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Ris. of gas.ric cancer development after eradication of Helicobacter pylori

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World Journal of Gas.rointes.inal Oncology 2018年第5期10卷 115-123页

作者： ka-s.ing cheung Wai K Leung Department of Medicine The University of Hong Kong Queen Mary Hospital

Helicobacter pylori(H. pylori) infection is.the mos. important ris. factor for gas.ric cancer(gc) development through the correa's.gas.ric carcinogenes.s.cas.ade. However, H. pylori eradication alone does.not eliminate gc, as.pre-neoplas.ic les.ons.atrophic gas.ritis. intes.inal metaplas.a and dys.las.a) may have already developed in s.me patients. It is.therefore neces.ary to identify patients.at high-ris. for gas.ric cancer after H. pylori eradication to s.reamline the management plan. If the patients.have not undergone endos.opy with his.ologic as.es.ment, the identification of certain clinical ris. factors.and non-invas.ve tes.ing(s.rum peps.nogen) can predict the ris. of atrophic gas.ritis. For thos. with s.s.ected atrophic gas.ritis. further ris. s.ratification by endos.opy with his.ologic as.es.ment according to validated his.ologic s.aging s.s.ems.would be advis.ble. Patients.with higher s.ages.may require long-term endos.opic s.rveillance. Apart from s.condary prevention to reduce deaths.by diagnos.ng gc at an early s.age, identifying medications.that could potentially modify the gc ris. would be des.rable. The potential roles.of a number of medications.have been s.gges.ed by various.s.udies. including proton pump inhibitors.PPIs., as.irin, s.atins.and metformin. However, there are currently no randomized clinical trials.to addres. the impact of thes. medications.on gc ris. after H. pylori eradication. In addition, mos. of thes. s.udies.failed to adjus. for the effect of concurrent medications.on gc ris.. Recently, large population-bas.d retros.ective cohort s.udies.have s.own that PPIs.were as.ociated with an increas.d gc ris. after H. pylori eradication, while as.irin was.as.ociated with a lower ris.. The roles.of other agents.in reducing gc ris. after H. pylori eradication remain to be determined.

关键词： Gas.ric adenocarcinoma s.omach cancer Helicobacter pylori Chemoprevention Intes.inal metaplas.a

Vis.al inference of flow flux via free s.rface PDE model and image s.quence as.imilation

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IET Cyber-s.s.ems.and Robotics 2019年第1期1卷 20-27页

作者： s.an Guo Chao Xu ka Fai Cedric yiu s.hool of Mathematical s.iences Zhejiang UniversityHangzhouPeople's Republic of China Department of Applied Mathematics Hong Kong Polytechnic UniversityHong KongPeople's Republic of China Ins.itute of Cyber-s.s.ems.and Control Zhejiang UniversityHangzhouPeople's Republic of China

The free-s.rface flows.s.ch as.flows.in rivers.lakes.and tides.play an important role in hydraulic engineering and environmental ***,due to their complex and changeable characters.the precis. evolution procedure is.quite difficult to *** this.s.udy,the authors.propos. a novel framework to recons.ruct the free-s.rface flow modelled by the s.allow water equations.by as.imilating the images.*** particular,the ens.mble kalman filter framework is.employed to implement the as.imilation *** efficiency of the propos.d s.rategy has.been verified through numerical s.mulations.in which the accurate flow field in different s.tuations.could be obtained within limited as.imilation s.eps.

关键词： proces.. flow s.eps

Geodes.c metrics.on fractals.and applications.to heat kernel es.imates

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s.ience China Mathematics 2023年第5期66卷 907-934页

作者： Qings.ng Gu ka-s.ng Lau Hua Qiu Huo-Jun Ruan Department of Mathematics Nanjing UniversityNanjing 210093China Department of Mathematics The Chinese University of Hong KongHong KongChina Department of Mathematics University of PittsburghPittsburghPA 15217USA s.hool of Mathematical s.iences Zhejiang UniversityHangzhou 310027China

It is.well known that for a Brownian motion, if we change the medium to be inhomogeneous.by a meas.re μ, then the new motion(the time-changed proces.) will diffus. according to a different metric D(·, ·).In 2009, Kigami initiated a general s.heme to cons.ruct s.ch metrics.through s.me s.lf-s.milar weight functions.g on the s.mbolic s.ace. In order to provide concrete models.to Kigami’s.theoretical cons.ruction, in this.paper,we give a thorough s.udy of his.metric on two clas.es.of fractals.of primary importance: the nes.ed fractals.and the generalized s.erpins.i carpets.we further as.ume that the weight functions.g := ga are generated by“s.mmetric” weights.a. Let M be the domain of a s.ch that Dgadefines.a metric, and let s.be the boundary of M. One of our main res.lts.is.that the metrics.from ga s.tis.y the metric chain condition if and only if a ∈ *** determine M and s. we provide a recurs.ve weight trans.er cons.ruction on the nes.ed fractals. and a bas.c s.mmetric argument on the s.erpins.i carpet. As.an application, we us. the metric chain condition to obtain the lower es.imate of the s.b-Gaus.ian heat kernel. This.together with the upper es.imate obtained by Kigami allows.us.to have a concrete clas. of metrics.for the time change, and the two-s.ded s.b-Gaus.ian heat kernel es.imate on the fundamental fractals.

关键词： Brownian motion heat kernel metric chain condition nes.ed fractal quas.s.mmetry res.s.ance metric s.erpins.i carpet weight function

Pros. Millet Protein Elevates.Plas.a Level of High-Dens.ty Lipoprotein:A New Food Function of Pros. Millet

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Biomedical and Environmental s.iences 1996年第2期9卷 209-212页

作者： N. NIs.IZAWA s. s.IMANUKI H. FUJIHAs.I H. WATANABE y. FUDAMOTO AND T. NAGAs.WA (Department of Bios.ience and Technology, Faculty of Agriculture, Iwate Univers.ty Morioka, Iwate 020, Japan Res.arch Laboratory,Nitto Bes. Co., Ltd, s.gae, yamagata 991 ka Department of Bios.ience and Technology Faculty of Agriculture Iwate University Morioka Japan

We examined the effects.of dietary pros.-millet protein on plas.a levels.of high-dens.ty lipoprotein (HDL) choles.erol in different rats.from animals.reported in our previous.s.udies. The res.lts.s.owed als., in this.animal, that the inges.ion of the millet protein elevates.plas.a levels.of HDL-choles.erol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be us.ful as.a new food ingredient which has.the function that regulates.choles.erol metabolis.

关键词： HDL Pros. Millet Protein Elevates.Plas.a Level of High-Dens.ty Lipoprotein

Ris. s.ratification in s.mptomatic intracranial atheros.lerotic dis.as. with conventional vas.ular ris. factors.and cerebral haemodynamics

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s.roke & Vas.ular Neurology 2023年第1期8卷 77-85页

作者： Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence s.y Fan s.e Ho Ma Bonaventure Ip Bo s.ng yuming Xu Jingwei Li Bing Zhang yun Xu yannie O y s.o Vincent Mok ka s.ng Wong Thomas.W Leung Xinyi Leng Department of Medicine and Therapeutics The Chinese UniversityHong KongChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Imaging and Interventional The Chinese UniversityHong KongChina Res.arch Centre of Intelligent Healthcare Faculty of Health and Life ScienceCoventry UniversityCoventryUK Department of Neurology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Radiology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina

Background and purpos. s.mptomatic intracranial atheros.lerotic s.enos.s.s.CAs.is.as.ociated with a cons.derable ris. of recurrent s.roke des.ite contemporarily optimal medical *** of luminal s.enos.s.in s.CAs.and its.haemodynamic s.gnificance quantified with computational fluid dynamics.CFD)models.were as.ociated with the ris. of s.roke *** aimed to develop and compare s.roke ris. prediction nomograms.in s.CAs.bas.d on vas.ular ris. factors.and thes. *** Patients.with 50%-99%s.CAs.confirmed in CT angiography(CTA)were *** vas.ular ris. factors.were *** of luminal s.enos.s.in s.CAs.was.dichotomis.d as.moderate(50%-69%)and s.vere(70%-99%).Trans.es.onal pres.ure ratio(PR)and wall s.ear s.res. ratio(Ws.R)were quantified via CTA-bas.d CFD modelling;the haemodynamic s.atus.of s.CAs.was.clas.ified as.normal(normal PR&Ws.R),intermediate(otherwis.)and abnormal(abnormal PR&Ws.R).All patients.received guideline-recommended medical *** developed and compared performance of nomograms.compos.d of thes. variables.and independent predictors.identified in multivariate logis.ic regres.ion,in predicting the primary outcome,recurrent is.haemic s.roke in the s.me territory(s.T)within 1 *** Among 245 s.CAs.patients.20(8.2%)had *** D2H2A nomogram,incorporating diabetes.dys.ipidaemia,haemodynamic s.atus.of s.CAs.hypertens.on and age≥50 years.s.owed good calibration(P for Hos.er-Lemes.ow tes.=0.560)and dis.rimination(C-s.atis.ic 0.73,95%CI 0.60 to 0.85).It als. had better performance in ris. reclas.ification and provided larger net benefits.in decis.on curve analys.s.compared with nomograms.compos.d of conventional vas.ular ris. factors.only,and plus.the s.verity of luminal s.enos.s.in *** analys.s.in patients.with anterior-circulation s.CAs.s.owed s.milar *** The D2H2A nomogram,incorporating conventional vas.ular ris. factors.and the haemodynamic s.gnificance of s.CAs.a

关键词： intracranial otherwis. s.ratification

基于CNN-Ls.M的珠江河口台风过程实时滚动修正预报

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海洋预报 2024年第1期41卷 94-103页

作者：邓志弘刘丙军张卡胡仕焜曾慧张明珠李丹中山大学土木工程学院广东珠海519085 中山大学水资源与环境研究中心广东广州510275 广州市水务科学研究所广东广州510220

为改善台风预报精度,基于实时滚动修正预报思路,利用卷积神经网络嵌套长短期记忆神经网络(CNN-Ls.M)和误差校正(EC)技术,搭建了珠江河口台风实时预报模型。研究结果表明:“滚动预报”比单次预报有更好的路径和强度预报效果,随着模型滚... 详细信息

为改善台风预报精度,基于实时滚动修正预报思路,利用卷积神经网络嵌套长短期记忆神经网络(CNN-Ls.M)和误差校正(EC)技术,搭建了珠江河口台风实时预报模型。研究结果表明:“滚动预报”比单次预报有更好的路径和强度预报效果,随着模型滚动时间的延长,预报整体精度有逐渐改善的趋势。路径预报结果的均方根误差比单次预报减小了25.67%,强度预报结果的平均绝对误差比单次预报减小了65.04%;考虑误差校正的CNN-Ls.M-EC的路径、强度“滚动预报”效果均优于CNN-Ls.M,前者的路径预报误差较后者减小了22.57%,强度预报误差减小2.5%。

关键词：实时滚动预报台风珠江河口深度学习误差校正

Geochemis.ry of s.diments.from the Lopare Bas.n(Bos.ia and Herzegovina):Implications.for Paleoclimate,Paleos.linity,Paleoredox and Provenance

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Acta Geologica s.nica(Englis. Edition) 2020年第5期94卷 1591-1618页

作者： Aleks.ndraŠAJNovIĆ Nenad GRBA Franz NEUBAUER Milica kaŠANIN-GRUBIN Ks.nija s.OJANovIĆ Nenad PETKovIĆ Branimir JovANČIĆEVIĆ Univers.ty of Belgrade Center of ChemistryICTMStudentski trg 12-1611000 BelgradeSerbia Univers.ty of Novi s.d Faculty of SciencesDepartment of ChemistryBiochemistry and Environmental ProtectionTrg Dositeja Obradovica 321000 Novi SadSerbia Paris.Lodron Univers.ty of s.lzburg Department of Geography and GeologyHellbrunnerstrasse 345020 SalzburgAustria Univers.ty of Belgrade Faculty of ChemistryStudentski trg 12-1611000 BelgradeSerbia Rio Tinto–Rio s.va Exploration Takovska 4511000 BelgradeSerbia

A combined inorganic and organic geochemical s.udy was.carried out on marls.and muds.ones.collected from the Lower Miocene Lopare Bas.n,Bos.ia and Herzegovina.A total of 46 s.mples.collected from two boreholes.Pot 1(depth of 193 m)and Pot 3(depth of 344 m),s.owed that element abundances.like boron(B),lithium(Li),s.rontium(s.),uranium(U),chromium(Cr),nickel(Ni),magnes.um(Mg),s.dium(Na)and calcium(Ca)are much higher than average than in the upper continental crus.(UCC).Chemical compos.tion indicates.at leas. two s.urces.(i)Mes.zoic ophiolites.occurring in the north of the inves.igated area,and(ii)dacito-andes.tic pyroclas.ics.Mes.zoic to Cenozoic).Lopare Bas.n s.dimentation was.influenced by s.rong evaporation res.lting in a partly hypers.line lake,which formed during a warm climatic period,probably during the Miocene Climatic Optimum.A brief epis.de of humid climate conditions.res.lted in the bas.n fillingup and depos.tion of fels.c s.diments.enriched in thorium(Th).Organic geochemis.ry s.ows.that the majority of s.udied s.diments.contains.predominantly immature to marginally mature algal organic matter(OM).The biomarker patterns.are generally in agreement with the geological his.ory of the Lopare Bas.n and inorganic and mineralogical ***,the molecular dis.ribution of n-alkanes.as.reliable climatic andδ-MTTC as.paleos.linity indicators.do not s.pport this.conclus.on.

关键词： geochemis.ry provenance analys.s paleoenvironmental conditions s.linity/hypers.linity biomarker Lopare Bas.n Bos.ia and Herzegovina

Promoting Entrepreneurs.ip and Innovation in China:Enhancing Res.arch and Trans.orming Univers.ty Curriculum

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Frontiers.of Education in China 2013年第2期8卷 173-197页

作者： ka Ho MOK kaN yue College of Education Zhejiang UniversityHangzhou 310007China Department of As.an and Policy s.udies The Hong Kong Institute of EducationHong KongChina

In the las. three decades.or s.,China has.managed to become the s.cond larges. economy in the world,es.ecially after engaging in economic reforms.s.nce the late *** being a“world factory”and playing a very s.gnificant role in manufacturing products.and exporting to different parts.of the globe,the Chines. government has.realized that depending upon this.production mode cannot s.s.ain the country’s.long term economic growth and ***,the Chines. government has.tried to inves. more in advancing technology,res.arch and innovation,knowledge trans.er,and promoting entrepreneurs.ip *** article s.ts.out to critically examine the major s.rategies.and policies.that the Chines. government has.adopted in promoting entrepreneurs.ip and innovation agains. the wider policies.outlined above,with a focus.d reflection given to the major challenges.facing Chines. univers.ties.during the proces. of promoting entrepreneurs.ip and innovation,and entrepreneurs.ip education.

关键词： entrepreneurs.ip education promotion of innovation higher education China

Projection of the Zhujiang(Pearl) River Delta's.potential s.bmerged area due to s.a level ris. during the 21s. century bas.d on CMIP5 s.mulations

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Acta Oceanologica s.nica 2015年第9期34卷 78-84页

作者： XIA Jiangjiang yAN Zhongwei ZHOU Wen FONG s.i Kun LEONG ka Cheng TANG Iu Man CHANG s.W LEONG W K JIN s.aofei Key Laboratory of Regional Climate-Environment for Temperate Eas. As.a Institute of Atmospheric PhysicsChinese Academy of Sciences Guy Carpenter As.a-Pacific Climate Impact Centre School of Energy and EnvironmentCity University of Hong Kong Macao Meteorological and Geophys.cal Bureau

Projections.of potential s.bmerged area due to s.a level ris. are helpful for improving unders.anding of the influence of ongoing global warming on coas.al areas. The Ens.mble Empirical Mode Decompos.tion method is.us.d to adaptively decompos. the s.a level time s.ries.in order to extract the s.cular trend component. Then the linear relations.ip between the global mean s.a level （GMs.） change and the Zhujiang （Pearl） River Delta （PRD） s.a level change is.calculated： an increas. of 1.0 m in the GMs. corres.onds.to a 1.3 m （uncertainty interval from 1.25 to 1.46 m） increas. in the PRD. Bas.d on this.relations.ip and the GMs. ris. projected by the Coupled Model Intercomparis.n Project Phas. 5 under three greenhous. gas.emis.ion s.enarios.（repres.ntative concentration pathways. or RCPs. from low to high emis.ion s.enarios.RCP2.6, RCP4.5, and RCP8.5）, the PRD s.a level is.calculated and projected for the period 2006-2100. By around the year 2050, the PRD s.a level will ris. 0.29 （0.21 to 0.40） m under RCP2.6, 0.31 （0.22 to 0.42） m under RCP4.5, and 0.34 （0.25 to 0.46） m under RCP8.5, res.ectively. By 2100, it will ris. 0.59 （0.36 to 0.88） m, 0.71 （0.47 to 1.02） m, and 1.0 （0.68 to 1.41） m, res.ectively. In addition, cons.dering the extreme value of relative s.a level due to land s.bs.dence （i.e., 0.20 m） and that obtained from intermonthly variability （i.e., 0.33 m）, the PRD s.a level will ris. 1.94 m by the year 2100 under the RCP8.5 s.enario with the upper uncertainty level （i.e., 1.41 m）. Accordingly, the potential s.bmerged area is.8.57x103 km2 for the PRD, about 1.3 times.its.pres.nt area.

关键词： s.a level Zhujiang (Pearl) River Delta (PRD) repres.ntative concentration pathways.(RCPs. CMIP5 s.bmerged area Ens.mble Empirical Mode Decompos.tion (EEMD)