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Pa.ients with helicobacter pylori positive and nega.ive duodenal ulcers have distinct clinical characteristics

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World Journal of Gastroenterology 2005年第23期11卷 3518-3522页

作者： Kent-Man Chu ka-Fai Kwok Simon Law kam-ho Wong Department of Surgery

AiM: To assess the clinical characteristics of helicobacterpylori(h pylori) nega.ive duodenal ***: Pa.ients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Pa.ients were considered to be nega.ive for hpylori, if both histological exa.ina.ion and ra.id urease test of biopsy specimens were nega.ive. A compa.ison was made between pa.ients with h pyloripositive and nega.ive duodenal ***: A total of 1 343 pa.ients were studied. Their mean age was 54.7±0.5 years. There was a male preponderance (M:F = 2.5:1). Three hundred and ninetyeight pa.ients (29.6%) did not have h pylori infection. The annual proportion of pa.ients with h pylori nega.ive duodenal ulcers increased progressively from 1996 to2002. On multiva.iate analysis, pa.ients with h pylorinega.ive duodenal ulcer were more likely to be older, have concomitant medical problem, pre-existing ma.ignancy, recent surgery, underlying sepsis, or taken non-steroidal anti-inflammatory drugs. in terms of clinical presenta.ions, pa.ients with h pylori nega.ive duodenal ulcer were more likely to present with bleeding, multiple ulcers and larger ***: The proportion of pa.ients with h pylori nega.ive duodenal ulcers is on the rise because of a continued drop in incidence of h pylori positive duodenalulcers in recent years. Such pa.ients have distinct clinical characteristics and it is important to ascertain the h pylori status before starting era.ica.ion therapy.

关键词： helicobacter pylori Duodenal ulcer

Post-hepatectomy liver failure:A timeline centered review

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hepatobiliary & Pancrea.ic Diseases interna.ional 2023年第6期22卷 554-569页

作者： Mohamed Bekheit Lisa Grundy Ahmed ka Sa.ih Petru Bucur Eric Vibert Mudassar Ghazanfar Department of Surgery NHS GrampianForesterhill Health CampusAshgrove RoadAB252ZN AberdeenUK institute of Medical Sciences Medical SchoolForesterhill Health CampusAshgrove RoadAB252ZN AberdeenUK hépa.ica Integrated Center of HPB CareElite HospitalAgriculture RoadAlexandriaEgypt Department of Surgery University Hospital ToursVal de la Loire 37000France Centre hépatobiliaire Paul Brousse Hospital12 Paul Valliant Couturier94804 VillejuifFrance

background: Post-hepatectomy liver failure(PhLF) is a lea.ing cause of postopera.ive morta.ity after liver surgery. Due to its significant impact, it is impera.ive to understand the risk stra.ifica.ion and preventa.ive strategies for PhLF. The main objective of this review is to highlight the role of these strategies in a timeline centered way around cura.ive resection. Data sources: This review includes studies on both humans and a.imals, where they addressed PhLF. A literature search was conducted across the Cochrane Library, Embase, MEDLiNE/Pub Med, and Web of Knowledge electronic databases for English language studies published between July 1997 and June 2020. Studies presented in other languages were equally considered. The qua.ity of included publica.ions was assessed using Downs and Black’s checklist. The results were presented in qua.ita.ive summa.ies owing to the lack of studies qua.ifying for quantita.ive analysis. Results: This systema.ic review with 245 studies, provides insight into the current prediction, prevention, diagnosis, and management options for PhLF. This review highlighted that liver volume ma.ipula.ion is the most frequently studied preventive measure against PhLF in clinical practice, with modest improvement in the treatment strategies over the past decade. Conclusions: Remnant liver volume ma.ipula.ion is the most consistent preventive measure against PhLF.

关键词： Post-hepatectomy liver failure Liver neoplasms Prediction Prevention Management

Assisting Ni catalysis by CeO_(2) with oxygen vacancy to optimize the hydrogen storage properties of Mgh_(2)

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Journal of Materials Science & Technology 2023年第28期159卷 62-71页

作者： Jiangchuan Liu Qinke Tang Yunfeng Zhu Yana Liu Jiguang Zhang Zhixin ba Xiaohui hu Liquan Li College of Materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech UniversityNanjing 211816China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China

Although Mgh_(2) has been widely regarded as a promising material for solid-state hydrogen storage,its high opera.ing temperature and slow kinetics pose a major bottleneck to its practical ***,a nanocomposite catalyst with interfa.ial coupling and oxygen defects,Ni/CeO_(2),is fabricated to promote h_(2) desorption and absorption properties of Mgh_(2).The interface of Ni/CeO_(2) contributes to both strong mecha.ical coupling towards sta.ilizing partial Ni and electronic coupling towards inducing a high con-centra.ion of oxygen vacancies in CeO_(2).Theoretical calcula.ions evidence that CeO_(2) with oxygen vacancy assist Ni in weakening the energy of Mg-h bond as well as enhancing the adsorption energy of Ni upon hydrogen atoms,and the extent of this assistance surprisingly increases with increa.ing oxygen vacancies *** a result,an impressive performance is achieved by Mgh_(2)-5 wt.%Ni/CeO_(2) with onset desorption temperature of only 165°C,and it absorbs approximately 80%hydrogen in just 800 s at 125°*** genera.ion mecha.ism of intermediate active species concerning Ni/CeO_(2) in different states has been analyzed for the first time,and the rela.ionship between interfa.ial coupling and phase evolution has been ***,a mecha.ism of the catalysis-assisting effect regarding oxygen defects is *** is believed that this work provides a unique perspective on the mecha.ism of interfa.ial coupling and the genera.ion of defects in composite catalysts.

关键词： hydrogen storage interfa.ial coupling Oxygen defects Catalysis-assisting

Effects of Carbona.ion on Micro Structures of hardened Cement Paste

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Journal of Wuhan University of Technology(Materials Science) 2016年第1期31卷 146-150页

作者：柳俊哲 yao senyuan ba mingfang he zhimin 李玉顺 Faculty of Architectural Civil Engineering and Environment Ningbo University Ningbo 315211 China

in order to investigate the effects of carbona.ion on the microstructure of cement concrete,the carbona.ion depth and microstructure of cement paste with 0.3,0.4 and 0.5 water/cement ra.io after 7,14,21 and 28 d accelerated carbona.ion were studied *** results showed that with the increase of waterto-cement ra.io and carbona.ion age,the carbona.ion depth was deepened with faster early carbona.ion speed and slower later carbona.ion *** densified the structure of hardened cement stone with refinement of pore structure and reduced ***,during the carbona.ion process from the surface to the inside of carbona.ion area.it was prone to form micro-cracks extending to the interior specimen,resulting in cement paste carbona.ion depth *** is further illustrated that the color reaction method using phenolphthalein solution combined with X-CT and X-ray diffraction analysis is much more reasonable to evaluate the cement concrete carbona.ion ***,during carbona.ion process sulfur element in cement paste migrated to the area un-carbonated and the concentrated shape of sulfur element is consistent with the coloring region in carbona.ion *** it was identified that carbona.ion not only reduced the p h value in cement concrete but also made prone to crack in carbona.ion zone,which increased the proba.ility of reinforcement corrosion.

关键词： hardened cement paste carbona.ion sulfur microstructure X-CT analysis

The D253N Muta.ion in the Polymerase Ba.ic 2 Gene in a.ian influenza(h9N2) Virus Contributes to the Pathogenesis of the Virus in Mamma.ian hosts

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Virologica Sinica 2018年第6期33卷 531-537页

作者： Jinfeng Zhang Rong Su Xiaoyun Jian hongliang An Ronbing Jiang Chris ka Pun Mok Laboratory Medicine Center Foshan Hospital of Traditional Chinese Medicine Guangzhou University of Chinese Medicine Department of Respiratory Medicine Foshan Hospital of Traditional Chinese Medicine Guangzhou University of Chinese Medicine State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University hKU-Pasteur Research Pole School of Public Health HKU Li Ka Shing Faculty of Medicine The University of Hong Kong

Muta.ions in the polymerase ba.ic 2(PB2) gene of a.ian influenza viruses are important signatures for their adapta.ion to mamma.ian hosts. Va.ious adaptive muta.ions have been identified around the 627 and nuclear loca.iza.ion sequence(NLS) domains of PB2 protein, and these muta.ions contribute to the replica.ive a.ility of a.ian influenza ***, few studies have focused on adaptive muta.ions in other regions of PB2. in this study, we investigated the functional roles of the D253N muta.ion in PB2 in an h9N2 virus. This muta.ion was found to affect an a.ino a.id residue in the middle domain of the PB2 protein. The virus with the D253N muta.ion showed higher polymerase activity and transiently increased viral replica.ion in human cells. however, the mutant did not show significant differences in viral replica.ion in the respiratory tract of mice upon infection. Our results supported that the D253N muta.ion in the middle domain of PB2, similar to muta.ions at the 627 and NLS domains, specifically contributed to the replica.ion of a.ian influenza viruses in human cells.

关键词： a.ian influenza virus Mamma.ian adapta.ion D253N Polymerase ba.ic 2(PB2) h9N2

Effect of herpesvirus infection on pancrea.ic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter hegyi balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária Szabolcs Réka Sári András Tóth Julius G Papp András Varró Mária K Kovács Mike A Gray barry E Argent Zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and Molecular Biosciences

AiM： To exa.ine the effect of acute infection caused by herpesvirus （pseudora.ies virus, PRV） on pancrea.ic ductal secretion. METhODS： The virulent ba-DupGreen （BDG） and non- virulent ka-RREp01acgfp （KEG） genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of hCO3 secretion [base efflux -λ（B）] was determined from the buffering capa.ity of the cells and the initial rate of intracellular a.idifica.ion （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic a.id （500 μmol/L） and a.iloride （200 μmol/L）, and （2） after alka.i loa.ing the ducts by exposure to Nh4Cl. All the experiments were performed in hCO3-buffered Ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visua.ized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. however, KEG infection did not modify -λB-）. After alka.i loa.ing the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. CONCLUSiON： incuba.ion with the BDG or KEG strains of PRV results in an effective i

关键词： Pancreas hypersecretion Ductal cells infection Pseudora.ies virus

Compa.ison of mantle lithosphere beneath early Triassic kimberlite fields in Siberian craton reconstructed from deep-seated xenocrysts

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Geoscience Frontiers 2016年第4期7卷 639-662页

作者： i.V.Ashchepkov S.S.Kuligin N.V.Vladykin h.Downes M.A.Va.ilov E.N.Nigmatulina S.A.babushkina N.S.Tychkov O.S.Khmelnikova lnstitute of Geology and Mineralogy SD RAS Koptyug ave 3NovosibirskRussia institute of Geochemistry SD RAS Favorskky str laIrkutskRussia Department of Earth and Planetary Sciences Birkbeck University of LondonLondonUK institute of Geology of Diamonds and Noble metals SD RAS Lenina ave 39YakutskRussia

Mantle xenocrysts from early Triassic kimberlite pipes from Kharamai, Ary-Mastakh and Kuranakh fields in the Anabar shield of Siberia revea.ing similar compositional trends were studied to estimate the superplume influence on the subcratonic lithosphere mantle （SCLM）. Pressure-temperature （PT） reconstructions using monomineral thermobarometry for 5 phases show division of the SCLM beneath the Kharamai field into 6 units： pyroxenitic Fe-rich （1-2 GPa） and Mg-rich （2-3 GPa） layers; middle with two levels of Gar-Sp pyroxenites at - 3 and 4-5 GPa; Gar-dunite-harzburgites - 4.5-6.5 GPa subjected to llm-Px vein metasoma.ism; and a Mg-rich dunite lower part. in the Anabar shield （Ary-Mastakh, Dyuken and Kuranakh fields） mantle lithosphere is composed of three large units divided into two parts： upper part with amphiboles and phlogopite; two levels of pyroxenites and eclogites at 3 and 4 GPa, and a lower part composed of refertilized dunites. Diagrams showing P-Fe#Gar clusters for garnets and ompha.ites illustrate the differences between SCLM of these loca.ities. Differences of Triassic SCLM from Devonian SCLM are in simple layering; abundance of Na-Cr-amphiboles and metasoma.ism in the upper SCLM part, thick pyroxenite-eclogite layer and lower part depletion, heated from SCLM base to 5.0 GPa. Kharamai mantle clinopyroxenes represent three geochemical types：（1） harzburgitic with inclined linear REE, hFSE troughs and elevated Th, U; （2） lherzolitic or pyroxenitic with round TRE patterns and decrea.ing incompa.ible elements; （3） eclogitic with Eu troughs, Pb peak and high LiLE content. Calculated parental melts for garnets with humped REE patterns suggest dissolution of former Cpx and depression means Cpx and garnets extraction. Clinopyroxenes from Ary-Mastakh fields show less in- dined REE patterns with hMREE troughs and an increase of incompa.ible elements. Clinopyroxenes from Kuranakh field show flatter spoon-like REE patterns and peaks in ba, U, Pb and St, similar to th

关键词： Mantle lithosphere Monomineral thermobarometry Mineral geochemistry Triassic kimberlite Layering

Contribution to the Study of Diabetic Kidney Disease in a Sub-Saharan Environment: An Example of the a.istide Le Dantec University hospital in Dakar

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Open Journal of Nephrology 2023年第4期13卷 339-348页

作者： Ahmed Tall Lemrabott Ma.ia Faye Niakhaleen Keita Seynabou Diagne Moustapha Faye bacary ba Abdou Niang El hadji Fary ka Nephrology Department Aristide Le Dantec University Hospital Dakar Senegal Nephrology Department Dalal Jamm National Hospital Center Dakar Senegal

introduction: Diabetic kidney disease (DKD) is a lea.ing cause of chronic kidney disease and dialysis admission. Few studies are available in Sub-Saharan Africa. The objective of this work was to study the epidemiological, clinical, diagnostic and therapeutic characteristics of DKD in our context. Pa.ients and Methods: We conducted an observa.ional, exhaustive and retrospective study focusing on diabetic pa.ients seen in consulta.ion or hospita.ized in the Nephrology Department of at the a.istide Le Dantec University hospital in Dakar during a period of 5 years from January 1, 2017 to December 31, 2021. Results: Of 4735 pa.ients seen during the study period, 491 had DKD, i.e. a hospital prevalence of 10.36%. The average age was 59.1 ± 11.4 years with a sex ra.io of 0.95. Type 2 diabetes predominated with 93.4%. The average dura.ion of diabetes was 11.5 ± 7.6 years. Diabetes was associated with high blood pressure in 78.81% of cases, dyslipidemia.in 23.2% of cases, active smoking in 6.7% of cases and obesity in 1.6% of cases. Renal failure was the main reason for referral 72.3%. One hundred and forty-eight pa.ients (30.1%) had uncontrolled diabetes. Macroalbuminuria was found in 64.8% and microalbuminuria.in 18.7% of cases. One hundred and eighty-five pa.ients (37.7%) were in Stage V of kidney disease and 137 pa.ients were in Stage iii (18.1% in Stage iiib and 9.8% in Stage iiia). Diabetic nephropathy was the main etiology at 61.30%. Nephropathy was mixed (diabetic and hypertensive) in 18.12 cases. Renin-angiotensin-aldosterone system (RAAS) blockers were prescribed in 83.5% of pa.ients. Conclusion: The different etiologies encountered during the study show the diversity of diabetic kidney disease. Diabetic nephropathy is not the only kidney damage that can occur in diabetics in our context.

关键词： Diabetic Kidney Disease (DKD) Microalbuminuria Diabetic Nephropathy

Conserva.ive Approach Might Be the Strategy by Default in Stable Angina Pa.ients: A Case Report

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World Journal of Cardiovascular Diseases 2020年第11期10卷 769-774页

作者： Serigne Cheikh Tidiane Ndao Mame Madjiguene ka Djibril Ma.ie ba Kha.idiatou Dia Mouhamed Chérif Mboup Pape Dia.ie Fall Department of Cardiology Hospital Principal Dakar Dakar Senegal

Management of stable angina.is still a matter of debate. Whether a conserva.ive or inva.ive approach is better remains unclear. Even though recent large-scale randomized trials depict the conserva.ive strategy as safe... 详细信息

Management of stable angina.is still a matter of debate. Whether a conserva.ive or invasive approach is better remains unclear. Even though recent large-scale randomized trials depict the conservative strategy as safe and efficient. In this report, we present a case of a 53-year-old male patient with cardiovascular risk factors of hypertension and hypercholesterolemia. He complained about typical chest pain at exertion. The coronary angiogram (CA) revealed severe stenosis of the proximal left anterior descending artery (LAD) ostium. After heart team discussion, coronary artery bypass graft (CABG) was advocated. However, due to a lack of means, the CABG was postponed. Meanwhile, he was managed with guideline-based medical therapy. In addition, he exercised regularly and adopted a healthy diet. Evolution was favorable with excellent symptoms control. A regular follow-up was organized with his cardiologist. A new CA before an eventual CABG six years later showed a significant plaque volume regression of the proximal LAD. We decided to continue conservative management. The stress echocardiogram to assess symptoms and exercise tolerance was normal. a.ily:"">Our pa.ient was sent to surgery on top of optimal medical therapy even though angioplasty was a good indica.ion and was fea.ible. however, while he was struggling to afford the CABG procedure, he adopted a very healthy lifestyle along with medical therapy. Six years later, the result of that approach was without appeal, suggesting and reinforcing the conserva.ive management

关键词： Stable Angina Chronic Coronary Syndrome Conserva.ive Treatment Case Report