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Walking pace and the risk of stroke:A meta-analysis of prospective cohort studies

Journal of Sport and health Science 2020年第6期9卷 521-529页

作者： Minghui Quan Pengcheng Xun Ru Wang ka he Peijie Chen School of Kinesiology Shanghai University of SportShanghai 200438China Department of Epidemiology and Biosta.istics School of Health-BloomingtonIndiana UniversityBloomingtonIN 47405USA

Purpose:The extent to which walking pace is associated with a reduced risk for stroke remains *** study exa.ined the associa.ion between walking pace and stroke risk based on prospective cohort ***:Databases of PubMed,EMbaSE,Web of Science,Scopus,and China Na.ional Knowledge internet were searched from the inception dates to January 31,2019,for prospective cohort studies focusing on walking pace and risk of stroke in *** reviewers independently extracted data and assessed the qua.ity of the *** dependent measure was stroke *** random-effects models,a metaanalysis was performed to estimate the overall rela.ive risks(RR)of stroke incidence and 95%confidence intervals(Cis)for the individuals with the fastest walking paces *** with the slowest walking paces.A dose-response rela.ionship was also ***:After screening 1294 titles/abstracts and 14 full-text studies identified in the search,7 studies(from 8 cohorts)were included in the *** 7 studies included a total of 135,645 participants(95.2%women;mean age 63.6 years)and 2229 stroke events(median follow-up time=8.0 years).Compared to individuals in the slowest walking-pace category(median=1.6 km/h),individuals in the fastest walking-pace category(median=5.6 km/h)had a 44%lower risk of stroke(pooled RR=0.56,95%Ci:0.48-0.65).There was also a linear dose-response rela.ionship(RR=0.87;95%Ci:0.83-0.91),with the risk of stroke decreased by 13%for every 1 km/h increment in baseline walking *** observed similar results across walking-pace assessment,type of stroke ascertainment,stroke subtypes,sex,sample size,and dura.ion of ***:Findings from this meta-analysis indicate that walking pace is inversely associated with the risk of stroke.

关键词： Dose response Meta-analytic review Stroke incidence Walking pace

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Modula.ion doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak ho Lim Mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-Jun Wang ka Wai Wong ka Ming Ng Yu Liu Andreu Cabot institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina iCREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research institute-iREC Sant Adria del BesosBarcelona 08930Spain

The commercial via.ility of thermoelectric(TE)devices relies hea.ily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorpora.ion of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mecha.ism of improvement on the transport properties of the mate-rial,we compare the interphase transport mecha.ism by incorpora.ing nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activa.ion of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modula.ion doping Thermoelectric interphase transport Charge flooding Phonon-carrier scattering

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Tracking Source Va.ia.ions of inhala.ion Cancer Risks and Ozone Forma.ion Potential in hong Kong over Two Decades(2000−2020)Using Toxic Air Pollutant Monitoring Data

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Environment & health 2024年第6期2卷 411-421页

作者： Yee ka Wong Wai Wai Chan Dasa Gu Jian Zhen Yu Alexis K.h.Lau Division of Environment and Sustaina.ility The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China institute for the Environment The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China institute for the Environment and Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China institute for the Environment and Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyKowloonHong Kong 000000China

Toxic air pollutants(TAPs)are a class of airborne chemicals known or suspected to cause serious health *** study,applying positive matrix factoriza.ion and inhala.ion unit risk estimates of TAPs,quantifies the changes in significant sources contributing to inhala.ion cancer risks(iCRs)from 2000 to 2020 in hong Kong,*** iCR decreased from 1701 to 451 cases per million between 2000−2004 and 2016−2020,largely attributed to the reduction in diesel particulate matter(DPM),gasoline and solvent use-related vola.ile orga.ic compounds(VOCs),and coal/biomass combustion-related polycyclic aroma.ic hydrocarbons and metal(loid)*** regional contribution of VOCs associated with industrial and halogenated solvent sources increased substantially,representing the largest non-DPM iCR contributor(37%)in 2016−2020,stressing the need for a more comprehensive risk evalua.ion across the fast-growing and densely populated Greater bay Area(Gba).iCRs in hong Kong and the Gba will likely remain over 100 cases per million by *** contributions to ozone forma.ion potential of VOC/carbonyl sources were quantified,which show a notable shift from being solvent/gasoline-dominant in 2000−2004 to being more evenly shared by va.ious sources in 2016−*** a similar TAP monitoring network in the GBa.is anticipated to provide the monitoring data needed to fa.ilitate the development of more informed air qua.ity management strategies.

关键词： toxic air pollutant hazardous air pollutant health risk assessment source apportionment ozone forma.ion potential air qua.ity management

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亚致死浓度的铜对虹鳟生理指标的影响

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动物学杂志 1999年第4期34卷 52-55页

作者： kaЗ.,h BoC.,MЗ 立陶宛生态学研究所

外部环境决定着有机体的功能状态；当有机体与外部环境之间相互关系遭到破坏时，无论机体的生理系统，还是其调节机能都会发生变化。生理指标反映出物体内环境对外部作用作出的反应，以此可确定外部作用的强度，阐明作用机制，确定机体... 详细信息

外部环境决定着有机体的功能状态；当有机体与外部环境之间相互关系遭到破坏时，无论机体的生理系统，还是其调节机能都会发生变化。生理指标反映出物体内环境对外部作用作出的反应，以此可确定外部作用的强度，阐明作用机制，确定机体的适应能力，并预测其影响（Хайн...

关键词：虹鳟铜亚致死浓度生理指标

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A-site ordered state in manga.ites with perovskite-like structure based on optimally doped compounds Ln0.70ba0.30MnO3（Ln=Pr,Nd）

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Journal of Rare Earths 2019年第11期37卷 1242-1249页

作者： S.V.Trukhanov VA Khomchenko D.V.karpinsky M.V.Silibin A.V.Trukhanov L.S.Lobanovsky h.Szymczak C.E.Botez i.O.Troyanchuk Na.ional University of Science and Technology MiSiS 119049 MoscowLeninsky Av.4Russia South Ural State University 454080 ChelyabinskLenin Av.76Russia Scientific-Practical Materials Research Centre of NASB 220072 MinskBelarus CFisUC Department of PhysicsUniversity of Coimbra3004-516 CoimbraPortugal Na.ional Research University of Electronic Technology"MiET 124498 ZelenogradMoscowRussia institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University2-4 Bolshaya Pirogovskaya St.119991 MoscowRussia institute of Physics Polish Academy of Sciences02-668 WarsawPoland The University of Texas at El Paso El PasoTX 79968-0515USA

in this paper,we report on the crystal structure and magnetic properties of the nano structured baordered phases of rare-earth manga.ites obtained from the optimally doped solid solutions Ln0.70ba0.30MnO3(Ln=Pr,Nd).The materials were studied by X-ray diffraction,scanning electron microscopy,energy dispersive spectroscopy and SQUiD-magnetometry *** is found that states with different degrees of ca.ion ordering in the A-sublattice of the ABO3 perovskite can be obtained by employing special conditions of chemical *** particular,reduction of the parent compounds results in the forma.ion of a nanocomposite containing ferrimagnetic a.ion-deficient ordered phase *** of the composite does not change an average size of the nanocrystallites,but drastically alters their phase composition to sta.ilize ferromagnetic stoichiometric ordered phase LnbaMn2O6 and ferromagnetic superstoichiometric disordered phase Ln0.90ba0.10MnO3+δ.it is shown that the magnetic properties of the materials are determined by the joint action of chemical(ca.ion ordering)and external(surface tension)pressures.

关键词： ionic order Magnetic transition Perovskite Manga.ite Rare earths

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Classifica.ion of ma.ine Ascomycota,Ba.idiomycota,Blastocla.iomycota and Chytridiomycota

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Fungal Diversity 2015年第4期73卷 1-72页

作者： E.B.Gareth Jones Sa.inee Suetrong Ja.iya Sakayaroj a.i h.ba.ka.i Mohamed A.Abdel-Wahab Teun Boekhout ka-Lai Pang Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Fungal Biodiversity Laboratory BIOTECNational Science and Technology Development Agency(NSTDA)113 Thailand Science ParkThanon PhahonyothinTombon Khlong NuengAmphoe Khlong LuangPathum Thani 12120Thailand Department of Botany Faculty of ScienceSohag UniversitySohagEgypt CBS Fungal Biodiversity Centre(KNAW) Uppsalalaan 83584CT UtrechtThe Netherlands institute of Ma.ine Biology and Center of Excellence for the Oceans Taiwan Ocean University2 Pei-Ning RoadKeelung 20224TaiwanRepublic of China

This paper lists the accepted names and classifica.ion of ma.ine fungi,upda.ing the scheme presented in *** classifica.ion includes 1,112 species(in 472 genera):Ascomycota 805(in 352 genera),Ba.idiomycota 21 species(in 17 genera),Chytridiomycota and related phyla 26 species(in 13 genera),Zygomycota three(in two genera),Blastocla.iomycota one species(one genus),asexual morphs of filamentous fungi 43(in 26 genera);and ma.ine yeasts:Ascomycota 138 species(in 35 genera),Ba.idiomycota 75 species(in 26 genera).These fungi belong to 129 fa.ilies and 65 *** halosphaeriaceae remains the largest fa.ily of ma.ine fungi with 141 species in 59 genera,while the most specious genera are Aspergillus(47 species),Penicillium(39 species)and the yeast genus Candida(64 species).The review includes details of recent higher order nomenclature changes,and accounts of new fa.ilies,genera and species described over the past 5 years.

关键词： Fungal classifica.ion Ma.ine fungi Molecular phylogeny New taxa Praelongicaulis gen nov Tirisporellales Torpedosporales ordo nov

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Regula.ion of adenosine triphosphate-sensitive potassium channels suppresses the toxic effects of amyloid-beta peptide(25-35)

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Neural Regenera.ion Research 2013年第1期8卷 56-63页

作者： Min Kong Maowen ba hui Liang Peng Shao Tianxia Yu Ying Wang Department of Neurology Yantaishan Hospital Department of Neurology Yuhuangding Hospital Affiliated to Qingdao Medical University

in this study, we treated PC12 cells with 0-20 μM amyloid-β peptide （25-35） for 24 hours to induce cytotoxicity, and found that 5-20 μM amyloid-β peptide （25-35） decreased PC12 cell via.ility, but adenosine triphosphate-sensitive potassium channel activator diazoxide suppressed the decrease in PC12 cell via.ility induced by amyloid-β peptide （25-35）. Diazoxide protected PC12 cells against amyloid-β peptide （25-35）-induced increases in mitochondrial membrane potential and intracellular reactive oxygen species levels. These protective effects were reversed by the selective mitochondrial adenosine triphosphate-sensitive potassium channel blocker 5-hydroxydecanoate. An inducible nitric oxide synthase inhibitor, Nw-nitro-L-arginine, also protected PC12 cells from amyloid-β peptide （25-35）-induced increases in both mitochondrial membrane potential and intracellular reactive oxygen species levels. however, the h202-degra.ing enzyme catalase could not reverse the amyloid-β peptide （25-35）-induced increase in intracellular reactive oxygen species. A 24-hour exposure to amyloid-13 peptide （25-35） did not result in apoptosis or necrosis, suggesting that the increases in both mitochondrial membrane potential and reactive oxygen species levels preceded cell death. The data suggest that amyloid-β peptide （25-35） cytotoxicity is associated with adenosine triphosphate-sensitive potassium channels and nitric oxide. Regula.ion of adenosine triphosphate-sensitive potassium channels suppresses PC12 cell cytotoxicity induced by amyloid-β peptide （25-35）.

关键词： neural regenera.ion neurodegenera.ive diseases amyloid-β peptide (25-35) PC12 cell adenosinetriphosphate-sensitive potassium channel inducible nitric oxide synthase mitochondrial membranepotential reactive oxygen species grant-supported paper photographs-containing paper neuroregenera.ion

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Assessing Sexual Function amongst hong Kong Chinese Pa.ients with Gynecological Cancer： Transla.ion and Va.ida.ion of the Sexual Function-Va.inal Changes Questionnaire （SVQ）

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Clinical oncology and cancer researeh 2010年第4期7卷 230-233页

作者： ka-ming ChOW Winnie K.W. SO Carmen W.h. ChAN Prince of Wales hospital Hong Kong SARChina The Nethersole School of Nursing Hong Kong SAR China The Chinese University of hong Kong Hong Kong SAR China The Chinese University of hong Kong Hong Kong SAR China.

OBJECTiVE The study aims to translate the Sexual FunctionVa.inal Changes Questionnaire （SVQ） into Chinese and to establish its psychometric *** A Chinese SVQ was developed by the use of the Brislin model of transla.ion. The content va.idity and semantic equivalence were assessed by an expert panel. The translated version of SVQ was administered to 75 hong Kong Chinese women who were suffered from gynecological cancer to test its psychometric *** The Chinese version of SVQ was compared to the original study for factor analysis. internal consistency, itemtoscale correla.ions and test-retest relia.ility were high. The convergent and divergent va.idities supported the Chinese SVQ to CONCLUSiON We conclude that the Chinese SVQ appears to be a va.id, reliable and fea.ible disease-specific tool for the assessment of sexual function among Chinese pa.ients.

关键词： sexual function-va.inal changes questionnaire sexual function hong Kong Chinese

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Mecha.ism of metasta.is by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第40期11卷 6269-6276页

作者： Ying-Chi ip Siu-Tim Cheung ka-Ling Leung Sheung-Tat Fan Centre for the Study of Liver Disease and Department of Surgery

AiM To investigate the precise role of membrane type 1-matrix metalloproteinase （NTi-NNP） in hepatocellular carcinoma （hCC） metasta.is. METhODS- human hCC cells hep3B with overexpression of MTT-MMP were established by stable transfection, and compared with control cells carrying the empty vector. Cells were exa.ined in vivo for their differences in the metasta.ic a.ility of athymic nude mice, and analyzed in vito for their differences in inva.ion a.ility by inva.ion chamber coated with Matrigel, adhesion towards collagen i and migra.ion through culture chamber. Cell prolifera.ion and apoptosis in adherent and suspension status were evaluated by MTr and flow cytometry analysis. RESULTS We found that overexpression of MT1-MMP could increase intrahepa.ic metasta.is in nude mice with orthotopic implanta.ion of hCC cells （incidence of 100% [MT1-MMP transfectants] vs 40% [vector control transfectants], P〈0.05）. NT1-MMP could also enhance cell inva.ion through Natrigel （107.7 vs 39.3 cells/field, P〈0.001）, adhesion towards matrix （0.30 vs 0.12 absorbance unit at 540 nm, P〈0.001）, cell migra.ion （89.3 vs 39.0 cells/field, P〈0.001）, and cell prolifera.ion （24.3 vs 40.5 h/doubling, P〈0.001）. We also observed that NTi-NNP supported cell survival （71.4% vs 23.9%, P〈0.001） with reduced apoptosis （43.7% vs51.0%, P〈0.05） in an attachment-free environment. CONCLUSiON： MT1-MMP overexpression could enhance metasta.is. in addition to its active role in matrix degrada.ion during tumor inva.ion, MT1-MMP enhances tumor cell survival upon challenge of detachment, which is important during metasta.is when cells enter the circula.ion.

关键词： MT1-MMPiMMP14 Liver cancer inva.ion Metasta.is

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RP-NBSR: A Novel Network Attack Detection Model based on Machine Learning

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Computer Systems Science & Engineering 2021年第4期37卷 121-133页

作者： Zihao Shen hui Wang Kun Liu Peiqian Liu Menglong ba MengYao Zhao School of Computer Science&Technology Henan Polytechnic UniversityJiaozuo Henan454000China College of Computer Science&Technology Jilin UniversityChangchun Jilin130012China Department of Computer Science University College LondonLondonUnited Kingdom

The ra.id progress of the internet has exposed networks to an increasednumber of threats. intrusion detection technology can effectively protect networksecurity against ma.icious attacks. in this paper, we propose a ReliefF-P-Naivebayes and softmax regression (RP-NBSR) model based on machine learningfor network attack detection to improve the false detection rate and F1 score ofunknown intrusion beha.ior. in the proposed model, the Pearson correla.ion coef-ficient is introduced to compensate for deficiencies in correla.ion analysis betweenfeatures by the ReliefF feature selection algorithm, and a ReliefF-Pearson correla.ion coefficient (ReliefF-P) algorithm is proposed. Then, the Relief-P algorithm isused to preprocess the UNSW-NB15 dataset to remove irrelevant features andobtain a new feature subset. Finally, naïve bayes and softmax regression (NBSR)classifier is constructed by casca.ing the naïve bayes classifier and softmaxregression classifier, and an attack detection model based on RP-NBSR is established. The experimental results on the UNSW-NB15 dataset show that the attackdetection model based on RP-NBSR has a lower false detection rate and higherF1 score than other detection models.

关键词： Naïve bayes softmax regression machine learning ReliefF-P attack detection

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