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Bio-Design and Manufacturing 2019年第3期2卷 172-180页

作者： Maha Alruwaili Jose a.lopez Kevin McCarthy Emmanuel G.Reynaud Brian J.Rodriguez Conway Institute of Biomolecular and Biomedical Research University College DublinDublinIreland School of Physics University College DublinDublinIreland School of Biomolecular and Biomedical Science University College DublinDublinIreland

Extrusion-based 3D bioprinting is a direct deposition approach used to create three-dimensional(3D)tissue scaffolds typically comprising *** are hydrated polymer networks that are chemically or physically ***,3D bioprinting is performed in air,despite the hydrated nature of hydrogels and the potential advantage of using a liquid phase to provide cross-linking and otherwise functionalize the *** this work,we print gelatin alginate hydrogels directly into a cross-linking solution of calcium chloride and investigate the influence of nozzle diameter,distance between nozzle and surface,calcium chloride concentration,and extrusion rate on the dimensions of the printed *** hydrogel layer height was generally found to increase with increasing extrusion rate and nozzle distance,according to the increased volume extruded and the available space,*** addition,the hydrogel width was generally found to increase with decreasing nozzle distance and cross-linking concentration corresponding to confinement-induced spreading and low crosslinking regimes,***/height ratios of^1 were generally achieved when the nozzle diameter and distance were comparable above a certain cross-linking *** these relationships,biocompatible 3D multilayer structures were successfully printed directly into calcium chloride cross-linking solution.

关键词： Gelatin alginate Hydrogel Additive manufacturing 3D printing 3D bioprinting Biomaterials Extrusion Bioplotting

The COVID-19 Pandemic and Consumption of Food away from Home:Evidence from High-frequency Rcstaurant Transaction Data

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China & World Economy 2021年第6期29卷 73-94页

作者： Chen Zhu Rigoberto a.lopez Yuan Gao Xiaoou Liu College of Economics and Management Academy of Global Food Economics and Policy(AGFEP)China Agricultural UniversityChina Department of Agricultural and Resource Economics University of ConnecticutUS School of Agricultural Economics and Rural Development Renmin University of ChinaChina

This article investigates how the COVID-19 pandemic and related public health measures affected the consumption of food away from home(FAFH)among Chinese *** obtained access to the complete sales records from a major restaurant chain in China,for 111 sites located in 12 cities,covering over 5.6 million high-frequency dining transactions made between 1 January 2019 and 31 December *** applying a high-dimensional fixed-effects model,we found that,on average,consumers spent more and ordered more calories(as well as carbohydrates,protein,fat,and sodium)after the COVID-19 outbreak than in *** results do not support the hypothesis that COVID-19 led to healthier eating behaviors during and after the *** results underline the importance of nutrition education and awareness programs to mitigate unhealthy eating habits generated by the pandemic and of the continued role of FAFH after the pandemic.

关键词： COVID-19 food-away-from-home food consumption government stringency nutritional intake

Properties of nuclear pastas

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Frontiers of physics 2021年第2期16卷 119-173页

作者： Jorge a.lopez Claudio O.Dorso Guillermo Frank Department of Physics University of Texax at El PasoEl PasoTexas 79968USA Departamento de Fisica FCENUniversidad de Buenos AiresNunezArgentina Unidad de Investigacion y Desarrollo de las Ingenierias Universidad Tecnologica NacionalFacultad Regional Buenos AiresBuenos AiresArentina

In this review we study the nuclear pastas as they are expected to be formed in neutron star *** start with a study of the pastas formed in nuclear matter(composed of protons and neutrons),we follow with the role of the electron gas on the formation of pastas,and we then investigate the pastas in neutron star matter(nuclear matter embedded in an electron gas).Nuclear matter(NM)at intermediate temperatures(1 MeV≤T≤***),at saturation and and sub-saturation densities,and with proton content ranging from 30%to 50%was found to have liquid,gaseous and liquid-gas mixed *** isospin-dependent phase diagram was obtained along with the critical points,and the symmetry energy was calculated and compared to experimental data and other *** low temperatures(T≤1 MeV)NM produces crystal-like structures around satura-tion densities,and pasta-like structures at sub-saturation *** of the pasta structures were studied with cluster-recognition algorithms,caloric curve,the radial distribution function,the Lindemann coefficient,Kolmogorov statistics,Minkowski functionals;the symmetry energy of the pasta showed a connection with its *** star matter(NSM)is nuclear matter embedded in an electron *** electron gas is included in the calculation by the inclusion of an screened Coulomb *** connect the NM pastas with those in neutron star matter(NSM),the role the strength and screening length of the Coulomb interaction have on the formation of the pastas in NM was *** was found to exist even without the presence of the electron gas,but the effect of the Coulomb interaction is to form more defined pasta structures,among other ***,it was determined that there is a minimal screening length for the developed structures to be independent of the cell *** star matter was found to have similar phases as NM,phase transitions,symmetry energy,structure function and thermal *** in NM,pasta f

关键词： nuclear pasta neutron star matter nuclear symmetry energy molecular dynamics nuclear phase transitions

Computing Recomposition of Maps with a New Sampling Asymptotic Formula

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Open Journal of Discrete Mathematics 2011年第2期1卷 43-49页

作者： Almudena Antuna Juan L.G.Guirao Miguel a.lopez Departamento de Analisis Economico y Finanzas Universidad de Castilla-La ManchaCuenca(Castilla-La Mancha)Spain Departamento de Matematica Aplicada y Estadstica Universidad Politecnica de CartagenaCartagena(Region de Murcia)Spain Departamento de Matematicas Universidad de Castilla-La ManchaCuenca(Castilla-La Mancha)Spain

The aim of the present paper is to state an asymptotic property Ρ of Shannon’s sampling theorem type, based on normalized cardinal sines, and keeping constant the sampling frequency of a not necessarilly band- limited signal. It generalizes in the limit the results stated by Marvasti et al. [7] and Agud et al. [1]. We show that Ρ is fulfilled for any constant signal working for every given sampling frequency. Moreover, we conjecture that Gaussian maps of the form e-Λt2 ,Λ∈R+, hold Ρ. We support this conjecture by proving the equality given by for the three first coefficients of the power series representation of e-Λt2 .

关键词： Band-Limited Signal Shannon's Sampling Theorem Approximation Theory

META-R:A software to analyze data from multi-environment plant breeding trials

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The Crop Journal 2020年第5期8卷 745-756页

作者： Gregorio Alvarado Francisco M.Rodríguez Angela Pacheco Juan Burgueño JoséCrossa Mateo Vargas Paulino Pérez-Rodríguez Marco a.lopez-Cruz Biometrics and Statistics Unit International Maize and Wheat Improvement Center(CIMMYT)MexicoDF 6-64106600Mexico Centro de Investigación en Matemáticas(CIMAT)A.C. Jalisco S/NCol.ValencianaGuanajuatoGto 40236023Mexico Universidad Autónoma Chapingo Carretera Federal México-Texcoco km 38.5TexcocoMéxico 6356230Mexico Colegio de Postgraduados Carretera México-Texcoco Km.36.5MontecilloTexcoco 6356231Mexico Department of Plant Soil and Microbial SciencesMichigan State University1066 Bogue StEast LansingMI 48824USA

META-R(multi-environment trial analysis in R)is a suite of R scripts linked by a graphical user interface(GUI)designed in Java *** objective of META-R is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(RCBD)and the alpha-lattice/lattice ***-R simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense *** parameters are very important in the selection of top performing genotypes in plant ***-R also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical *** genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated ***-R performs multi-environment analyses by using the residual maximum likelihood(REML)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability.

关键词： environments breeding variance

Refractive error study in young subjects：results from a rural area in Paraguay

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 467-472页

作者： Isabel Signes-soler Non-govemmental Organization Vision Without Borders (Visio Sense Fronteres) Alicante 03710 Spain School of Advanced Education Research and Accreditation (SAERA) Castellon de la Plana 12001 Spain Faculty of Optics and Optometry University Complutense of Madrid Madrid 28037 Spain European University of Madrid Madrid 28108 Spain Foundation for the Visual Quality (FUNCAVIS) Alicante 03016 Spain Department of Optics Pharmacology and Anatomy University of Alicante Alicante 03690 Spain

AIM：To evaluate the distribution of refractive error in young subjects in a rural area of Paraguay in the context of an international cooperation campaign for the prevention of blindness. METHODS：A sample of 1466 young subjects（ranging from 3 to 22 years old）,with a mean age of 11.21±3.63 years old,were examined to assess their distance visual acuity（VA）and refractive error. The first screening examination performed by trained volunteers,included visual acuity testing,autokeratometry and non-cycloplegic autorefraction. Inclusion criteria for a second complete cycloplegic eye examination by an optometrist were VA 〈20/25（0.10 log MAR or 0.8 decimal）and/or corneal astigmatism ≥1.50 D. RESULTS：An uncorrected distance VA of 0 log MAR（1.0decimal）was found in 89.2% of children. VA 〈20/25 and/or corneal astigmatism ≥1.50 D was found in 3.9% of children（n=57）,with a prevalence of hyperopia of 5.2%（0.2%of the total）in this specific group. Furthermore,myopia（spherical equivalent ≤-0.5 D）was found in 37.7% of the refracted children（0.5% of the total）. The prevalence of refractive astigmatism（cylinder ≤-1.50 D）was 15.8%（0.6% of the total）. Visual impairment（VI）（0.05≤VA≤0.3）was found in 12/114（0.4%）of the refracted eyes. Main causes for VI were refractive error（58%）,retinal problems（17%,2/12）,albinism（17%,2/12）and unknown（8%,1/12）.CONCLUSION：A low prevalence of refractive error has been found in this rural area of Paraguay,with higher prevalence of myopia than of hyperopia.

关键词： refractive error blindness visual impairment myopia hyperopia

Weak Gravity Conjecture and extremal black holes

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Science China(Physics,Mechanics & Astronomy) 2019年第11期62卷 69-86页

作者： William Cottrell Gary Shiu Pablo soler Department of Physics University of WisconsinMadison WI53706USA Institut fur Theoretische Physik Universitat HeidelbergPhilosophenweg19Heidelberg D-69120Germany

Motivated by the desire to improve our understanding of the Weak Gravity Conjecture, we compute the one-loop correction of charged particles to the geometry and entropy of extremal black holes in 4D. We use the entropy function formalism to extend previous analysis that dealt with neutral particles, and obtain the corrections to the horizon entropy for different regimes of black hole masses. These corrections are small in general. They are furthermore reduced when supersymmetry is present, and disappear in N = 4 supergravity. We provide some speculative arguments that in a theory with only sub-extremal particles, classical Reissner-Nordstrom black holes actually possess an infinite microcanonical entropy, though only a finite amount is visible to an external observer, as shown by the horizon entropy computation.

关键词： black holes string theory entropy

Foreword to Sperm morphometrics today and tomorrow special issue in Asian Journal of Andrology

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Asian Journal of Andrology 2016年第6期18卷 815-818页

作者： Caries soler Trevor G Cooper Department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain Department of R+D ProJser R+D Science Park University of Valencia 46980 Paterna Valencia Spain Tuen Mun New Territories Hong Kong SAR China

Earlyin his investigations, Leeuwenhoek （1670s）1 deduced that spermatozoawere alive and an integral part of semen, rather than artifacts or parasites. He eventually observed spermatozoa in the semen of men, dogs, horses, birds, fishes, amphibians, molluscs, and many insects, and concluded that they must be a universal feature of male reproduction.

关键词： @@

Unexpected bonds:ubiquitin-like conjugation of cGAS/CDNTases supports their enzymatic activity and antiphage defense

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3899-3901页

作者： Katarzyna Andryka-Cegielski Sofía soler Eva Bartok Institute of Experimental Haematology and Transfusion Medicine University HospitalUniversity of BonnBonnGermany Institute of Clinical Chemistry and Clinical Pharmacology University HospitalUniversity of BonnBonnGermany

In their recently published study in Nature,Jenson et al.1 provide compelling,unexpected evidence that bacterial cGAMP synthase(cGAS)and other cGAS/DncV-like Nucleotidyltransferases(CD-NTase)undergo ubiquitin-like conjugation(ULC)in type-II cyclic-oligonucleotide-based anti-phage signaling systems(CBASS).cGAS conjugation promotes cyclic-nucleotide(CN)formation and thus antiphage ***,the authors also reveal a new class of phage-encoded CBASS inhibitor,T4 Vs.4,a CN-sponge which limits CBASS effector function and promotes phage replication,revealing another weapon in the“arms race”between phages and their bacterial hosts.

关键词： bonds enzymatic sponge