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Assessment of groundwater suitability for different activities in Toshka district,south Egypt

Journal of Groundwater Science and Engineering 2024年第1期12卷 34-48页

作者： Marwa M Aly Shymaa AK Fayad a.med mi abd elha.id Faculty of Engineering Mataria Helwan UniversityCairo 11718Egypt Division of Engineering International Academy for Engineering and Media Science(IAEMS)6th of October City 15515Egypt Hydraulics Research Institute National Water Research CenterMWRICairo 13621Egypt

Globally,groundwater has globally emerged as a crucial freshwater source for domestic,irrigation,and industrial *** evaluation of groundwater quality in the Toshka region is imperative to ensure its suitability for the extensive agricultural and industrial activities underway in this promising,groundwater-dependent development *** is particularly significant as Egypt increasingly relies on groundwater reserves to address freshwater deficits and to implement mega-development projects in barren *** this study,fifty-two samples were collected from the recently drilled wells tapping into the Nubian Sandstone Aquifer(NSA)in the Toshka *** quality was assessed through hydrochemical analysis,Piper diagram,and various indicators such as Na%,SAR,RSC,KR,MH and *** hydrochemical analysis revealed improved groundwater quality characteristics,attributed to continuous recharge from Lake *** Piper diagram categorised most of the water samples as"secondary salinity"water *** all wells proved suitable for irrigation with only two wells unsuitable based on MH values and six wells based on KR *** Total Hardness(TH)values,all samples were classified as"Soft",indicating their suitability for domestic and industrial *** Quality Index(WQI)results concluded that all samples met WHO and FAO guidelines for drinking and irrigation,*** distribution maps,constructed using GIS,facilitate the interpretation of the *** monitoring of quality parameters is essential to detect any deviation from permissible limits.

关键词： Nubian Sandstone Aquifer Water Quality Assessment Hydro-chemical Analysis Irrigation Quality Indicators Domestic Use Water Quality Index

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SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4164-4173页

作者： Zhu, Kaixiang Song, Lili Wang, Linyue Hua, Lei Luo, Ziyu Wang, Tongyun Qin, Bo Yuan, Shuofeng Gao, Xiaopan mi, Wenyi Cui, Sheng Chinese Acad med Sci & Peking Union med Coll Natl Inst Pathogen Biol NHC Key Lab Syst Biol Pathogens Beijing 100730 Peoples R China Peking Union med Coll Key Lab Pathogen Infect Prevent & Control Minist Educ Beijing 100730 Peoples R China Yanan Univ Med Sch Yanan 716000 Shaanxi Peoples R China Tianjin med Univ Tianjin Med Univ Gen Hosp Prov & Minist Cosponsored Collaborat Innovat Ctr M Dept ImmunolKey Lab Immune Microenvironm & DisMi Tianjin 300070 Peoples R China Univ Hong Kong Li Ka Shing Fac Med State Key Lab Emerging Infect Dis Pokfulam Hong Kong Peoples R China Univ Hong Kong Dept Microbiol Li Ka Shing Fac Med Pokfulam Hong Kong Peoples R China

Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis. CUL2(ZYG11B) known as the substrate receptor of cullin-2 RING E3 ligase, is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity, leading to degradation of IFT46, a protein component of the intraflagellar transport (IFT) complex B. This results in dysfunctional cilia, which explains certain symptoms that are specific to COVid-19. However, the precise molecular mechanism of how ORF10 recognizes CUL2(ZYG11B) remains unknown. Here, we determined the crystal structure of CUL2(ZYG11B) complexed with the N-terminal extension (NTE) of SARS-CoV-2 ORF10 (2.9 & Aring;). The structure reveals that the ORF10 N-terminal heptapeptide (NTH) mimics the Gly/N-degron to bind CUL2(ZYG11B). Mutagenesis studies identified key residues within ORF10 that are key players in its interaction with CUL2(ZYG11B) both in ITC assay and in vivo cells. In addition, we prove that enhancement of CUL2(ZYG11B) activity for IFT46 degradation by which ORF10-mediated correlates with the binding affinity between ORF10 and CUL2(ZYG11B). Finally, we used a Global Protein Stability system to show that the NTH of ORF10 mimics the Gly/N-degron motif, thereby binding competitively to CUL2(ZYG11B) and inhibiting the degradation of target substrates bearing the Gly/N-degron motif. Overall, this study sheds light on how SARS-CoV-2 ORF10 exploits the ubiquitination machinery for proteasomal degradation, and offers valuable insights for optimizing PROTAC-based drug design based on NTH CUL2(ZYG11B) interaction, while pinpointing a promising target for the development of treatments for COVid-19. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia.medica, Chinese Academy of medical Sciences. This is an open access article underthe CC BY license (http://***/licenses/by/4.0/).

关键词： SARS-CoV-2 ORF10 Crystal structure cullin-2 RING E3 ligase Drug design

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晚清土默特蒙古社会的户籍赋役制度与立嗣承产纠纷

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原生态民族文化学刊 2024年第2期16卷 94-103,155页

作者：田宓吕洪婷云南大学历史与档案学院昆明650000

清朝通过“户”管控蒙古社会,实现赋役征派。“户”是“壮丁”与“土地”的结合。为了赋役承应的延续性,每户都必须有壮丁不断承受家产。这就使户籍赋役制度和家族立嗣承产发生联系。蒙古人在初次分配财产之后,其家产在最初登记的“户... 详细信息

清朝通过“户”管控蒙古社会,实现赋役征派。“户”是“壮丁”与“土地”的结合。为了赋役承应的延续性,每户都必须有壮丁不断承受家产。这就使户籍赋役制度和家族立嗣承产发生联系。蒙古人在初次分配财产之后,其家产在最初登记的“户”的后世子孙中不断承受。一般是族中分门析分家产,并以合同分单的形式加以约定。但由于家族族人的竞夺、蒙旗官吏的觊觎,立嗣承产的过程有时演变成旷日持久的抢夺战。每当纠纷发生时,清廷关于户籍赋役和立嗣承产的法律规定,就成为各方人士竞争与协商的主要依凭和谈判策略。

关键词：户籍赋役立嗣承产蒙古社会土默特家族

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Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 3931-3948页

作者： Fu, Wenkang Lin, Yanyan Bai, mingzhen Yao, Jia Huang, Chongfei Gao, Long mi, Ningning Ma, Haidong Tian, Liang Yue, Ping Zhang, Yong Zhang, Jinduo Ren, Yanxian Ding, Liyun Dai, Lunzhi Leung, Joseph W. Yuan, Jinqiu Zhang, Wenhua Meng, Wenbo Lanzhou Univ Sch Clin Med 1 Lanzhou 730030 Peoples R China Lanzhou Univ Hosp 1 Key Lab Biotherapy & Regenerat Med Gansu Prov Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Hosp 1 Dept Gen Surg Lanzhou 730030 Peoples R China Lanzhou Univ Sch Phys Sci & Technol Lanzhou 730000 Peoples R China Sichuan Univ West China Hosp Natl Clin Res Ctr Geriatr Chengdu 610041 Peoples R China Sichuan Univ West China Hosp Dept Gen Practice State Key Lab Biotherapy Chengdu 610041 Peoples R China UC Davis med Ctr Div Gastroenterol Sacramento CA 95817 USA Sacramento Va.med Ctr Sacramento CA 95817 USA Sun Yat Sen Univ Affiliated Hosp 7 Clin Res Ctr Big Data Ctr Shenzhen 518107 Guangdong Peoples R China Lanzhou Univ Sch Life Sci Lanzhou 730000 Peoples R China

Cholangiocarcinoma (CCA) is a bile duct malignancy with a dismal prognosis. This study systematically investigated the role of the ribosomal protein S6 ( RPS6 ) gene, which is dependent in CCA. We found that RPS6 upregulation in CCA tissues was correlated with a poor prognosis. Functional investigations have shown that alterations in RPS6 expression, both gain- and loss-of function could affect the proliferation of CCA cells. In xenograft tumor models, RPS6 overexpression enhances tumorigenicity, whereas RPS6 silencing reduces it. Integration analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle, especially DNA replication. Immunoprecipitation followed by mass spectrometry has identified numerous spliceosome complex proteins associated with RPS6. Transcriptomic profiling revealed that RPS6 affects numerous alternative splicing (AS) events, and combined with RNA immunoprecipitation sequencing, revealed that minichromosome maintenance complex component 7 ( MCM7 ) binds to RPS6, which regulates its AS and increases oncogenic activity in CCA. Targeting RPS6 with vivo phosphorodiamidate morpholino oligomer (V-PMO) significantly inhibited the growth of CCA cells, patient-derived organoids, and subcutaneous xenograft tumor. Taken together, the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids PROTEIN S6 PHOSPHORYLATION PRE-MESSENGER-RNA EXPRESSION CANCER BINDING BIOGENESIS ACTIVATION GENERATION IMPAIRMENT THERAPIES

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失落的乡土:旅游飞地效应下传统村落发展迷思

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黑龙江生态工程职业学院学报 2024年第3期37卷 49-52页

作者：陈密暨南大学深圳旅游学院旅游管理系广东深圳518000

基于旅游飞地理论,以广西壮族自治区桂林市雁山区大埠乡大岗埠传统村落为个案,运用田野调查和口述史的研究方法,在实地调研过程中追溯大岗埠传统村落旅游发展过程中飞地现象的成因,从空间、社会文化、经济三个方面探究旅游飞地对传统村... 详细信息

基于旅游飞地理论,以广西壮族自治区桂林市雁山区大埠乡大岗埠传统村落为个案,运用田野调查和口述史的研究方法,在实地调研过程中追溯大岗埠传统村落旅游发展过程中飞地现象的成因,从空间、社会文化、经济三个方面探究旅游飞地对传统村落可持续发展的影响,通过进一步讨论分析得出破解旅游飞地消极效应的对策,为缓解当地社区和旅游景区之间的矛盾冲突提出建议,助力大岗埠传统村落振兴发展。

关键词：旅游飞地传统村落地中海俱乐部

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Analysis and optimal synthesis of single loop spatial mechanisms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第9期12卷 665-679页

作者： med Amine LARIBI Lotfi ROMDHANE Sad ZEGHLOUL Laboratoire de Génie Mécanique LAB-MA-05 Ecole Nationale d'Ingénieurs de Sousse Institut Pprime-UPR 3346 CNRS-Université de Poitiers-ENSMA Département Génie Mécanique et Systémes Complexes SP2MIBP30179 86962 Futuroscope France

In this work, a systematic approach is presented to obtain the input-output equations of a single loop 4-bar spatial mechanisms. The dialytic method along with Denavit-Hartenberg parameters can be used to obtain these equations efficiently. A genetic algorithm （GA） has been used to solve the problem of spatial mechanisms synthesis. Two types of mechanisms, e.g., RSCR and RSPC （R： revolute; S： spherical; C： cylindrical; P： prismatic）, have illustrated the application of the GA to solve the problem of function generation and path generation. In some cases, the GA method becomes trapped in a local minimum. A combined GA-fuzzy logic （GA-FL） method is then used to improve the final result. The results show that GAs, combined with an adequate description of the mechanism, are well suited for spatial mechanism synthesis problems and have neither difficulties inherent to the choice of the initial feasible guess, nor a problem of convergence, as it is the case for deterministic methods.

关键词： Spatial mechanisms Genetic algorithm-fuzzy logic (GA-FL) method Denevit-Hartenberg parameters Mechanism synthesis

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The Impact of the Techniques and Tactics Appropriate by the Athletes in Phase Triple Jump and Their Relationships with the Finale Results

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Journal of Sports Science 2015年第4期3卷 179-185页

作者： Zerf Moha.med Mokkedes Moulay idriss Bengoua Ali Bendahmane med Nasreddin Guebli abd-el-Kader Physical Education Institute Laboratory OPAPS University Abdel Hamid lbn Badis Mostaganem Mostaganem 27000 Algeria

The purposes of this study were to describe and compare the techniques used by elite world triple jumper and the Algerian elite team to determine the impact of distribution modality phases allowing the elite to exceeds 17-meter. Our subjects were two world elite 2009 and two Algerian national elite 2013. In the lack of new technology Modem measuring instruments kinematics or kinetics, our study based in measure of the Phase distribution ratio as measure of Stride length Jump distance. That literature review two schools, the Russian technique （which emphasizes the hop phase） and the Polish technique （which emphasizes the jump phase）. Our aims for this study are： Are there any statistically significant differences between the results of the samples in the distance achieved？ Are there any statistically significant differences between practical Ratio relative distances （world 2009-national 2013）？ Are there any statistically significant differences between Stride length phase distances （world 2009-national 2013）？ For that, we have chosen the analysis of variance and correlation of the distances achieved in each of the phases with the official distance of jumper and ＂T＂ student to compare implementation distribution of phases （hop, step and jump） with the results accuses. Based on the practices and weaknesses of elites in practice, we confirm：（1） All the samples practice the Russian technique as model in the distribution of the phase ratio; （2） The problem of our elites is in the hop phase distribution and its relationship with other phases; （3） Improve achieve horizontal vertical velocity in hop phase as solution.

关键词： The ratio phase techniques tactics appropriate triple jump.

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6种第二代抗精神病药物治疗药物监测结果的回顾性分析

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中国医院药学杂志 2024年第1期44卷 88-93页

作者：丁靖张锁邢欢李璐瑶龚阳泽田秘陈延明杨柳西安市精神卫生中心药学实验室陕西西安710100 西安市精神卫生中心药剂科陕西西安710100 西安市精神卫生中心精神科陕西西安710100 西安市精神卫生中心科教科陕西西安710100

目的:分析6种第二代抗精神病药物治疗药物监测结果,为6种药物治疗精神分裂症的个体化、合理化用药提供参考。方法:采用回顾性分析方法,收集西安市精神卫生中心2020年1-12月在门诊及住院进行6种第二代抗精神病药物治疗药物监测的结果。采... 详细信息

目的:分析6种第二代抗精神病药物治疗药物监测结果,为6种药物治疗精神分裂症的个体化、合理化用药提供参考。方法:采用回顾性分析方法,收集西安市精神卫生中心2020年1-12月在门诊及住院进行6种第二代抗精神病药物治疗药物监测的结果。采用med Calc 5.2医学统计软件进行数据分析。结果:6种药物监测1次频率的比例均为门诊>住院(P门诊(P0.05)。6种药物及其代谢物中,奥氮平血药浓度在治疗窗比例最高(约为74.98%),氯氮平最低(约为20.53%)。氨磺必利、阿立哌唑、阿立哌唑+脱氢阿立哌唑血药浓度均明显高于共识所推荐参考范围,而氯氮平及去乙基喹硫平血药浓度均明显低于共识所推荐参考范围。结论:在临床实践中,应加强门诊及住院患者治疗药物监测的重视程度,从而为患者实施个体化给药,保障临床用药的安全、有效。

关键词：第二代抗精神病药物治疗药物监测回顾性分析精神分裂症

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A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

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Chinese Journal of Natural medicines 2021年第7期19卷 505-520页

作者： mi Li LI Yu-Chen SUN Meng-Ru ZHANG Pei-Lin LI Yi YANG Hua State Key Laboratory of Natural medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

The tubers and roots of Aconitum(Ranunculaceae)are widely used as heart medicine or analgesic agents for the treatment of coronary heart disease,chronic heart failure,rheumatoid arthritis and neuropathic pain since ancient *** a type of natural products mainly extracted from Aconitum plants,Aconitum alkaloids have complex chemical structures and exert remarkable biological activity,which are mainly responsible for significant effects of Aconitum *** present review is to summarize the progress of the pharmacological,toxicological,and pharmacokinetic studies of Aconitum alkaloids,so as to provide evidence for better clinical *** data concerning pharmacological,toxicological and pharmacokinetic studies of Aconitum alkaloids were collected from different scientific databases(Pubmed,CNKI,Google Scholar,Baidu Scholar,and Web of Science)using the phrase Aconitum alkaloids,as well as generic *** alkaloids are both bioactive compounds and toxic ingredients in Aconitum *** produce a wide range of pharmacological activities,including protecting the cardiovascular system,nervous system,and immune system and anti-cancer ***,Aconitum alkaloids also exert strong cardiac toxicity,neurotoxicity and liver toxicity,which are supported by clinical ***,pharmacokinetic studies indicated that cytochrome P450 proteins(CYPs)and efflux transporters(ETs)are closely related to the low bioavailability of Aconitum alkaloids and play an important role in their metabolism and detoxification in vivo.

关键词： Aconitum alkaloids Pharmacological activities Toxicity Pharmacokinetics

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奥培米芬治疗绝经后外阴阴道萎缩效果的meta分析

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中国医药导报 2024年第6期21卷 106-110页

作者：刘洪慧刘巍王国成米鑫王君北京市顺义区妇幼保健院妇二科北京101300 北京市顺义区妇幼保健院实验室北京101300 北京市顺义区妇幼保健院副院长室北京101300

目的评估奥培米芬治疗绝经后外阴阴道萎缩的效果,为外阴阴道萎缩的临床治疗提供一定的理论支撑。方法检索中国知网、万方知识服务平台、维普网、中国生物医学数据库、Pub med、Embase、Cochrane Library、Web of Science核心合集数据... 详细信息

目的评估奥培米芬治疗绝经后外阴阴道萎缩的效果,为外阴阴道萎缩的临床治疗提供一定的理论支撑。方法检索中国知网、万方知识服务平台、维普网、中国生物医学数据库、Pub med、Embase、Cochrane Library、Web of Science核心合集数据库中关于奥培米芬治疗绝经外阴阴道萎缩的中英文文献,搜索时间为建库至2023年4月。文献质量评价采用Cochrane手册中随机对照试验偏倚风险评估工具;使用Review Manager 5.3对纳入文献进行meta分析。结果最终纳入7篇随机对照试验,包括2 649例患者,其中奥培米芬组1 624例,安慰剂组1 025例。两组子宫内膜增殖情况比较,差异无统计学意义(OR=3.74,95%CI:0.79,17.75,P=0.10)。奥培米芬较安慰剂组子宫内膜增厚发生率增加(OR=1.22,95%CI:1.01,1.47,P=0.03)、阴道p H值下降(SMD=-1.22,95%CI:-1.45,-0.98,P<0.000 01)、阴道干涩缓解(SMD=-0.38,95%CI:-0.55,-0.21,P<0.000 1)、不良反应发生率增加(OR=1.49,95%CI:1.28,1.74,P<0.000 01)。结论奥培米芬可增厚子宫内膜、降低阴道p H值及缓解阴道干涩,虽然在一定程度上增加不良反应的发生率,但仍是治疗外阴阴道萎缩的可靠方法。

关键词：奥培米芬绝经外阴阴道萎缩 meta分析

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