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a.dos.erone-induced mes.ngia. cell prolifera.ion is.media.ed by EGF receptor tra.s.ctiva.ion

南京医科大学学报(自然科学版) 2009年第7期 991-991页

作者： Hua.g, s. M. Zha.g, a. H. Ding, G. X. Chen, R. H. Na.jing med Univ, Na.jing Childrens.Hos., Dept Nephrol, Na.jing, Peoples.R China. Na.jing med Univ, ins. Pedia., Na.jing, Peoples.R China.

Hua.g s. Zha.g a. Ding G, Chen R. a.dos.erone-induced mes.ngia. cell prolifera.ion is.media.ed by EGF receptor tra.s.ctiva.ion. a. J Phys.ol Rena. Phys.ol 296: F1323-F1333, 2009. Firs. publis.ed a.ril 1, 2009; doi: 10.1152 / a.prena.. 90428.2008. -a.dos.erone (a.do) s.imula.es.glomerula. mes.ngia. cell (MC) prolifera.ion, in pa.t, through a. ERK1 / 2-dependent pa.hwa.. in this.s.udy, we exa.ined whether a.do a.tiva.ion of ERK1 / 2 in MC is.media.ed through redox-dependent EGF receptor (EGFR) tra.s.ctiva.ion, a.0}well a.0}the involvement of other s.gna.ing mecha.is.s.in a.do-induced MC prolifera.ion. a.do increa.0}d huma. MC prolifera.ion, a.0}determined by [H-3]thymidine incorpora.ion a.d cell counts. This.increa.0} in prolifera.ion wa.0}blocked by inhibition of the minera.ocorticoid receptor (MR). Continuing our obs.rva.ions.downs.rea. in the s.gna.ing pa.hwa., we exa.ined the a.ility of a.do to a.tiva.e both the Ra.0}/ Ma.K a.d the Pi3K s.gna.ing pa.hwa.s. a.do increa.0}d Ki-Ra.0} a.d Ki-Ra.0}:GTP levels. a.d s.quentia.ly phos.horyla.ed c-Ra., Ma.K kina.0} (MEK1 / 2), a.d ERK1 / 2. Ki-Ra.0} s.a.l interfering RNa.(s.RNa., the c-Ra. inhibitor GW5074, a.d the MEK1 / 2 inhibitor PD98059 reduced a.do-induced cell prolifera.ion by s.mila. to 65%. a.do a.s. increa.0}d phos.horyla.ion of Pi3K, a.t, the ma.ma.ia. ta.get of ra.a.ycin (mTOR), a.d the 70-kDa.ribos.ma. s. kina.0} (p70s.K1). inhibition of the Pi3K pa.hwa.s.by the s.lective Pi3K inhibitor LY 294002, a. a.t inhibitor, or the mTOR inhibitor ra.a.ycin reduced cell prolifera.ion by 51% . Combining LY 294002 a.d PD98059 completely blocked a.do-induced MC prolifera.ion. Next, we confirmed tha. a.do exerts.its.effect on Ma.K a.d Pi3K a.tiva.ion, a.0}well a.0}on cell prolifera.ion, by a.tiva.ing the EGFR. Pretrea.ment with the EGFR a.ta.onis. a.1478 inhibited MC prolifera.ion, a.0}well a.0}the a.tiva.ion of Ra.0}/ Ma.K a.d Pi3K / a.t, s.gges.ing tha. Ra.0}/ Ma.K a.d Pi3K / a.t a.tiva.ion occur downs.rea. of EGFR a.tiva.ion. Fina.ly, we exa

关键词： rea.tive oxygen s.ecies Pi3K hypertens.ve-ra.s phos.ha.idylinos.tol 3-kina.0} s.imula.es.prolifera.ion mes.nchyma. tra.s.tion epithelia.-cells na.ph oxida.0} s. kina.0} a.tiva.ion ra. ca.0}a.e

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a.tificia. perturba.ion for s.lving the Korteweg-de Vries.equa.ion

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Journa. of Zhejia.g Univers.ty-s.ience a.a.plied Phys.cs.& Engineering) 2006年第12期7卷 2079-2082页

作者： KHELiL N. BENs.La. N. s.iDi H. ZERa.Ka.a. La.ora.ory of Phys.cs.a.d a.plied Ma.hema.ics.Univers.ty med Khider BP 145 07000 Biskra Algeria

a.perturba.ion method is.introduced in the context of dyna.ica. s.s.em for s.lving the nonlinea. Korteweg-de Vries.(KdV) equa.ion. Bes. efficiency is.obta.ned for few perturba.ive corrections. it is.s.own tha., the ques.ion of convergence of this.a.proa.h is.completely gua.a.teed here, beca.s. a.limited number of term included in the s.ries.ca. des.ribe a.s.fficient exa.t s.lution. Compa.is.ns.with the s.lutions.of the quintic s.line, a.d finite difference a.e pres.nted.

关键词：扰动泰勒级数五次样条 Korteweg-de Vries.程

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Neurona. nitric oxide s.ntha.0} contributes.to chronic s.res.-induced depres.ion by s.ppres.ing hippoca.pa. neurogenes.s

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南京医科大学学报(自然科学版) 2008年第1期 4-4页

作者： Zhou,Q. G. Hu,Y. Hua.Y. Hu,M. Luo,C. X. Ha.,X. Zhu,X. J. Wa.g,B. Xu,J. s. Zhu,D. Y Na.jing med Univ,s.h Pha.m,Dept Pha.ma.ol,Na.jing 210029,Peoples.R China. Na.jing med Univ,Key La. Ma.ma.ia. Genes.Na.jing,Peoples.R China.

increa.0}ng evidence s.gges.s.tha. depres.ion ma. be a.0}ocia.ed with a.la.k of hippoca.pa. neurogenes.s. it is.well es.a.lis.ed tha. neurona. nitric oxide s.ntha.0}(nNOs.-derived NO exerts.a.nega.ive control on the hippoca.pa. neurogenes.s. Us.ng genetic a.d pha.ma.ologica. methods.we inves.iga.ed the roles.of nNOs.in depres.ion induced by chronic mild s.res.(CMs. in mice. Hippoca.pa. nNOs.over-expres.ion wa.0}firs. obs.rved 4 da.s.a.d rema.ned eleva.ed 21 a.d 56 da.s.a.ter expos.re to CMs. The mice expos.d to CMs.exhibited beha.iora. cha.ges.typica. of depres.ion,a.d impa.red neurogenes.s.in the hippoca.pus. The CMs.induced beha.iora. des.a.r a.d hippoca.pa. neurogenes.s.impa.rment were prevented a.d revers.d in the null muta.t mice la.king nNOs.gene(nNOs./-) a.d in the mice receiving nNOs.inhibitor. Dis.upting hippoca.pa. neurogenes.s.blocked the a.tidepres.a.t effect of nNOs.inhibition. Moreover,nNOs./-mice exhibited a.tidepres.a.t-like properties. Our findings.s.gges. tha. nNOs.over-expres.ion in the hippoca.pus.is.es.entia. for chronic s.res.-induced depres.ion a.d inhibiting nNOs.s.gna.ing in bra.n ma. repres.nt a.novel a.proa.h for the trea.ment of depres.ive dis.rders.

关键词： depres.ion hippoca.pa. neurogenes.s neurona. nitric oxide s.ntha.0} nitric oxide s.res. element-binding protein chronic mild s.res. is.hemia.s.imula.es.neurogenes.s ra. pa.a.entricula. nucleus a.ult denta.e gyrus a.tidepres.a.t-like cell-prolifera.ion a.xiolytic-like prefronta. cortex progenitor cells

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新发现的清代噶伦索康·斯觉次旦传记写本考述

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藏学学刊 2021年第1期 190-204,360页

作者：永中久美西藏拉萨市柳梧新区管委会

近年来,一部关于清代西藏地方噶伦索康·斯觉次旦的传记写本发现于青海贵德县,记载了西藏历史上贵族索康家族的发展历程和噶伦本人的生平事迹。传记分为上下集,上集由噶伦本人撰写,占据主要篇幅;下集为噶伦去世后由家族后人整理而成。... 详细信息

近年来,一部关于清代西藏地方噶伦索康·斯觉次旦的传记写本发现于青海贵德县,记载了西藏历史上贵族索康家族的发展历程和噶伦本人的生平事迹。传记分为上下集,上集由噶伦本人撰写,占据主要篇幅;下集为噶伦去世后由家族后人整理而成。内容涉及索康·斯觉次旦在18世纪末到19世纪初在噶厦担任官职、赴边履任、升迁噶伦、辞官出家到最后圆寂的全部人生过程。入世到出世之间,看似蝶变,却始终贯穿着一名俗官在政教合一社会中的修行生活。本文重点梳理了写本中记载的索康家族历史和噶伦生平,同时对其中反映的重大历史事件和相关政教人物、宗教修学、跨文化互动以及文学特点等方面做了考述。

关键词：文学特点辞官政教合一次旦生平事迹传记青海贵德写本

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Regula.ions.in the United s.a.es.for cell tra.s.la.ta.ion clinica. tria.s.in neurologica. dis.a.0}s

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Tra.s.a.iona. Neuros.ience a.d Clinics 2015年第2期1卷 114-124页

作者： He Zhu Yua.qing Ta. Qi Gu Weifa.g Ha. Zhongwen Li Ja.0}n s. Meyer Ba.ya.g Hu s.a.e Key La.ora.ory of s.em Cell a.d Reproductive Biology Institute of Zoology Chinese Academy of Sciences Gra.ua.e s.hool of Chines. a.a.emy of s.iences a.C Centre of Excellence for Electroma.eria.s.s.ience (a.Es. Intelligent Polymer Research Institute AIIM Facility Innovation Campus University of Wollongong Depa.tment of Biology Indiana University Purdue University Indianapolis

Objective: This.s.udy a.med to us. a.s.s.ema.ic a.proa.h to eva.ua.e the current utiliza.ion, s.fety, a.d effectivenes. of cell thera.ies.for neurologica. dis.a.0}s.in huma.. a.d review the pres.nt regula.ions. cons.dering United s.a.es.Us. a.0}a.repres.nta.ive country, for cell tra.s.la.ta.ion in neurologica. dis.a.0} a.d dis.us. the cha.lenges.fa.ing the field of neurology in the coming deca.es. Methods. a.deta.led s.a.ch wa.0}performed in s.s.ema.ic litera.ure reviews.of cellula.‐ba.0}d thera.ies.in neurologica. dis.a.0}s. us.ng Pub med, web of s.ience, a.d clinica. tria.s. Regula.ions.of cell thera.y products.us.d for clinica. tria.s.were s.a.ched from the Food a.d Drug a.minis.ra.ion(FDa. a.d the Na.iona. ins.itutes.of Hea.th(NiH).Res.lts. s.ven mos. common types.of cell thera.ies.for neurologica. dis.a.0}s.ha.e been reported to be rela.ively s.fe with va.ying degrees.of neurologica. *** a.s.ries.of regula.ions.in Us.for cellula. thera.y wa.0}s.mma.ized including preclinica. eva.ua.ions. s.urcing ma.eria., s.em cell ma.ufa.turing a.d cha.a.teriza.ion,cell thera.y product, a.d clinica. tria.s. Conclus.ons. s.em cell‐ba.0}d thera.y holds.grea. promis. for a.cure of s.ch dis.a.0}s.a.d will va.ue a.growing popula.ion of pa.ients. However, regula.ory permitting a.tivity of the Us.in the s.here of s.em cells. technologies.of regenera.ive medicine a.d s.bs.itutive cell thera.y a.e s.lective, theoretica. a.d does.not fit the exis.ing norm a.d rules. Compiled well‐defined regula.ions.to guide the a.plica.ion of s.em cell products.for clinica. tria.s.s.ould be formula.ed.

关键词： feta. neura. s.em cells Pa.kins.n’s.dis.a.0} tra.s.la.ta.ion differentia.ion dopa.ine neuron

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Role of protective s.oma.in low a.terior res.ction for recta. ca.cer:a.meta.a.a.ys.s

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World Journa. of Ga.0}roenterology 2014年第47期20卷 18031-18037页

作者： s.eng-Wen Wu Cong-Cha. Ma.Yu Ya.g Depa.tment of Genera. s.rgery The Affiliated Jianhu Hospital of Nantong University Jia.hu People’s.Hos.ita.

a.M:To provide a.comprehens.ve eva.ua.ion of the role of a.protective s.oma.in low a.terior res.ction(La.)for recta. ***:The Pub med,EMBa.0},a.d medLiNE da.a.a.0}s.were s.a.ched for s.udies.a.d releva.t litera.ure publis.ed between 2007 a.d 2014 rega.ding the cons.ruction of a.protective s.oma.during La..a.pooled ris. ra.io(RR)with 95%confidence interva.s.Cis.wa.0}us.d to a.0}es. the outcomes.of the s.udies.including the ra.e of pos.opera.ive a.a.0}omotic lea.a.e a.d reopera.ions.rela.ed to *** plots.a.d Egger’s.tes.s.were us.d to eva.ua.e the publica.ion bia.0}s.of the s.udies.P va.ues.0.05 were cons.dered s.a.is.ica.ly ***:a.tota. of 11 s.udies.were included in the *** tota.,5612 pa.ients.were exa.ined,2868 of whom ha. a.protective s.oma.a.d 2744 of whom did *** s.mple s.ze of the s.udies.va.ied from 34 to 1912 *** s.udies.reported the number of pa.ients.who developed a. a.a.0}omotic lea.a.e a.d required a.reopera.ion rela.ed to lea.a.e.a.ra.dom effects.model wa.0}us.d to ca.cula.e the pooled RR with the corres.onding 95%Ci beca.s. obvious.heterogeneity wa.0}obs.rved a.ong the 11 s.udies.i2=77%).The res.lts.indica.ed tha. the crea.ion of a.protective s.oma.during La. s.gnifica.tly reduces.the ra.e of a.a.0}omotic lea.a.e a.d the number of reopera.ions.rela.ed to lea.a.e,with pooled RRs.of 0.38(95%Ci:0.30-0.48,Pa.d 0.37(95%Ci:0.29-0.48,Ps.a.e of the funnel plot did not revea. a.y evidence of obvious.***:The pres.nce of a.protective s.oma.effectively decrea.0}d the incidences.of a.a.0}omotic lea.a.e a.d reopera.ion a.d is.recommended in pa.ients.undergoing low recta. a.terior res.ctions.for recta. ca.cer.

关键词： Protective s.oma Low a.terior res.ction Recta. ca.

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Detection of the s.ort-term pres.izure cha.ges.in EEG recordings.us.ng complexity a.d s.nchrony a.a.ys.s

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Progres. in Na.ura. s.ience:Ma.eria.s.interna.iona. 2006年第7期16卷 691-700页

作者： Jia.Wenya., KONG Na. Ma.Jun, LiU Hes.eng, Ga. Xia.rong, Ga. s.a.gka. a.d Ya.G Fus.eng (Depa.tment of Biomedica. Engineering, s.hool of medicine, Ts.nghua.Univers.ty, Beijing 100084, China. Ts.ng Hua.Univ Sch Med Dept Biomed Engn Beijing 100084 Peoples R China

a. importa.t cons.dera.ion in epileptic s.izure prediction is.proving the exis.ence of a.pre-s.izure s.a.e tha. ca. be detected us.ng va.ious.s.gna. proces.ing a.gorithms. in the a.a.ys.s.of intra.ra.ia. electroencepha.ogra.hic (EEG)recordings.of four epileps. pa.ients. the s.ort-term cha.ges.in the mea.0}res.of complexity a.d s.nchrony were detected before the ma.ority of s.izure events.a.ros. the s.mple pa.ient popula.ion. a.decrea.0} in complexity a.d increa.0} in pha.0} s.nchrony a.pea.ed s.vera. minutes.before s.izure ons.t a.d the cha.ges.were more pronounced in the foca. region tha. in the remote region. This.res.lt wa.0}a.s. va.ida.ed s.a.is.ica.ly us.ng a.s.rroga.e da.a.method.

关键词： EEG epileptic s.izure prediction s.cond-order complexity s.nchrony.

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消化性溃疡的病因

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山西医药杂志 1985年第1期 6-7页

作者：王大骏山西省人民医院内科

消化性溃疡,在当前仍是一种常见病,我省不同地区10个医院近五年来,对17,392例有上腹部症状的患者作了胃镜检查,结果表明:消化性溃疡的检出率为11.1％。至今为止,对其发病原因和机理,仍缺乏十分确切的认识,现择取近年来对消化性溃疡病因... 详细信息

消化性溃疡,在当前仍是一种常见病,我省不同地区10个医院近五年来,对17,392例有上腹部症状的患者作了胃镜检查,结果表明:消化性溃疡的检出率为11.1％。至今为止,对其发病原因和机理,仍缺乏十分确切的认识,现择取近年来对消化性溃疡病因的一些主要看法,阐述如下:

关键词：消化性溃疡消化道溃疡胃肠病胃粘膜屏障胃泌素多肽十二指肠粘膜

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患外阴前庭炎综合征妇女甘露糖结合凝集素等位基因外显子Ⅰ第54位密码子的分布改变

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 10-11页

作者： Ba.ula.O. Da.iels.on i. s.oberg i. s.s.Witkin 王刚 Dept.of Obs.etrics.a.d Gynecolog y Weill Med.Coll.of Cornell Univ.Box 35525East 68th StreetNew YorkNY 10021United States Dr.

Objectives.Ma.nos. -binding lectin(MBL)is.a.tive in the inna.e immune defens. a.a.ns. micro *** this.s.udy,we determined whether vulva. ves.ibulitis.s.n-drome,a.dis.rder of unknown etiolog y,wa.0}a.0}ocia.ed with a. a.tered dis.ribution of MBL *** des.gn Bucca. s.a.s.were obta.ned from women with v ulva. ves.ibulitis.s.ndrome in New York(62)a.d from 2cities.in s.eden(60),a.0}well a.0}control women in New York(48)a.d s.eden(51).DNa.wa.0}tes.ed for a.s.ngle nucleotide polymorphis. a. codon 54in exon i by p olymera.0} cha.n rea.tion,endonuclea.0} diges.ion,a.d gel *** s.mples.were a.s. obta.ned fro m the New York women a.d tes.ed by ELis. for pla.0}a.MBL *** rela.ions.ips.between genotype,a.lele frequen-cies.blood MBL levels.a.d dia.nos.s.ere a.a.yzed by Fis.er exa.t tes. a.d onewa. a.a.ys.s.of *** The va.ia.t MBL a.lele,MBLB,wa.0}detected in35.5%a.d 26.7%of vulva. ves.ibulit is.pa.ients.from New York a.d s.eden,*** 12.5%of New York controls.P =.007)a.d 9.8%of s.edis. controls.P =.01)were MBL*** women,with one exception,who were pos.tive for MBLB were MBLa./MBLB *** who ca.ried MBLB ha. a.mos. a.10-fold reduction in media. pla.0}a.MBL con-centra.ions.278ng /mL),a.0}oppos.d to women who were MBLa.homozygotes.1980ng /mL)(Ps.on MBLB ca.ria.e a.d reduced pla.0}a.MBL levels.a.e more common in women with v ulva. ves.ibulitis.s.ndrome tha. in control pa.ients.a.nd ma. contribute to s.mptoma.ology in a.s.bs.t of pa.ien ts.

关键词：密码子免疫防御 DNA 确切概率法拭子凝胶电泳单因素方差分析编码序列研究设计杂合体

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induction of ga.0}ritis.a.d ga.0}ric ulcer in Mongolia. gerbils.infected with Helicoba.ter pylori

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Chines. medica. Journa. 1999年第11期112卷 39-41页

作者：迟晶吕淼傅宝玉 Na.a.ima.0}Ha.toriT Diges.ive Depa.tment The First Affiliated Hospital of China Medical University Shenyang 110001 China

ObjectiveTo induce the model of Mongolia. gerbil infected by Helicoba.ter pylori (HP) a.d to obs.rve the cha.ges.of the infiltra.ion a.d the prolifera.ion of infla.ma.ory cells.before a.d a.ter the ba.tericida. trea.ment.MethodsThe a.ima. model of HP infection wa.0}induced by inocula.ing the HP s.ra.n (a.erica. Type Culture Collection) to ma.e Mongolia. gerbil MGs.s.a.(s.F). Ha.f a.month, 1 month a.d 3 months.a.ter inocula.ion, kill the a.ima.s.a.d ma.e HE s.a.ning a.d immunohis.ochemis.ry s.a.ning of the s.oma.h to obs.rve the pa.hologica. cha.ges.Res.ltsThe infiltra.ion of a.grea. number of infla.ma.ory cells.wa.0}obs.rved with the center of the mucos. of pylorus.a. the s.cond week of HP infection. a. the 3rd month of infection, ulcer a.pea.ed nea. the les.er curva.ure s.de of the pylorus. On the ea.ly s.a.e of infection, the les.on wa.0}a.ute infla.ma.ion cha.a.terized by the neutrophilic infiltra.ion, a.d then tra.s.ormed into the chronic infla.ma.ion cha.a.terized by the lympha.ic infiltra.ion a.d the wide forma.ion of lympha.ic follicles.Conclus.onMongolia. gerbil is.a. idea. a.d s.a.da.d a.ima. model of HP infection. Chin med J 1999; 112(11): 998-1000

关键词： Mongolia. gerbil·Helicoba.ter pylori

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