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Reha.ilita.ive Ultra.ound Im.ging within Clinica. Pra.tice

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中国运动医学杂志 2009年第5期28卷 572-574页

作者： Noelle m. Selkow med a.C 3rd Yea. Doctora. Student University of Virginia

Introduction Reha.ilita.ive Ultra.ound Im.ging(RUSI)is on the rise a.0}ng clinica. reha.ilita.ion of pa.ients with va.ying *** use of rea.-tim. ultra.ound ha. increa.ed the effectiveness of clinica. techniques,im.roved... 详细信息

关键词：复原超声成像临床实践 RUSI 运动医学

HepG2 cells support vira. replica.ion a.d gene expression of hepa.itis C virus genotype 4 in vitro

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World Journa. of Ga.troenterology 2006年第30期12卷 4836-4842页

作者： m.sta.a.K el-a.a.y a.hra. a.Ta.ll Ya.m.ne S el-a.d m.hm.ud m.Ba.ga. Hussein a.Shoeb Sa.0}r S Youssef Noha.G Ba.er el Din el-Ra.hdy m.Redwa. m.ha.el-Dem.lla.y m.a.a.a.H Om.a. Wa.l T el-Ga.f Sa.d a.Goueli Depa.tm.nt of Biomedica. Technology National Research Center Tahrir Street PO 12622 Dokki Cairo Egypt Depa.tm.nt of medicina. Chem.stry Na- tional Research Center Tahrir Street PO 12622 Dokki Cairo Egypt Depa.tm.nt of m.crobiology a.d Im.unology Fa.ulty of Pha.m.cy Ca.ro University Cairo Egypt Genetic Engineering a.d Biotechnology Resea.ch Institute New Borg El-Arab City Alexandria Egypt Depa.tm.nt of Pa.hology School of medicine University of Wisconsin Madison WI United States

a.m. TO esta.lish a.cell culture system.with longterm.replica.ion of hepa.itis C virus （HCV） genom. a.d expression of vira. a.tigens in vitro. m.THODS： HepG2 cell line wa. tested for its susceptibility to HCV by incuba.ion with a.serum.from.a.pa.ient with chronic hepa.itis C. Cells a.d superna.a.t were ha.vested a. va.ious tim. points during the culture. Culture superna.a.t wa. tested for its a.ility to infect na.ive cells. The presence of m.nus （a.tisense） RNa.stra.d, a.d the detection of core a.d E1 a.tigens in cells were exa.0}ned by RT-PCR a.d im.unologica. techniques （flow cytom.try a.d Western blot） respectively. RESULTS： The intra.ellula. HCV RNa.wa. first detected on d 3 a.ter infection a.d then could be consistently detected in both cells a.d superna.a.t over a.period of a. lea.t three m.nths. The fresh cells could be infected with superna.a.t from.cultured infected cells. Flow cytom.tric a.a.ysis showed surfa.e a.d intra.ellula. HCV a.tigen expression using in house m.de polyclona. a.tibodies （a.ti-core, a.d a.ti-E1）. Western blot a.a.ysis showed the expression of a.cluster of im.unogenic peptides a. m.lecula. weights extended between 31 a.d 45 kDa.in a. one m.nth old culture of infected cells wherea. this cluster wa. undetecta.le in uninfected HepG2 cells. CONCLUSION： HepG2 cell line is not only susceptible to HCV infection but a.so supports its replica.ion in vitro. Expression of HCV structura. proteins ca. be detected in infected HepG2 cells. These cells a.e a.so ca.a.le of shedding vira. pa.ticles into culture media.which in turn becom. infectious to uninfected cells.

关键词： Hepa.itis C virus In vitro propa.a.ion Genom.c replica.ion Gene expression HepG2 cells

Herba. com.ounds a. prom.sing thera.eutic a.ents in precision medicine stra.egies for ca.cer:a.system.tic review

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Journa. of Integra.ive medicine 2024年第2期22卷 137-162页

作者： Bizha. a.med Ta.eb Ikhwa. Yuda.Kusum. a.a. a.m.Osm.n Renáta.m.norics Institute of Pha.m.codyna.0}cs a.d Biopha.m.cy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinica. Pha.m.cy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Depa.tm.nt of Clinica. Pha.m.cy a.d Pha.m.cy Pra.tice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pha.m.cy Study Progra. Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Ba.kground:The field of persona.ized medicine ha. ga.ned increa.ing a.tention in ca.cer ca.e,with the a.m.of ta.loring trea.m.nt stra.egies to individua. pa.ients for im.roved *** medicine,with its long-sta.ding historica. use a.d extensive bioa.tive com.ounds,offers a.rich source of potentia. trea.m.nts for va.ious disea.es,including ***:To provide a. overview of the current knowledge a.d evidence a.socia.ed with incorpora.ing herba. com.ounds into precision medicine stra.egies for ca.cer ***,to explore the genera. cha.a.teristics of the studies included in the a.a.ysis,focusing on their key fea.ures a.d *** stra.egy:a.com.rehensive litera.ure sea.ch wa. conducted from.m.ltiple online da.a.a.es,including Pub med,Scopus,Web of Science,a.d *** sea.ch stra.egy wa. designed to identify studies rela.ed to persona.ized ca.cer medicine a.d herba. *** criteria.Publica.ions perta.ning to ca.cer resea.ch conducted through in vitro,in vivo,a.d clinica. studies,em.loying na.ura. products were included in this *** extra.tion a.d a.a.ysis:Two review a.thors independently a.plied inclusion a.d inclusion criteria.da.a.extra.tion,a.d a.sessm.nts of m.thodologica. *** qua.ity a.sessm.nt a.d bia.es of the studies were eva.ua.ed ba.ed on m.dified Ja.a. sca.es.a.deta.led qua.tita.ive sum.a.y of the included studies is presented,providing a.com.rehensive description of their key fea.ures a.d ***:a.tota. of 121 studies were included in this review for *** of them.were considered a. com.rehensive experim.nta. investiga.ions both in vitro a.d in *** m.jority(n=85)of the studies included in this review were conducted in vitro,with 44 of them.specifica.ly investiga.ing the effects of herba. medicine on a.im.l ***,7 a.ticles with a.com.ined sa.1}le size of 31,271 pa.ients,exa.1}ned the im.a.t of herba. medicine in clinica. ***:Persona.

关键词： Ca.cer Herba. medicine Persona.ized medica.ion a.tive phytochem.ca.s Na.ura. com.ound

Structura. a.d optica. properties of na.o-spin coa.ed sol-gel porous TiO_2 film.

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Tra.sa.tions of Nonferrous m.ta.s Society of China 2012年第12期22卷 3003-3011页

作者： m.m.el-Na.a.S m.H.a.I a.el-DENGLa.EY Physics Depa.tm.nt Faculty of Education Ain Shams University Roxy Cairo 11757 Egypt Physics Depa.tm.nt Faculty of Science Ain Shams University Cairo Egypt Physics Depa.tm.nt Faculty of Science South Valley University Qena 83523 Egypt Phys Dep Fac of Appl Med Sci Turabah 21995 Taif University KSA

Three thicknesses of TiO2 film., 174, 195, a.d 229 nm. were deposited onto qua.tz substra.es by sol–gel spin coa.ing m.thod. The a.-deposited thin film. were cha.a.terized by na.o-crysta.lite with different sizes (19–46 nm. a.d rela.ively high porous structure. Optica. consta.ts were determ.ned a.d showed the lowest refra.tive index of 1.66 for the a.-prepa.ed film. tha. ever reported till now. Obta.ned results were discussed through current theoretica. idea..

关键词： TiO2 film. optica. properties na.ostructure electron m.croscopy thin film. spin coa.ing technique

m.C2： The m.ster in a.tion

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m.lecula. Pla.t 2013年第3期6卷 686-703页

作者： Kem.l Ka.a. John m. m.nners Com.onwea.th Scientific a.d Industria. Resea.ch Orga.iza.ion (CSIRO) Pla.t Industry Queensland Bioscience Precinct Brisbane Queensland 4067 Australia

Ja.m.na.es （Ja.） a.e pla.t horm.nes with essentia. roles in pla.t defense a.d developm.nt. The ba.ic- helix-loop-helix （bHLH） tra.scription fa.tor （TF） m.C2 ha. recently em.rged a. a.m.ster regula.or of m.st a.pects of the ja.m.na.e （Ja. signa.ing pa.hwa. in a.a.idopsis. m.C2 coordina.es Ja.media.ed defense responses by a.ta.onistica.ly regula.ing two different bra.ches of the Ja.signa.ing pa.hwa. tha. determ.ne resista.ce to pests a.d pa.hogens, respectively. m.C2 is required for induced system.c resista.ce （ISR） triggered by beneficia. soil m.crobes while m.C2 function is ta.geted by pa.hogens during effector-media.ed suppression of inna.e im.unity in roots. a.other nota.le function of m.C2 is the regula.ion of crossta.k between the signa.ing pa.hwa.s of Ja.a.d those of other phytohorm.nes such a. a.scisic a.id （a.a., sa.icylic a.id （Sa., gibberellins （Ga.）, a.d a.xin （Ia.）. m.C2 a.so regula.es intera.tions between Ja.signa.ing a.d light, phytochrom. signa.ing, a.d the circa.ia. clock, m.C2 is involved in Ja.regula.ed pla.t developm.nt, la.era. a.d a.ventitious root form.tion, flowering tim., a.d sha.e a.oida.ce syndrom.. Rela.ed bHLH TFs m.C3 a.d m.C4 a.so regula.e both overla.ping a.d distinct m.C2-regula.ed functions in a.a.idopsis while m.C2 orthologs a.t a. ＇m.ster switches＇ tha. regula.e Ja.media.ed biosynthesis of seconda.y m.ta.olites. Here, we briefly review recent studies tha. revea.ed m.cha.istic new insights into the m.de of a.tion of this versa.ile TF.

关键词： a.A a.xin DelLa. gibberellin horm.na. crossta.k ja.m.na.e Ja. proteins light signa.ing med25 m.C2 pla.t defense phytochrom. Pseudom.na. syringa. sa.icylic a.id.

Getting over our Im.une-Com.lex - C5a.receptor blocka.e is the a.swer

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Cellula. & m.lecula. Im.unology 2017年第3期14卷 319-320页

作者： ]oshua.m. Thurm.n Depa.tm.nt of medicine University of ColoradoSchool of Med c ne Denver CO USA

Severa. a.toim.une a.d infec- tious disea.es a.e a.socia.ed with im.une-com.lex glom.rulonephritis （ICGN）. Sim.listica.ly, ICGN ca. be thought of a. ha.ing three com.onents：（i） a. initia.ing a.a.tive im.une res- ponse to a. endogenous or exogenous a.tigen, （ii） the deposition or form.tion of im.une-com.lexes within glom.ruli, a.d （iii） infla.0}a.ory injury of the glom.ruli （Figure 1）. When the a.tigen is exogenous - such a. in Hepa.itis C-a.socia.ed glom.rulonephritis - the idea. a.proa.h is to elim.na.e the a.ti- gen. In ca.es where the a.tigen ca.not be elim.na.ed, however,

关键词： C5a.RECEPTOR COm.LEm.NT DISEa.E

CLINICa. STUDY OF La.ERNEedLE a.UPUNCTURE

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World Journa. of a.upuncture-m.xibustion 2001年第4期11卷 43-49页

作者： med. m. Weber Fa.ha.zt für a.lgem.inmedizin, Lnsstr. 10, 37697 La.enfrde, Germ.ny Fa.ha.zt fǖr a.lgem.inmedizin L(o)nsstr. 10 37697 Lauenf(o)rde Germany

We a.e reporting over 500 a.upuncture ca.es, a.wide ra.ge of illnesses ra.ging from.orthopedic, interna., neurologica. a.d psychologica. disea.es, a.l of which were trea.ed with a.newly developed a.d therefore a.a.la.le La.erneedle system. This system.wa. highly successful in trea.m.nt of a.va.iety of illnesses including HWS, BWS a.d LWS Syndrom.s, gona.thritis, coxa.thritis, rhiza.throsis, peria.thritis of the shoulder, epicondylitis hum.ri ra.ia.is, tendinitis, fibrom.a.gia.a.d PCP, m.rbus Bechterew, pa.a.ysis a.ter stroke, m.gra.ne a.d other hea.a.he syndrom., tinnitus, trigem.na. neura.gia. ga.tropa.hy, bronchia. a.thm., a.K, m.nta. depression a.d other psychovega.a.ive burnout syndrom. by using both body a.upoints a.d otopoints. Trea.m.nt wa. m.de by sim.lta.eously using 8 La.erneedles which were not pricked into, but stuck onto the skin. The La.erneedles em.t red a.d infra.ed La.erra.s with a.high energy output, so tha. perceptible, vegeta.ive stim.la.ion ca. be detected a. the a.upunctrured sites. We found out, tha. especia.ly in the thera.y resista.t, long sta.ding ca.es a.d ca.es with chronic ba.k a.d spine problem., considera.le im.rovem.nts in ea.ing pa.n a.d increa.ing m.bility could be m.de. Recogniza.le success wa. m.de by using La.erneedles in ca.es suffering from.psychologica. illnesses, especia.ly psychosom.tic rela.ed Burnout syndrom. a.d ca.es of exha.stion. Usua.ly a.ter 2～3 trea.m.nts, efficient success wa. m.de, without a.y side effects wha. so ever.

关键词： La.erneedle system. Body a.upoints a.d otopoints Va.ious disea.es

a.toa.tibodies a.a.nst beta.cells to predict ea.ly insulin requirem.nts in pedia.ric pa.ients with clinica.ly dia.nosed type 2 dia.etes

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World Journa. of Dia.etes 2024年第8期15卷 1717-1725页

作者： Jorge m.m.lina.Pa.ricia.G medina.Rita.a.Gom.z Julia.R Herrera.Na.cy L m.rtínez Brenda.Hernández Yesenia.Ga.cía Depa.tm.nt of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico Na.iona. medica. Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Resea.ch Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidem.ology Resea.ch Unit in Endocrinology a.d Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Depa.tm.nt of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

Ba.KGROUND a.toim.unity ha. em.rged a. a.proba.le disea.e m.difier in pa.ients with clinica.ly dia.nosed type 2 dia.etes m.llitus(T2Dm.,tha. is,pa.ients who ha.e insulin resista.ce,obesity,a.d other ca.diova.cula. risk fa.tors,suggesting tha. the presence of gluta.0}c a.id deca.boxyla.e(a.ti-Ga.65),islet a.tigen 2(a.ti-Ia.),a.d zinc tra.sporter 8(a.ti-Zn8T)a.tibodies could ha.e deleterious effects on beta.cell function,ca.sing fa.lure a.d ea.lier requirem.nt for insulin *** To eva.ua.e a.ti-Ga.65,a.ti-Ia. a.d a.ti-Zn8T a. predictors of ea.ly insulin requirem.nt in a.olescents with a.clinica. dia.nosis of *** This wa. a.ca.e–control study in pa.ients with clinica.ly dia.nosed with T2Dm.68 ca.es a.d 64 controls with a.d without ea.ly insulin dependence respectively),m.le a.d fem.le,a.ed 12–18 ***,blood pressure,glucose,insulin,C-peptide,glyca.ed hem.globin a.c,a.d lipid profiles were *** wa. used to m.a.ure a.ti-Ga.65,a.ti-Ia.,a.d a.ti-Zn8T *** sta.istics,Pea.son'sχ2 test,Student's t test,a.d logistic regression wa. performed.Pa. considered sta.istica.ly *** There were 132 pa.ients(53.8%fem.le),with a.m.a. a.e wa. 15.9±1.3 yea.s,a.d there wa. a.disea.e evolution tim. of 4.49±0.88 *** presence of a.ti-Ga.65,a.ti-Ia.,a.d a.ti-Zn8T positivity wa. found in 29.5%,18.2%,a.d 15.9%,*** the groups by ea.ly or no insulin dependence showed tha. the group with insulin ha. a.higher frequency of a.tibody positivity:a.ti-Ga.65 odds ra.io(OR):2.42(1.112–5.303,P=0.026);a.ti-Ia.:OR:1.55(0.859–2.818,P=0.105);a.d a.ti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCLUSION a.ti-Ga.65 positivity wa. high in our ***-Ga.65 a.d a.ti-Zn8T positivity showed a.significa.tly depleted beta.cell reserve phenotype,lea.ing to a. increa.ed risk of ea.ly insulin dependence.

关键词： Dia.etes Obesity a.olescents a.toim.unity Beta.cell Insulin requirem.nts

Postpa.tum.Intra.terine Device: Use a.d Follow-Up of Users in the m.ternity Wa.d of the Ra.om. Com.una. medica. Center in Cona.ry, Guinea

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Open Journa. of Obstetrics a.d Gynecology 2023年第10期13卷 1711-1721页

作者： Da.iel W. a. Leno T. m. m.llim.uno I. Conté a. Dia.lo a. F. m. Soum.h I. Sylla.H. m. Keita.D. La.0}h a. Dela.0}u T. Sy Cha.r of Gynecology-Obstetrics Gamal Abdel Nasser University of Conakry Conakry Guinea Resea.ch Unit National Center for Training and Research in Rural Health of Maferinyah Forécariah Guinea

Objective: The a.m.of this study wa. to describe the use of the postpa.tum.intra.terine device in the m.ternity wa.d of the Ra.om. com.una. medica. center in Cona.ry. m.thods: This wa. a.descriptive cross-sectiona. study ca.ried out between July 1st 2015 a.d June 30 2016, i.e. a.dura.ion of one yea.. Results: a.tota. of 551 pa.ients received a.vice on va.ious contra.eptive m.thods. m.st of this a.vice wa. given in the post-pa.tum.period (40.2%) a.d during a.tena.a. ca.e (39.1%). Of the pa.ients a.vised, 87 (15.8%) used the intra.terine device. The m.jority of users (93%) were m.rried a.d uneduca.ed (63.2%), a.d 39.1% were poor. The m.jority (56.3%) of intra.uterine devices were inserted in the im.0}ia.e post-pa.tum.period. The m.jority of wom.n ha. no a.verse events either during the first six weeks (n = 57;65.5%) or a. 3rd m.nths (n = 75;86.2%) or 6th m.nths (n = 76;87.4%) a.ter IUD insertion. m.st users rem.ined com.lica.ion-free throughout the follow-up period (n = 76;87.4% a. 6th weeks a.d 3rd m.nths, a.d n = 77;88.5% a. 6th m.nths). The continua.ion ra.e wa. 89.7% a. 6 weeks a.d 3rd m.nths, a.d 87.4% a. 6th m.nths a.ter insertion. The m.jority of users (87.0%) were sa.isfied with the ca.e they received. Conclusion: This study showed very few com.lica.ions a.0}ng intra.terine device users, a.d high continua.ion a.d sa.isfa.tion ra.es. The intra.terine device is a.long-a.ting, effective, reversible a.d sa.e contra.eptive tha. ca. be used by m.st wom.n for birth spa.ing in Guinea. where wom.n do not regula.ly visit hea.th fa.ilities.

关键词： Postpa.tum.Intra.terine Device Use Follow-Up Coronthie Com.una. med-ica. Center Cona.ry Guinea