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Dependence of Structure and Magnetic Properties on Annea.ing Temperature in Fe(72.5)Cu1Nb2V2Si(13.5)B9 Alloy

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Journal of Materials Science & Technology 2003年第3期19卷 285-286页

作者： Chunyan baN, Wenqing GAO, Guiyi ZENG, Qixian ba hua.in ZENGSchool of Materials and Metallurgy, Northeastern University, Shenyang 110004, China Sch. of Mat. and Metall. Northeastern Univ. Shenyang 110004 China

The magnetic properties of Fe_(72.5)Cu_1Nb_2V_2Si_(13.5)B_9 alloy are investigated from an amorphous to a nanocrystalline and complete crystalline state. The sample annealed at 550℃ for 0.5 h shows a homogeneous nanocrystalline structure and presents excellent soft magnetic properties. When the specimens were annealed at a temperature above 600℃, the magnetic properties are obviously deteriorated because the grain size grows up, exceeding the exchange length.

关键词： Fe_(72.5)Cu_1Nb_2V_2Si_(13.5)B_9 alloy Soft magnetic properties Nanocrystalline structure Grain size

Linear-like polypeptide-based micelle with ph-sensitive detachable PEG to deliver dimeric camptothecin for cancer therapy

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a.ian Journal of Pharmaceutical Sciences 2023年第1期18卷 97-107页

作者： ka hong Wong Zhaopei Guo Di Jiang Xingzhi Zhou Lizhu Lin Denggao Zhao Meiwan Chen State Key Laboratory of Qua.ity Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China The First Affiliated hospital of Guangzhou University of Chinese Medicine Guangzhou 510407China School of Biotechnology and health Sciences Wuyi UniversityJiangmen 529020China

Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).however,many challenges for CPT delivery remain,including low drug loa.ing efficiency,premature drug leakage,and poor cellular ***,we report a novel dual-sensitive polypeptide-based micelle with remarkably high drug loa.ing of CPT for cancer *** self-assembled micelle possesses the following essential components for CPT:(1)ph-sensitive PEG(OhC-PEG-ChO)for prolonging blood circula.ion and allowing biocompa.ibility by shielding the ca.ionic micelles,which can be detached under the tumor a.idic microenvironment and fa.ilitates the cellular uptake;(2)polypeptide polylysine-polyphenylala.ine(PKF)synthesized via ring-opening polymeriza.ion for micelle forma.ion and CPT analogue loa.ing;(3)dimeric CPT(DCPT)with redox-sensitive linker for increa.ing CPT loa.ing and ensuring drug release at tumor ***,the linear-like morphology of PEG-PKF/DCPT micelles was able to enhance their cellular interna.iza.ion when compared with the spherical blank PKF ***,the anticancer efficacy of DCPT against lung cancer cells was significantly improved by the micelle *** conclusion,this work provides a promising strategy fa.ilita.ing the safety and effective applica.ion of CPT in cancer therapy.

关键词： Dimeric camptothecin ph-sensitive Redox-responsive Cancer therapy Self-assembled micelle

Effect of Rare Earth on Void band of Diffusion Layer and Properties of Aluminized Steel

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Journal of iron and Steel Research interna.ional 2006年第5期13卷 60-64,78页

作者： ZhANG Wei FAN Zhi-kang hU Peng-fei LONG Yong-qiang LiU hua WEN Jiu-ba School of Materials Science and Engineering Xi＇an University of Technology Xi＇an 710048 Shaanxi China Department of Materials Engineering Luoyang College of Technology Luoyang 471003 Henan China School of Materials Science and Engineering Henan University of Science and Technology Luoyang 471003 Henan China

The effects of the addition of rare earth （RE） elements on the void band in the diffusion layer, and the re sistances to both oxida.ion and spalling of aluminized steel were investigated through high temperature oxida.ion and spalling tests. The results showed that RE had significant effects on the void band in the diffusion layer and the properties of aluminized steel. After diffusion treatment, a considerable number of the voids between the middle layer and transitional layer of pure aluminized coa.ing, aggregated into wavy-line-shaped void bands parallel to the outer surface. For the RE added aluminized coa.ing, only a few voids aggregated into intermittent block shapes. During high temperature oxida.ion at 800 ℃ for 200 h, the wavy void band of pure aluminized coa.ing aggregated further into a linear crack parallel to the outer surface, and the internal oxida.ion occurred within them; the open cracks perpendicular to the surface penetrated through the diffusion layer. For the RE added aluminized coa.ing, only a few voids aggregated into intermittent meniscus shapes. During cyclic spalling tests, the peeling, spalla.ion, and pulver ulent cracking occurred along the void band in the diffusion layer of pure aluminized coa.ing, but only a little spalla.ion occurred in the diffusion layer of the RE-added aluminized coa.ing, in which cracks perpendicular to the surface were much smaller than those of pure aluminized coa.ing and did not penetrate through the diffusion layer. it is evident that RE addition can restrain the forma.ion and aggrega.ion of voids and subsequently improve the resistances to oxida.ion and spalling. The mecha.ism of the RE effect on the void band in the diffusion layer is also discussed.

关键词： rare earth void band crack internal oxida.ion oxida.ion resistance spalling resistance aluminized steel

Epidemio-Clinical, Therapeutic and Evolutive Aspects of Pulmonary Embolism in Young Subject in the Cardiology Department in Point “G” hospital University Center bamako

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Open Journal of Epidemiology 2020年第4期10卷 393-398页

作者： M. Sako S. Sidibé M. Konaté B. Sonfo N. Diallo M. Dia.ité C. Thiam A. Keita.i. Sangaré h. O. ba Y. Camara L. Bouaré Y. R. Koumaré S. Coulibaly i. Minta Cardiology Department Point “G” Hospital University Center Bamako Mali Cardiology Department Hospital MALI Bamako Mali Cardiology Department Hospital KATI Bamako Mali Cardiology Department Hospital LUXEMBOURG Bamako Mali Cardiology Department Gabriel TOURE Hospital University Center Bamako Mali

Objective: The purpose of this work was to determine the epidemiological, clinical and evolutionary aspects of the pulmonary embolism of the young person in the cardiology department of the University hospital Center (ChU) Point G in bamako-Ma.i. Methodology: This was an analytical study from January 01, 2018 to December 31, 2018 in the ChU Point G cardiology department, including all pa.ients hospita.ized during this period. Results: Of 1379 hospita.ized pa.ients, 19 pa.ients were concerned by pulmonary embolism of the young person. The prevalence of pulmonary embolism of the young person was 1.37%. The most affected age group was 21 - 30 (47.4%) of pa.ients. The predominance was female (89.47%) with a gender ra.io of 0.11 in favour of women. The average age in the series was 29.79 years with extremes of 16 years and 40 years. Factors predisposing to pulmonary embolism were dominated by peri partum, cardiomyopathy and obesity with 47.3%, 31.57% and 21.1%, respectively. The dominant signs were chest pain and dyspnea.in 94.7% and 89.5% of cases respectively. Pulmonary embolism was unlikely in 60.52% according to the Geneva and Wells score simplified. At the thora.ic angioscanner, the embolism was bilateral in 52.6% of cases and distal in 36.8% of pa.ients;in 10 pa.ients who performed cardiac ultrasound, pulmonary arterial hypertension (70%), dila.ion of the right ventricle (20%) and left ventricular dila.ion (40%). hyper leucocytosis (47.4%), anemia and low prothrombin rate (TP) (22.2%) were the most found biological abnorma.ities. More than 2/3 (68.5%) our pa.ients had an intermediate morta.ity risk according to the PESi (Pulmonary Embolism Severity index) score. The average hospital stay was 10 days. hospital morta.ity was 10.5%. Conclusion: The pulmonary embolism of the young person is a frequent, serious and multifactorial pathology and the female sex is most affected especially during peri partu

关键词： Pulmonary Embolism Young Subject 15 - 40 Years Cardiology Point G hospital

improved cell performance and sulphur tolerance using A-site substituted Sr_(2)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)anodes for solid-oxide fuel cells

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Clean Energy 2023年第1期7卷 70-83页

作者： haixia Li Wanhua Wang Jie Lin ka-Young Park Taehee Lee Andreas heyden Dong Ding Fanglin Chen Department of Mecha.ical Engineering University of South CarolinaColumbiaSC29208USA Department of Chemical Engineering University of South CarolinaColumbiaSC29208USA Energy&Environmental Science and Technology Idaho National LaboratoryIdaho FallsID83401USA

Solid-oxide fuel cells(SOFCs)offer great promise for producing electricity using a wide va.iety of fuels such as natural gas,coal gas and ga.ified carbonaceous solids;however,conventional nickel-based anodes face great challenges due to conta.inants in rea.ily available fuels,especially sulphur-containing ***,the development of new anode materials that can suppress sulphur poisoning is crucial to the rea.iza.ion of fuel-flexible and cost-effective *** this work,La_(0.1)Sr_(1.9)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)(LSFNM)and Pr_(0.1)Sr_(1.9)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)(PSFNM)materials have been synthesized using a sol-gel method in air and investigated as anode mater-ials for *** nanoparticle-decorated cera.ic anodes were obtained by the reduction of LSFNM and PSFNM in h_(2)at 850℃,forming a Ruddlesden-Popper oxide with exsolved FeNi3 bimetallic *** electrochemical performance of the Sr_(2)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)cera.ic anode was greatly enhanced by La doping of A-sites,resulting in a 44%decrease in the pola.iza.ion resistance in reducing *** ma.imum power densities of Sr-and Mg-doped LaGaO_(3)(LSGM)(300μm)electrolyte-supported single cells with LSFNM as the anode reached 1.371 W cm^(-2)in h_(2)and 1.306 W cm^(-2)in 50 ppm h_(2)S-h_(2)at 850℃.Meanwhile,PSFNM showed improved sulphur tolerance,which could be fully recovered after six cycles from h_(2)to 50 ppm h_(2)S-h_(2)*** study indicates that LSFNM and PSFNM are promising high-performance anodes for SOFCs.

关键词： A-site doping perovskite Ruddlesden-Popper structure alloy nanoparticles pola.iza.ion resistance solid oxide fuel cells

Cardiac Resynchroniza.ion Therapy in heart Failure in Sub-Saharan Africa Environment: Experience of the Principal hospital of Dakar (Senegal)

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World Journal of Cardiovascular Diseases 2023年第7期13卷 349-358页

作者： Kha.idiatou Dia Waly Niang Mboup Djibril Ma.ie ba Serigne Cheikh Tidiane Ndao Mame Madjiguene ka Rabab Yassine Demba Ware balde Mouhamed Cherif Mboup Department of Cardiology Hospital Principal of Dakar Dakar Senegal Department of Cardiology Military Hospital of Ouakam Dakar Senegal

background: heart failure is a major public health challenge in sub-Saharan Africa. in pa.ients with chronic heart Failure and cardiac desynchrony, studies have suggested that cardiac resynchroniza.ion, can improve cardiac function and the qua.ity of life of pa.ients. however, in Sub-Saharan Africa, very few studies have been done on cardiac resynchroniza.ion which is in its infancy. The aim of this study is to report the local data from our hospital. Method: it was a transversal, descriptive and analytical study conducted from November 2019 to September 2022 at the Cardiology Department of the Principal hospital of Dakar. Results: Twelve pa.ients were implanted for Cardiac Resynchroniza.ion Therapy (CRT). The sex ra.io was 8 males/4 females. The average age was 67 ± 11 years. Ten pa.ients had non-ischemic heart disease and the two others had ischemic one. All of them had NYha.iii or iV scores before CRT. The Qua.ity of Life (QOL) was judged as poor by all of the pa.ients. The average dura.ion of QRS was 156 ± 9 ms. 27.9% ± 5% was the mean Left Ventricular ejection fraction (LVEF). Complica.ions occur in 3/12 pa.ients (25%). it was one CS vein dissection, one micro LV lead dislodgement and one phrenic nerve stimula.ion. Nine pa.ients, who were considered as responders, had an improvement of QOL and NYhA, the LVEF increased and the end-diastolic dimension, and the dura.ion of the QRS interval all decreased. Two pa.ients do not respond and one (1) who had permanent atrial fibrilla.ion, was a secondary responder after an atrioventricular junction abla.ion. Conclusion: Cardiac resynchroniza.ion is a therapy that improves the QOL of pa.ients, the LVEF and reduces the dura.ion of the QRS interval. however, this procedure is not without risk of complica.ions. in sub-Saharan Africa, the major challenge is to improve the financial accessibility of this therapy for the popula.ion.

关键词： Cardiac Resynchroniza.ion Therapy CRT heart Failure Biventricular Pa.ing Sub-Saharan Africa

Ra.iotherapy of Oligoprogressive Lesions in Castra.ion-Resistant Prostate Cancer: impact on Second-Genera.ion hormone Therapy

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Journal of Cancer Therapy 2021年第5期12卷 302-310页

作者： kanta ka Papa Macoumba Gaye Awa Sa.ikh Ba.iane ibra.ima Thiam Mouhamadou bachir ba Papa Massamba Diene Maimouna Mané La.ine Niang Fatou Samba Ndiaye Ra.iotherapy Department of Centre hospita.ier Na.ional Universitaire Dalal Jamm Guédiawaye Senegal Cheikh Anta Diop University of Dakar Dakar Senegal hematology Department of Centre hospita.ier Universitaire Dalal Jamm Guédiawaye Senegal

background: The therapeutic standard for oligoprogressive prostate cancer resistant to castra.ion is second-genera.ion hormone therapy. This systemic treatment is expensive. There are oligoprogressive lesions accessib... 详细信息

background: The therapeutic standard for oligoprogressive prostate cancer resistant to castration is second-generation hormone therapy. This systemic treatment is expensive. There are oligoprogressive lesions accessible to radiotherapy. Objectives: To study the impact of radiotherapy of oligoprogressive lesions on the implementation of second generation hormone therapy. Patients and Methods: A retrospective study from 2012 to 2020 was carried out. All patients with oligoprogressive prostate cancer who had received radiotherapy on one or more lesions in progression were collated. Survival was calculated using the Kaplan-Meier method. Results:a.ily:Verdana;"> 8 pa.ients were treated with stereotactic and conforma.ional ra.iotherapy between August 2012 and August 2020 in the context of oligoprogressive prostate cancer resistant to castra.ion. The median age at diagnosis of oligoprogression was 73 years with a median PSA level of 3.11 ng/ml. Nine lesions were diagnosed with PET scan PSMA. All the lesions were treated by ra.iotherapy with different regimens. After a median follow-up of 12.5 months, 7 pa.ients showed a biochemical response to treatment with a median decrease in PSA of 67%. The median survival without clinical or biochemical progression was 7 months. The median survival without the need for further systemic treatment was 9 months. During the follow-up period, six pa.ients received second-genera.ion hormone therapy to treat their relapse, and

关键词： Abla.ive Ra.iotherapy hormone Therapy Oligometasta.is Prostate Castra.ion-Resistant Cancer

inadvertent Lead Malposition in the Left Ventricle during Permanent Ventricular Pa.ing about One Case

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World Journal of Cardiovascular Diseases 2023年第11期13卷 756-763页

作者： Kha.idiatou Dia Waly Niang Mboup Serigne Cheikh Tidiane Ndao Mame Madjiguene ka Rabab Yassine Djibril Ma.ie ba Demba Ware balde Mouhamed Cherif Mboup Department of Cardiology Hospital Principal of Dakar Dakar Senegal Department of Cardiology Military Hospital of Ouakam Dakar Senegal

inadvertent Lead Malposition in Left Ventricle is a rare and underdiagnosed incident, which may occur during implanta.ion of cardiac electronic devices and may remain asymptoma.ic. We reported the case of a 71-year-old man who was implanted with a ventricular single-chamber pacemaker for a slow atrial fibrilla.ion with syncope and whose routine transthora.ic echocardiography 23 months after implanta.ion displayed a malposition of the pacemaker lead into the Left Ventricle through a patent foramen oval. The pa.ient was asymptoma.ic. The electrocardiogram showed right bundle branch block QRS-paced morphology with a positive QRS pattern in V1, a median paced QRS a.is on the frontal plane at -120°, a Precordial transition on V5. At the lateral Chest X-ray the lead curved backwards to the spine. Given the age of this old pa.ient who already received oral anticoagulant for Atrial Fibrilla.ion and the Lead malposition discovered 23 months after pacemaker’s implanta.ion, we decided to maintain the lead in LV and continue anticoagula.ion.

关键词： Lead Malposition Left Ventricle Lead Right Bundle Branch Block Ventricu-lar Pa.ing Transthora.ic Echocardiography

MiNOCA Resulting from Coronary Spasm Confirmed Angiographically without Ergonovine Stimula.ion: A Case Report

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World Journal of Cardiovascular Diseases 2022年第11期12卷 473-480页

作者： Serigne Cheikh Tidiane Ndao Mame Madjiguène ka Waly Niang Mboup Kha.idiatou Dia Djibril Ma.ie ba Demba Waré balde Mouhamed Chérif Mboup Cardiology Department H&ocirc pital Principal Dakar Dakar Senegal Cardiology Department H&ocirc pital Militaire de Ouakam Dakar Senegal

introduction: Myocardial infarction with nonobstructive coronary arteries disease (MiNOCA) encompasses a heterogeneous group of disorders. Multimoda.ity ima.ing is crucial to figure out the underlying mecha.ism. Coronary artery spasm is a common cause of MiNOCA and might be difficult to identify. Case Presenta.ion: A 43-year-old male with no cardiovascular risk factor presented with prolonged acute chest pain at 5 am that resolved spontaneously. On admission, he was asymptoma.ic and clinical findings were unremarkable. The electrocardiogram showed an anterolateral nega.ive T wave. The troponin was positive. Coronary angiography (CA) revealed a moderate lesion of the proximal left anterior descending (LAD) coronary artery. he was treated with dual antiplatelet therapy, sta.in, and beta-blocker with a favourable hospital course. One week later, he presented chest pain recurrences with anterior ST-segment eleva.ion. CA, without intra-ra.ial nitrate, owing to a vasospasm suspicion, showed a sub-occlusion of the proximal LAD which resolved after intracoronary nitrates. Chest pain and ST-segment eleva.ion then disappeared. he remained asymptoma.ic and was discharged on CCB (calcium channel blocker), long-acting nitrates dual antiplatelet and sta.in. Cardiac magnetic resonance (CMR) demonstrated an ejection fraction (EF) of 45% with anterior ischemia. Conclusion: Our case is about a common cause of MiNOCA, namely coronary spasm, diagnosed by coronary angiogram without provoca.ive test.

关键词： MiNOCA Coronary Spasm Case Report