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FOUR NEW TAXOIDS FROm.THE NEedLES OF TAXUS WALLICHIANA ZUCC

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Chinese Chem.cal Letters 1995年第11期6卷 971-974页

作者： Zhang, JZ Fang, QC Liang, XT Kong, m.He, WY Chinese Acad med Sci Inst Mat Med Beijing 100050 Peoples R China Beijing Union med Coll Beijing 100050 Peoples R China

Four new taxoids with rearranged taxane skeleton,named taxawallins C(1),D(2), F(3)and H(4),were isolated from.the needles of Taxus wallichiana Zucc.. Their structures were elucidated by spectroscopic techniques.

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Physical activity during pregnancy and the role of theory in prom.ting positive behavior change:A system.tic review

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Journal of Sport and Health Science 2017年第2期6卷 198-206页

作者： Erika L.Thom.son Cheryl A.Vam.s Ellen m.Daley Departm.nt of Com.unity and Fam.ly Health University of South Florida Tampa FL 33612 USA

Background: Physical activity(PA) during pregnancy provides physical and psychological benefits for m.ther and child. U.S. guidelines recom.end ≥30 m.n of m.derate exercise for healthy pregnant wom.n m.st days of the week; however, m.st wom.n do not m.et these recom.endations. Theory assists in identifying salient determ.nants of health behavior to guide health prom.tion interventions; however, the application of theory to exam.ne PA am.ng pregnant wom.n has not been exam.ned cohesively am.ng m.ltiple levels of influence(e.g.,intrapersonal, interpersonal, neighborhood/environm.ntal, and organizational/political). Subsequently, this system.tic review aim. to identify and evaluate the use of health behavior theory in studies that exam.ne PA during ***: Articles published before July 2014 were obtained from.Pub med and Web of Science. Inclusion criteria applied were:(1) em.iricallybased;(2) peer-reviewed;(3) m.asured factors related to PA;(4) com.rised a pregnant sam.le; and(5) applied theory. Fourteen studies were included. Each study's application of theory and theoretical constructs were ***: Various theories were utilized to explain and predict PA during pregnancy; yet, the m.jority of these studies only focused on intrapersonal level determ.nants. Five theoretical fram.works were applied across the studies—all but one at the intrapersonal level. Few determ.nants identified were from.the interpersonal, neighborhood/environm.ntal, or organizational/political ***: This system.tic review synthesized the literature on theoretical constructs related to PA during pregnancy. Interpersonal, com.unity,and societal levels rem.in understudied. Future research should em.loy theory-driven m.lti-level determ.nants of PA to reflect the interacting factors influencing PA during this critical period in the life course.

关键词： Physical activity Pregnancy Theory

TWO NEW TAXOIDS FROm.THE NEedLES OF TAXUS WALLICHIANA ZUCC

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Chinese Chem.cal Letters 1995年第11期6卷 967-970页

作者： Zhang, JZ Fang, QC Liang, XT Kong, m.He, WY Chinese Acad med Sci Inst Mat Med Beijing 100050 Peoples R China Beijing Union med Coll Beijing 100050 Peoples R China

Two new taxoids, named taxawallin A(1)and taxawallin G(2) were isolated from.the needles of Taxus wallichiana Zucc.. Their structures were established by spectral m.thods.

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青老年大鼠分辨学习能力与脑内m.胆碱受体数量关系的探讨

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石河子医学院学报 1987年第2期 66-71页

作者：单迪芳张复俞霭瑶陈明林育忠新疆石河子医学院药理教研室新疆石河子医学院生理教研室上海第二医科大学药理教研组

本文采用大鼠三臂迷宫法证明青年大鼠对光、电刺激的逃避反应正确率为92.5％,而老年大鼠为85％;青年大鼠的反应时为7.2±1.8(秒),而老年大鼠为10±2.5(秒),提示青年大鼠的分辨学习能力较强且反应迅速。大鼠全脑m.R(m.胆碱受体)与[3H]... 详细信息

本文采用大鼠三臂迷宫法证明青年大鼠对光、电刺激的逃避反应正确率为92.5％,而老年大鼠为85％;青年大鼠的反应时为7.2±1.8(秒),而老年大鼠为10±2.5(秒),提示青年大鼠的分辨学习能力较强且反应迅速。大鼠全脑m.R(m.胆碱受体)与[3H]—QNB([3H]—二羟苯乙酸奎宁酯),结合试验测得的总受体数(Bm.x)及解离常数(K_D);青、老年大鼠的Bm.x分别为2.815Pm.m.,2.159pm.m.;K_D则分别为0.096μm.0.098μm.提示老年大鼠大脑中的m.R比青年大鼠减少24％,而亲和力则几乎相等。从而推测老年大鼠学习分辨能力较差和中枢神经系统申m.R数目的减少有一定的关系。

关键词：三臂迷宫法学习分辨能力 m.胆碱受体亲和力逃避反应放射配体结合试验 Hill系数

m.R疫苗接种后高热惊厥易感人群及长期预后的研究

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 3-4页

作者： Vestergaard m. Hviid A. m.dsen K.m. 黄卫东 Dept. of Epidem.ol. and Social med Danish Epidemiology Science Centre Aarhus University Vennelyst Blvd 6 DK-8000 Aarhus C Denmark

Context: The rate of febrile seizures increases following m.asles, m.m.s, and rubella (m.R) vaccination but it is unknown whether the rate varies according to personal or fam.ly history of seizures, perinatal factors, or socioeconom.c status. Furtherm.re, little is known about the long term.outcom. of febrile seizures following vaccination. Objectives: To estim.te incidence rate ratios (RRs) and risk differences of febrile seizures following m.R vaccination within subgroups of children and to evaluate the clinical outcom. of febrile seizures following vaccination. Design, Setting, and Participants: A population based cohort study of all children born in Denm.rk between January 1, 1991, and Decem.er 31, 1998, who were alive at 3 m.nths; 537171 children were followed up until Decem.er 31, 1999, by using data from.the Danish Civil Registration System.and 4 other national registries. m.in Outcom. m.asures: Incidence of first febrile seizure, recurrent febrile seizures, and subsequent epilepsy. Results: A total of 439251 children (82% ) received m.R vaccination and 17986 children developed febrile seizures at least once; 973 of these febrile seizures occurred within 2 weeks of m.R vaccination. The RR of febrile seizures increased during the 2 weeks following m.R vaccination (2.75; 95% confidence interval , 2.55- 2.97), and thereafter was close to the observed RR for nonvaccinated children. The RR did not vary signifi cantly in the subgroups of children that had been defined by their fam.ly history of seizures, perinatal factors, or socioeconom.c status. At 15 to 17 m.nths, the risk difference of febrile seizures within 2 weeks following m.R vaccination was 1.56 per 1000 children overall (95% CI, 1.44- 1.68), 3.97 per 1000 (95% CI, 2.90- 5.40) for siblings of children with a history of febrile seizures, and 19.47 per 1000 (95% CI, 16.05- 23.55) for children with a personal history of febrile seizures. Children with febrile seizures following m.R vaccinations had a slightl

关键词：疫苗接种 m.R疫苗高热惊厥易感人群惊厥发生率癫痫病史癫痫发生率围生期注册系统亚群

m.tations in foregut SOX2^+ cells induce efficient proliferation via CXCR2 pathway

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Protein & Cell 2019年第7期10卷 485-495页

作者： Tom.aki Hishida Eric Vazquez-Ferrer Yuriko Hishida-Nozaki Ignacio Sancho-m.rtinez Yuta Takahashi Fum.yuki hatanaka Jun Wu Alejandro Ocam.o Pradeep Reddy m.n-Zu Wu Laurie Gerken Reuben J. Shaw Concepcion Rodriguez Esteban Christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni Castells Josep m. Cam.istol Guang-Hui Liu Juan Carlos Izpisua Belm.nte Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Advaneed Innovation Center for Hum.n Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Beijing 100053 China National Laboratory of Biom.crom.lecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of the Chinese Academ. of Sciences Beijing 100049 China Insitute for Stem.Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Beijing Institute for Brain Disorder Beijing 100069 China Universidad Catolica San Antonio de Murcia Campus de los Jeronimos 135 Guadalupe 30107 Spain m.lecular and Cell Biology Laboratory Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Howard Hughes medical Institute Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Integrative Genom.cs Core Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Division of Gastroenterology Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Abram.on Cancer Center University of Pennsylvania Philadelphia PA 19104 USA Departm.nt of Traum.tology and Research Unit Clinica CEMTRO Av. Ventisquero de la Condesa 42 Madrid 28035 Spain Gastroenterology Departm.nt Hospital Clinic University of Barcelona IDIBAPS CIBEREHD Barcelona 08036 Spain

Identification of the precise m.lecular pathways involved in oncogene-induced transform.tion m.y help us gain a better understanding of tum.r initiation and prom.tion. Here, we dem.nstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transform.tion upon m.tagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experim.nts indicate that SOX2^+ cells are the cells-of-origin of esophagus and stom.ch hyperplasia. Our observations indicate distinct roles for oncogenic KRAS m.tation and P53 deletion. p53 hom.zygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tum.r form.tion. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic m.dels presented here dem.nstrate that stratified epithelial cells are susceptible to oncogenic insults, which m.y lead to a better understanding of tum.r initiation and aid in the design of new cancer therapeutics.

关键词： Sox2 tum.r CXCR2 stratified epithelia

Output feedback control of pantograph–catenary system.with adaptive estim.tion of catenary param.ters

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Journal of m.dern Transportation 2015年第4期23卷 252-261页

作者： E.Chater D.Ghani F.Giri m.haloua LAII Lab EMI Med V University UNICAEN GREYC Lab UMR CNRS Normandie Universite'

With the increasing railway vehicle speed, pantograph--catenary （PAC） system.has becom. an im.ortant part as its incidents still stand am.ng the prin- cipal causes of railway traffic interruption. Indeed, when a rail vehicle m.ves, the pantograph should constantly press against the underside of the catenary. Nonetheless, it is difficult to get around the com.lexity of the physical interaction between the pantograph and the contact wire, which could deteriorate the quality of the electricity transfer. Thus, PAC system.perform.nces could dram.ti- cally be reduced because of bad current collection. Therefore, in this paper, we present an output feedback solution in order to design an active control of PAC system. The proposed solution is based on the backstepping control and an adaptive observer that estim.tes both the （unknown） catenary param.ters and the system.state. All synthesis steps are given and the closed-loop analysis shows asym.totic tracking behavior regardless of the tim.-vary- ing catenary stiffness. Furtherm.re, a num.rical exam.le shows that the PAC contact can be regulated with desired effect.

关键词： Transportation system. Periodic system.analysis Control of oscillations

Rapunzel syndrom. is not just a m.re surgical problem. A case report and review of current m.nagem.nt

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World Journal of Clinical Cases 2017年第2期5卷 50-55页

作者： Obinna Obinwa David Cooper Faraz Khan Jam.s m.O'Riordan Departm.nt of Surgery the Adelaide and Meath Hospital Dublin Incorporating the National Children’s Hospital

Recurrent Rapunzel syndrom.(RRS) is a rare clinical presentation with fewer than six cases reported in the Pub med literature. A report of RRS and literature review is presented. A 25-year-old fem.le was adm.tted to hospital with a 4-wk history of epigastric pain and swelling. She had a known history of trichophagia with a previous adm.ssion for Rapunzel syndrom. requiring a laparotom. nine years earlier, aged 16. Psychological treatm.nt had been successfully achieved for nine years with outpatient hypnotherapy sessions only, but she defaulted on her last session due to stressors at hom.. The abdom.nal exam.nation dem.nstrated an epigastric m.ss. Com.uter tom.graphy scan revealed a large gastric bezoar and features of aspiration pneum.nia. The patient underwent em.rgency open surgical laparotom. for rem.val as the bezoar could not be rem.ved endoscopically. The bezoar was cast in a shape that m.m.cked the contours of the stom.ch and proxim.l sm.ll bowel, hence the diagnosis of RRS. The patient was seen by a psychiatrist and was com.enced on Quetiapine before discharge. She continues to attend follow-up.

关键词： Trichobezoars Rapunzel syndrom. Recurrence Obsessive com.ulsive disorders Case report

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息肉状脉络膜血管病变的息肉状损害的可塑性

世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 35-36页

作者： Okubo A. Sam.shim. m. Sakam.to T. 王媛 Departm.nt of Ophthalm.logy Kagoshima University Graduate School of Med./Dental Sci. Sakuragaoka 8- 35- 1 890- 8520 Kagoshima Japan

Purpose: The aim.of this study was to describe the clinical course in a patient with polypoidal choroidal vasculopathy (PCV). m.thods: A 68- year- old m.n with PCV in the left eye was followed up by m.ans of routine exam.nations including fluorescein angiography and indocyanine green angiography for over 60 m.nths. Results: Throughout the follow- up period, the patient experienced repeated lesions in the m.cula, such as serosanguineous detachm.nt of the retinal pigm.nt epithelium.and neurosensory retina, but retained good visual acuity. Indocyanine green angiography disclosed spontaneous regression of polypoidal vessels followed by significant changes in the choroidal circulation: a group of polypoidal structures disappeared, and after several m.nths a sm.ll choroidal vessel becam. apparent that was distant from.the previously observed polypoidal structure rather than representing an extension of the original lesion. Conclusion: The clinical observation suggests that in som. cases of PCV the choroidal vasculature m.y be altered with tim., in that som. vessels in the inner choroid and even the choriocapillaris m.y close and collateral vessels and/or new vessels m.y develop to form.com.lex such as that described here.

关键词：息肉状脉络膜血管吲哚青绿视网膜色素上皮浆液性脱离神经视网膜血管造影视敏度常规检查方法侧副管