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On the functions of astrocyte-mediated neuronal slow inward currents

neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs pál Department of physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic n-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,n-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization nMDA receptor paroxysmal depolarizational shift slow inward current

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nonlinear-Optical Analogies in nuclear-like Soliton Reactions:Selection Rules,nonlinear Tunneling and Sub-Barrier Fusion–Fission

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Chinese physics letters 2024年第8期41卷 1-7页

作者： T.l.Belyaeva V.n.Serkin Universidad Autonoma del Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Autonoma de puebla Av.4 Sur 104C.P.72001PueblaMexico

The main goal of our study is to reveal unexpected but intriguing analogies arising between optical solitons and nuclear physics,which still remain hidden from *** consider the main cornerstones of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core *** the base of this model,we reveal the most intriguing properties of the nonlinear tunneling of nucleus-like solitons and the soliton selfinduced sub-barrier transparency *** describe novel interesting and stimulating analogies between the interaction of nucleus-like solitons on the repulsive barrier and nuclear sub-barrier *** main finding of this study concerns the conservation of total number of nucleons(or the baryon number)in nuclear-like soliton *** show that inelastic interactions among well-dressed repulsive-core solitons arise only when a“cloud”of“dressing”spectral side-bands appears in the frequency spectra of the *** property of nucleus-like solitons is directly related to the nuclear density distribution described by the dimensionless small shape-squareness *** the Fourier spectra of nucleus-like solitons are similar to the nuclear form *** show that the nuclear-like reactions between well-dressed solitons are realized by“exchange”between“particle-like”side bands in their spectra.

关键词： solitons soliton nonlinear

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Effect of cold-working on corrosion induced damage in lug joints

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Defence Technology（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.n Chikmath l. Murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

lug joints are preferred joineries for transferring heavy loads to parent components in aerospace *** experience corrosion due to environmental conditions,improper surface finishes and rubbing displacement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is modelled as a through-pit at one of the identified critical locations through stress *** effect of this pit on fatigue crack initiation life is ***-hole is pre-stressed by cold-working and the benefits of inducing plastic wake on the intended performance of the lug joint during the damages due to corrosion are brought out and compared with non-cold-worked *** analysis is performed on this lug joint with *** results obtained highlight the benefits of cold-working and the methodology can be extended to damage growth and analyse the effect of surface treatments for better structural integrity of components of aerospace vehicles.

关键词： lug joint Corrosion Crack initiation Cold-working Structural integrity

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Resistance of full-scale beams against close-in *** modeling and field tests

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Defence Technology（防务技术） 2024年第10期40卷 35-47页

作者： A.prado A.Alañón R.Castedo A.p.Santos l.M.lópez M.Chiquito M.Bermejo C.Oggeri Escuela politécnica Superior déAvila Universidad de SalamancaÁvila05003Spain E.T.S.I.Minas y Energía Universidad Politecnica de MadridMadrid28003Spain Department of Engineering Aviation and TechnologySaint Louis UniversityMadrid28003Spain Department of Environment Land and Infrastructure Engineering(DIATI)Politecnico di TorinoTorino10129Italy

This paper explores the performances of a finite element simulation including four concrete models applied to a full-scale reinforced concrete beam subjected to blast *** test data has been used to compare model results for each *** numerical modelling has been,carried out using the suitable code *** code integrates blast load routine(COnWEp)for the explosive description and four different material models for the concrete including:Karagozian&Case Concrete,Winfrith,Continuous Surface Cap Model and RiedeleHiermaiereThoma models,with concrete meshing based on 10,15,and 20 *** full-scale beams were tested:four of them used for the initial calibration of the numerical model and two more tests at lower scaled *** calibration,field data obtained employing pressure and accelerometers transducers were compared with the results derived from the numerical *** surfaces and the shape of rupture in the beams have been used as references for *** of the meshing on accelerations has been put in evidence and for some models the shape and size of the damage in the beams produced maximum differences around 15%.In all cases,the variations between material and mesh models are shown and discussed.

关键词： Blast test numerical simulation lS-DYnA Concrete model Mesh effect Full-scale beams

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langmuir-Schaefer Film Investigation and Density Functional Theory Band Gap Calculations of Calix[n]arene-para-Aminobenzoic Acid for Drug nanosensor Application

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1311-1318页

作者： WOnG Yeong Yi F l Supian A Radzwan M Musa n F n Abd Karim Department of physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Department of Chemistry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect pABA,the primary sunscreen *** study investigates the interaction of calix[4]arene(C4),calix[6]arene(C6),and pABA using the langmuir method and first-principle density functional theory(DFT).Using the langmuir-Schaefer(lS)technique,an ultrathin film composed of calix[n]arenes and their complexes with pABA was deposited on various *** on the langmuir study,the pABA molecule was bonded to the lower rims of both C4 and C6 with the host-guest ratio of 1:*** of the lS films formed were then characterized by ultravioletvisible spectroscopy(UV-Vis),Fourier-transform infrared spectroscopy(FTIR)and carbon,hydrogen,nitrogen,sulfur elemental analyzer(CHnS).The band gap reduction obtained in the DFT study denotes the charge transfer interaction with promising reactivity between the calix[n]arenes and *** sensing of pABA by C4 and C6 is successful based on the formation of bonding between them due to the hosts’effective trapping *** outcomes of this study could be applied to drug delivery systems for future pharmaceutical and medical applications.

关键词： calix[n]arenes band gap density functional theory langmuir-Schaefer pABA sensor

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Simultaneous removal of critical rare earth elements and chalcogen oxyanions by anaerobic granular sludge

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Rare Metals 2024年第9期43卷 4595-4611页

作者： Chiara Belloni Mohanakrishnan logan Stefano papirio piet n.l.lens University of Galway Galway H91 TK33Ireland Department of Civil Architectural and Environmental EngineeringUniversity of Naples Federico II80125 NaplesItaly

Conventional mining of economically and strategically important critical rare earth elements(REEs)(such as neodymium,lanthanum and dysprosium),and chalcogens(such as selenium and tellurium)are associated with a huge economic and environmental ***,the need to recover REEs as well as chalcogens from different waste streams including wastewaters is becoming *** assays on synthetic chalcogen/REE-laden wastewater showed that the presence of REEs significantly improved the tellurite removal rate(>80%)and enhanced selenate removal by 66%±10%.Three 3.9 l continuous upflow anaerobic granular sludge bed(UASB)reactors were operated at a hydraulic retention time of 24 h and 30℃.Selenate reduction was achieved with a removal efficiency of~98% with an influent p H of 4.0 for more than 28 *** effect of REEs on tellurite removal in the UASB bioreactor could not be clearly established since a soluble tellurium removal efficiency of more than 98%was observed already before the addition of REEs at elevated tellurite *** complete REE removal in both batch assays and UASB reactors at higher pH(7.0±0.5)was attributed to precipitation,whereas chalcogen oxyanions removal was due to microbial ***,at acidic p H,biosorption was responsible for REE's removal,and the Se-enriched sludge exhibited a superior REE's removal efficiency than the non-enriched and Te-enriched sludge.

关键词： Rare earth elements Selenium Tellurium Bioreduction Adsorption

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Improving the radiological diagnosis of hepatic artery thrombosis after liver transplantation: Current approaches and future cha.l.nges

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World Journal of Transplantation 2024年第1期14卷 1-8页

作者： Cristian lindner Raúl Riquelme Rodrigo San Martín Frank Quezada Jorge Valenzuela Juan p Maureira Martín Einersen Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile Department of Statistics Catholic University of MauleTalca 3460000Chile neurovascular Unit Department of RadiologyHospital Clínico Regional Guillermo Grant BenaventeConcepción 4030000Chile

Hepatic artery thrombosis(HAT)is a devastating vascular complication following liver transplantation,requiring prompt diagnosis and rapid revascularization treatment to prevent graft *** present,imaging modalities such as ultrasound,computed tomography,and magnetic resonance play crucial roles in diagnosing *** imaging techniques have improved sensitivity and specificity for HAT diagnosis,they have limitations that hinder the timely diagnosis of this *** this sense,the emergence of artificial intelligence(AI)presents a transformative opportunity to address these diagnostic *** development of machine learning algorithms and deep neural networks has demonstrated the potential to enhance the precision diagnosis of liver transplant complications,ena.l.ng quicker and more accurate detection of *** article examines the current landscape of imaging diagnostic techniques for HAT and explores the emerging role of AI in addressing future cha.l.nges in the diagnosis of HAT after liver transplant.

关键词： liver transplantation postoperative complications Hepatic artery Thrombosis Radiology Artificial intelligence

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Sustainability assessment of solar drying systems:a comparative life-cycle analysis of phase-change material-based *** solar dryers

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Clean Energy 2024年第4期8卷 183-196页

作者： nakum Divyangkumar Kirtika Sharma n.l.panwar Gande Saichandhu Department of Renewable Energy Engineering Maharana Pratap University of Agriculture and TechnologyUdaipur(Rajasthan)313001India Environmental Management Jawaharlal Nehru University TechnologyHyderabadIndia

Solar drying systems are becoming a popular alternative to traditional energy-based drying systems for agricultural products due to their effectiveness and reduced fuel *** the efficiency of solar drying systems has been thoroughly investigated,their sustainability has not been studied *** study aims to fill that gap by conducting a life-cycle assessment of two new solar drying systems built in Udaipur,Rajasthan,*** environmental implications of an innovative cylindrical solar-assisted drying system and a phase-change material-based solar drying system were evaluated using cradle-to-gate life-cycle *** study uses the ReCipe 2016 endpoints(H)technique to calculate various aspects such as midpoint,endpoint,single score,normalization result,and network diagram for phase-change material-based solar drying and cylindrical solar-assisted *** show that phase-change material-based solar drying has an average of 40%more impact on the environment than cylindrical solar-assisted drying,with a high impact found in human non-carcinogenic toxicity,mainly due to the production of phase-change ma***,cylindrical solar-assisted drying system crossover phase-change material based solar drying in terms of its impact on human carcinogenic toxicity and fossil resource *** contribution to global warming of phase-change material-based solar drying is 13.7%more than that of cylindrical solar-assisted *** endpoint characterization indicates that phase-change material-based solar drying exceeds in terms of human health(40%)and ecosystem(37.04%),whereas cylindrical solar-assisted drying surpasses phase-change material-based solar drying in terms of impacts on resources,at 14%.The early drying in phase-change material-based solar drying makes up for its higher impact than that in cylindrical solar-assisted drying,which takes 3 hours longer to *** study offers guidance and methods for making the best choice of

关键词： solar drying cylindrical hybrid solar dryer pCM-based solar dryer life-cycle assessment ReCipe method impact assessment

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Unmixing detrital zircon U-pb ages reveals tectonic and climatic depositional influences on the Carboniferous Ansilta Formation,Calingasta-Uspallata Basin,Western Argentina

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Geoscience Frontiers 2024年第4期15卷 61-77页

作者： J.R.Malone J.E.Malone J.l.Isbell D.H.Malone J.p.Craddock K.n.pauls Department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinAustinTX 78712USA Iowa Geological Survey University of IowaIowa CityIA 52240USA Department of Geosciences University of Wisconsin-MilwaukeeMilwaukeeWI 53211USA Department of Geography Geology and the EnvironmentIllinois State UniversityNormalIL 61790-4400USA

The late paleozoic Ice Age(lpIA)was a principal control of sedimentation across Gondwana from the late Devonian through early *** assess the hypothesis that glacial to interglacial transitions in western Argentina were the primary control influencing sediment routing patterns among the various Carboniferous-permian basins in western *** Carboniferous Ansilta Formation consists of glaciomarine,nearshore,and fluvial systems deposited during the lpIA along the eastern margin of the Calingasta-Uspallata Basin in *** lower,glacially influenced succession of the Ansilta Formation records at least five glacial advances;the upper succession of consists of progradational shallow marine,deltaic,and fluvial *** combine 1225 new U-pb zircon ages from six samples of the Carboniferous Ansilta Formation in the Calingasta-Uspallata Basin with 5864 U-pb ages from 147 pub-lished samples in the detrital pymix forward mixture model to characterize provenance *** the glacially influenced lower Ansilta Formation,sediment was derived locally from the protoprecordillera,which was a prominent highland with alpine glaciers flowing west and east into the Calingasta-Uspallata and paganzo basins,***,there was little or no connection between these two basins during Serpukhovian-Bashkirian *** fluvial/deltaic upper Ansilta had distal sediment sources in the Sierras ***,our results support the collapse of the protoprecordillera topographic barrier,ena.l.ng drainage patterns connecting the paganzo and Calingasta-Uspallata basins by late pennsylvanian-early permian time.

关键词： late paleozoic Ice Age Argentina Calingasta-Uspallata Basin Ansilta Formation Detrital zircon provenance

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RBC aggregation,deformation and adhesion to endothelium:Role of nitric oxide derived from l-Arginine and sodium nitroprusside

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 53-65页

作者： M.K.Maksimov p.B.Ermolinskiy O.n.Scheglovitova n.n.Sklyankina A.V.Muravyov A.E.lugovtsov A.V.priezzhev Faculty of physics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Center for Epidemiology and Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State pedagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which impacts hemorheology and *** turn,RBC properties depend on di®erent endogenous and exogenous *** such factor is nitric oxide(nO),which is mainly produced by endothelial cells(EC)from l-arginine amino acid in the circulatory *** the mechanisms of the RBC-endothelium interplay are not clear up to date and considering its possible clinical importance,the aims of this study are to investigate in vitro:(1)The e®ect of l-arginine induced nO on RBC aggregation and adhesion to endothelium;(2)the nO e®ect on RBC aggregation and deformation induced by l-arginine and sodium nitroprusside without the presence of endothelium in the *** RBC aggregation and adhesion to a monolayer of EC were studied using optical tweezers(OT).The RBC deformability and aggregation without endothelium in the samples were studied using the°ow chamber method and Myrenne *** con¯rmed that nO increases deformability and decreases aggregation of *** showed that the soluble guanylate cyclase pathway appears to be the only nO signaling pathway *** the samples with the endothelium,the\bell-shaped"dependence of RBC aggregation force on l-arginine concentration was observed,which improves our knowledge about the process of nO production by ***,data related to l-arginine accumulation by endothelium were obtained:necessity of the presence of extracellular l-arginine stated by other authors was put under *** our study,nO decreased the RBC-endothelium adhesion,however,the tendency appeared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attempt to measure the forces of RBC adhesion to endothelium monolayer with OT.

关键词： Red blood cells aggregation l-arginine endothelium optical tweezers Myrenne flow chamber

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