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Rehabilitative Ultrasound Imaging within Clinical Practice

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中国运动医学杂志 2009年第5期28卷 572-574页

作者： Noelle m. Selkow med ATC 3rd Year Doctoral Student University of Virginia

Introduction Rehabilitative Ultrasound Imaging(RUSI)is on the rise among clinical rehabilitation of patients with varying *** use of real-time ultrasound has increased the effectiveness of clinical techniques,improved... 详细信息

关键词：复原超声成像临床实践 RUSI 运动医学

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

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Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar a.med Tayeb Ikhwan Yuda Kusuma Alaa A.m.Osman Renáta minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

Evaluation of large language models for the classification of medical device software

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BIO-DESIGN AND mANUFACTURING 2024年第5期7卷 819-822页

作者： Han, Yu Ceross, Aaron Bourgeois, Florence Savaget, Paulo Bergmann, Jeroen H. m. Univ Oxford Dept Engn Sci Old Rd Campus Oxford OX3 7DQ England Harvard med Sch Harvard MIT Ctr Regulatory Sci Boston MA 02115 USA Univ Southern Denmark Dept Technol & Innovat Odense Denmark Boston Childrens Hosp Computat Hlth Informat Program CHIP Boston MA USA

Amidst the rapidly expanding integration of large language models(LLms)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m molina Patricia G medina Rita A Gomez Julia R Herrera Nancy L martínez Brenda Hernández Yesenia García Department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National medical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology Research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUND Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus(T2Dm),that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutamic acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirement for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm(68 cases and 64 controls with and without early insulin dependence respectively),male and female,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hemoglobin A1c,and lipid profiles were *** was used to measure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was performed.Pmale),with a mean age was 15.9±1.3 years,and there was a disease evolution time of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCLUSION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoimmunity Beta cell Insulin requirements

腐胺通过线粒体相关内质网膜改善高龄卵母细胞质量

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南京医科大学学报（自然科学版） 2024年第7期44卷 891-900页

作者：倪曼程丽郭爽腊博雅严正杰崔毓桂覃莲菊刘嘉茵南京医科大学第一附属医院生殖医学中心生殖医学与子代健康全国重点实验室江苏南京210029

目的:评估体外成熟(in vitro maturation,IVm)培养液中添加腐胺是否可改善高龄小鼠卵母细胞质量,及腐胺对高龄小鼠卵母细胞中线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membrane,mAm)的影响。方法:取生发泡期(... 详细信息

目的:评估体外成熟(in vitro maturation,IVm)培养液中添加腐胺是否可改善高龄小鼠卵母细胞质量,及腐胺对高龄小鼠卵母细胞中线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membrane,mAm)的影响。方法:取生发泡期(germinal vesicle,GV)小鼠卵母细胞进行体外成熟培养至减数分裂(meiosis,m)Ⅱ期,分别使用8周龄小鼠卵母细胞作为年轻对照组,40周龄小鼠卵母细胞作为老龄对照组,IVm液中添加0.5 mmol/L腐胺的40周龄小鼠卵母细胞作为老龄实验组。通过检测mⅡ期卵母细胞的第一极体排出率、二细胞率、囊胚率、皮质颗粒分布、纺锤体异常率和染色体异常率评估卵母细胞的质量。使用透射电镜观察mⅡ期卵母细胞的mAm,qPCR检测mAm间Ca2+传递的关键分子含量,Ca2+探针测定线粒体、内质网和胞质的Ca2+水平,并通过检测线粒体膜电位、ATP含量和活性氧(reactive oxygen species,ROS)水平评估线粒体功能。结果:腐胺提高了高龄小鼠卵母细胞的第一极体排出率(PmAm间距缩短变化(PmAm间Ca2+快速传递引起的线粒体钙超载(PmAm间Ca2+传递缓解线粒体钙超载,改善线粒体功能。

关键词：腐胺线粒体相关内质网膜卵母细胞高龄

CLINICAL STUDY OF laSERNEEDLE ACUPUNCTURE

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World Journal of Acupuncture-moxibustion 2001年第4期11卷 43-49页

作者： med. m. Weber Facharzt für Allgemeinmedizin, Lnsstr. 10, 37697 lauenfrde, Germany Facharzt fǖr Allgemeinmedizin L(o)nsstr. 10 37697 Lauenf(o)rde Germany

We are reporting over 500 acupuncture cases, a wide range of illnesses ranging from orthopedic, internal, neurological and psychological diseases, all of which were treated with a newly developed and therefore available laserneedle system. This system was highly successful in treatment of a variety of illnesses including HWS, BWS and LWS Syndromes, gonarthritis, coxarthritis, rhizarthrosis, periarthritis of the shoulder, epicondylitis humeri radialis, tendinitis, fibromyalgia and PCP, morbus Bechterew, paralysis after stroke, migraine and other headache syndrome, tinnitus, trigeminal neuralgia, gastropathy, bronchial asthma, AVK, mental depression and other psychovegatative burnout syndrome by using both body acupoints and otopoints. Treatment was made by simultaneously using 8 laserneedles which were not pricked into, but stuck onto the skin. The laserneedles emit red and infrared laserrays with a high energy output, so that perceptible, vegetative stimulation can be detected at the acupunctrured sites. We found out, that especially in the therapy resistant, long standing cases and cases with chronic back and spine problems, considerable improvements in easing pain and increasing mobility could be made. Recognizable success was made by using laserneedles in cases suffering from psychological illnesses, especially psychosomatic related Burnout syndrome and cases of exhaustion. Usually after 2～3 treatments, efficient success was made, without any side effects what so ever.

关键词： laserneedle system Body acupoints and otopoints Various diseases

Geophysics Contribution for the Determination of Aquifers with a Case Study

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International Journal of Geosciences 2012年第1期3卷 117-125页

作者： latifa Ouadif lahcen Bahi a.med Akhssas Khadija Baba.med menzhi 3GE laboratory Mohammadia Engineering School Mohammed V Agdal University Rabat Morocco

The determination and monitoring of aquifer formations on the eastern border of moroccan Gharb basin are very difficult because of their spatial and temporal variation. To delimit these formations, a geophysical survey of 52 geoelectric soundings was performed with a mesh of 500 m and electrodes distance between 1000 m and 3000 m. Geoelectric sections and resistivity maps show a horst and graben structure. The correlation of existing oil drillings shows that the Jurassic and Neogene formations are both affected by normal faults causing Jurassic deposits collapse with local thickening of the miocene deposits, and reverse faults delimiting tectonic slices due to tension caused by prerifaine nappe advance. This fact confirms the generated structure by the resistivity method. The isobath map of resistant formations's roof show average depths extending from 400 to 800 m for calcareous sandstone that are potential aquifers while oil drillings indicate over 1000 m depths.

关键词： Aquifer Prerifaine Nappe Resistivity method Geophysical Survey Gharb Basin

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自己的肌肤自己救

自己的肌肤自己救

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

2020年

作者： medPartner美的好朋友医疗团队

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GENOmICS PROTEOmICS & BIOINFORmATICS 2024年第2期22卷 qzae031页

作者： Li, Yanni van den Berg, Eline H. Kurilshikov, Alexander Zhernakova, dasha, V Gacesa, Ranko Hu, Shixian Lopera-maya, Esteban A. Zhernakova, Alexandra de meijer, Vincent E. Sanna, Serena Dullaart, Robin P. F. Blokzijl, Hans Festen, Eleonora A. m. Fu, Jingyuan Weersma, Rinse K. Univ Groningen Univ Med Ctr Groningen Dept Gastroenterol & Hepatol NL-9713 GZ Groningen Netherlands Univ Groningen Univ Med Ctr Groningen Dept Genet NL-9713 GZ Groningen Netherlands Tianjin med Univ Tianjin Med Univ Gen Hosp Dept Gastroenterol & Hepatol Tianjin 300052 Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Inst Precis Med Guangzhou 510080 Peoples R China ITmO Univ Ctr Comp Technol Lab Genom Divers St Petersburg 199034 Russia Univ Groningen Univ Med Ctr Groningen Dept Pediat NL-9713 GZ Groningen Netherlands Univ Groningen Univ Med Ctr Groningen Dept Surg Sect Hepatobiliary Surg & Liver Transplantat NL-9713 GZ Groningen Netherlands Univ Groningen Univ Med Ctr Groningen Dept Endocrinol NL-9713 GZ Groningen Netherlands

Genetic susceptibility to metabolic associated fatty liver disease (mAFLD) is complex and poorly characterized. Accurate characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk factors. We performed genome-wide association study (GWAS) on two noninvasive definitions of hepatic fat content: magnetic resonance imaging proton density fat fraction (mRI-PDFF) in 16,050 participants and fatty liver index (FLI) in 388,701 participants from the United Kingdom (UK) Biobank (UKBB). Heritability, genetic overlap, and similarity between hepatic fat content phenotypes were analyzed, and replicated in 10,398 participants from the University medical Center Groningen (UmCG) Genetics Lifelines Initiative (UGLI). meta-analysis of GWASs of mRI-PDFF in UKBB revealed five statistically significant loci, including two novel genomic loci harboring CREB3L1 (rs72910057-T, P = 5.40E-09) and GCm1 (rs1491489378-T, P = 3.16E-09), respectively, as well as three previously reported loci: PNPla3, Tm6SF2, and APOE. GWAS of FLI in UKBB identified 196 genome-wide significant loci, of which 49 were replicated in UGLI, with top signals in ZPR1 (P = 3.35E-13) and FTO (P = 2.11E-09). Statistically significant genetic correlation (rg) between mRI-PDFF (UKBB) and FLI (UGLI) GWAS results was found (rg = 0.5276, P = 1.45E-03). Novel mRI-PDFF genetic signals (CREB3L1 and GCm1) were replicated in the FLI GWAS. We identified two novel genes for mRI-PDFF and 49 replicable loci for FLI. Despite a difference in hepatic fat content assessment between mRI-PDFF and FLI, a substantial similar genetic architecture was found. FLI is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content mAFLD Genome-wide association study Fatty liver index magnetic resonance imaging proton density fat fraction LIVER-DISEASE ASSOCIATION VARIANT LOCI SUSCEPTIBILITY PATHOGENESIS INSIGHTS TARGETS ENZYmES CONFERS