检索结果-南通市图书馆

中华医学杂志 1947年第3期33卷 58-58页

作者： G. s. Innes. Brit. med. Bull. 4:51,1946. 陈又新国立上海医学院内科系

Association of serum bilirubin and non-alcoholic fatty liver disease: A feasible therapeutic avenue?

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pharmacology 2014年第4期3卷 209-216页

作者： Mohamed s Anwar John F Dillon Michael H Miller Gut Group Medical Research Institute Ninewells Hospital and Medical School University of Dundee Dundee DD1 9SY United Kingdom

AIM： To the look at the current strength of evidence and the potential application of anti-oxidants in this ***： Two electronic databases （Pubmed and Web of Knowledge） were searched to January 2013 to find studies addressing serum bilirubin levels in non-alcoholic fatty liver disease （NAFLD）. The search used key word combinations in relation to NAFLD and serum bilirubin specifc to human adults only. After screening selected studies were reviewed in depth by two inde-pendent reviewers. Data synthesis with further metaanalysis was planned but not possible due to the het-erogeneity of the outcome measures in these ***： Out of 416 studies screened only seven studies were considered suitable for inclusion. All seven studies consistently reported an inverse association of bilirubin with NAFLD despite the heterogeneous sample of studies. Only two studies were prospective. No negative studies were ***： Most studies suggest a correlation between high bilirubin levels of any type are inversely correlated with NAFLD. But to date most of these stud-ies have been poorly designed to allow meaningful con-clusions, except one cohort study. There is a need for a large prospective cohort study in multiple populations to test this hypothesis fully before mechanistic associa-tions can be established and therapeutic options of the apparent anti-oxidant effect of bilirubin be explored in NAFLD. Furthermore these studies should include analysis of UGT1A1 gene to expound upon underlying cause of unconjugated hyperbilirubinaemia.

关键词： Review systematic Bilirubin Hyperbiliru-binemia Anti-oxidants Adult Non-alcoholic fatty liver disease

Innate Immunity of Phlomis purpurea against Phytophthora cinnamomi: A Transcriptomic Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Agricultural science and Technology(A) 2021年第1期11卷 22-46页

作者： Aladje Baldé Maria salomés.Pais Alfredo Cravador Universidade Jean Piaget Bissau 999114Guiné-Bissau Academia das Ciências de Lisboa R.da Academia das Ciências de Lisboa-R.da Academia das Ciênciasno.19Lisboa 1200-119Portugal med-mediterranean Institute for Agriculture Environment and DevelopmentUniversidade do AlgarveCampus de GambelasFaro 8005-139Portugal

Phlomis purpurea *** spontaneously in dry and stony habitats from the south of Iberian Peninsula and in cork oak(Quercus suber L.)and holm oak(*** ***,Lam.)plantations infested with Phytophthora cinnamomi(Rands).The aim of this study is to understand the genetic basis of *** innate immunity to this *** transcriptome analysis of *** upon challenging with *** revealed a set of up-regulated genes,related to signaling,transcription factors and response to *** involved in the synthesis of a number of proteins,namely:ANKYRIN,AP2,AQUAPORIN,ARMADILLO,At1G69870-LIKE,BHLH,BON1,CALMODULIN,CALNEXIN,CALRETICULINE,CC-NBs-LRR,CHAPERONE,CYTOCHROME,DUF,GH3,GMP,G-TYPE,LIPOXYGENAsE,MLO-LIKE,MYB,NAC,NBs-LRR,PENTATRICOPEPTIDE,sUBTILIsIN,WAK,bZIP and hormones such as BRAssINOsTEROID,JAsMONATE,sALICYLATE,ETHYLENE-REsPONsIVE were *** ability to cope with *** attack is based on the expression of a set of transcription factors and signaling molecules targeted by the *** information gathered contributes to the elucidation of the overall response of *** to *** attempted infection which can be helpful for improving woody species resistance to pathogenic oomycetes.

关键词： Phlomis purpurea transcriptomics Phytophthora cinnamomi plant immune response stress regulatory network

Managementofearlyasymptomaticgastrointestinalstromaltumorsofthe stomach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2014年第7期6卷 266-271页

作者： scherübl H Faiss s Knoefel WT Wardelmann E Hans scherübl Klinik für Innere Medizin II Gastroenterologie GI Onkologie und Infektiologie Vivantes Klinikum Am Urban 10967 Berlin GermanySiegbert Faiss III. Med. Abteilung Asklepios Klinik Barmbek 22291 Hamburg GermanyWolfram-Trudo Knoefel Klinik für Allgemein- Viszeral- und Kinderchirurgie Universit?tsklinikum 40225 Düsseldorf GermanyEva Wardelmann Gerhard-Domagk-Institut für Pathologie Universit?tsklinikum Münster 48149 Münster Germany

Gastrointestinal stromal tumors(GIsT) are the most common mesenchymal tumors of the digestive tract. Approximately two thirds of clinically manifest tumors occur in the stomach, nearly one third in the small bowel, and the rest in the colorectal region with a few cas-es in the esophagus. GIsT originate within the smooth muscle layer in the wall of the tubular gastrointestinal tract and grow mostly toward the serosa, far less often toward the mucosa. In the latter case, ulceration may develop and can cause gastrointestinal bleeding as the cardinal symptom. However, most GIsT of the stomach are asymptomatic. They are increasingly detected incidentally as small intramural or submucosal tumors during endoscopy and particularly during endoscopic ultra-sound. Epidemiological and molecular genetic findings suggest that early asymptomatic GIsT of the stomach(show self-limiting tumorigenesis. Thus, early(symptomatic gastric GIsT(synonym: micro-GIsT) are found in 20%-30% of the elderly. The mostlyelderly people with early gastric GIsT have an excellent GIsT-specific prognosis. Patients with early GIsT of the stomach can therefore be managed by endoscopic sur-veillance.

关键词： Mirco-gastrointestinal stromal tumors Gas-trointestinal stromal tumor Gastric Neoplasia Cancer Endoscopy Endoscopic ultrasound

Antibody to El peptide of hepatitis C virus genotype 4 inhibits virus binding and entry to HepG2 cells in vitro

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第16期12卷 2530-2535页

作者： Mostafa K EL-Awady Ashraf A Tabll Khaled Atef samar s Yousef Moataza H Omran Yasmin EI-Abd Noha G Bader-Eldin Ahmad M salem samir F Zohny Wael T EI-Garf Department of Biomedical Technology National Research CenterCairoEgypt Department of Biochemistry Faculty of ScienceAin Shams UniversityCairoEgypt

AIM： To analyze the neutralizing activity of antibodies against E1 region of hepatitis C virus （HCV）. specific polydonal antibody was raised via immunization of New Zealand rabbits with a synthetic peptide that had been derived from the E1 region of HCV and was shown to be highly conserved among HCV published genotypes. METHODs： Hyper-immune HCV E1 antibodies were incubated over night at 4 ℃ with serum samples positive for HCV RNA, with viral loads ranging from 615 to 3.2 million IU/mL. Treated sera were incubated with HepG2 cells for 90 min. Blocking of viral binding and entry into cells by anti E1 antibody were tested by means of RTPCR and flow cytometry. REsULTs： Direct immunostaining using FITC conjugated E1 antibody followed by Flow cytometric analysis showed reduced mean fluorescence intensity in samples pre-incubated with E1 antibody compared with untreated samples. Furthermore, 13 out of 18 positive sera （72%） showed complete inhibition of infectivity as detected by RT-PCR. CONCLUsION： In house produced E1 antibody, blocks binding and entry of HCV virion infection to target cells suggesting the involvement of this epitope in virus binding and entry. Isolation of these antibodies that block virus attachment to human cells are useful as therapeutic reagents.

关键词： Flow cytometry Hepatitis C virus E1 envelope Therapeutic antibodies Direct immuno-fluorescence HepG2 cells

实验性癫痫及电针抗痫时大鼠海马内胆囊收缩素基因表达的变化

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

针刺研究 1996年第2期21卷 62-66页

作者：杨茹王布尔程介士上海医科大学医学神经生物学国家重点实验室上海200032

采用原位杂交，NorthernBlot及计算机图像处理技术，观察青霉素致癫痫动物及加电针后海马内胆囊收缩素（CCK）mRNA水平的变化。发现癫痫时，在间脑冠状切面、背海马的齿状回和CA3区，CCKmRNA水平明显提高，电针后，CCKmRNA水平回降，同... 详细信息

采用原位杂交，NorthernBlot及计算机图像处理技术，观察青霉素致癫痫动物及加电针后海马内胆囊收缩素（CCK）mRNA水平的变化。发现癫痫时，在间脑冠状切面、背海马的齿状回和CA3区，CCKmRNA水平明显提高，电针后，CCKmRNA水平回降，同时在中脑冠状切面、腹海马的下托、背海马的齿状回和CA3区，可见癫痫时CCKmRNA量增加．而电针进一步增加了CCKmRNA的含量。结果提示：电针对青霉素致痫在脑电和行为上表现出来的抑制作用可能与其在海马不同区域调控CCK基因的表达有关。

关键词：胆囊收缩素癫痫电针疗法

维普期刊数据库

Management of pancreatic duct stone

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2008年第1期7卷 9-10页

作者： Li Li and sheng-Ning Zhang Department of Hepatobiliary Pancreatic surgery, First People’s Hospital of Kunming, Kunming medical College, Kunming 650011, China Kunming med Coll Peoples Hosp Kunming 1 Dept Hepatobiliary Pancreat Surg Kunming 650011 Peoples R China

Pancreatic duct stone is a rare disease. With the advancement of radiological techniques in diagnosis and in-depth study the incidence of the disease has appeared to be rising in recent years especially in the Western world. Defined as stone or calcification in the pancreatic duct, the pathogenesis of the disease remains unknown, but many theories are available for its formation.[1, 2] Chronic pancreatitis, pancreatic duct

关键词： MRCP Management of pancreatic duct stone

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

晋升中科学的考核(试)方法

继续医学教育 1989年第3期3卷 116-121,151页

作者：史玉环李玲华魏岩巍李华平

本文阐述了为扭转当前临床上青年医师中普遍存在的轻医德修养及临床能力的倾向,注重发挥专业技术职务评聘工作中的杠杆作用,制订了一套全面考核,突出重点,逐项淘汰,有利于促进青年医师健康成长的考核(试)方法,通过公正、平等、合理的竞... 详细信息

本文阐述了为扭转当前临床上青年医师中普遍存在的轻医德修养及临床能力的倾向,注重发挥专业技术职务评聘工作中的杠杆作用,制订了一套全面考核,突出重点,逐项淘汰,有利于促进青年医师健康成长的考核(试)方法,通过公正、平等、合理的竞争,最后选拔了约占百分之二十的优秀人才,晋升为主治医师。这在青年医师中引起了震动,收到了良好效果,达到了预期目的,总结了实施过程中的体会及存在问题。

关键词：晋升考核方法

维普期刊数据库

Antibiotics for eradicating meningococcal carriages:Network meta-analysis and investigation of evidence inconsistency

在线全文

学校读者我要写书评

暂无评论

World Journal of Meta-Analysis 2016年第4期4卷 77-87页

作者： Asmaa s Abdelhamid Yoon K Loke Ibrahim Abubakar Fujian song Norwich medical school University of East Anglia Institute of Epidemiology and Health University College of London

AIMTo compare different antibiotics for eradicating the carriage of Neisseria meningitidis （N. meningitidis ）, and to investigate heterogeneity and evidence *** a search of Pubmed and published systematic reviews, we identifed 23 trials evaluating 15 antibiotics that could be connected in a trial network. The outcome of interest is the eradication of N. meningitidis . We used WinBUGs to conduct random-effects, mixed treatment comparisons. Heterogeneity and evidence inconsistency was investigated by meta-regression modelling and examining characteristics of trial participants and inter-ventions *** Rifampin, ciprofloxacin, minocycline, ceftriaxone, and azythromycin were statistically significantly （P 〈 0.05） more effective than placebo. The probability of being the best was 67.0% for a combination of rifampin and minocycline, 25.0% for ceftriaxone, 1.7% for azythromycin, and below 1% for the remaining regimens. signifcant inconsistency between the direct and indirect estimates was observed for the comparison of rifampin and ciprofoxacin （ P 〈 0.01）, which may be caused by different types of carriers and different doses of *** range of prophylactic antibiotic regimens are effective for eradicating meningococcal carriages, and treatment choice will depend on the individual priorities of the patients and physicians. In clinical situations where complete eradication is considered to be of the utmost importance, a combination of rifampin and minocycline seems to offer the highest likelihood of success. Ceftriaxone as a single intramuscular injection is also likely to be more effective as compared with the other two antibiotics （ciprofoxacin or rifampin） recommended by the current guidelines.

关键词： Chemoprophylaxis Antibiotics Nersseria meningitidis Meningococcal infection Network metaanalysis

Non-alcoholic Fatty Liver Disease: A Review of Anti-diabetic Pharmacologic Therapies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2018年第2期6卷 168-174页

作者： Heather s.snyder sami A.sakaan Katherine L.March Osama siddique Rosann Cholankeril Carolyn D.Cummings Chiran Gadiparthi sanjaya K.satapathy Aijaz a.med George Cholankeril Department of Pharmacy Methodist University HospitalMemphisTNUSA College of Pharmacy University of Tennessee Health Science CenterMemphisTNUSA Department of medicine Memorial Hospital of Rhode IslandProvidenceRIUSA Roger Williams medical Center ProvidenceRIUSA Methodist University Hospital Transplant Institute University of Tennessee Health Sciences CenterMemphisTNUSA Division of Gastroenterology and Hepatology Stanford University School of MedicineStanfordCAUSA

Non-alcoholic fatty liver disease(NAFLD),the most common cause of liver disease,affects approximately 75 to 100 million *** with concurrent NAFLD and type 2 dia-betes mellitus have a higher risk of progressing to advanced fibrosis and non-alcoholic steatohepatitis compared to *** modifications,including weight loss,remain the mainstay of treatment for NAFLD,as there are no med-ications currently indicated for this disease ***-diabetic pharmacologic therapies a.med at improving insulin sensitivity and decreasing insulin production have been studied to determine their potential role in slowing the progression of *** this review,we focus on the evidence surrounding anti-diabetic medications and their ability to improve disease progression in patients with NAFLD.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Diabetes mellitus