观察青霉素致癫痫动物及加电针后海马内胆囊收缩素（CCK）mRNA水平的变化。发现癫痫时，在间脑冠状切面、背海马的齿状回和CA3区，CCKmRNA水平明显提高，电针后，CCKmRNA水平回降，同... 详细信息

采用原位杂交，NorthernBlot及计算机图像处理技术，观察青霉素致癫痫动物及加电针后海马内胆囊收缩素（CCK）mRNA水平的变化。发现癫痫时，在间脑冠状切面、背海马的齿状回和CA3区，CCKmRNA水平明显提高，电针后，CCKmRNA水平回降，同时在中脑冠状切面、腹海马的下托、背海马的齿状回和CA3区，可见癫痫时CCKmRNA量增加．而电针进一步增加了CCKmRNA的含量。结果提示：电针对青霉素致痫在脑电和行为上表现出来的抑制作用可能与其在海马不同区域调控CCK基因的表达有关。

关键词：胆囊收缩素癫痫电针疗法

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Detection of the short-term preseizure changes in EEG recordings using complexity and synchrony analysis

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Progress in Natural science:materials International 2006年第7期16卷 691-700页

作者： JIA Wenyan, KONG Na, ma Jun, LIU Hesheng, GAO Xiaorong, GAO shangkai and YANG Fusheng (Department of Biomedical Engineering, school of medicine, Tsinghua University, Beijing 100084, China) Tsing Hua Univ Sch Med Dept Biomed Engn Beijing 100084 Peoples R China

An important consideration in epileptic seizure prediction is proving the existence of a pre-seizure state that can be detected using various signal processing algorithms. In the analyses of intracranial electroencephalographic (EEG)recordings of four epilepsy patients, the short-term changes in the measures of complexity and synchrony were detected before the majority of seizure events across the sample patient population. A decrease in complexity and increase in phase synchrony appeared several minutes before seizure onset and the changes were more pronounced in the focal region than in the remote region. This result was also validated statistically using a surrogate data method.

关键词： EEG epileptic seizure prediction second-order complexity synchrony.

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Development of a functional electrical stimulation system base on the body area network for stroke and sCI rehabilitation

Development of a functional electrical stimulation system ba...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong-En QU,Ting WANG,Ning LAN~* The Institute of Rehabilitation Engineering,The med-X Research Institute,school of Biomedical Engineering, shanghai Jiao Tong University,shanghai 200030,China

＜正＞Objective This paper describes a functional electrical stimulation（FEs） system based on the body area network（BAN） for helping the stroke survivors and sCI patients in the *** FEs system not only has very high performance to perform the stimulation and control deciding required in the application of relearning or restoring the motor function,but also has the high flexibility to expand to other related clinical applications such as the medical monitoring platform and rehabilitation *** To achieve the aim,we design three main hardware components of the networked FEs system including a master unit（MU）,a distributed stimulation-sensor unit（DssU）,and a clinical *** we also develop a Body Area Network and use it to organize the whole FEs system following the network *** MU as the controller of this system manages all distributed stimulation-sensor units as the stimulation channels as the network node in *** this structure,the FEs system can conveniently provide the multi-channel preprogra.med stimulation current at the same *** We have completed a prototype of system including the hardware and software *** test of the FEs system shows that the stimulation current amplitude ranges from 1 ma to 58 ma and that the stimulation pulse width can be from 10μs to 1 000μs with 1 us *** The evaluation test indicates that the system performance meets design *** BAN FEs system has been designed and tested for *** MU and DssU design in the networked FEs system is proposed and a prototype has been constructed and tested in laboratory.

关键词： functional electrical stimulation body area network motor rehabilitation

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Portal hypertensive gastropathy:A systematic review of thepathophysiology,clinical presentation,natural history andtherapy

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World Journal of Hepatology 2016年第4期8卷 231-262页

作者： Mihajlo Gjeorgjievski Mitchell s Cappell Division of Gastroenterology and Hepatology William Beaumont HospitalRoyal OakMI 48073United States Oakland University William Beaumont school of medicine Royal OakMI 48073United States

AIM: To describe the pathophysiology, clinical presentation, natural history, and therapy of portal hypertensive gastropathy(PHG) based on a systematic literature ***: Computerized search of the literature was performed via Pub med using the following medical subject headings or keywords: "portal" and "gastropathy"; or "portal" and "hypertensive"; or "congestive" and "gastropathy"; or "congestive" and "gastroenteropathy". The following criteria were applied for study inclusion: Publication in peer-reviewed journals, and publication since 1980. Articles were independently evaluated by each author and selected for inclusion by consensus after discussion based on the following criteria: Well-designed, prospective trials; recent studies; large study populations; and study emphasis on PHG. REsULTs: PHG is diagnosed by characteristic endoscopic findings of small polygonal areas of variable erythema surrounded by a pale, reticular border in a mosaic pattern in the gastric fundus/body in a patient with cirrhotic or non-cirrhotic portal hypertension. Histologic findings include capillary and venule dilatation, congestion, and tortuosity, without vascular fibrin thrombi or inflammatory cells in gastric submucosa. PHG is differentiated from gastric antral vascular ectasia by a different endoscopic appearance. The etiology of PHG is inadequately understood. Portal hypertension is necessary but insufficient to develop PHG because many patients have portal hypertension without *** increases in frequency with more severe portal hypertension, advanced liver disease, longer liver disease duration, presence of esophageal varices, and endoscopic variceal obliteration. PHG pathogenesis is related to a hyperdynamic circulation, induced by portal hypertension, characterized by increased intrahepatic resistance to flow, increased splanchnic flow, increased total gastric flow, and most likely decreased gastric mucosal flow. Gastric mucosa in PHG shows increased susceptibilit

关键词： Portal hypertensive gastropathy Congestivegastropathy Portal hypertension Cirrhosis Cirrhotic Chronic liver disease Nonvariceal upper gastrointestinalbleeding Esophageal varices Hepatic fibrosis

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Contemporary solutions for patients with microtia and congenital aural atresia-Hong Kong experience

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Journal of Otology 2016年第4期11卷 -页

作者： Willis s.s.Tsang Michael C.F.Tong Peter K.M.Ku Kunwar s.s.Bhatia Joannie K.Y.Yu Terence K.C.Wong C.Andrew van Hasselt Department of Otorhinolaryngology Head and Neck Surgery The Chinese University of Hong Kong Prince of Wales Hospital Department of Imaging & Interventional Radiology The Chinese University of Hong Kong Prince of Wales Hospital

managing microtia patients is always a challenge. Multidisciplinary approach, good family support, well established doctorepatient rela-tionship and well organised patient-support groups are the essential elements for success. With the advancement of implantable hearing devices, more options will be available for the microtia patients. Otologists play a leading role in the whole management process. They not only provide proper guidance to the patients in choosing the correct path of the treatment, but also play a key role in organising and maintaining a cost-effective multidisciplinary rehabilitation team for the microtia patients.

关键词： Microtia Congenital aural atresia Implantable hearing aids Bone conduction

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Multimolecular complex of Par-4 and E2F1 binding to smac promoter contributes to glutamate-induced apoptosis in human-bone mesenchymal stem cells

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南京医科大学学报(自然科学版) 2008年第11期 1493-1493页

作者： Lu,C.Chen,J.Q.Zhou,G.P.Wu,s.H.Guan,Y.F.Yuan,C.s.Nanjing med Univ,Dept Pediat,Affiliated Hosp 1,Nanjing 210029,Jiangsu,Peoples R China.

Neural cells undergo glutamate-induced apoptosis in ischaemic brain tissue,in which prostate apoptosis response-4 gene (Par-4)is ***-bone mesenehymal stem cells can be utilized as an effective therapy for ischemic brain *** this study,we found that glutamate could induce apoptosis in human-bone mesenehymal stem cells,accompanied by increased expression of Par-4 gene and smac release from *** Par-4 expression attenuated the glutamate-induced *** Par-4 protein and E2F1 protein could bind to E2F1-binding Bs3 site on smac promoter and participated in the formation of a pro- teins-DNA ***,in the eomplex,E2F1,not Par-4,was found to be directly bound to the smac promoter,suggesting that Par-4 exerted indireetly its transcriptional control on the smac gene though interacting with *** of full-length Par-4 in human-bone mesenchymal cells resulted in increased activity of the smac *** addition,the indirect transcripional regula- tion of Par-4 on smac depended on its COOH terminus-mediated interaction between Par-4 and *** conclude that the forma- tion of proteins-DNA complex,containing Par-4 protein,E2F1 protein and the smac promoter,contributes to the pro-apoptotic effect on glutamate-treated human-bone mesenchymal stem cells.

关键词： protein-kinase-c transcription smac/diablo mechanisms stroke target cancer apaf-1 bcl-2 arf

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麻醉与镇痛 2011年第4期7卷 46-55页

作者： matthias Haenggi, MD Heidi Ypparila-Wolters, PhD sarah Buerki, cand. med Rebekka schlauri, cand. med Ilkka Korhonen, PhD Jukka Takala, MD, PhD stephan M. Jakob, MD, PhD 马競(译) 王焱林(校) Department of Intensive Care medicine Bern University Hospital and University of Bern Bern Switzerland VTF Technical Research Centre of Finland Tampere Finland 不详

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始... 详细信息

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始倍受青睐：我们想明确听觉诱发相关电位（ERPs）、脑电双频指数（BIs）和墒（Entropy）是否也能够评估临床镇静深度。方法选择10例择期全麻下行胸部或腹部手术的患者。手术后进入ICU，逐渐减少丙泊酚和瑞芬太尼靶控镇静程度[采用Rickmond Agitation镇静评分（RAss），-5分极深镇静，-4分深度镇静，-3～-1分中度镇静，0分清醒]期间，记录脑电图、BIs、状态熵（sE）、反应墒（RE）和ERPs。手术前或手术后数天测量指标的相关基础水平。结果基线、PAss-5分、RAss-4分、RAss-3至-1分和PAss-0分，对应的BIs值分别是94[4]（中位数，四分位数间距）、47[15]、68[9]、75[10]和88[6]；对应的sE值分别是87[3]、46[10]、60[22]、74[21]和87[5]；对应的RE值分别是97[4]、48[9]、71[25]、81[8]和96[3]（P〈0．05，Friedman检验）。BIs和墒都有高变异度。当单独考虑ERP振幅100时，各个镇静水平的ERPs值差异无显著性：但是、复括双参数主要变量分析的ERP辨别分析显示区别深度镇静、中度镇静和清醒状态的推算概率PK大约是0．89。与PK对应的RE，sE和BIs值分别是0．88、0．89和0．85。结论ERPs、BIs和熵均不能替代基于标准评分系统的临床镇静评估。全麻后对于极深镇静、深度到中度镇静和清醒的辨别，ERPs和脑电图仅能提供相似的PK值。BIs和熵存在较高的个体间和个体自身变异度，使其难以确定预测镇静水平的目标值范围，因而在危重患者中的使用受到限制。ERPs的变异度还不清楚。

关键词：脑电双频指数重症监护病房镇静评分危重患者相关电位听觉诱发状态熵 Friedman

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基于PIC16C57单片机的智能低电阻测量仪

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现代电子技术 2002年第4期25卷 27-29页

作者：尹波邓奕湖南江南机器厂科技部湘潭411207 湖南工程学院机械工程系湘潭411101

介绍一种以 PIC16 C5 7单片机为核心的低电阻测量仪 ,与普通的低电阻测量仪不同的是 :该测量仪的测试电流仅为 0 .5 m A并加有多种保护电路 ,具有很高的安全性能。主要应用于军工、国防。

关键词：智能低电阻测量仪 PIC单片机火工品保护电路

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