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Metabolomics in Schizophrenia and major Depressive Disorder

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Frontiers in Biology 2016年第3期11卷 222-231页

作者： ira Petrovchich Alexandra Sosinsky Amsh Konde Abigail Archibald David Henderson Mirjana maletic-Savatic Snezana Milanovic massachusetts General Hospital Department of Psychiatry MGH Clinical Trials Network Institute MGH Division of Global Psychiatry MGH Depression Clinical and Research Program Boston MA 02114 USA School of Nursing University of California San Francisco (UCSF) San Francisco CA 94143 USA massachusetts General Hospital Department of Psychiatry MGH Center for Women's Mental Health Boston MA 02114 USA Louisiana State University Health Science Center Department of Internal-Medicine Lafayette LA 70112 USA massachusetts General Hospital Department of Psychiatry MGH Depression Clinical and Research Program Boston MA 02114 USA Boston Medical Center Department of Psychiatry Boston MA 02118 USA Baylor College of Medicine Neurology Research Institute Houston TX77030 USA

Defining pathophenotype, a systems level consequence of a disease genotype, together with environmental and stochastic influences, is an arduous task in psychiatry. It is also an appealing goal, given growing need for appreciation of brain disorders biological complexity, aspiration for diagnostic tests development and ambition to identify novel drug targets. Here, we focus on the Schizophrenia and major Depressive Disorder and highlight recent advances in metabolomics research. As a systems biologytool, metabolomics holds a promise to take part in elucidating interactions between genes and environment, in complex behavioral traits and psychopathology risk translational research.

关键词： Schizophrenia major Depressive Disorder omics metabolomics systems biology

Sample preparation for isotopic determination of boron in clay sediments

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Chinese Journal Of Geochemistry 2013年第2期32卷 203-211页

作者： ZHANG Yanling XIAO Yingkai ma Yunqi ZHUGE Qin LIU Zhiqi HE maoyong LUO Chongguang ma Haizhou Key Laboratory of Salt Lake Resources and Chemistry Qinghai Institute of Salt Lakes Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences

The procedures of sample preparation for isotopic determination of boron in clay sediments is very cumbersome, by far, there haven't been relevant reports on that. In order to establish an effective method for sample preparation, a series of experiments were carried out. In this paper, boron in clay sediments was extracted with HCl solution and purified by two-step ion exchange method. Extracted HCl solution should be adjusted to alkalescency before passing through the Amberlite ira 743 resin column due to the fact that Amberlite ira 743 resin absorbs boron only from alkalescent solution. However, a mass of hydroxides of Al and Fe will be precipitated when the extracted HCl solution becomes alkalescent. Hydroxides of Al and Fe have a strong adsorption capacity for boron, which can cause boron isotope fractionation. To treat precipitated hydroxides of Al and Fe, four procedures, namely direct ion exchange (DRIE), decationizing ion exchange (DCIE), once sedimentation ion exchange (OSIE) and repeated sedimentation ion exchange (RSIE) were used and assessed. The influences of the four procedures on separation and extraction and isotopic composition of boron in experimental solutions and clay sediments were also discussed. According to the results, the DRIE, DCIE and OSIE are improper. The result of sample determination indicates that when extracting boron via RSIE, with the increase of precipitation times, there's an obvious decrease in boron content in the precipitated hydroxides while a sharp increase in recovery of boron and it is favorable for weakening the influence of boron isotope fractionation. But the process of RSIE is time consuming and it may introduce boron. It needs further research to establish a more effective sample preparation method for isotopic deter- mination of boron in clay sediments.

关键词：硼同位素组成同位素测定样品制备沉积物粘土离子交换法沉淀时间 HCl溶液

Trends of Urban Air Pollution in Zhengzhou City in 1996-2008

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Chinese Geographical Science 2012年第4期22卷 402-413页

作者： DU Xile LU Changhe WANG Hairong ma Jianhua Institute of Geographic Sciences and Natural Resources Research Chinese Academy Sciences Beoing 100101 China' Graduate University of Chinese Academy of Sciences Beijing 100049 China The Second Battalion ofNon-ferrous Metal Geology and Mineral Resources Bureau Zhengzhou 450016 China Institute ofNatural Resources and Environmental Science Henan University Kaifeng 475004 China)

Urban air pollution is a commonly concerned environmental problem in the *** of air quality trend using long-term monitoring data is helpful to understand the effectiveness of pollution control *** study,using data from six monitoring stations in Zhengzhou City,analyzed the changing trend in concentrations of SO 2,NO x /NO 2 and TSP/PM 10 in 1996-2008,based on non-parametric mann-Kendall test and Sen's slope estimator,and evaluated the comprehensive air pollution level using Multi-Pollutant Index(MPI).It was found that the concentration of each pollutant exceeded obviously the World Health Organization(WHO) guideline value,but the changing trend varied:SO 2 and NO 2 were significantly increased mainly due to an increase in coal consumption and vehicle number,while NO x,TSP and PM 10 *** air pollution was serious,and differed markedly among the three functional regions:it is the most severe in the Industrial and Residential Area(ira),followed by the Transportation Hub and Business District(THBD),and then the High-tech,Cultural and Educational Area(HCEA).Different from NO 2 concentration that had a similar change trend/rate among the function regions,the change rate of PM 10 concentration differed spatially,decreased much more obviously in THBD than other two *** the whole city,the comprehensive air pollution level declined gradually,illustrating that the air quality in Zhengzhou was improved in the last decade.

关键词：城市大气污染郑州市 mann-Kendall检验发展趋势城市空气污染 PM10浓度污染物浓度空气质量

Assessment of culprit lesions by intravascular ultrasound in patients with acute myocardial infarction

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Chinese Medical Journal 2009年第6期122卷 665-669页

作者： LIU Jian LIU Chuan-fen LU Ming-yu ma Yu-liang WANG Long CHEN Hong WANG Wei-min Heart Center Peking University People's Hospital Beijing 100044 China

Background Intravascular ultrasound has become the standard invasive method for diagnosing coronary artery disease. The aim of the present study was to evaluate the ability of intravascular ultrasound for assessment of culprit lesion morphology during primary percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI）.Methods We performed 18 intravascular ultrasound assessments preintervention during the primary PCi for AMI. intravascular ultrasound analysis included qualitative and quantitative measurements of reference and lesion external elastic membrane （EEM）, lumen, and plaque plus media （P＆M） area. Positive remodeling was defined as lesion/mean reference EEM 〉1.0. Culprit lesions were identified by a combination of electrocardiogram （ECG） and coronary angiography.Results There was an average of- 1.44 infarct-related artery （ira） plaques per patient. The incidences of thrombus and plaque ruptures were 28% （5） and 33% （6）, respectively. Hypoechoic plaque was observed in 72% （13） of AMI patients. Calcified lesions could be found in 33% （6） of culprit lesions. Sixty percent of the culprit lesion sites presented with positive remodeling.Conclusions Intravascular ultrasound is a safe and feasible imaging modality in patients with AMI and can help identify plaque rupture, intracoronary thrombus or calcification. The culprit lesion site in AMI cases often presents with positive remodeling.

关键词： acute myocardial infarction culprit lesion intravascular ultrasound

第三支柱个人养老金制度的税收优惠模式分析——以美国ira为例

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辽宁大学学报（哲学社会科学版） 2023年第2期51卷 83-93页

作者：马源中国社会科学院大学经济学院北京102488

税收优惠模式是第三支柱个人养老金制度政府激励措施中的重要内容。文章通过分析EET和TEE两种税收优惠模式,探讨两者的内在特征并进行比较,发现两者在总体账户积累和税收让利等方面没有明显区别,并以美国ira制度为例,分析其制度特征和... 详细信息

税收优惠模式是第三支柱个人养老金制度政府激励措施中的重要内容。文章通过分析EET和TEE两种税收优惠模式,探讨两者的内在特征并进行比较,发现两者在总体账户积累和税收让利等方面没有明显区别,并以美国ira制度为例,分析其制度特征和实施效果。制度中的传统ira和罗斯ira分别体现了两种税收优惠模式,二者的不同主要体现在账户缴费和资金领取的方式、税率变动和个人的参保行为及心理预期等方面。文章分析发现税收优惠政策在个人的缴费、投资及领取阶段会产生不同的激励效应,并基于此就激励我国第三支柱个人养老金制度的有效参与提出了建议。

关键词：税收优惠模式传统ira 罗斯ira

Modeling of a slurry bubble column reactor for Fischer-Tropsch syn- thesis

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Journal of Coal Science & Engineering(China) 2012年第1期18卷 88-95页

作者： Qian, Wei-xin ma, Hong-fang Li, Tao Ying, Wei-yong Fang, Ding-ye Engineering Research Center of Large Scale Reactor Engineering and Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai China

On the basis of the global CO consumption rate model, the lumped product distribution model and the sedimentation-dispersion model of a catalyst, a steady-state, one-dimensional mathematical model of the slurry bubble column reactor for Fischer-Tropsch synthesis were established. The mathematical simulation of the slurry bubble column reactor for Fischer-Tropsch synthesis was carried out under the following typical industrial operating conditions: temperature 230 °C, pressure 3.0 MPa, gas flow 5×105 m3/h, catalyst content in slurry phase 30%, reactor diameter 5.0 m and the composition of feed gas: y(H2)=0.60, y(CO)=0.30, y(N2)=0.10. The influences of operating pressure, temperature and m(H2)/m(CO) in feed gas on the reactor’s reaction performance were simulated.

关键词：浆态鼓泡床浆态反应器 Fischer-Tropsch合成费托合成一维数学模型建模论文鼓泡塔反应器

Comparative effects of percutaneous coronary intervention for infarct-related artery only or for both infarct- and non-infarct- related arteries in patients with ST-elevation myocardial infarction and multi-vessel disease

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Chinese Medical Journal 2008年第23期121卷 2384-2387页

作者： HAN Ya-ling WANG Bin WANG Xiao-zeng LI Yi WANG Shou-li JING Quan-min WANG Geng ma Ying-yan LUAN Bo Department of Cardiology Shenyang General Hospital of PLA Shenyang Liaoning 110016 China

Background Rapid recanalization of infarct-related artery （ira） has become the major target during primary percutaneous coronary intervention （PCI） for patients with ST-elevation myocardial infarction （MI）, but strategy for treatment of non-ira lesions in this setting remains unclear. This study aimed to compare long-term effects between PCI for ira only and that for both ira and non-ira in ST-elevation MI patients with multi-vessel disease.Methods A total of 242 eligible patients with ST-elevation MI and at least two diseased coronary arteries （luminal narrowing 〉70%） undergoing primary PCI were included. Of them, 149 patients underwent primary PCI for ira only （group 1）, and 93 received primary PCI for ira followed by elective PCI for non-ira 7 to 15 days after acute myocardial infarction （AMI）（group 2）. Drug-eluting stents （DESs） were deployed in more than 90% of the patients. Results The two groups did not differ with respect to baseline clinical and angiographic characteristics. No significant differences were observed in 12-month clinical follow-up results regarding major adverse cardiac events （11.5% vs 15.1%, P 〉0.05） and target lesion revascularization （8.1% vs 7.6%, P 〉0.05） between the two groups. However, patients in group 1 had higher rates of recurrent angina （10.1% vs 2.1%, P 〈0.05） and depressed left ventricular ejection fraction evaluated by echocardiography （0.56±0.22 vs 0.63±0.25, P 〈0.05）. Conclusion With the use of DESs, complete revascularization with elective PCI for non-ira after primary PCI may exert a beneficial effect on long-term symptomatology and left ventricular function in patients with ST-elevation Mt and multi-vessel disease.

关键词： multi-vessel disease percutaneous coronary intervention revascularization ST-elevation myocardial infarction

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压缩感知重构算法综述

红外与激光工程 2013年第S1期42卷 225-232页

作者：李珅马彩文李艳陈萍中国科学院西安光学精密机械研究所陕西西安710119 中国科学院大学北京100049

现代社会信息量的激增带来了信号采样、传输和存储的巨大压力,而近年来出现的压缩感知理论(Compressed Sensing,CS)为解决该问题提供了契机。该理论指出:对于稀疏或可压缩的信号,能够以远低于奈奎斯特频率对其进行采样,并通过设计重构... 详细信息

现代社会信息量的激增带来了信号采样、传输和存储的巨大压力,而近年来出现的压缩感知理论(Compressed Sensing,CS)为解决该问题提供了契机。该理论指出:对于稀疏或可压缩的信号,能够以远低于奈奎斯特频率对其进行采样,并通过设计重构算法来精确的恢复该信号。介绍了压缩感知理论的基本框架并讨论了该理论关于信号压缩的采样过程;综述了压缩感知理论的重构算法,其中着重介绍了最优化算法和贪婪算法并比较了各种算法之间的优劣,最后探讨了压缩感知理论重构算法未来的研究重点。通过对压缩感知理论重构算法较为系统的介绍和比较,为压缩感知重构算法的改进和应用提供了理论依据。

关键词：压缩感知信号采样稀疏重构算法

The protective effect of IL-1β on subcortical ischemic vascular dementia in mice via a promotion on OPCs proliferation

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The protective effect of IL-1β on subcortical ischemic vasc...