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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest l.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 exercise immunology SARS-CoV-2 T-Cells Vaccine

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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： Ayşe e.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.KUTlU İsmail e.KIlIÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

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Highly-efficient VCSel breaking the limit

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light(Science & Applications) 2024年第6期13卷 1021-1021页

作者： Dieter Bimberg Fumio Koyama Kenichi iga TU Berlin Hardenbergstr.3610623BerlinGermany Bimberg Chinese-German Center for Green Photonics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesNo.3888 Dong Nan Hu RoadChangchun130033China Tokyo Institute of Technology Nagatsuta 4259Midori-kuYokohama226-8501Japan

VCSels have become indispensable in the realms of datacenter networks and three-dimensional sensing thanks to their high-energy efficiencies,low-cost and the scalability of their two-dimensional *** boast high energy-efficiency,exceeding 50%at low bias currents,superiority over edge-emitting lasers,particularly for optical interconnects within datacenter ***,there has been no breakthroughs in the efficiency of VCSels for over a decade.

关键词： limit breakthrough Highly

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On B(5,20)2-Groups

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Algebra Colloquium 2024年第3期31卷 429-440页

作者： e.A.Alhassan Y.l.Tan Y.li School of Mathematical Sciences Jiangsu UniversityZhenjiangJiangsu 212013China Department of Mathematics Brock UniversitySt.CatharinesOntario L2S 3A1Canada

A finite group G is said to be a B(n,k)group if for any n-element subset[a_(1),…,a_(n)]of G,|{a_(i)a_(j)|1≤i,j≤n}|≤*** is of interest to characterize the structure of B(n,k)groups for n(n+1)/2≤k≤n^(2)-*** B(5,k)groups for 15≤k≤19 have been investigated by several *** this paper,we give a complete characterization of B(5,20)2-groups by showing there are five classes of such groups which are nontrivial and nonabelian.

关键词： B(n,k)groups small squaring property central extension GAP

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When Fleeing Matters:Differences in escape Behaviours of Three Northeast Asian Anurans

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Asian Herpetological Research 2024年第1期15卷 41-48页

作者： Yoonjung YI Zoljargal PUReVDORJ Irina MASlOVA Yikweon JANG Amaël BORZÉe laboratory of Animal Behaviour and Conservation College of Life SciencesNanjing Forestry UniversityNanjing 210037JiangsuChina Division of ecoScience and Department of life Sciences Ewha Womans UniversitySeoul 03760Republic of Korea Department of Biology School of MathematicsMongolian State University of EducationUlaanbaatar 210648Mongolia Department of Forest and environmental Resources Chungnam National UniversityDaejeon 34134Republic of Korea Federal Scientific Center of the east Asia Terrestrial Biodiversity Far Eastern Branch of Russian Academy of SciencesVladivostok 690022Russia

Prey species may have their own optimal escape strategy to balance predation risks and the energetic cost of *** species have an advantage when maintaining a short fleeing distance,while others may favour an earlier escape based on microhabitat,size,or body ***,we examined the escape behaviour of the three syntopic Northeast Asian anuran species:Mongolian toads(Strauchbufo raddei),Amur brown frogs(Rana amurensis),and Japanese treefrogs(Dryophytes japonicus)in Mongolia,Russia,China and DPR *** examined flight initiation distance(FID;the distance from a potential predator to the point when the individual starts to flee)and distance fled(DF;distance between flight initiation and flight termination points)of each species and the effects of microhabitat,sex,and body *** raddei and *** had a longer FID than ***,and *** also had a longer DF than *** trends remained similar when dividing FID and DF by a size proxy(snout-vent length)for all *** suggests that the treefrog *** used a strategy to stay immobile even when they were detected,and the toad *** reacted quicker and more sensitively to predators despite the presence of *** *** had a significantly longer FID than males suggesting that females are more sensitive to predation risk in this species,but body size was not significant for any of the three *** results indicate that the three sympatric species have different escaping strategies,likely related to differences in physiology and crypticity.

关键词： amphibian distance fled escape behaviour flight initiation distance predation

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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： leonardo Goliatt C.M.Saporetti l.C.Oliveira e.Pereira Department of Computational and Applied Mechanics Federal University of Juiz de ForaJuiz de ForaBrazil Department of Computational Modeling Polytechnic InstituteRio de Janeiro State UniversityNova FriburgoBrazil Petrobras Rio de JaneiroBrazil Department of Stratigraphy and Paleontology Rio de Janeiro State UniversityRio de JaneiroBrazil

Rock samples'TOC content is the best indicator of the organic matter in source *** origin rock samples’analysis is used to calculate it manually by *** method requires time and resources because it relies on samples from many well intervals in source ***,research has been done to aid this *** learning algorithms can estimate total organic carbon instead of well logs and stratigraphic *** light of these efforts,the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and *** algorithms,differential evolution,particle swarm optimization,grey wolf optimization,artificial bee colony,and evolution strategies were used to improve machine learning models to predict *** six metaheuristics were integrated into four machine learning methods:extreme learning machine,elastic net linear model,linear support vector regression,and multivariate adaptive regression *** samples from the YuDong-Nan shale gas field,located in the Sichuan basin,were used to evaluate the hybrid *** findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict *** results show that,independent of the metaheuristic used to guide the model selection,optimized extreme learning machines attained the best performance scores according to six *** hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning evolutionary algorithms Geology

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Phanerozoic co-evolution of O2-CO2 and ocean habitability

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National Science Review 2024年第6期11卷 18-21页

作者： Zunli lu Rosalind e.M.Rickaby Jonathan l.Payne Ashley N.Prow Department of earth & environmental Sciences Syracuse University Department of earth Sciences University of Oxford Department of earth and Planetary Sciences Stanford University

Atmospheric carbon dioxide and oxygen concentrations are partially linked via the geological cycle of organic carbon （Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active components, controls on their concentrations, and implications for the complexity of the biosphere and habitability of earth have been hotly debated, but are generally considered independently.

关键词： CO2-CONCeNTRATING MeCHANISM OXYGeN eVOlUTION ANOXIA

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exploring the effects of anthropogenic disturbance on predator inspection activity in Trinidadian guppies

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Current Zoology 2024年第1期70卷 109-111页

作者： Alix J.P Brusseau laurence e.A.Feyten Adam l.Crane Grant e.Brown Department of Biology Concordia UniversityMontrealQCH4B 1R6Canada Department of Biomedical Sciences WCVMUniversity of SaskatchewanSaskatoonSKCanada

Prey animals are often faced with uncertainty due to having imperfect information regarding current local conditions,including predation risks and the availability of reliable foraging opportunities(Dall 2010).As this uncertainty increases,the probability of making costly behavioral errors also increases,leading to more risk averse behavioral tactics(Feyten et al.2019).For example,Trinidadian guppies Poecilia reticulata are far more risk averse when faced with multiple unknown sources of risk assessment information than when faced with a mix of known and unknown cues(Feyten et al.2019).Prey can reduce uncertainty by gathering and integrating private and social information regarding current risk levels within microhabitats(Dall 2010;Munoz and Blumstein 2012).

关键词： human disturbance information availability information reliability predator-prey interactions risk assessment uncertainty

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In situ Hydrothermal Oxidation of Ternary FeCoNi Alloy electrode for Overall Water Splitting

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energy & environmental Materials 2024年第2期7卷 161-170页

作者： Yuwei Chen lixia Yang Chao li Yuqiu Wu Xiao lν Hairen Wang Jun'e Qu Key laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China Faculty of Material science and Chemistry China University of GeosciencesWuhan 430074China

exploring noble metal-free catalyst materials for high efficient electrochemical water splitting to produce hydrogen is strongly desired for renewable energy *** this article,a novel bifunctional catalytic electrode of insitu-grown type for alkaline water splitting based on FeCoNi alloy substrate has been successfully prepared via a facile one-step hydrothermal oxidation route in an alkaline hydrogen peroxide *** shows that the matrix alloy with the atom ratio 4∶3∶3 of Fe∶Co∶Ni can obtain the best catalytic performance when hydrothermally treated at 180℃for 18 h in the solution containing 1.8 M hydrogen peroxide and 3.6 M sodium *** as-prepared Fe_(0.4)Co_(0.3)Ni_(0.3)-1.8 electrode exhibits small overpotentials of only 184 and 175 mV at electrolysis current density of 10 mA cm^(-2)for alkaline OeR and HeR processes,*** overall water splitting at electrolysis current density of 10 mA cm^(-2)can be stably delivered at a low cell voltage of 1.62 *** characteristics including the large specific surface area,the high surface nickel content,the abundant catalyst species,the balanced distribution between bivalent and trivalent metal ions,and the strong binding of in-situ naturally growed catalytic layer to matrix are responsible for the prominent catalytic performance of the Fe_(0.4)Co_(0.3)Ni_(0.3)-1.8 electrode,which can act as a possible replacement for expensive noble metal-based materials.

关键词： alkaline water electrolysis bifunctional electrocatalyst FeCoNi alloy hydrothermal oxidation in-situ growing

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A Systematic Review of Cannabidiol effects in Coronary Syndromes: Challenges to Clinical Translation

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Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario e. Zuñiga-Ayala Alejandra Meaney-Martínez Alejandro Alcocer-Chauvet Vidal Gonzalez-Coronado Nestor Rubio-Infante Gerardo Garcia-Rivas Department of Cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional Cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. Cannabidiol (CBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of CBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Review of Animal Data from experimental Studies (CAMARADeS) guidelines, in the electronic database from PubMed, Web of Science and Scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: Currently there are no good-quality clinical trials with the use of CBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with CBD. Mechanisms of CBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. Conclusion: No clinical recommendation can be issued with the current evidence, on the use of CBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include CBD in the management of coronary syndromes.

关键词： Cannabis Cannabidiol Acute Coronary Syndromes Myocardial Infarction Myocardial Ischemia and Oxidative Stress

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