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In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. Don, an Endangered medicinal Plant

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1297-1310页

作者： Qian Tao Guiqi Han Bujin ma Hongmei Jia Can Zhao Wenshang Li Zhuyun Yan Chengdu University of Traditional Chinese medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest ChinaChengdu610000China

Fritillaria cirrhosa ***(Liliaceae)is an endangered perennial bulbous plant and its dry bulb is a valuable med-icinal material with antitussive and expectorant ***,lack of resources and expensive prices make it difﬁcult to meet clinical *** study presents a regeneration system a.med at overcoming the challenge of inadequate supply in ***,focusing on:(1)callus induction,(2)bulblets and adventitious bud induction,and(3)artiﬁcial seed *** development was achieved in 84.93%on Murashige and Skoog(MS)medium fortiﬁed with 1.0 mg·L^(-1) *** optimal medium for callus differentiation into regenerated bulb-lets was MS medium supplemented with 1.0 mg·L^(-1)6-benzyladenine(6-BA)and 0.2 mg·L^(-1)α-naphthaleneacetic acid(NAA).Subsequently,bulblets and adventitious buds were induced from regenerated bulblet sections cul-tured on MS medium fortiﬁed with 0.3 mg·L^(-1)6-BA+1.0 mg·L^(-1)2,4-dichlorophenoxyacetic acid(2,4-D),2.0 mg·L^(-1)6-BA+0.5 mg·L^(-1),and the induction rates were 88.17%and 84.24%,*** regenerated bulblets were transplanted into a substrate of humus soil,river sand,and pearlite(1:1:1)after low-temperature *** germination rate was 42.80%after culture for 30 *** bulblets were used for encap-sulations in liquid MS medium containing 3%sucrose(w/v)+0.5 mg·L^(-1) NAA+2.0 mg·L^(-1)6-BA+3%sodium alginate(w/v)with a 10 min exposure to 2%CaCl_(2).Under non-aseptic conditions,the germination rate reached 81.67%,while the rooting rate was 20.56%after 45 *** capsule added 1.0 g·L^(-1) carbendazim and 1.0 g·L^(-1) activated carbon was the best component of artiﬁcial *** study successfully established an efﬁcient regen-eration system for the rapid propagation of ***,involving in vitro bulblet regeneration and artiﬁcial seed *** method introduces a novel approach for efﬁcient breeding and germplasm preservation,making it suitable for large-scale industrial resou

关键词： Artiﬁcial seed callus induction Fritillaria cirrhosa organogenesis plant propagation

血液透析患者牙周状况与营养不良-炎症-动脉粥样硬化综合征的相关性分析

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医药论坛杂志 2024年第4期45卷 354-358,363页

作者：杨冰马东红王玉华新乡医学院第一附属医院河南卫辉453100 新乡医学院第一附属医院肾脏病医院肾脏免疫研究所河南卫辉453100 郑州公交医院郑州450012

目的旨在探讨血液透析(hemodialysis,HD)患者口腔牙周状况与营养不良-炎症-动脉粥样硬化综合征(malnutrition-inflammation-atherosclerosis syndrome,MIA)之间的关联。方法选取2022年12月至2023年12月于郑州公交医院血液透析中心符合纳入与排除标准的HD患者共76例作为研究对象,根据牙周病诊断标准,分为无牙周病、轻度牙周病,中度牙周病,重度牙周病4组,各组患者均进行老年营养风险指数(geriatric nutrition-al risk index,GNRI)评估、血清廋素(leptin,LP)、血清白蛋白(human serum albumin,HSA)、血红蛋白(hemoglobin,Hb)等营养相关指标检测及血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、降钙素原(procal-citonin,PCT)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素6(interleukin-6,IL-6)等相关炎症指标检测及脉压指数、血管内膜厚度等动脉粥样硬化指标检测,建立多因素线性回归模型分析各组HD患者营养状况指标、炎症指标及动脉粥样硬化指标的差异,探讨HD患者MIA综合征的潜在促进因素。结果随着牙周病严重程度提高,LP、HSA、Hb及GNRI水平均显著下降,hs-CRP、IL-6、TNF-α及颈动脉内膜厚度显著上升,差异具有统计学意义(P<0.01)。牙周病与GNRI、hs-CRP及颈动脉内膜厚度等指标的相关分析显示,牙周病严重程度与hs-CRP、TNF-α及颈动脉内膜厚度呈正相关,与LP、HSA、Hb及GNRI呈负相关。结论牙周健康受损在HD患者中非常普遍,重度牙周病是HD患者MIA综合征发生的独立危险因素。临床工作中应该重视HD患者牙周病与MIA综合征的综合干预和治疗。

关键词：营养不良牙周病晚期肾脏疾病 MIA综合征血液透析

Effects of Duhuojisheng Tang and combined therapies on prolapse of lumbar intervertebral disc:a systematic review of randomized control trails

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Journal of Traditional Chinese medicine 2013年第2期33卷 145-155页

作者： Yanxu ma Minghua Huang Jingyan Cui Kai Meng Yuhao Zhao Department of Orthopedics Beijing Traditional Chinese Medicine HospitalCapital Medical University editorial Board(Chinese edition) Journal of Traditional Chinese Medicine College of Health Administration and education under Capital medical University Capital Base for Research into Health Administration and Policy School of Traditional Chinese medicine Capital Medical University

OBJECTIVE： A systematic review of the literature was conducted to evaluate the curative effect and safety of Duhuojisheng Tang on prolapse of the lumbar intervertebral disc. METHODS： The databases of Pubmed, China Na- tional Knowledge Infrastructure （CNKI）, Chinese Sci- entific Journals Database （VlP）, Chinese Biomedical Literature Database （CBM） and Chinese medical Ci- tation Index （CMCl） were searched up to January 30, 2012. Randomized controlled trials were select- ed to compare Duhuojisheng Tang with one ormore of the following treatments： traction, acu- puncture, massage, cupping and Western medical treatment. The quality-evaluating standard and the software Revman 5.1 in Cochrane coordinative net were used to analyze the data. The effective index- es of the results were clinical curative rate, effective- ness of alleviating clinical symptoms and adverse reaction. RESULTS： Thirty-one randomized controlled trials of low quality, involving 3915 patients were system- atically evaluated. Statistical analyses showed that good curative effect was achieved in both the group using Duhuojisheng Tang alone and with combined therapies. CONCLUSION： Using Duhuojisheng Tang alone or combined with other therapies can effectively im- prove pain, leg-raising height and other clinical symptoms of patients with prolapse of lumbar in- tervertebral disc. Due to low methodological quali- ty of the articles, no exact recommendations can be made.

关键词： Intervertebral disc displacement Ran-domized controlled trials Review DuhuojishengTang

High Power SiGe X-Band (8～10GHz) Heterojunction Bipolar Transistors and Amplifiers

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Journal of Semiconductors 2006年第2期27卷 270-275页

作者： ma Zhenqiang Wang Guogong Jiang Ningyue Ponchak G E Alterovitz S A Department of Electrical and Computer Engineering University of Wisconsin-Madison Madison WI 53706 USA NASA-Glenn Research Center Cleveland OH 44135 USA

Limited by increased parasitics and thermal effects as device size increases, current commercial SiGe power HBTs are difficult to operate at X-band （8--12GHz） frequencies with adequate power added efficiencies at high power levels. We find that, by changing the heterostructure and doping profile of SiGe HBTs, their power gain can be significantly improved without resorting to substantial lateral scaling. Furthermore,employing a common-base configuration with a proper doping profile instead of a common-emitter configuration improves the power gain characteristics of SiGe HBTs,thus permitting these devices to be efficiently operated at X-band frequencies. In this paper,we report the results of SiGe power HBTs and MMIC power amplifiers operating at 8 *** 10GHz,a 22.5dBm （178mW） RF output power with a concurrent gain of 7.32dB is measured at the peak power-added efficiency of 20.0%, and a maximum RF output power of 24.0dBm （250mW） is achieved from a 20 emitter finger SiGe power HBT. The demonstration of a single-stage X-band medium-power linear MMIC power amplifier is also realized at 8GHz. Employing a 10-emitter finger SiGe HBT and on-chip input and output matching passive components, a linear gain of 9.7dB, a maximum output power of 23.4dBm,and peak power add- ed efficiency of 16% are achieved from the power amplifier. The MMIC exhibits very low distortion with 3rd order intermodulation （im） suppression C/I of -13dBc at an output power of 21,2dBm and over 20dBm 3^rd order output intercept point （OIP3）.

关键词：晶体管放大器基极发射极掺杂

Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway

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World Journal of Gastroenterology 2010年第24期16卷 3002-3010页

作者： Zhao, Hai-Dong Zhang, Feng Shen, Gang Li, Yu-Bing Li, Ying-Hua Jing, Hui-Rong ma, Ling-Fei Yao, Ji-Hong Tian, Xiao-Feng Dalian med Univ Affiliated Hosp 2 Dept Gen Surg Dalian 116023 Liaoning Prov Peoples R China Dalian med Univ Dept Pharmacol Dalian 116044 Liaoning Prov Peoples R China

Aim: To investigate the effect of sulforaphane (SFN) on regulation of NF-E2-related factor-2 (Nrf2)-antiox-idant response element (ARE) pathway in liver injury induced by intestinal ischemia/reperfusion (I/R). METHODS: Rats were divided randomly into four ex-perimental groups: control, SFN control, intestinal I/R and SFN pretreatment groups (n = 8 in each group). The intestinal I/R model was established by clamping the superior mesenteric artery for 1 h and 2 h reperfu-sion. In the SFN pretreatment group, surgery was performed as in the intestinal I/R group, with intraperitoneal administration of 3 mg/kg SFN 1 h before the op-eration. Intestine and liver histology was investigated. Serum levels of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured. Liver tissue superoxide dismutase (SOD), myeloperoxidase (MPO), glutathione (GSH) and glutathione peroxidase (GSH-Px) activity were assayed. The liver transcription factor Nrf2 and heme oxygenase-1 (HO-1) were determined by immunohistochemical analysis and Western blotting ***: Intestinal I/R induced intestinal and liver injury, characterized by histological changes as well as a signif icant increase in serum AST and ALT levels (AST: 260.13 ± 40.17 U/L vs 186.00 ± 24.21 U/L, P educed by pretreatment with SFN, respectively (AST: 260.13 ± 40.17 U/L vs 216.63 ± 22.65 U/L, P ed after intestinal I/R (P ed by SFN pretreatment (P ed with the control group, SFN markedly reduced liver tissue MPO activity (P ed liver tissue GSH and GSH-Px activity (P ed level of liver Nrf2 and HO-1 ***: SFN pretreatment attenuates liver injury induced by intestinal I

关键词： Sulforaphane Liver injury Intestinal isch-emia reperfusion NF-E2-related factor-2 Antioxidant response element

Effect of Tangnaikang on TGF-β_1-induced transdifferentiation of human renal tubular epithelial HK-2 cells

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Journal of Traditional Chinese medicine 2013年第3期33卷 388-393页

作者： Lixia Yang Xinhuan ma Tao Cheng Tonghua Liu Lili Wu Wen Sun margetts Peter Joseph Central Laboratory of Gansu Province Academy of Traditional Chinese medicine Pharmacy Department Gansu Province Hospital of Traditional Chinese Medicine Institute of Traditional Chinese medicine Information Gansu Province Academy of Traditional Chinese Medicine Science and Technology Department Beijing University of Traditional Chinese Medicine Department of Nephrology St. Joseph's Hospital of McMaster University

OBJECTIVE： To explore the function of Tangnai- kang （TNK） in the prevention and treatment of re- nal interstitial fibrosis through transdifferentiation of the human renal tubular epithelial cell line HK-2 induced bytransforming growth factor-β1 （TGF-β1）. METHODS： HK-2 cells cultured in dulbecco＇s modi- fied eagle medium/F12 （1：1） with 10% fetal calf se- rum were divided into six groups： blank control group, TGF-β1 group （TGF-β1 10 ng/mL）, serum con- trol group （TGF-β1 10 ng/mL ＋ 10% serum）, treat- ment group 1 （TGF-β1 10 ng/mL ＋ 5% TNK serum）, treatment group 2 （TGF-β1 10 ng/mL＋10% TNK se-rum）, and treatment group 3 （TGF-β1 10 ng/mL＋ 20% TNK serum）. Cell proliferation was detected by 4,5-Dimethylthiazol-2-yl）-2,5-diphenyltetrazoliu m bromide assay. Expression of a-smooth muscle ac- tin （a-Sma） and E-cadherin were observed by im- munohistochemical assay. The contents of collagen Ⅰ （Col Ⅰ）, collagen Ⅲ（ColⅢ）, and fibronectin （FN） in the culture medium supernatant were detected by ELISA. RESULTS： E-cadherin was expressed and α-Sma was not expressed in normal HK-2 cells. In HK-2 cells cultured with TGF-β1, α-Sma expression signifi- cantly increased, HK-2 cells significantly proliferat- ed, and secretion of Col Ⅰ, Col Ⅲ, and FN significantly increased compared with the blank control group （all P〈0.05）. In the HK-2 cells cultured with TGF-β1 and TNK serum, the expression of α-Sma signifi- cantly decreased, the expression of E-cadherin sig- nificantly increased, and the cell proliferation and the secretion of Col Ⅰ, Col Ⅲ and FN were significant- ly inhibited compared with the TGF-β1 group （all P〈 0.05. CONCLUSION： TNK can inhibit cell proliferation and reduce secretion of Col Ⅰ, Col Ⅲ, and *** in- dicates that TNK can inhibit transdifferentiation of human renal tubular epithelial cells induced by TGF-β1, with the effect of preventing and treating renal interstitial fibrosis.

关键词： Transforming growth factor beta 1 Epi-thelial cells Cell proliferation Cell Transdifferentia-tion Tangnaikang

开放性骨折修复：创面感染、植入物选择及预后评价

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中国组织工程研究 2015年第26期19卷 4258-4264页

作者：马翔宇王东山西医科大学第二医院山西省太原市030000

背景:开放性骨折多伴随软组织损伤严重甚至缺损、高风险感染、骨折骨缺损等特点,往往导致修复术后并发症多、肢体功能受限,给临床治疗带来极大困难,修复此类骨折的方方面面也因此存在着一些争议,相对应的动物实验以及临床研究成为近年... 详细信息

背景:开放性骨折多伴随软组织损伤严重甚至缺损、高风险感染、骨折骨缺损等特点,往往导致修复术后并发症多、肢体功能受限,给临床治疗带来极大困难,修复此类骨折的方方面面也因此存在着一些争议,相对应的动物实验以及临床研究成为近年来研究的热点。目的:综述近年来关于开放性骨折修复方面存在的一些争议以及与之相对应的最新研究进展。方法:第一作者应用计算机检索2005年1月至2015年1月Pub med数据库、中国知网等中英文期刊全文数据库相关内容文章,英文检索词"Open fracture,Evaluation and prognosis of injury,Antibiotics,Debirdement,Treatment of fracture,Wound repair";中文检索词"开放性骨折,损伤及预后评估,抗生素,清创,骨折治疗,创面修复"。共检索到100余篇相关文献,47篇文献符合纳入标准。结果与结论:经过大量动物试验以及临床应用,开放性骨折的清创、预防感染、植入物选择及预后评价等方面的研究也越来越深入,尤其是治疗骨缺损的植入物研究方面,金属3D打印机的出现改变了传统植入物的观念,纳米二氧化钛/PEEK生物活性复合材料等骨代替材料也成为近年的研究热点。

关键词：植入物骨植入物开放性骨折植入物选择预后评价清创预防感染

维生素预防冠状动脉造影术后对比剂肾病的Meta分析

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中国循环杂志 2018年第2期33卷 181-186页

作者：唐庚马根山东南大学医学院临床医学系江苏省南京市210000

目的:通过Meta分析评价维生素预防冠状动脉造影术后对比剂肾病(CIN)的作用。方法:检索Pub med、medLINE、Cochrane Library Central Register of Controlled Trials、Clinical ***数据库中关于CIN预防的相关文献,检索时间均从建库至2016-12。按纳入标准、排除标准选择符合条件的随机对照研究(RCT),并提取数据。采用Rev man 5.3统计软件行Meta分析。结果:共纳入11项RCT,患者1 810例,其中维生素类组有951例,安慰剂组有859例,各研究平均年龄在60~73岁,男性比例45.9%~92.2%。Meta分析结果显示,维生素类组CIN发生率明显低于安慰剂组(RR=0.54,95%CI:0.39~0.73);与安慰剂组相比,维生素类组维生素类药物的使用可使冠状动脉造影术后CIN发生率降低46%。使用维生素C患者的CIN发生率较安慰剂组明显降低(RR=0.58,95%CI:0.37~0.90);与安慰剂组相比,维生素C可以使冠状动脉造影术后CIN发生率下降42%。结论:维生素类药物可使冠状动脉造影术后的CIN发生率降低46%,其中维生素C可使CIN发生率下降42%。

关键词：维生素对比剂肾损伤 Meta分析

一种以企业为主导的“产学研”集成创新模式——基于合作关系与控制权视角的建模分析

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科学学研究 2014年第1期32卷 130-139页

作者：马家喜金新元温州大学瓯江学院浙江温州325035

有效的"产学研"合作技术创新模式是有力提升企业技术能力与创新能力的核心途径之一;同时也是高校提升自身科研成果转化率的关键。从创新的类型、主体以及创新过程中资源与能力优化配置的角度出发,归纳出两种典型"产学研"合作技术创新模... 详细信息

有效的"产学研"合作技术创新模式是有力提升企业技术能力与创新能力的核心途径之一;同时也是高校提升自身科研成果转化率的关键。从创新的类型、主体以及创新过程中资源与能力优化配置的角度出发,归纳出两种典型"产学研"合作技术创新模式:以高校为主导兴建的企业模式以及以企业为主导的集成创新模式,并着重对后一种创新模式进行了分析。在此模式下,鉴于控制权与合作关系是影响创新效应的两个核心变量;将高校-企业合作关系分成两类:长期合作关系与短期合作关系,将控制权类型分为两种类型:集中控制与分散控制。在此基础上,着眼于"产学研"合作创新过程:企业从契约提供、合作创新过程的有效组织及产业竞争的系统维度,以动态博弈与委托-代理等理论为工具,建立了一个三阶段动态博弈模型,分别得出了短期合作关系下集中控制、短期合作关系下分散控制、长期合作关系下集中控制、长期合作关系下分散控制四种不同情形的子博弈完美纳什均衡解,并对每种情形及其博弈结果进行了细化分析。最后,从双边关系的类型、控制权类型以及委托-代理效应三个不同维度,从静态与动态两个方面比较分析了创新的知识投入、工资、产量、价格、利润等均衡变量的差异性。

关键词： “产学研” 创新模式动态博弈委托-代理合作关系控制权