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Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis

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Neural Regeneration Research 2024年第3期19卷 642-649页

作者： Xiuling Tang Tao Yan Saiying Wang Qingqing Liu Qi Yang Yongqiang Zhang Yujiao Li Yumei Wu Shuibing Liu Yulong ma Le Yang Precision Pha.ma.y&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Clinical Pha.ma.y Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Department of Pha.ma.ology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a type of phytosterol that occurs naturally in *** studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-infla.ma.ory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic *** we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced *** investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic *** addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its *** conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.

关键词： apoptosis blood-brain barrier β-sitosterol cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1L1

Constacyclic and cyclic codes over finite chain rings

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 122-125页

作者： QIAN Jian-fa.ma.Wen-ping National Key Laboratory of ISN Xidian University Xi' an 710071 China

The problem of Gray image of constacyclic code over finite chain ring is studied. A Gray map between codes over a finite chain ring and a finite field is defined. The Gray image of a linear constacyclic code over the finite chain ring is proved to be a distance invariant quasi-cyclic code over the finite field. It is shown that every code over the finite field, which is the Gray image of a cyclic code over the finite chain ring, is equivalent to a quasi-cyclic code.

关键词： constacyclic code Gray map quasi-cyclic code cyclic code

Quantifying the Temperature Effects on the Morbidity of Digestive Diseases In an Inland Plateau-Valley City

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Biomedical and Environmental Sciences 2024年第9期37卷 1101-1105页

作者： Pan ma Yang Yang Ning Zhou Xinzi Wang Yulu Wang Wenjuan Feng Zhaoqin Bai Shigong Wang Plateau Atmosphere and Environment Key Laboratory of Sichuan Province College of Atmospheric ScienceChengdu University of Information TechnologyChengdu 610225SichuanChina Chengdu Plain Urban Meteorology and Environment Observation and Research Station of Sichuan Province Chengdu 610225SichuanChina The Infectious Disease Department The First People’s Hospital of LanzhouLanzhou 730050GansuChina Meteorological Bureau of Jinnan District Tianjin 300350China Gansu University of Chinese Medicine Lanzhou 730000GansuChina

Extreme air temperature and increased weather oscillations caused by climate change have been threatening global *** conditions are external inducers that may trigger the onset of gastrointestinal diseases,in addition... 详细信息

关键词： Plateau weather consumption

地基云雷达与FY-4A卫星云顶高度联合反演方法

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气象 2024年第7期50卷 859-867页

作者：张婷胡树贞陶法赵培涛刘文忠马婷印佳楠河北省气象技术装备中心石家庄050000 中国气象局气象探测中心北京100081

基于地基毫米波云雷达与FY-4A卫星对云顶同步观测的特点,分析云雷达垂直顶空观测的云顶高度与FY-4A卫星AGRI载荷通道数据之间关系,提出了地基云雷达与FY-4A卫星云顶高度联合反演方法,实现云雷达安装点周边区域卫星云顶高度的融合反演,... 详细信息

基于地基毫米波云雷达与FY-4A卫星对云顶同步观测的特点,分析云雷达垂直顶空观测的云顶高度与FY-4A卫星AGRI载荷通道数据之间关系,提出了地基云雷达与FY-4A卫星云顶高度联合反演方法,实现云雷达安装点周边区域卫星云顶高度的融合反演,并对反演结果进行验证分析。结果表明,AGRI载荷的第11~14通道值与云雷达观测云顶高度呈线性相关,且卫星通道值与云雷达观测云顶高度比值呈现冬季最小、春秋季次之、夏季最大的季节性变化特点;星地融合反演云顶高度与云雷达观测云顶高度相关系数0.84,融合后比融合前均方根误差减小了0.7 km,提高了卫星云顶高度的反演精度。

关键词：云云顶高度 FY-4A 毫米波云雷达数据融合

Evolution Handoff Strategy for Real-Time Video Transmission over Practical Cognitive Radio Networks

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China Communications 2015年第2期12卷 141-154页

作者： LIU Fa.ma.Yongkui ZHAO Honglin DING Kai Communication Research Center Harbin Institute of Technology Department of Electrical Engineering and Computer Science University of California

The transmission delay of realtime video packet mainly depends on the sensing time delay(short-term factor) and the entire frame transmission delay(long-term factor).Therefore,the optimization problem in the spectrum handoff process should be formulated as the combination of microscopic optimization and macroscopic *** this paper,we focus on the issue of combining these two optimization models,and propose a novel Evolution Spectrum Handoff(ESH)strategy to minimize the expected transmission delay of real-time video *** the microoptimized model,considering the tradeoff between Primary User's(PU's) allowable collision percentage of each channel and transmission delay of video packet,we propose a mixed integer non-linear programming *** scheme is able to achieve the minimum sensing time which is termed as an optimal stopping *** the macro-optimized model,using the optimal stopping time as reward function within the partially observable markov decision process framework,the EHS strategy is designed to search an optimal target channel set and minimize the expected delay of packet in the long-term real-time video ***,the minimum expected transmission delay is obtained under practical cognitive radio networks' conditions,i.e.,secondary user's mobility,PU's random access,imperfect sensing information,etc..Theoretical analysis and simulation results show that the ESH strategy can effectively reduce the transmission delay of video packet in spectrum handoff process.

关键词： practical cognitive radio networks spectrum handoff process partially observable markov decision process video transmission

汜水河(荥阳段)入河排污口水体微塑料赋存特征及风险评估

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环境科学 2024年第3期45卷 1457-1467页

作者：赵长民和兵李和通张瑞琪李银月张发文桂新马丽河南省郑州生态环境监测中心郑州450007 河南农业大学林学院郑州450046

城市河流是微塑料的主要接纳者与传输者.探明城市河流微塑料污染状况及其环境风险,可为进一步控制微塑料污染提供依据.以黄河支流汜水河作为研究对象,采集汜水河(荥阳段)9个排污口的污水样品,通过显微镜对微塑料尺寸、形状及颜色等赋存... 详细信息

城市河流是微塑料的主要接纳者与传输者.探明城市河流微塑料污染状况及其环境风险,可为进一步控制微塑料污染提供依据.以黄河支流汜水河作为研究对象,采集汜水河(荥阳段)9个排污口的污水样品,通过显微镜对微塑料尺寸、形状及颜色等赋存形态进行分析,发现微塑料在排污口水体中多以透明状的纤维和碎片形式存在,且500μm以下占比较高;进一步采用激光红外成像仪对微塑料种类进行鉴定,发现PET和PE聚合物是主要的微塑料种类,且二者显著相关,表明它们在来源上有相似性.环境风险评价结果表明,微塑料种类是影响评价结果的主要因素,有PVC检出的6个排污口水体环境风险值较高,而污染负荷指数评价结果显示整个研究区段处于低风险水平.

关键词：微塑料城市河流特征分析相关分析风险评估

miR-182-5p调控初级纤毛的缺失增加甲状腺乳头状癌细胞系TPC-1的迁移

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中华内分泌代谢杂志 2024年第2期40卷 158-163页

作者：马承旭马小妮马丽华傅松波兰州大学第一临床医学院兰州大学第一医院内分泌科兰州730000

目的探讨miR-182-5p调控初级纤毛的缺失对甲状腺乳头状癌(PTC)细胞系TPC-1迁移的影响。方法收集10例兰州大学第一医院PTC组织和癌旁组织,qPCR检测癌旁组织、PTC组织和TPC-1细胞中miR-182-5p的表达量,免疫荧光检测初级纤毛的形成;过表达m... 详细信息

目的探讨miR-182-5p调控初级纤毛的缺失对甲状腺乳头状癌(PTC)细胞系TPC-1迁移的影响。方法收集10例兰州大学第一医院PTC组织和癌旁组织,qPCR检测癌旁组织、PTC组织和TPC-1细胞中miR-182-5p的表达量,免疫荧光检测初级纤毛的形成;过表达miR-182-5p,qPCR和Western blot检测TPC-1细胞中PI3K的表达量,Transwell实验检测TPC-1细胞迁移数量,免疫荧光检测初级纤毛的形成;siRNA-IFT88干扰TPC-1细胞,Transwell实验检测TPC-1细胞迁移数量,免疫荧光检测初级纤毛的形成,吉姆萨染色检测形态学变化,Western blot检测E-cadherin和N-cadherin的蛋白表达量。结果与癌旁组织相比,PTC组织中初级纤形成受损;miR-182-5p表达量显著上调。与Nthy-ori3-1相比,TPC-1细胞中初级纤毛的频率减少;miR-182-5p表达量显著上调(P=0.001);miR-182-5p mimic治疗后的TPC-1细胞中PI3K的表达量降低,迁移数量增加(P=0.001),初级纤毛频率降低为27%(P=0.002);siRNA-IFT88治疗后的TPC-1细胞表面初级纤毛变短变细,频率减少(P=0.001),迁移数量增加(P<0.001)。结论miR-182-5p通过PI3K通路调控初级纤毛的缺失有助于TPC-1细胞的迁移,初级纤毛的丢失对PTC预后具有不利的影响。

关键词：甲状腺乳头状癌迁移初级纤毛 miR-182-5p TPC-1

An INS/GNSS integrated navigation in GNSS denied environment using recurrent neural network

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Defence Technology（防务技术） 2020年第2期16卷 334-340页

作者： Hai-fa Dai Hong-wei Bian Rong-ying Wang Heng ma Navigation Engineering Lab Naval Engineering UniversityWuhanCO430033China

In view of the failure of GNSS signals,this paper proposes an INS/GNSS integrated navigation method based on the recurrent neural network(RNN).This proposed method utilizes the calculation principle of INS and the memory function of the RNN to estimate the errors of the INS,thereby obtaining a continuous,reliable and high-precision navigation *** performance of the proposed method is firstly demonstrated using an INS/GNSS simulation ***,an experimental test on boat is also conducted to validate the performance of the *** results show a promising application prospect for RNN in the field of positioning for INS/GNSS integrated navigation in the absence of GNSS signal,as it outperforms extreme learning machine(ELM)and EKF by approximately 30%and 60%,respectively.

关键词： Inertial navigation system(INS) Global navigation satellite system(GNSS) Integrated navigation Recurrent neural network(RNN)

Phosphine-Relayed Aldehyde-Olefination and Aza-Wittig Reaction with 2,2,2-Trifluorodiazoethane

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Chinese Journal of Chemistry 2018年第8期36卷 723-730页

作者： fa-Guang Zhang Ning Lv Yan Zheng Jun-An ma Department of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic Sciences and Tianjin Collaborative Innovation Center of Chemical Science & Engineering Tianjin University Tianjin 300072 China

Phosphine-relayed olefination and aza-Wittig reactions of readily available aldehydes with 2,2,2-trifluorodiazoethane （CF3CHN2） have been realized. This protocol enables the facile construction of a series of triflu... 详细信息

关键词： diazo compounds olefination Wittig reactions 2,2,2-trifluorodiazoethane phosphine