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Chinese Physics Letters 2011年第8期28卷 364-367页

作者： Atul tyagi keerti Sharma Department of Mathematics and Statistics University College of ScienceMLS UniversityUdaipur 313001(Raj.)India Department of Mathematics Medi-caps Institute of Technology and ManagementIndore(MP)India

The locally rotationally symmetric Bianchi type-II magnetized string cosmological model with bulk viscous fluid is *** magnetic field is due to an electric current produced along the x−*** the magnetic field is in the y–z plane and F23 is the only non−vanishing component of electromagnetic field tensor *** obtain the deterministic model in terms of cosmic time t,we have assumed the conditionξθ=const,whereξis the coefficient of bulk viscosity andθis the expansion in the model.

关键词： Bianchi string Cosmo

Golgi localization and dynamics of hyaluronan binding protein 1 (HABP1/p32/C1QBP) during the cell cycle

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Cell Research 2005年第3期15卷 183-186页

作者： Aniruddha SENGUPTA,Bhaswati BANERJEE,Rakesh k. tyagi,kasturi DATTA Biochemistry Laboratory School of Environmental Sciences Jawaharlal Nehru University New Delhi-110067 India Biochemistry Laboratory School of Environmental Sciences Jawaharlal Nehru University New Delhi-110067 India Special Centre for Molecular Medicine Jawaharlal Nehru University New Delhi India Biochemistry Laboratory School of Environmental Sciences Jawaharlal Nehru University New Delhi-110067 India2Special Centre for Molecular Medicine Jawaharlal Nehru University New Delhi India

Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellular localization of HABP1 and its dynamics during mitosis. We wanted to determine whether it distributes in any distinctive manner after mitotic nuclear envelope disassembly or is dispersed randomly throughout the cell. Our results reveal the golgi localization of HABP1 and demonstrate its complete dispersion throughout the cell during mitosis. This distinctive distribution pattern of HABP1 during mitosis resembles its ligand hyaluronan, suggesting that in concert with each other the two molecules play critical roles in this dynamic process.

关键词： Hyaluronan Binding Protein 1 (HABP1) hyaluronan sub-cellular localization golgi mitosis.

The Receptor-Like Cytoplasmic kinase （OsRLCk） Gene Family in Rice： Organization, Phylogenetic Relationship, and Expression during Development and Stress

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Molecular Plant 2008年第5期1卷 732-750页

作者： Shubha Vij Jitender Giri Prasant kumar Dansana Sanjay kapoor Akhilesh k. tyagi Interdisciplinary Centre for Plant Genomics and Department of Plant Molecular Biology University of Delhi South Campus Benito Juarez Road New Delhi 110021 India

Receptor-like cytoplasmic kinases （RLCks） in plants belong to the super family of receptor-like kinases （RLks）. These proteins show homology to RLks in kinase domain but la.k.the transmembrane domain. Some of the functionally characterized RLCks from plants have been shown to play roles in development and stress responses. Previously, 149 and 187 RLCk encoding genes were identified from Arabidopsis and rice, respectively. By using HMM-based domain structure and phylogenetic relationships, we have identified 379 OsRLCks from rice. OsRLCks are distributed on all 12 chromosomes of rice and some members are located on duplicated chromosomal segments. Several OsRLCks probably also undergo alternative splicing, some having evidence only in the form of gene models. To understand their possible functions, expression patterns during landma.k.stages of vegetative and reproductive development as well as abiotic and biotic stress using microarray and MPSS-based data were analyzed. Real-time PCR-based expression profiling for a selected few genes confirmed the outcome of microarray analysis. Differential expression patterns observed for majority of OsRLCks during development and stress suggest their involvement in diverse functions in rice. Majority of the stress-responsive OsRLCks were also found to be localized within mapped regions of abiotic stress QTLs. Outcome of this study would help in selecting organ/development stage specific OsRLCk genes/targets for functional validation studies.

关键词： abiotic stress biotic stress genome-wide analysis kinase rice RLCk.

Artificial neural network based modeling of liquid membranes for separation of dysprosium

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Journal of Rare Earths 2023年第3期41卷 440-445,I0005页

作者： Jawad Iqbal Arjun tyagi Manish Jain Department of Applied Chemistry Delhi Technological UniversityDelhi110042India

In recent years,the liquid membrane process has been widely investigated to remove rare earth ***,transport modeling of this process requires the accurate values of several parameters,which are difficult to ***,the accurate simulation of this process is a challenging *** this study,the artificial neural network(ANN)based approach is used to model the liquid membrane process for removing *** results from a previous study were used to train the ***,the number of neurons in the hidden layer was *** minimum mean squared error between experimental results and model predictions is found with ten *** predictions were successfully validated with experimental results with correlation factor(R)of 0.9987,which confirms the authenticity of the trained *** ANN was then used to study the effects of different operating parameters on transport *** higher volume ratio of membrane solution to feed solution(3-4)with 50-60 min of operation,higher feed pH(5),HCl concentration in stripping solution of 2 mol/L,and moderate concentration of carrier species(0.5 mol/L)with 0.5×10^(-4) mol/L dysprosium initial concentration are found to be optimum values of operating conditions for maximizing the transport rate.

关键词： Rareearth metal separation Artificial neural network Dysprosium separation Liquid membranes

Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives

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Neural Regeneration Research 2015年第10期10卷 1565-1567页

作者： Anuradha.k.lani Neetu tyagi Department of Physiology and Biophysics School of Medicine University of Louisville

Exosomes：Exosomes are a sub-population of micro-vesicles ranging from 40–100 nm that were earlier thought as artefacts under electron *** recently came into attention for their storage of biological information,cell-to-cell communication,serving as bioma.k.rs and potential use in neural protection and regeneration （kalani et al., 2013, 2014a）.

关键词： Exosomes in neurological disease neuroprotection problems and perspectives repair and therapeutics

Bianchi Type-IX String Cosmological Models for Perfect Fluid Distribution in General Relativity

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Chinese Physics Letters 2010年第7期27卷 299-301页

作者： Atul tyagi keerti Sharma Payal Jain Department of Mathematics and Statistics College of Science MLS University Udaipur-313001 India Department of Mathematics Techno India NJR Institute of Technology Udaipur-313004 India

The present study deals with Bianchi type-IX string cosmological models for perfect fluid distribution. We consider two cases：（i） ρ ＋ λ = 0, （ii） ρ - λ = 0, where ρ and λ are the rest energy density and the tension density of a string cloud, respectively. The physical and geometrical properties of the models are discussed.

关键词： Models Dormancy Density

A high methionine,low folate and vitamin B_6/B_(12) containing diet can be associated with memory loss by epigenetic silencing of netrin-1

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Neural Regeneration Research 2019年第7期14卷 1247-1254页

作者： Anuradha.k.lani Pa.k.j Chaturvedi komal kalani Pradip k.kamat Poonam Chaturvedi Neetu tyagi Department of Physiology School of MedicineUniversity of Louisville Medicinal Chemistry Department CSIR-Central Institute of Medicinal and Aromatic Plants Pharmacology Department and Toxicology Higuchi Biosciences CenterUniversity of Kansas Department of Neurology Dr.Ram Manohar Lohia Institute of Medical Sciences

Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current *** hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing global DNA methylation and therefore,silencing the netrin-1 gene,which encodes the glycoprotein involved in neurogenesis,axonal guidance and maintenance of the synaptic *** type(C57 BL/6 J) mice were fed with a diet containing excess methionine(1.2%),low-folate(0.08 mg/kg),vitamin B_6(0.01 mg/kg),and B_(12)(10.4 mg/kg) for 6 *** were examined weekly for the long-term memory function,using a passive avoidance test,which determined loss of fear-motivated long-term memory starting from the fourth week of ***,an increase in brain %5-methyl cytosine was observed starting from the 4 th week of diet in *** fed with a high methionine,low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation,as determined by methylation-sensitive restriction enzyme-polymerase chain reaction *** increase in methylation of netrin-1 gene was validated by high-resolution melting and sequencing ***,the association of netrin-1 with memory was established by administering netrin that considerably restored long-term fear motivated *** together,these results suggest that a diet rich in methionine and la.k.ng in folate and vitamin B_6/B_(12) can induce defects in learning and ***,the data indicates that decrease in netrin-1 expression due to hyper-methylation of its gene can be associated with memory *** animal procedures were approved by the Institutional Animal Care and Use Committee,University of Louisville,USA(No.A3586-01) on February 2,2018.

关键词： Alzheimer’s disease epigenetics memory methionine 5-methylcytosine methylation netrin-1

Application of Fractional Order PID Controller for AGC Under Deregulated Environment

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International Journal of Automation and computing 2018年第1期15卷 84-93页

作者： Nagendra.k.mar Barjeev tyagi Vishal kumar Department of Electrical Engineering Indian Institute of Technology

In this paper, a fractional order proportional integral derivative （FOPID） controller for multiarea automatic generation control （AGC） scheme has been designed. FOPID controller has five parameters and provides two additional degrees of flexibility in comparison to a proportional integral derivative （PID） controller. The optimal values of parameters of FOPID controller have been determined using Big Bang Big Crunch （BBBC） search algorithm. The designed controller regulates real power output of generators to achieve the best dynamic response of frequency and tie-line power on a load perturbation. The complete scheme for designing of the controllers has been developed and demonstrated on multiarea deregulated power system. The performance of the designed FOPID controllers has been compared with the optimally tuned PID controllers. It is observed from the results that the FOPID controller shows a considerable improvement in the performance as compared to the conventional PID controller.

关键词： Automatic generation control (AGC) deregulation Big Bang Big Brunch (BBBC) algorithm fractional order propor-tional integral derivative (FOPID) controller optimization.

Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 117-134页

作者： Mahavir Singh Suresh C tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine

Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.

关键词： CRISPR/Cas9 precision medicine genetic ophthalmology genome engineering inflammation single nucleotide polymorphism

Metalloproteinases as mediators of inflammation and the eyes： molecular genetic underpinnings governing ocular pathophysiology

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1308-1318页

作者： Mahavir Singh Suresh C tyagi Eye and Vision Science Laboratory Department of Physiology University of Louisville School of Medicine Louisville KY 40202 USA

There are many vision threatening diseases of the eye affecting millions of people worldwide. In this article, we are summarizing potential role of various matrix metalloproteinases （MMPs）; the Zn （2＋）-dependent endoproteases in eye health along with pathogenesis of prominent ocular diseases such as macular degeneration, diabetic retinopathy, and glaucoma via understanding MMPs regulation in affected patients, interactions of MMPs with their substrate molecules, and key regulatory functions of tissue inhibitor of metalloproteinases （TIMPs） towards maintaining overall homeostasis.

关键词： age-related macular degeneration choroidal neovascularization diabetes glaucoma metalloproteinases tissue inhibitors of metalloproteinases