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垂体瘤卒中的MRI表现和临床对照研究

华中科技大学学报（医学版） 2004年第6期33卷 749-751,759页

作者：张华楸舒凯董芳永汤浩李龄雷霆华中科技大学同济医学院附属同济医院神经外科武汉430030

目的　结合临床分析垂体卒中的MRI表现 ,探讨MRI对诊断、治疗垂体卒中的意义。方法　对 31例垂体卒中患者行MRI检查 ,并结合临床症状、手术情况和病理结果进行对照研究。结果　①本组所有病例均为大腺瘤或巨腺瘤。②MRI中瘤体出血多表现... 详细信息

目的　结合临床分析垂体卒中的MRI表现 ,探讨MRI对诊断、治疗垂体卒中的意义。方法　对 31例垂体卒中患者行MRI检查 ,并结合临床症状、手术情况和病理结果进行对照研究。结果　①本组所有病例均为大腺瘤或巨腺瘤。②MRI中瘤体出血多表现为T1WI高信号 ,T2 WI高信号或等高混杂信号 ;坏死或囊变表现为T1WI低信号 ,T2 WI高信号或等高混杂信号。根据卒中部位可分为中央型、周围型、不规则型和全瘤型。③发现垂体瘤卒中存在某些特殊的MRI表现 ,如靶心征 ,分层现象等。④本组病例中侵袭性垂体瘤占 5 8% ,非侵袭性垂体瘤占 4 2 %。PRL腺瘤占 5 2 % ,其它激素腺瘤占 4 8%。结论　MRI对于垂体卒中的诊断和治疗有很高的临床价值。侵袭性垂体瘤比非侵袭性垂体瘤 ,PRL激素腺瘤比其他激素腺瘤都更易出现垂体腺瘤卒中。

关键词：垂体卒中 MRI表现侵袭性垂体瘤腺瘤 PRL WI 临床对照研究混杂分层现象部位

Mat hematical modeling and analysis of innate and humoral immune responses to dengue infections

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International Journal of Biomathematics 2019年第7期12卷 95-110页

作者： sulanie Perera s.s.N.Perera Research and Development Center for Mathematical Modeling Faculty of ScienceUniversity of ColomboColombo 3Sri Lanka

Dengue is an acute arthropode-borne virus,belonging to the family ***,there are no vaccines or treatments available against *** it is important to understand the dynamics of dengue in order to control the *** this paper,we study the long-term dynamics of the model that is presented in[*** and ***,simulation model for dynamics of dengue with innate and humoral immune responses,*** med.2018(2018)8798057,18 ***:10.1155/2018/8798057]which describes the interaction of virus with infected and uninfected cells in the presence of innate and humoral immune *** was found the model has three equilibria,namely:infection free equilibrium,no immune equilibrium and endemic equilibrium,then analyzed its stability *** analytical findings of each model have been exemplified by numerical *** the fact that intensity of dengue virus replication at early times of infection could determine clinical outcomes,it is important to understand the impact of innate immunity,which is believed to be the first line of defense against an invading *** this we carry out a simulation case study to investigate the importance of innate immune response on dengue virus dynamics.A comparison was done assurming that innate immunity was active;innate immunity was in quasi-steady state and innate immunity was inactive during the virus replication *** a further analysis of the qualitative behavior of the quasi-steady state,it was observed that innate immune response plays a pivotal role in dengue virus *** can change the dynamical behavior of the system and is essential for the virus clearance.

关键词： Dengue humoral inate equilibrium stability quasi-steady state

Methods and parameters of melting curve analysis for identification of Leishmania species:A scoping review

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Asian Pacific Journal of Tropical medicine 2021年第12期14卷 528-542页

作者： Juliana J G Ferreira Fernanda s Nascimento Glaucia E B Marcon Eros A de Almeida sandra C B Costa Laboratório de Diagnóstico de Doenças Infecciosas por Técnicas de Biologia Molecular Departamento de Clínica MédicaFaculdade de Ciências MédicasUniversidade Estadual de Campinas(UNICAMP)Campinas13083-887SPBrazil Fundação Oswaldo Cruz Mato Grosso do sul(FIOCRUZ Ms) Rua Gabriel Abrão92Jardim das NaçõesCampo Grande79081-746 MSBrazil Grupo de Estudos em Doença de Chagas Departamento de Clínica MédicaFaculdade de Ciências MédicasUniversidade Estadual de Campinas(UNICAMP)Campinas13083-887SPBrazil

Leishmaniasis is a set of diseases with a worldwide distribution that affects mainly economically underprivileged populations in developing countries. It has a major impact on public health, with a global cost of billions of dollars per year. The treatment and control of leishmaniasis vary according to the Leishmania species involved, which require reliable methods for species identification. since most of the currently used methods have limitations, there is a need for assays that allow rapid, precise identification of the offending species. Real-time polymerase chain reactions in conjunction with dissociation curve analysis have been used to detect differences in the DNA composition of selected genes of Leishmania spp. Kinetoplast DNA is the main molecular target used because of its high copy number per parasite, but other targets have also been studied. As part of an effort to establish melting temperature standards for each target gene, we have reviewed the pertinent literature available in public databases, including Pub med, Web of science, sci ELO and LILACs, using the keywords "Leishmania", "leishmaniasis", "realtime PCR", "melting temperature", and "melting curve", alone or in combination. After applying eligibility criteria, 27 articles were selected for analysis. A considerable variation in the methodologies analyzed was found regarding molecular targets, standardization of the methods, reproducibility and specificity. Because of this, statistical analysis was not performed. In most cases, the methods were able to differentiate the parasite at the subgenus level or few species regardless of the target chosen.

关键词： Leishmaniasis Melting temperature Real-time PCR

采用图像信息学方法研究三维支架中细胞的信号通路

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上海交通大学学报 2014年第9期48卷 1257-1262页

作者：郭进 TZERANIs Dimitrios s sO Peter T C 魏勋斌复旦大学化学系生物医学研究院上海200433 麻省理工学院生物工程系美国剑桥021390 上海交通大学med-X研究院上海200030

通过慢病毒介导的短发夹RNA对成纤维细胞的转化生长因子β(TGF-β)信号通路进行干扰,采用双光子荧光显微成像技术并结合基于细胞-细胞外基质三维系统的图像信息学方法,研究了植于多孔胶原蛋白支架中成纤维细胞分化过程的TGF-β信号通路... 详细信息

通过慢病毒介导的短发夹RNA对成纤维细胞的转化生长因子β(TGF-β)信号通路进行干扰,采用双光子荧光显微成像技术并结合基于细胞-细胞外基质三维系统的图像信息学方法,研究了植于多孔胶原蛋白支架中成纤维细胞分化过程的TGF-β信号通路.结果表明,在介导成纤维细胞分化的过程中,生长因子TGF-β1比TGF-β3发挥的作用更大,在TGF-β1介导的成纤维细胞分化过程中,蛋白sMAD1和sMAD3通过不同方式也发挥了重要作用.所得结果与通过生化或遗传学方法的结果相吻合.

关键词：图像信息学双光子荧光显微成像转化生长因子β 成纤维细胞多孔胶原蛋白支架

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微型葡萄糖微传感器的研制及其应用

济宁医学院学报 2002年第4期25卷 7-9页

作者：孙勤枢王宁孙懿济宁医学院生物电化学与药物化学研究室济宁医学院九八级一班

目的　研究微型葡萄糖传感器的制备与电化学性能。方法　以注射用不锈钢针作壳体 ,碳纤维束作基质电极 ,二茂铁作电子传递体 ,用新鲜蛋清加戊二醛固定葡萄糖氧化酶和酶介体 ,制备电流式葡萄糖微型传感器。结果　传感器的外径可小至 0 3... 详细信息

目的　研究微型葡萄糖传感器的制备与电化学性能。方法　以注射用不锈钢针作壳体 ,碳纤维束作基质电极 ,二茂铁作电子传递体 ,用新鲜蛋清加戊二醛固定葡萄糖氧化酶和酶介体 ,制备电流式葡萄糖微型传感器。结果　传感器的外径可小至 0 35mm ,实现工作电极、参比电极和辅助电极一体化。结论　响应时间小于 5s ,检测的线性范围为 0 0 2～ 15mmol/L ,11次平行测试的相对标准偏差为 2 .9% ,2 5℃放置 3个月 ,酶活性仍为原来的 75 %。室温 2 5℃下 ,该传感器在 2个月内连续测试 ,电流响应基本上保持不变。

关键词：微型葡萄糖微传感器研制应用

Impact of Drug-Drug Interaction between CDK4/6 Inhibitors and Proton Pump Inhibitors on survival Outcomes in the Treatment of Metastatic Breast Cancer—Real World Data from a Portuguese Center

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Journal of Cancer Therapy 2022年第5期13卷 266-274页

作者： Joana Reis Inês Costa Mariana Cos.a.a.a.Valente Catarina Almeida Marta Freitas Cláudia Caeiro Catarina Fernandes Nuno Tavares Miguel Barbosa Centro Hospitalar sÃ O JOÃ O E.P.E. Porto Portugal

Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFs). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (Os) and PFs. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. sPss software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value s considered significant. Results: 80 patients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower Os (Os-3 years 42.6% vs. 63.4%, p = 0.254) and PFs (PFs med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world dat

关键词： Drug Interaction survival Impact Advanced Breast Cancer CDK4/6 Inhibitors Proton Pump Inhibitors

CPA—2系统与多道记录仪测定左室收缩时间间期的对照分析

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暨南大学学报（自然科学与医学版） 1992年第4期13卷 35-37页

作者：黄铮陈玉琼林利雅暨南大学暨南大学附属医院内科

采用多道生理记录仪直接描记法测定的 sTI 作为对照,用 CPA-2系统对31例病人(自身对照)进行 sTI 值的测定,以评价 CPA-2系统这一新的无创性心功能检测方法.结果显示两者所测得的 HR、Q-s_2、LVET、PEP 及 PEP/LVET均具有显著性正相关(P<... 详细信息

采用多道生理记录仪直接描记法测定的 sTI 作为对照,用 CPA-2系统对31例病人(自身对照)进行 sTI 值的测定,以评价 CPA-2系统这一新的无创性心功能检测方法.结果显示两者所测得的 HR、Q-s_2、LVET、PEP 及 PEP/LVET均具有显著性正相关(PsTI.

关键词： CPA-2系统左室收缩时间时期

Fatal and non-fatal injuries due to suspension trauma syndrome: A systematic review of definition, pathophysiology, and management controversies

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World Journal of Emergency medicine 2021年第4期12卷 253-260页

作者： Patrizio Petrone sofía Espinoza-Villalobos Gerard ABaltazar Kjetil søreide Adam stright Collin E.M.Brathwaite D’Andrea K.Joseph Department of surgery NYU Long Island School of MedicineNYU Langone Hospital–Long IslandMineola 11501USA 2 Department of Gastrointestinal SurgeryStavanger University HospitalStavanger 4011Norway

BACKGROUND: suspension trauma syndrome is a life-threatening event that occurs when a person is "trapped" in a prolonged passive suspension. It is most commonly seen in people who engage in occupational or sport activities that require harness suspension. The aim of this study is to identify the predisposing factors, pathophysiology, and management of suspension ***: A review and analysis of the literature published in English and spanish from 1972 to 2020 on suspension trauma were performed. search sources were Pub med, medline, Cochrane Library, MesH, Up To Date, and Google scholar. Articles referring to suspension trauma associated with other injury mechanisms(traumatic impact injuries, drowning, asphyxiation, or bleeding), case reports, and pediatric population were ***: Forty-one articles were identified. Of these, 29 articles related to mechanism, pathophysiology, and management of individuals who suffered prolonged suspension trauma without associated traumatic injuries were included in the study. We encountered several controversies describing the putative pathophysiology, ranging from blood sequestration in the lower extremities versus accumulation of metabolic waste and hyperkalemia to dorsal hook-type harness as a trigger cause of positional asphyxia;to vascular compression of femoral vessels exerted by the harness causing decreased venous return. Pstients suspended in a full-body harness with dorsal hook showed more hemodynamic alterations in response to the compressive effect on the rib cage, causing a reduction in perfusion by presenting a decrease in pulse pressure. Management strategies varied across ***: Progress has been made in individualizing the population at risk and in the management of suspension trauma. We recommend the formation of consensus definitions, larger cohort or registry studies to be conducted, and experimental animal models to better understand the mechanisms in order to develop management

关键词： suspension trauma Reflux syndrome suspension trauma syndrome Harness suspension

8-chloroadenosine induces apoptosis in human MOLT-4 cell line

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Chinese science Bulletin 1997年第7期42卷 592-597页

作者： Wang, XT Zheng, DX Liu, R Liu, YX Xiao, s Min, JM Zheng, P Zhang, LH Liu, sL CHINEsE ACAD med sCI PEKING UNION MED COLLSTATE KEY LAB MED MOL BIOLBEIJING 100005PEOPLES R CHINA

THE 8-chloroadenosine (8CA) is a novel analog of adenosine synthesized in the National Research Laboratories of Natural and Biomimetic Drugs. Fang et al. reported that 8CA is capable of inhibiting the cell growth in v... 详细信息

关键词： 8-chloroadenosine apoptosis MOLT-4 cells.