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CrABP1-mediated non-canonical retinoic a.id signa.ing in motor neurons and neural stem cells

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Neural regenera.ion research 2024年第6期19卷 1169-1170页

作者： Li-na Wei Department of Pharmacology University of Minnesota Medical School

retinoic a.id(rA), the active metabolite of vita.in A(the retinoids), elicits a wide spectrum of biological activities critical to the development and health of most of the organ systems including the nervous systems(Corcoran et al., 2002). The effects of rA are mediated by two very distinct pathways; the first is ma.ifested in the nucleus by binding to a large fa.ily of nuclear rA receptors(rArs) to regulate proper expression of rAtargeted genes,

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Asynchronous gain-scheduled control of deepwater drilling riser system with hybrid event-triggered sampling and unreliable communica.ion

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Frontiers of informa.ion Technology & Electronic Engineering 2024年第2期25卷 272-285页

作者： na PANG Dawei ZHANG Shuqian ZHU School of Mathema.ics Shandong UniversityJinan250100China

This paper investigates the recoil control of the deepwater drilling riser system with nonlinear tension force and energy-bounded friction force under the circumstances of limited network resources and unreliable *** from the existing linea.iza.ion modeling method,a triangle-based polytope modeling method is applied to the nonlinear riser *** on the polytope model,to improve resource utiliza.ion and accommodate random data loss and communica.ion delay,an asynchronous gain-scheduled control strategy under a hybrid event-triggered scheme is *** asynchronous linear parameter-varying system that blends input delay and impulsive update equa.ion is presented to model the nonlinear networked recoil control system,where the asynchronous devia.ion bounds of scheduling parameters are *** to the Lyapunov-Krasovskii functional method,some solvable conditions of disturbance attenua.ion analysis and recoil control design are derived such that the resulting networked system is exponentially mean-square stable with prescribed H∞*** obtained numerical results verified that the proposed nonlinear networked control method can achieve a better recoil response of the riser system with less transmission data compared with the linear control method.

关键词： riser system recoil control Asynchronous gain-scheduled control Data loss Event-triggered scheme

Properties of collective flow and pion production in intermediate-energy heavy-ion collisions with a rela.ivistic quantum molecular dyna.ics model

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Nuclear Science and Techniques 2024年第1期35卷 155-169页

作者： Si-na Wei Zhao-Qing Feng School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

The rela.ivistic mean-field approach was implemented in the Lanzhou quantum molecular dyna.ics transport model(***). Using the ***, the properties of collective flow and pion production were investigated systema.ically for nuclear reactions with va.ious isospin asymmetries. The directed and elliptic flows of the *** are able to describe the experimental data of STAr Collabora.ion. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For va.ious collision energies, the ra.io between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ra.io of the pion transverse momentum spectra also increased with decrea.ing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich ***, it is difficult to constrain the stiffness of the symmetry energy with the double ra.io because of the lack of threshold energy correction on the pion production.

关键词： Heavy-ion collision Collective flow Pion production Symmetry energy rela.ivistic mean field

Partial Linear Model Avera.ing Prediction for Longitudinal Data

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Journal of Systems Science & Complexity 2024年第2期37卷 863-885页

作者： Li na FEi Yu ZHANG Xinyu Faculty of Science Kunming University of Science and TechnologyKunming 650500China School of Sta.istics and Mathema.ics Yunnan University of Finance and EconomicsKunming 650221China Academy of Mathema.ics and Systems Science Chinese Academy of SciencesBeijing 100190China

Prediction plays an important role in data *** avera.ing method generally provides better prediction than using any of its *** though model avera.ing has been extensively investigated under independent errors,few authors have considered model avera.ing for semiparametric models with correlated *** this paper,the authors offer an optimal model avera.ing method to improve the prediction in partially linear model for longitudinal *** model avera.ing weights are obtained by minimizing criterion,which is an unbiased estimator of the expected in-sample squared error loss plus a *** properties,including asymptotic optima.ity and consistency of avera.ing weights,are established under two scena.ios:(i)All candidate models are misspecified;(ii)Correct models are available in the candidate *** studies and an empirical example show that the promise of the proposed procedure over other competitive methods.

关键词： Asymptotic optima.ity longitudinal data model avera.ing estimator partially linear model prediction

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A review on nanomaterial-based Strategies for Ma.ipula.ing Tumor Microenvironment to Enhance Chemodyna.ic Therapy

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Chemical research in Chinese Universities 2024年第2期40卷 202-212页

作者： CAO Mengyu XiNG Xiner SHEN Xiaotong OUYANG Jin na na Key Laboratory of ra.iopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875P.R.China Department of Chemistry College of Arts and SciencesBeijing Normal University at ZhuhaiZhuhai519087P.R.China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430074P.R.China

Cancer is a lea.ing cause of death worldwide,and a series of strategies has been reported for tumor-specific ***,chemodyna.ic therapy(CDT)has become a research hotspot for antitumor treatment due to its advantages of high specificity,endogenous stimula.ion,and high ***,the therapeutic effects of CDT are normally limited in the complex tumor microenvironment(TME),such as insufficient a.idity,tumor hypoxia,low hydrogen peroxide(H2O2),and high glutathione(GSH).Consequently,different kinds of multifunctional nanomaterials have been designed to ma.ipulate TME conditions,which provided more opportunities to improve the efficiency of *** review focuses on nanomaterial-based strategies for enhancing CDT through ma.ipula.ing *** CDT enhancements,this review would provide a reference for the future development of efficient CDT nanomaterials.

关键词： Chemodyna.ic therapy Tumor microenvironment nanomaterial Ma.ipula.ing strategy Fenton/Fenton-like reaction

Public transport inclusion and active a.ing: A systema.ic review on elderly mobility

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Journal of Traffic and Transporta.ion Engineering(English Edition) 2024年第2期11卷 312-347页

作者： na Zhang Qi Yang School of Huma.ities Chang'an UniversityXi'an 710064China School of Transporta.ion Engineering Chang'an UniversityXi'an 710064China School of Economics and Management Chang'an UniversityXi'an 710064China

Global a.ing has brought attention to addressing the elderly mobility dilemma,and a commitment to address inclusive transport in *** inclusion for older adults aims at establishing an age-friendly transport *** a direct policy goal and promoting active a.ing as an indirect social goal,to help older popula.ions gain access to transport and social *** on the analysis of scientific knowledge mapping over the past 30 years,this study visua.izes the hotspots and trends in elderly mobility *** a qua.ita.ive analysis of 138 papers,this paper reviews the theoretical founda.ions for transport inclusion and three themes of elderly mobility research,proposes a framework for public transport(PT)inclusion research as well as future research *** study suggests that transport inclusion can help enhance elderly health,social participa.ion,and subjective *** can improve their travel opportunities for active a.ing in four ways:opportunity accessibility,physical accessibility,age-friendly informa.iona.iza.ion,and cost *** research should pay attention to exa.ining the mecha.ism of perceived transport inclusion on active a.ing,expanding the multilevel research space of the capa.ility approach(CA),and exploring the subjectiveobjective integrated research model for PT *** research contributes to the overall knowledge of the theoretical and empirical researches on PT inclusion for the elderly and promotes the integrated applica.ion of interdisciplinary knowledge in the field.

关键词： Transporta.ion engineering Elderly mobility Transport-related social exclusion Transport inclusion Active a.ing

Land use change and its driving factors in the ecological function area:A case study in the Hedong region of the Gansu Province,China

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Journal of a.id Land 2024年第1期16卷 71-90页

作者： WEi Zhudeng DU na YU Wenzheng School of Geographical Science Nanjing University of Information Science&TechnologyNanjing 210044China

Land use and cover change(LUCC)is important for the provision of ecosystem *** increa.ing number of recent studies link LUCC processes to ecosystem services and human well-being at different scales ***,the dyna.ic of land use and its drivers receive insufficient attention within ecological function areas,particularly in quantifying the dyna.ic roles of climate change and human activities on land use based on a long time *** study utilizes geospa.ial analysis and geographical detectors to exa.ine the temporal dyna.ics of land use patterns and their underlying drivers in the Hedong region of the Gansu Province from 1990 to *** indicated that grassland,cropland,and forestland collectively accounted for approximately 99% of the total land *** initially increased and then decreased after 2000,while grassland decreased with *** contrast,forestland and construction land were continuously expanded,with net growth areas of 6235.2 and 455.9 km^(2),*** 1990 to 2020,cropland was converted to grassland,and both of them were converted to forestland as a *** expansion of construction land prima.ily originated from *** 2000 to 2005,land use experienced intensified temporal dyna.ics and a shift of rela.ively active zones from the central to the southeastern *** yield,economic factors,and precipita.ion were the major factors accounting for most land use *** impacts on land use changes were stronger before 1995,succeeded by the impact of a.imal husbandry during 1995-2000,followed by the impacts of grain production and gross domestic product(GDP)after ***,agricultural and pastoral activities,coupled with climate change,exhibited stronger enhancement effects after 2000 through their interaction with popula.ion and economic *** patterns closely correlated with ecological restora.ion projects in China since *** study implies the importance of synergy be

关键词： land use land type geographic detector driving mecha.ism Hedong region

Compara.ive analysis of the microbiome of sympatric wintering Bean Geese,Domestic Ducks,humans,and soil at Shengjin Lake of China.reveals potential public risk to human health

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a.ian research 2024年第2期15卷 279-286页

作者： Gang Liu na Xu Chongyang Yu College of Life Sciences Anhui Medical UniversityHefei 230032China

The gut microbiota of migratory waterbirds is affected by va.ious complex factors,including cross-species transmission,which increases the risk of pathogen sprea.ing among sympatric a.imals and poses a potential public health risk to *** this study,we investigated the microbial communities of wintering Bean Geese(Anser faba.is),Domestic Ducks(*** domesticus),humans,and soil using high-throughput sequencing of the 16S rrna gene region in Shengjin Lake,*** total,6,046,677 clean reads were obtained,representing 41,119 opera.ional taxonomic units(OTUs)across the four *** dominant microbial phyla were the Proteobacteria,Firmicutes,Bacteroidota,and *** Sorensen simila.ity index and alpha and beta diversity results showed that the gut microbial communities of Bean Geese and Domestic Ducks were more similar to those of the other *** analysis revealed that Faeca.ibacterium prausnitzii,Pseudomonas fra.i,and Bradyrhizobium elka.ii were hubs of the three major *** common microbiomes were iden-tified in Bean Geese,Domestic Ducks,humans,and soil in Shengjin Lake.A total of 96 potential pathogens were identified among the four groups,with 20 specific potentially pathogenic microbiomes found in the gut of Bean *** of these pathogens are responsible for significant financial losses in the poultry industry and pose risks to human *** pneumoniae,Morganella morga.ii,Escherichia coli,and ralstonia.insidiosa are potential core pathogens found in the four groups at Shengjin Lake that can cause diseases in humans and an-imals and fa.ilitate cross-species transmission through va.ious ***,humans are at risk of con-tracting these pathogens from migratory birds because of their frequent contact with domestic ***,further studies are required to explore the potential pathogenic species and transmission pathways among sympatric wintering Bean Geese,Domestic Ducks,humans,and soil.

关键词： Microbiome Migratory waterbird Pathogens Poultry Sympatric species

Anoma.ies of Precipita.ion over China on Days with Tropical Cyclone Activity over the Bay of Bengal: role of Moisture Transport

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Journal of Meteorological research 2024年第2期38卷 368-382页

作者： na WEi Ying Li Xiaoting FAN nanjing Joint institute for Atmospheric Sciences Nanjing 210041 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Department of Atmospheric and Ocea.ic Sciences and institute of Atmospheric Sciences Fudan UniversityShanghai 200433

Tropical cyclones over the Bay of Bengal(BoBTC)affect the precipita.ion over China,with distinct seasonal and daily *** study quantita.ively exa.ines the daily standardized precipita.ion anoma.ies(SPAs)over China on the days with BoBTC activities(storm-days)and related circula.ions,based on rainfall measurements at surface meteorological sta.ions and ECMWF reanalysis data on a 0.25°×0.25°resolution during *** positive SPa.is found over the sta.ions in the two adjacent regions around BoB(Southwest China.in May/November and southern Tibetan Plateau in October)and three distant regions(Southeast China and the northeastern boundary of the Qinghai-Tibet Plateau in May,and central North China.in October).The SPA distributions are remarkably consistent with the integrated water vapor transport(iVT)*** iVT is found associated with the interaction between southwesterly(southerly)of the BoBTC circula.ion and low-level monsoonal flow in May(midlevel westerly in winter months).The proba.ilities of extreme precipita.ion(EP)occurrences over the above regions all increase on *** adjacent regions,EP is significantly correlated with the northward iVT anoma.ies to the east of BoBTC circula.ion,which strengthen the water vapor input through the southern *** iVT anoma.ies are stronger in May,benefited by the deep monsoonal southwesterlies than those in *** distant regions,EP is more closely related to the iVT anomaly extending back from *** moisture from BoB concentrates along a local low-level convergence line over Southeast China,being further fa.ilitated by coexistence of the BoBTC depression and midlevel westerly trough in *** results highlight the interactions between BoBTCs and local weather systems that influence the general precipita.ion anoma.ies and occurrence of EP over China,especially over distant regions.

关键词： tropical cyclone Bay of Bengal precipita.ion anomaly moisture transport