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Chance and challenge of associating liver partition and portal vein ligation for staged hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 214-222页

作者： Fei Xiang ze-Min Hu Department of General Surgery Jiangning Hospital of Nanjing Medical University Nanjing 211100 China Department of General Surgery Zhongshan People’s Hospital Zhongshan 528403 China

Background: The associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) was first performed in 2007. The critical patient selection, timing to perform the second stage operation, and minimally invasive technique are three key factors for patient outcomes. The aim of this review is to summarize published data on these three aspects. Data sources: Studies were identified by searching Pub med for articles published from January 2007 to October 2018, using the keywords “associating liver partition and portal vein ligation for staged hepatectomy” or “ALPPS” or “in situ split”. Studies on colorectal liver metastasis(CRLM), perihilar cholangiocarcinoma(PHC), and hepatocellular carcinoma(HCC) indicated for ALPPS, cutoff values to determine the timing of stage 2, as well as modifications of ALPPS were included. Results: The mortality of ALPPS for CRLM is declining, for PHC is high. In patients with HCC, essential hypertrophy makes the ALPPS safer. However, the degrees of fibrosis affect the hypertrophy. The future liver remnant volume is still the gold standard to start the second stage. Hepatobiliary scintigraphy plays an important role in quantitatively assessing liver function, whereas cutoff values need to be further calibrated. Less-invasive ALPPS modifications have increased and led to a decreased mortality. Conclusions: ALLPS improved the CRLM outcomes;ALPPS is feasible in patients with PHC after failure of portal vein embolization;ALPPS may be an option for HCC patients with major vascular invasion and thrombosis. The simplified and less-invasive ALPPS is the trend.

关键词： Hepatectomy Liver regeneration Portal vein Colorectal liver metastasis Hepatocellular carcinoma Perihilar cholangiocarcinoma

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基于动态图注意力与标签传播的实体对齐

计算机工程 2024年第4期50卷 150-159页

作者：莫少聪陈庆锋谢泽刘春雨邱俊铼广西大学计算机与电子信息学院广西南宁530004

实体对齐是多源数据库融合的有效方法,旨在找出多源知识图谱中的共指实体。近年来,图卷积网络(GCN)已成为实体对齐表示学习的新范式,然而,不同组织构建知识图谱的目标及规则存在巨大差异,要求实体对齐模型能够准确发掘知识图谱之间的长... 详细信息

实体对齐是多源数据库融合的有效方法,旨在找出多源知识图谱中的共指实体。近年来,图卷积网络(GCN)已成为实体对齐表示学习的新范式,然而,不同组织构建知识图谱的目标及规则存在巨大差异,要求实体对齐模型能够准确发掘知识图谱之间的长尾实体特征,并且现有的GCN实体对齐模型过于注重关系三元组的结构表示学习,忽略了属性三元组丰富的语义信息。为此,提出一种实体对齐模型,引入动态图注意力网络聚合属性结构三元组表示,降低无关属性结构对实体表示的影响。同时,为缓解知识图谱的关系异构问题,引入多维标签传播对实体邻接矩阵的不同维度进行压缩,将实体特征根据压缩后的知识图谱邻接关系进行传播以获得关系结构表示,最后通过线性规划算法对实体表示相似度矩阵进行迭代以得到最终的对齐结果。在公开数据集ENFR-15K、EN-ZH-15K以及中文医学数据集med-BBK-9K上进行实验,结果表明,该模型的Hits@1分别为0.942、0.926、0.427,Hits@10分别为0.963、0.952、0.604,MRR分别为0.949、0.939、0.551,消融实验结果也验证了模型中各模块的有效性。

关键词：数据库融合图卷积网络实体对齐标签传播线性规划

Clinical results and intramedullary signal changes of posterior decompression with transforaminal interbody fusion for thoracic myelopathy caused by combined ossification of the posterior longitudinal ligament and ligamentum flavum

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Chinese medical Journal 2013年第20期126卷 3822-3827页

作者： Wang Lin-feng Liu fa-jing Zhang Ying-ze Shen Yong Ding Wen-yuan Xu Jia-xin Hebei med Univ Hosp 3 Dept Spine Surg Shijiazhuang 050051 Hebei Peoples R China Handan Cent Hosp Dept Orthoped 2 Handan 056001 Hebei Peoples R China

Background Surgical treatment of thoracic myelopathy caused by ossification of the posterior longitudinal ligament （OPLL） and ossification of the ligamentum flavum （OLF） is technically demanding, and the results tend to be unfavorable. Various operative approaches and treatment strategies have been attempted, and posterior decompression with transforaminal thoracic interbody fusion （PTTIF） may be the optimal method with which the anterior-posterior compression was removed in one step. It is comparatively less traumatic with fewer serious complications.

关键词： transforaminal thoracic interbody fusion," thoracic myelopathy ossification of posterior longitudinal ligament," ossification of ligamentum flavum intramedullary signal change

Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo

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Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 414-422页

作者： fan, Yue-Zu Zhao, ze-Ming Fu, Jin-Ye Chen, Chun-Qiu Sun, Wei Tongji Univ Sch Med Tongji Hosp Dept Surg Shanghai 200065 Peoples R China Shanghai Jiao Tong Univ Peoples Hosp 9 Dept Surg Shanghai 200065 Peoples R China

BACKGROUND: Gallbladder carcinoma, a lethal malignant neoplasm with poor prognosis, has dismal results of surgical resection and chemoradiotherapy. We previously reported that norcantharidin (NCTD) is useful against growth, proliferation, and invasion of human gallbladder carcinoma GBC-SD cells in vitro. In this study, we further studied the inhibitory effect of NCTD on the growth of xenografted tumors of human gallbladder carcinoma in nude mice in vivo and the underlying mechanisms. METHODS: The tumor xenograft model of human gallbladder carcinoma in nude mice in vivo was established with subcutaneous GBC-SD cells. The experimental mice were randomly divided into control, 5-FU, NCTD, and NCTD+5-FU groups which were given different treatments. Tumor growth in terms of size, growth curve, and inhibitory rate was evaluated. Cell cycle, apoptosis, and morphological changes of the xenografted tumors were assessed by flow cytometry and light/electron microscopy. The expression of the cell cycle-related proteins cyclin-D1 and p27 as well as the apoptosis-related proteins Bcl-2, Box, and survivin were determined by the streptavidin-biotin complex (SABC) method and RT-PCR. RESULTS: NCTD inhibited the growth of the xenografted tumors in a dose- and time-dependent manner. Tumor volume decreased (5.61+/-0.39 vs. 9.78+/-0.61 cm(3), P=0.000) with an increased tumor inhibitory rate (42.63% vs. 0%, P=0.012) in the NTCD group compared with the control group. The apoptosis rate increased (15.08+/-1.49% vs. 5.49+/-0.59%, P=0.0001) along with a decreased percentage of cells in S phase (43.47+/-2.83% vs. 69.85+/-1.96%, P=0.0001) in the NTCD group compared with the control group. The morphological changes of apoptosis such as nuclear shrinkage, chromatin aggregation, chromosome condensation, and typical apoptosis bodies in the xenografted tumor cells induced by NCTD were observed by light and electron microscopy. The expression of cyclin-D1, Bcl-2 and survivin proteins/mRNAs decreased s

关键词： norcantharidin gallbladder neoplasm tumor growth apoptosis cell cycle

Conversion therapy and suitable timing for subsequent salvage surgery for initially unresectable hepatocellular carcinoma: What is new?

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World Journal of Clinical Cases 2018年第9期6卷 259-273页

作者： ze-Feng Zhang Yu-Jun Luo Quan Lu Shi-Xue Dai Wei-Hong Sha Department of Gastroenterology and Hepatology Guangdong Geriatrics Institute Guangdong General Hospital Guangdong Academy of Medical Sciences

AIM To review the conversion therapy for initially unre-sectable hepatocellular carcinoma(HCC) patients and the suitable timing for subsequent salvage surgery. METHODS A Pub med search was undertaken from 1987 to 2017 to identify articles using the keywords including "unresectable" "hepatocellular carcinoma", "hepate-ctomy", "conversion therapy", "resection", "salvage surgery" and "downstaging". Additional studies were investigated through a manual search of the references from the articles. The exclusion criteria were duplicates, case reports, case series, videos, contents unrelated to the topic, comments, and editorial essays. The main and widely used conversion therapies and the suitable timing for subsequent salvage surgery were discussed in detail. Two members of our group independently performed the literature search and data extraction. RESULTS Liver volume measurements [future liver remnant(FLR)/total liver volume or residual liver volume/bodyweight ratio] and function tests(scoring systems and liver stiffness) were often performed in order to justify whether patients were suitable candidates for surgery. Successful conversion therapy was usually defined as downstaging the tumor, increasing FLR and providing subsequent salvage surgery, without increasing com-plications, morbidity or mortality. The requirementsfor performing salvage surgery after transcatheter arterial chemoembolization were the achievement of a partial remission in radiology, the disappearance of the portal vein thrombosis, and the lack of extrahepatic metastasis. Patients with a standardized FLR(sF LR) > 20% were good candidates for surgery after portal vein embolization, while other predictive parameters like growth rate, kinetic growth rate were treated as an effective supplementary. There was probably not enough evidence to provide a standard operation time after associating liver partition and portal vein ligation for staged hepatectomy or yttrium-90 microsphere radioembolization. The i

关键词： Unresectable Hepatocellular carcinoma Hepatectomy Conversion therapy Salvage surgery Downstaging

Orthopaedics and traumatology in China： current status and future

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Chinese medical Journal 2012年第22期125卷 3929-3930页

作者： ZHANG Ying-ze Hebei med Univ Hosp 3 Dept Orthopaed Surg Shijiazhuang 050051 Hebei Peoples R China

With the advancement of China＇s social progress and economic growth, and consequent development of international academic exchanges in orthopaedic traumatology, along with many other related professions, the discipli... 详细信息

关键词： orthopaedics traumatology China

Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis

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World Journal of Gastroenterology 2010年第15期16卷 1916-1923页

作者： Deng, Xin Liang, Jian Lin, Zhi-Xiu Wu, fa-Sheng Zhang, Ya-Ping Zhang, Zhi-Wei Guangxi Tradit Chinese med Univ Affiliated Ruikang Hosp Nanning 530011 Guangxi Zhuang Peoples R China Chinese Univ Hong Kong Sch Chinese Med Shatin Hong Kong Peoples R China

AIM:To study the differential expression of proteins between natural taurine treated hepatic stellate cells and controls, and investigate the underlying regulatory mechanism of natural taurine in inhibiting hepatic ***: A proteomic strategy combining two-dimensional gel electrophoresis and ultraperform ance liquid chromatographyelectrospray ionizationtandem mass spectrometry (UPLCESIMS/MS) was used to study the differential expression of proteins and Western blotting was used to validate the results. Gene ontology (GO) method was utilized to analyze the functional enrichment of differentially expressed proteins. Flow cytometry was performed to compare the apoptosis rate between taurinetreated and untreated hepatic stellate cells (HSCs).RESULTS: Nineteen differentially expressed proteins (11 upregulated and 8 downregulated) were identifiedby 2D/MS, and the expression profiles of GLO1 and ANXA1 were validated by Western blotting. GO analysis found that these differentially expressed proteins were enriched within biological processes such as "cellular apoptosis", "oxidation reaction" and "metabolic process" in clusters. Flow cytometric analysis showed that taurinetreated HSCs had a significantly increased apoptosis rate when compared with the control ***: Natural taurine can promote HSC apoptosis so as to inhibit hepatic fibrosis.

关键词： Natural taurine Proteomics Hepatic stellate cell Hepatic f ibrosis Apoptosis

Expression of NF-kappaB in rotavirus-induced damage to the liver and biliary tract in neonatal mice

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 188-193页

作者： Huang, Lei Gu, Wei-Zhong Si, Xin-Min Wei, Ming-fa Feng, Jie-Xiong Huazhong Univ Sci & Technol Dept Pediat Surg Tongji Hosp Wuhan 430030 Peoples R China Zhejiang Univ Sch Med Dept Pathol Childrens Hosp Hangzhou 310003 Peoples R China Wuhan Univ Renmin Hosp Dept Gastroenterol Wuhan 430060 Peoples R China

BACKGROUND: Biliary atresia, the etiology of which still remains unclear, occurs exclusively in newborns and most are infected with rotavirus. In this study, we a.med to investigate the histopathological patterns of different kinds of rotavirus in the liver and biliary tract of neonatal mice and the expression of NF-kappa B in the liver and biliary tract of infected mice. METHODS: Twenty-three adult mice (8 were male and 15 female) were divided into 8 breeding pairs, and each pair (I male and 2 females) was housed in a cage in a laminar flow hood. Newborn mice, 24-48 hours old were randomly divided into A, B and C groups. The A and B groups were respectively inoculated with MMU18006 and SA11 rotavirus through the intraperitoneal route, while group C as blank control was only inoculated with culture medium. The liver was dissected after 5, 10, 15, 21 and 28 days; the weight of each mouse and the histopathological patterns in the liver were recorded. The expression of NF-kappa B in the liver and intrahepatic bile ducts was detected by immunohistochemical staining and the expression intensity was analyzed with a GT-2 imaging instrument. RESULTS: The average increase in weight of infected mice was significantly slower than that of the normal control, while the growth rate of group A (injected with MMU18006 rotavirus) was slower than that of group B (SA11 rotavirus). In infected mice, the acute and chronic inflammation of liver and intra- and extra-hepatic bile ducts was more significant in group A. Stenosis was found in most intrahepatic bile ducts, and sporadically in extrahepatic bile ducts. The expression of NF-kappa B in infected mice was dramatically higher than that of the normal control, while the expression in group A was higher than in group B. CONCLUSIONS: Significant damage to the liver and biliary tract of neonatal mice can be induced by inoculating MMU18006 rotavirus through the intraperitoneal route, which is very similar to the pathology of biliary atresi

关键词： rotavirus biliary atresia NF-kappa B

Cerebral lipiodol embolism following transcatheter arterial chemoembolization for hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第3期16卷 398-402页

作者： Wu, Lu Yang, Ye-fa Liang, Jun Shen, Shu-Qun Ge, Nai-Jian Wu, Meng-Chao Second Mil med Univ Dept Intervent Radiol 1 Eastern Hepatobiliary Surg Hosp Shanghai 200438 Peoples R China

Cerebral lipiodol embolism (CLE) is an extremely rare complication of transcatheter arterial chemoembolization for hepatocellular carcinoma (HCC). The authors present a case of CLE that occurred after the second hepatic arterial chemoembolization for HCC, and attempt to introduce several plausible mechanisms of CLE, after reporting the clinical and radiological findings and reviewing the medical literature.

关键词： Intracranial embolism Lipiodol Chemotherapeutic embolization Hepatocellular carcinoma