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Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review

World Journal of Gastroenterology 2015年第6期21卷 1945-1955页

作者： Michael s Broder David Beenhouwer Jonathan R strosberg Maureen P Neary Dasha Cherepanov Partnership for Health Analytic Research LLC Beverly Hills H. Lee Moffitt Cancer Center and Research Institute Novartis Pharmaceuticals Corporation

AIM:To review literature on efficacy and safety of octreotide-long-acting repeatable(LAR)used at doses higher than the Food and Drug Administration(FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors(NETs).METHODs:We searched Pub med and Cochrane Library from 1998-2012,5 conferences(American society of Clinical Oncology,Endocrine society,European Neuroendocrine Tumor society,European society for medical Oncology,North American Neuroendocrine Tumor society)from 2000-2013 using Me sH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and *** of accepted articles were also *** reviewers reviewed titles,abstracts,and full-length *** that reported data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,published in any language were included in the ***:The search identified 1086 publications,of which 238 underwent full-text review(20 were translated into English);17 were included in the *** varied in designs,subjects,octreotide-LAR regimens,and definition of *** studies reported use of higher doses to control symptoms and tumor progression,although symptom severity and formal quality-of-life analysis were not quantitatively *** studies reported efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/*** studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor *** studies reported safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/***:As reported in this review,octreotide-LAR at doses>30 mg/mo is being prescribed for symptom and tumor control in NET ***,expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal sy

关键词： Carcinoma Neuroendocrine Carcinoid syndrome Carcin

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Is there a difference between 19G core biopsy needle and 22G core biopsy needle in diagnosing the correct etiology?——A meta-analysis and systematic review

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World Journal of Meta-Analysis 2017年第2期5卷 54-62页

作者： Manasa Kandula Matthew L Bechtold Kaninika Verma Bhagat s Aulakh Deepak Taneja srinivas R Puli Division of Internal medicine University of Illinois College of Medicine at Peoria Division of Gastroenterology and Hepa-tology University of Missouri School of Medicine at Columbia Illinois Lung and Critical Care Institute University of Illinois College of Medicine at Peoria Division of Gastroenterology and Hepatology University of Illinois College of Medicine at Peoria

AIM To compare the accuracy of endoscopic ultra-sonography(EUs) 19 G core biopsies and 22 G core biopsies in diagnosing the correct etiology for a solid *** Articles were searched in medline, Pub med, and Ovid journals. Pooling was conducted by both fixed and random effects models. REsULTs Initial search identified 4460 reference articles for 19 G and 22 G, of these 670 relevant articles were selected and reviewed. Data was extracted from 6 studies for 19G(n = 289) and 16 studies for 22G(n = 592) which met the inclusion criteria. EUs 19 G core biopsies had a pooled sensitivity of 91.6%(95%CI: 87.1-95.0) and pooled specificity of 95.9%(95%CI: 88.6-99.2), whereas EUs 22 G had a pooled sensitivity of 83.3%(95%CI: 79.7-86.6) and pooled specificity of 64.3%(95%CI: 54.7-73.1). The positive likelihood ratio of EUs 19 G core biopsies was 9.08(95%CI: 1.12-73.66) and EUs 22 G core biopsies was 1.99(95%CI: 1.09-3.66).The negative likelihood ratio of EUs 19 G core biopsies was 0.12(95%CI: 0.07-0.24) and EUs 22 G core biopsies was 0.25(95%CI: 0.14-0.41). The diagnostic odds ratio was 84.74(95%CI: 18.31-392.26) for 19 G core biopsies and 10.55(95% CI: 3.29-33.87) for 22 G needles. CONCLUsION EUs 19 G core biopsies have an excellent diagnostic value and seem to be better than EUs 22 G biopsies in detecting the correct etiology for a solid mass.

关键词： Endoscopic ultrasound guided fine needle aspiration solid mass lesions Endoscopic ultrasound Pancreatic mass Pancreatic cytology Core biopsies 19G procore needle Meta-analysis systematic review 22G procore needle

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survivin和COX-2在膀胱移行细胞癌中的表达

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宁夏医学院学报 2008年第2期30卷 173-175,F0004页

作者：卢冠军陈福宝张宁妹徐永辉宁夏医学院附属医院泌尿外科银川750004 宁夏医学院附属医院病理科银川750004

目的探讨survivin和COX-2在人膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法采用s-P免疫组化技术分别观察40例BTCC和10例正常膀胱组织标本中survivin和COX-2的表达,分析其表达水平与BTCC临床病理参数之间的关系。结果survivin和COX-... 详细信息

目的探讨survivin和COX-2在人膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法采用s-P免疫组化技术分别观察40例BTCC和10例正常膀胱组织标本中survivin和COX-2的表达,分析其表达水平与BTCC临床病理参数之间的关系。结果survivin和COX-2基因在BTCC中的表达与在正常膀胱黏膜比较差异均有统计学意义(均为Psurvivin和COX-2表达的差异具有统计学意义(Psurvivin和COX-2的高表达是BTCC预后不良的指征,有望成为BTCC预后不良的独立性指标。

关键词：移行膀胱癌 survivin COX-2

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银川市郊区2925名中小学生先天性心脏病及血压参考值的调查分析

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宁夏医学杂志 1989年第6期 327-329页

作者：刘天锡张毓洪刘兰陈树兰强艳魏永新宁夏医学院流行病学教研室宁夏医学院附属医院盐池县卫生防疫站

经1988年的一次分层整群随机抽样调查(共检查2,925名学龄儿童和少年),银川市郊区中、小学生先天性心脏病患病率为1.71‰,男2.02‰,女1.39‰;血压值7～13岁在92～105/60～67mmHg±1.96s范围内,14～18岁在106～115/68～75mmHg±1.96s范围内。

关键词：血压收缩压血压值参考值中、小学生先天性心脏病心脏先天畸形舒张压

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Regulations in the United states for cell transplantation clinical trials in neurological diseases

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Translational Neuroscience and Clinics 2015年第2期1卷 114-124页

作者： He Zhu Yuanqing Tan Qi Gu Weifang Han Zhongwen Li Jason s. Meyer Baoyang Hu state Key Laboratory of stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Graduate school of Chinese Academy of sciences ARC Centre of Excellence for Electromaterials science (ACEs) Intelligent Polymer Research Institute AIIM Facility Innovation Campus University of Wollongong Department of Biology Indiana University Purdue University Indianapolis

Objective: This study a.med to use a systematic approach to evaluate the current utilization, safety, and effectiveness of cell therapies for neurological diseases in human. And review the present regulations, considering United states(Us) as a representative country, for cell transplantation in neurological disease and discuss the challenges facing the field of neurology in the coming decades. Methods: A detailed search was performed in systematic literature reviews of cellular‐based therapies in neurological diseases, using Pub med, web of science, and clinical trials. Regulations of cell therapy products used for clinical trials were searched from the Food and Drug Administration(FDA) and the National Institutes of Health(NIH).Results: seven most common types of cell therapies for neurological diseases have been reported to be relatively safe with varying degrees of neurological *** a series of regulations in Us for cellular therapy was summarized including preclinical evaluations, sourcing material, stem cell manufacturing and characterization,cell therapy product, and clinical trials. Conclusions: stem cell‐based therapy holds great promise for a cure of such diseases and will value a growing population of patients. However, regulatory permitting activity of the Us in the sphere of stem cells, technologies of regenerative medicine and substitutive cell therapy are selective, theoretical and does not fit the existing norm and rules. Compiled well‐defined regulations to guide the application of stem cell products for clinical trials should be formulated.

关键词： fetal neural stem cells Parkinson’s disease transplantation differentiation dopamine neuron

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川西北草地牛皮蝇蛆病的研究

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西南民族学院学报（自然科学版） 1996年第2期22卷 185-190页

作者：蒋锡仕黄孝玢杨晓农宋远军何世明昌旺西南民族学院阿坝州畜牧兽医研究所

对川西北草地牛皮蝇蛆病的流行情况、季节动态及防治技术的研究表明：（１）临床检查牦牛１１４９头、黄牛５９９头，皮蝇蛆寄生率分别为８４．２５％和７０．２８％，寄生强度为１８．３２个和２．１７个；剖杀检查牦牛１１４头，皮蝇... 详细信息

对川西北草地牛皮蝇蛆病的流行情况、季节动态及防治技术的研究表明：（１）临床检查牦牛１１４９头、黄牛５９９头，皮蝇蛆寄生率分别为８４．２５％和７０．２８％，寄生强度为１８．３２个和２．１７个；剖杀检查牦牛１１４头，皮蝇蛆寄生率为１００％，寄生强度为７１．６６个．（２）川西北草地皮蝇的种类，经形态学和生化特性鉴定定为牛皮蝇Ｈ．ｂｏｖｉｓ、纹皮蝇Ｈ．ｌｉｎｅａｔｕｍ和中华皮蝇Ｈ．ｓｉｎｒｎｓｅ等三种．（３）弄清了皮蝇各期幼虫在牛体内的寄生季节、寄生部位、移行动态、三期幼虫寄生方位、入土化蛹羽化规律、成虫活动规律等．（４）害获灭（Ｉｖｏｍｅｃ）是防治牛皮蝇蛆病的首选药物，具有效果好、广谱、剂量小、安全、使用方便、易于推广等优点。

关键词：寄生率牦牛牛牛皮蝇蛆病寄生虫病防治

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禽流感病毒鸭源分离株的动物感染试验

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动物科学与动物医学 2004年第2期21卷 55-57页

作者：李芙蓉王永坤王建业庄国宏扬州大学畜牧兽医学院江苏扬州225009

选择两株新近分离的具有脑坏死病变特征的番鸭源禽流感病毒(AIV)毒株和两株前期分离的无脑坏死病变的AIV毒株,进行不同动物的感染试验,以期获得病毒在不同动物的致病病变特征和不同动物的易感性比较。结果表明,番鸭源AIV毒株较其他两毒... 详细信息

选择两株新近分离的具有脑坏死病变特征的番鸭源禽流感病毒(AIV)毒株和两株前期分离的无脑坏死病变的AIV毒株,进行不同动物的感染试验,以期获得病毒在不同动物的致病病变特征和不同动物的易感性比较。结果表明,番鸭源AIV毒株较其他两毒株致病力强,且四毒株对鸡、鹅的致病力比对不同品种的鸭强。

关键词：禽流感病毒鸭源分离株动物感染试验致病力易感性

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用Digoxigenin标记DNA探针作基因转移山羊的整合检测

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生物技术 1992年第4期2卷 11-13,20页

作者：成国祥王捍东成勇吴维芬穆宗尧李国忠江苏农学院畜牧兽医系

对采用外源基因原核显微注射法生产的基因转移山羊,用一种新的DNA非同位素标记法即地高辛配基标记DNA探针作外源基因整合检测.结果表明:地高辛标记核酸探针能检测出基因转移动物基因组中整合的外源基因.

关键词：地高辛配基转基因整合检测山羊

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电针“内关”穴抗过敏性休克作用与脑内催产素含量的关系

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针刺研究 2001年第1期26卷 10-14页

作者：夏保芦程标涂宗苹武汉市职工医学院生理学教研室武汉430016 四川省人民医院心内科成都610072 同济医科大学生理学教研室武汉430030

本实验在 67只豚鼠过敏性休克模型上 ,观察不同强度或频率电针“内关”穴对过敏性休克豚鼠低血压反应的影响 ,并用放免法测定下丘脑、垂体前后叶催产素 (OT)的含量 ,试图初步探讨电针“内关”穴抗过敏性休克的作用机理。结果提示 ,电针... 详细信息

本实验在 67只豚鼠过敏性休克模型上 ,观察不同强度或频率电针“内关”穴对过敏性休克豚鼠低血压反应的影响 ,并用放免法测定下丘脑、垂体前后叶催产素 (OT)的含量 ,试图初步探讨电针“内关”穴抗过敏性休克的作用机理。结果提示 ,电针“内关”穴有明显而快速的抗过敏性休克的作用。电针频率相同时 ,高强度电针“内关”穴的升压效应比低强度的好 ;电针强度不变时 ,高频电针“内关”穴的抗过敏性休克作用显著优于低频者。电针“内关”穴抗过敏性休克的作用均有OT介导。高强度电针时OT似乎是通过促进垂体前叶ACTH等激素释放实现的 ;而高频电针的升压效应可能是促进了下丘脑OT的释放所致。

关键词：电针过敏性休克平均动脉压催产素内关穴

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罗非昔布预防结肠直肠腺癌临床试验中出现的心血管事件

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 3-4页

作者： Bresalier R.s sandler R.s 朱国栋 Dept. Gastroint est. med. and Nutr. Univ.of TX M.D. Anderson Cancer C. 1515 Holcombe Blvd. Ho uston TX 77030-4009 United States.Dr

BACKGROUND: selective inhibition of cyclooxygenase-2 (COX-2) may be associat ed with an increased risk of thrombotic events, but only limited long-term data have been available for analysis. We report on the cardiovascular outcomes asso ciated with the use of the selective COX-2 inhibitor rofecoxib in a long-term, multicenter, randomized,placebo-controlled, double-blind trial designed to de termine the effect of three years of treatment with rofecoxib on the risk of rec urrent neoplastic polyps of the large bowel in patients with a history of colore ctal ***: A total of 2586 patients with a history of colorectal ade nomas underwent randomization: 1287 were assigned to receive 25 mg of rofecoxib daily, and 1299 to receive placebo. All investigator-reported serious adverse e vents that represented potential thrombotic cardiovascular events were adjudicat ed in a blinded fashion by an external committee. REsULTs: A total of 46 patient s in the rofecoxib group had a confirmed thrombotic event during 3059 patient-y ears of follow-up (1.50 events per 100 patient-years), as compared with 26 pat ients in the placebo group during 3327 patient-years of follow-up(0.78 event p er 100 patient-years); the corresponding relative risk was 1.92 (95 percent con fidence interval, 1.19 to 3.11; P=0.008). The increased relative risk became apparent after 18 m onths of treatment; during the first 18 months, the event rates were similar in the two *** results primarily reflect a greater number of myocardial infa rctions and ischemic cerebrovascular event s in the rofecoxib group. There was earlier separation (at approximately five months) between groups in the incidence of nonadjudicated investigator-reported congestive heart failure, pulmonary edema, or cardiac failure (hazar d ratio for the comparison of the rofecoxib group with the placebo group, 4.61 ; 95 percent confidence interval, 1.50 to 18.83). Overall and cardiovascular mor tality was similar in the two gro

关键词：罗非昔布结肠直肠腺癌心血管事件临床试验结肠直肠腺瘤环氧化酶安慰剂对照发病风险血栓性心血管疾病

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