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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of tra.itional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

magnetic resonance cholangiopancreatography for the detection of pancreatic duct stones in patients with chronic pancrea.itis

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World Journal of Gastroenterology 2009年第20期15卷 2543-2546页

作者： Zhen-Hua ma Qing-Yong ma Huan-Chen sha Sheng-Li Wu Jun Wen Department of Hepatobiliary Surgery the First Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM:To assess the role of magnetic resonance cholangiopancreatography(MRCP) in detection of pancreatic duct stones(PDS) in patients with chronic pancrea.itis(CP).METHODS:Clinical data of 78 CP patients who were treated at the First Affi liated Hospital of Xi'an Jiaotong University(China) between January 2004 and July 2008 were retrospectively analyzed.A predictive model of pancreatic duct stones was established through logistic regression and its effectiveness was verifi *** these patients, MRCP was performed in 60 patients who served as a control group, while 44 patients with a higher predictive value than the entry threshold of the predictive model served as an experimental ***:The positive rate of PDS in the 78 patients with CP was 19.2%(15/78).The predictive entry threshold of the predictive model was 5%(P rance(IGT) and positive B-mode ultrasound *** incidence of PDS in the experimental group was higher than that in the control group(P itive B-mode ultrasound results.

关键词： Chronic pancrea.itis Pancreatic duct stone magnetic resonance cholangiopancreatography B-mode ultrasound Logistic regression

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang Juan Yang Kailimai Su Pengjun ma Yanan Deng Xianfeng Fan Wanjun Chen Key laboratory for Electronic materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 ma cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

High performance strain sensor based on leather activated by micro-cracking conductive layer

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Collagen and Leather 2023年第4期5卷 76-87页

作者： Jianzhong ma Zhijie Cheng sha Tan Tian Zheng Yan Zong College of Bioresources Chemical and materials Engineering Shaanxi University of Science and TechnologyXi'an 710021China Xi'an Key laboratory of Green Chemicals and Functional materials Xi'an 710021China materials Characterization and Fabrication Platform Department of Chemical EngineeringUniversity of MelbourneParkvilleMelbourne 3010Australia

Flexible strain sensors are capable to detect external force induced strain change owing to their unique ability to convert deformation into electrical ***,micro/nano patterning of conductive layer in strain sensor is an effective method to improve its sensitivity,however the sophisticated manipulation process is limited only in laboratory *** this report,a simple and scalable fabrication strategy was used to create micro-cracking conductive layer as an alternative patterning method to achieve high performance of strain *** details,the sensor was fabricated using leather as the substrate to filtrated acidified multi-walled carbon nanotubes(a-MWCNTs)/layered double hydroxides(LDHs)*** stretching process,micro-cracking structure emerged on the percolated a-MWCNTs/LDHs layer,causing a rise up of resistance according to increasing strain and generated a detectable electrical *** prepared sensor had a large detecting range(60%),high sensitivity(GF of 7238.92 at strain 30-60%),fast response(tensile response time of 270 ms),good stability and *** sensor also inherited the advantages of leather,such as biodegradability and good air permeability,and the introduction of a-MWCNTs/LDHs further enhanced its fire retardancy *** features ensured the sensor as an eco-friendly,comfortable and safe electronic device for human motion detection.

关键词： a-MWCNTs LDHs Leather Flexible strain sensor

Fully integrated modeling of surface water and groundwater in coastal areas

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Journal of Hydrodynamics 2018年第3期30卷 441-452页

作者： sha Lou Shu-guang Liu Gangfeng ma Gui-hui Zhong Bo Li Department of Hydraulic Engineering Tongji University Shanghai 200092 China Key laboratory of Yangtze River Water Environment Ministry of Education Tongji University Shanghai 200092 China Department of Civil and EnvironmentalEngineering Old Dominion University Norfolk VA USA School of Engineering Nagasaki University Nagasaki Japan

This paper presents an improved model based on a three-dimensional non-hydrostatic wave model NHWAVE to simulate the interactions between the surface water and the groundwater affected by tides or waves in coastal areas. With the model, both the surface water flow and the groundwater flow are calculated based on the well-balanced Volume-averaged Reynolds-averaged Navier-Stokes equations. The spatially varying porosity and hydraulic conductivity are used to identifiy the domains for the surface water and the groundwater. The model is calibrated and validated using a wide range of laboratory measurements reported in the literature, involving the tide propagation through a sandy embankment, the tide-induced groundwater table fluctuation in a sandy beach, and the wave setup in a sloping sandy beach. The interactions between the surface water and the groundwater are analyzed and the influencing factors on the groundwater flow are discussed. The phase lag between the surface water elevation and the groundwater table fluctuation is mainly influenced by the hydraulic conductivity of the porous media. The wave attenuation in the groundwater is proportional to its propagation distance. The computed wave setup elevationin the permeable beach is smaller than in the impermeable beach. It is shown that the fully integrated model is capable of simulating the interactions between the surface water and the groundwater affected by tides or waves in coastal areas. It can be an efficient tool to study the tide and wave dynamics in the permeable sandy beach.

关键词： Non-hydrostatic model surface water and groundwater interactions wave setup porous media

Genome editing in cancer:Challenges and potential opportunities

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Bioactive materials 2023年第3期21卷 394-402页

作者： dor Breier Dan Peer laboratory of Precision Nanomedicine Shmunis School of Biomedicine and Cancer ResearchGeorge S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Department of materials Sciences and Engineering Iby and Aladar Fleischman Faculty of EngineeringTel Aviv UniversityTel AvivIsrael Center for Nanoscience and Nanotechnology Tel Aviv UniversityTel AvivIsrael Cancer Biology Research Center Tel Aviv UniversityTel AvivIsrael

Ever since its mechanism was discovered back in 2012,the CRISPR/Cas9 system have revolutionized the field of genome *** at first it was seen as a therapeutic tool mostly relevant for curing genetic diseases,it has been recently shown to also hold the potential to become a clinically relevant therapy for ***,there are multiple challenges that must be addressed prior to clinical ***,the safety of the system when used for in-vivo therapies,including off-target activity and the effects of the double strand break induction on genomic ***,we will focus on the inherent challenges in the CRISPR/Cas9 system and discuss various opportunities to overcoming these challenges.

关键词： Genome editing CRISPR/Cas systems Cancer therapy Off-target activity

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基于仿真方法的共享换电站价值量化分析

北京工业大学学报 2025年第1期51卷 22-31页

作者：沙玲汪静张海峰王岱上海工程技术大学机械与汽车工程学院上海201620 上海蔚来汽车有限公司上海201800

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个... 详细信息

相较于电动汽车充电站,换电站具有补能时间短、空间面积小等优点。多品牌电动汽车高效共享换电站,能够极大程度优化补能结构,减少资源浪费。为了量化共享换电站对电动汽车用户的价值,基于排队理论,利用蔚来汽车品牌的运行数据,搭建一个模拟用户换电行为的仿真器,通过量化用户的平均排队时间和换电站数量,评估电动汽车用户在不同电动汽车规模和换电站渗透率下的换电体验。结果表明,电动汽车品牌共享换电站资源,能够显著减少电动汽车用户的排队时间,以及将排队时间保持在期望阈值内所需的换电站数量,从而提高用户的充电体验并节省换电站建设成本。

关键词：电动汽车换电站共享排队论换电体验仿真

mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang Yuan Yao shaoliang Lin Xiang ma Binbin Xu shanghai Key laboratory of Advanced Polymeric materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology shanghai Synchrotron radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key laboratory for Advance materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,tra.itional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capa.itive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan Zhang Jie ma Zhiqun Lin Amor Abdelkader maria‑magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capa.itive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capa.itive deionization Current collector Tip effect Desalination