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Occupational physical activity, all-cause, cardiovascular disease, and cancer mortality in 349,248 adults: Prospective and longitudinal analyses of the MJ Cohort

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Journal of Sport and Health Science 2024年第4期13卷 579-589页

作者： Emmanuel Stamatakis Matthew N.Ahmadi Tiana-Lee Elphick Bo-Huei Huang Susan Paudel Armando Teixeira-Pinto Li-jung Chen Borja del Pozo Cruz Yun-ju Lai Andreas Holtermann Po-Wen Ku Sydney School of Health Sciences Faculty of Medicine and HealthCharles Perkins CentreUniversity of SydneySydneyNSW 2006Australia Sydney School of Public Health Faculty of Medicine and HealthUniversity of SydneySydneyNSW 2006Australia Department of Exercise Health Science “National”Taiwan University of SportTaichung 40404China Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark Division of endocrinology and Metabolism Department of Internal MedicinePuli Branch of Taichung Veterans General HospitalNantou 54552China National Research Centre for the Working environment Copenhagen 2100Denmark Graduate Institute of Sports and Health Management “National”Chung Hsing UniversityTaichung 40227China

Background:Evidence on the health benefits of occupational physical activity(OPA)is *** examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer mortality and survival ***:This study included prospective and longitudinal data from the MJ Cohort,comprising adults over 18 years recruited in 1998-2016,349,248 adults(177,314 women)with baseline OPA,of whom 105,715(52,503 women)had 2 OPA measures at 6.3±4.2 years(mean±SD)*** were baseline OPA,OPA changes,and baseline leisure-time physical ***:Over a mean mortality follow-up of 16.2±5.5 years for men and 16.4±5.4 years for women,11,696 deaths(2033 of CVD and 4631 of cancer causes)in men and 8980 deaths(1475 of CVD and 3689 of cancer causes)in women *** moderately heavy/heavy baseline OPA was beneficially associated with all-cause mortality in men(multivariable-adjusted hazard ratio(hr)=0.93,95%confidence interval(95%CI):0.89-0.98 compared to light OPA)and women(hr=0.86,95%CI:0.79-0.93).Over a mean mortality follow-up of 12.5±4.6 years for men and 12.6±4.6 years for women,OPA decreases in men were detrimentally associated(hr=1.16,95%CI:1.01-1.33)with all-cause mortality,while OPA increases in women were beneficially(hr=0.83,95%CI:0.70-0.97)associated with the same *** or changes in OPA showed no associations with CVD or cancer ***:Higher baseline OPA was beneficially associated with all-cause mortality risk in both men and *** longitudinal OPA analyses partly confirmed the prospective findings,with some discordance between sex groups.

关键词： Cancer Cardiovascular disease Epidemiology Mortality

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Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

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Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao LI Hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG Qiu-ju DenG Yong-Chen HAO Na YANG Li-Zhen HAN Zhao YANG Ping-Ping JIA Yue QI Jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(hr)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(hr=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(hr=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity

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Analysis of Bright Source Hardness Ratios in the 4 yr Insight-HXMT Galactic Plane Scanning Survey Catalog

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Research in Astronomy and Astrophysics 2024年第2期24卷 154-170页

作者： Chen Wang Jin-Yuan Liao ju Guan Yuan Liu Cheng-Kui Li Na Sai Jing Jin Shuang-Nan Zhang Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Astronomy School of Physics and TechnologyWuhan UniversityWuhan 430072China WHU-NAOC Joint Center for Astronomy Wuhan UniversityWuhan 430072China

We conduct a statistical analysis of the hardness ratio(hr)for bright sources in the 4 yr Galactic Plane Scanning Survey catalog of *** on the stable(variable)flux F_(s)(F_(v))or spectrum S_(s)(S_(v))of each source,the bright sources are classified into three groups:F_(v)&S_(v),F_(v)&S_(s),and F_(s)&_(s).Our study of the hr characteristics in different types of sources reveals that accretion-powered neutron star(NS)low-mass X-ray binaries(LMXBs)exhibit softer energy spectra than NS high-mass X-ray binaries(HMXBs),but harder energy spectra than black hole binaries in most *** difference is probably due to their different magnetic field ***,Fv&Sv LMXBs tend to be harder than Fv&Ss LMXBs below 7 keV,while the opposite is true for *** results suggest that LMXBs may dominate unclassified sources,and NS binaries are likely to be the primary type of X-ray binaries with ambiguous compact *** comparing the hr of transient sources in their outburst and low-flux states,it is found that the averaged hr of four sources in the two states are roughly comparable within *** also investigate the spatial properties of the three groups and find that Fv&Sv sources are mainly located in the longitude of-20°entrated in 19°hr spatial distributions shows the absorption of soft X-rays(primarily below 2 keV)in the Galactic Plane.

关键词： catalogs-surveys-methods data analysis-X-rays general

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Tissue inhibitor of metalloproteinase-3 expression affects clinicopathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma

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World Journal of Hepatology 2024年第8期16卷 1131-1144页

作者： Qiu-ju Liang Qin-Qin Long Feng-Qin Tian Qun-Ying Su Xiao-Ying Zhu Xi-Dai Long Clinicopathological Diagnosis and Research Center The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Tumor Pathology Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education InstitutesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND The dysregulation of tissue inhibitor of metalloproteinase-3(TIMP3)was positively correlated with the progression of hepatocellular carcinoma(HCC).However,it is not clear whether TIMP3 expression is associated with the clinico-pathological features and prognosis of aflatoxin B1(AFB1)-related HCC(AHCC).A retrospective study,including 182 patients with AHCC,was conducted to explore the link between TIMP3 expression in cancerous tissues and the clinico-pathological characteristics and prognosis of ***3 expression was detected by immunohistochemistry and its effects on the clinicopathological features and prognosis of AHCC were evaluated by Kaplan-Meier survival analysis and Cox regression survival *** ratio,hazard ratio(hr),median overall survival time(MST),median tumor recurrence-free survival time(MRT),and corresponding 95%confidential interval(CI)was calculated to RESULTS Kaplan-Meier survival analysis showed that compared with high TIMP3 expression,low TIMP3 expression in tumor tissues significantly decreased the MST(36.00 mo vs 18.00 mo)and MRT(32.00 mo vs 16 mo)of patients with *** Cox regression survival analysis further proved that decreased expression of TIMP3 increased the risk of death(hr=2.85,95%CI:2.04-4.00)and tumor recurrence(hr=2.26,95%CI:1.57-3.26).Furthermore,decreased expression of TIMP3 protein in tissues with AHCC was significantly correlated with tumor clinicopatho-logical features,such as tumor size,tumor grade and stage,tumor microvessel density,and tumor blood ***,TIMP3 protein expression was also negatively associated with amount of AFB1-DNA adducts in tumor *** These findings indicate that the dysregulation of TIMP3 expression is related to AHCC biological behaviors and affects tumor outcome,suggesting that TIMP3 may act as a prognostic biomarker for AHCC.

关键词： Tissue inhibitor of metalloproteinase-3 expression Aflatoxin B1 Hepatocellular carcinoma Clinicopathological feature Prognosis

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Effectiveness and Safety of Qishen Yiqi Dripping Pill in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention:3-Year Results from a Multicentre Cohort Study

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Chinese Journal of Integrative Medicine 2024年第10期30卷 877-885页

作者： BAI Rui-na GU Feng CHE Qian-zi ZHANG Xuan CAI Ya-jie XI Rui-xi ZHAO Yang GUO Ming DONG Guo-ju GAO Zhu-ye FU Chang-geng WANG Pei-li DU Jian-peng ZHANG Da-wu DUAN Wen-hui LI Li-zhi YANG Qiao-ning SHI Da-zhuo Department of Cardiovascular Xiyuan Hospital China Academy of Chinese Medical Sciences National Clinical Research Center for Chinese Medicine Cardiology Department of Evidence-Based Medicine Basic Research Laboratory Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Department of Traditional Chinese Medicine Beijing Shangdi Hospital National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine

Objectives: To evaluate the effectiveness and safety of Qishen Yiqi Dripping Pill(QSYQ) in patients with acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI). Methods: This multicentre prospective cohort study was conducted at 40 centers in China. Patients with ACS after PCI entered either the QSYQ or Western medicine(WM) groups naturally based on whether they had received QSYQ before enrollment. QSYQ group received QSYQ(0.52 g, 3 times a day for 12 months) in addition to WM. The primary endpoint included cardiac death, non-fatal myocardial infarction, and urgent revascularization. The secondary endpoint included rehospitalization due to ACS, heart failure, stroke, and other thrombotic events. Quality of life was assessed by the Seattle Angina Questionnaire(SAQ). Results: A total of 936 patients completed follow-up of the primary endpoint from February 2012 to December 2018. Overall, 487 patients received QSYQ and WM. During a median follow-up of 566 days(inter quartile range, IQR, 517–602), the primary endpoint occurred in 46(9.45%) and 65(14.48%) patients in QSYQ and WM groups respectively [adjusted hazard ratio(hr) 0.60, 95% confidence interval(CI) 0.41–0.90; P=0.013]. The secondary endpoint occurred in 61(12.53%) and 74(16.48%) patients in QSYQ and WM groups, respectively(adjusted hr 0.76, 95% CI 0.53–1.09; P=0.136). In sensitivity analysis, the results still demonstrated that WM combined with QSYQ reduced the risk of the primary endpoint(hr 0.67, 95% CI 0.46–0.98; P=0.039). Moreover, QSYQ improved the disease perception domain of the SAQ(Pents with ACS after PCI, QSYQ combined with WM reduced the incidence of the primary endpoint. These findings provide a promising option for managing ACS after PCI and suggest the potential treatment for reducing the risk of primary endpoint included cardiac death, non-fatal myocardial infarction, and urgent revascularization through intermittent administration of QSYQ.(Registra

关键词： Qishen Yiqi Dripping Pill acute coronary syndrome percutaneous coronary intervention primary and secondary endpoint

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大气PM_(2.5)暴露与帕金森病关系的meta分析

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环境与职业医学 2024年第2期41卷 168-174页

作者：王一先吴建军胡睿居静娟温州医科大学公共卫生学院浙江温州325035

[背景]现有研究提示大气细颗粒物(PM_(2.5))暴露与帕金森病(PD)可能存在关联,但目前的流行病学研究结论尚不一致。[目的]系统评价大气PM_(2.5)暴露与PD发病风险的相关性,并探讨可能的影响因素,以期为PD早期预防策略的制定提供相关信息。... 详细信息

[背景]现有研究提示大气细颗粒物(PM_(2.5))暴露与帕金森病(PD)可能存在关联,但目前的流行病学研究结论尚不一致。[目的]系统评价大气PM_(2.5)暴露与PD发病风险的相关性,并探讨可能的影响因素,以期为PD早期预防策略的制定提供相关信息。[方法]检索The Cochrane Library、PubMed、Web of Science、Medline、Embase、中国知网(CNKI)、万方和维普中文科技期刊数据库,检索词包括:帕金森病、PM_(2.5)、细颗粒物、Parkinson’disease、particulate matter 2.5。搜集关于大气中PM_(2.5)暴露与PD发生风险相关的队列研究,从各数据库建库检索至2023年6月26日。对文献进行筛选,提取纳入研究及其研究对象的基本信息、各研究的结局指标和结果测量数据以及主要偏倚风险的评估内容,用纽卡斯尔-渥太华量表评估纳入队列研究的文献质量,并使用Stata 15.0对数据进行meta分析、亚组分析、敏感性分析及发表偏倚风险评估。[结果]经筛选,纳入队列研究数12个,包括17443136例参与者,随访时间为3.5~22年,采用随机效应模型进行meta分析,结果显示:大气中PM_(2.5)暴露可使PD的发生风险增加6%[hr=1.06(95%CI:1.02~1.11),P=0.006]。亚组分析结果显示:大气PM_(2.5)的暴露使北美和东亚地区人群PD的发生风险分别增加6%[hr=1.06(95%CI:1.00~1.12),P=0.033]和17%[hr=1.17(95%CI:1.02~1.33),P=0.020],但对欧洲人群的影响无统计学意义。与平均年龄60岁人群不同,平均年龄≥60岁人群在PM_(2.5)暴露后,PD的发生风险可升高7%[hr=1.07(95%CI:1.02~1.14),P=0.011]。不同质量浓度(简称浓度)的PM_(2.5)暴露均能增加PD的发生风险。是否校正PD相关合并症不影响大气PM_(2.5)暴露可增加PD发生风险的结论。随访时间≥5年、PD发生数≥1000例的纳入研究提示大气PM_(2.5)暴露可显著增加PD的发生风险[hr=1.06(95%CI:1.01~1.12),P=0.012;hr=1.06(95%CI:1.01~1.11),P=0.027],相反地,随访时间hr=1.09(95%CI:0.95~1.26),P=0.214;hr=1.12(95%CI:0.98~1.02),P=0.092]。敏感性分析结果显示本研究结果具有较好的稳定性。发表偏倚风险评估联合剪补法结果显示本研究结果稳健。[结论]大气中PM_(2.5)暴露可增加PD的发病风险,不同地区和年龄是影响PD发生风险的因素,随访时间和纳入的PD发生数可能影响研究结果。

关键词：帕金森病细颗粒物大气污染 meta分析

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内置亥姆霍兹谐振器阵列的蜂窝微穿孔吸声体设计及性能分析

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声学技术 2024年第4期43卷 527-535页

作者：李琦吴锦武琚欣陈明浩南昌航空大学飞行器工程学院江西南昌330063

蜂窝微穿孔结构广泛用于吸声降噪领域,因此必须有良好的宽频带吸声降噪的性能使用要求。为弥补单层微穿孔板结构低频吸声性能的不足,实现中低频宽带降噪,文章在传统的单层微穿孔板结构单元基础上引入了亥姆霍兹谐振器(Helmholtz Resonat... 详细信息

蜂窝微穿孔结构广泛用于吸声降噪领域,因此必须有良好的宽频带吸声降噪的性能使用要求。为弥补单层微穿孔板结构低频吸声性能的不足,实现中低频宽带降噪,文章在传统的单层微穿孔板结构单元基础上引入了亥姆霍兹谐振器(Helmholtz Resonator,hr)阵列的支撑结构,并基于粒子群优化(Particle Swarm Optimization,PSO)算法对设计的吸声体结构进行吸声性能优化。通过数值分析、有限元仿真和实验测试验证了内置hr阵列的蜂窝微穿孔吸声体的宽频带吸声特性。分析结果表明,内置hr阵列的蜂窝微穿孔吸声体经过优化设计在中低频吸声性能良好,在200~400 Hz频率范围内吸声性能明显改善,在0~1000 Hz频率范围内超过65%吸声效率的带宽占比达到70%以上。

关键词：亥姆霍兹(Helmholtz)谐振器蜂窝结构低频宽带微穿孔板粒子群优化(PSO)算法

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床旁超声指导下早期液体复苏对脓毒症休克患者血流动力学及终点事件的影响

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中华医院感染学杂志 2024年第1期34卷 134-138页

作者：杨利利景云烟林菊王斌王辉杭州师范大学附属医院重症监护室浙江杭州310000

目的探讨床旁超声指导下早期液体复苏在脓毒症休克患者中的应用效果,以及对患者血流动力学及终点事件发生情况的影响。方法选取2019年1月-2022年12月杭州师范大学附属医院重症监护室(ICU)收治的脓毒症休克患者86例为研究对象,根据早期... 详细信息

目的探讨床旁超声指导下早期液体复苏在脓毒症休克患者中的应用效果,以及对患者血流动力学及终点事件发生情况的影响。方法选取2019年1月-2022年12月杭州师范大学附属医院重症监护室(ICU)收治的脓毒症休克患者86例为研究对象,根据早期液体复苏治疗方法的不同将其分为对照组42例和试验组44例。对照组于脉搏指示连续心排血量(PICCO)指导下行早期液体复苏,试验组于床旁超声指导下行早期液体复苏,比较两组治疗后24、48 h的总液体量,治疗前和治疗后24 h炎症因子、血流动力学指标水平及终点事件发生情况。结果试验组治疗后24 h、48 h的液体输入量及正平衡量均低于对照组(P6(IL-6)及心率(hr)均降低(P<0.05),且试验组低于对照组(P<0.05);中心静脉压(CVP)、平均动脉压(MAP)及中心静脉血氧饱和度(ScvO_(2))均升高(P<0.05),且试验组高于对照组(P<0.05);与对照组比较,试验组持续肾脏替代治疗、3 d内肺水肿患者占比更低(P<0.05),机械通气及住院时间更短(P<0.05)。结论床旁超声指导下早期液体复苏可有效减少脓毒症休克患者液体复苏量,并可有效调节患者炎症因子及血流动力学指标水平,减轻机体炎症,改善血流动力学,进而有利于改善患者临床结局。

关键词：脓毒症休克床旁超声液体复苏血流动力学终点事件

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不同剂量瑞马唑仑用于颅内动脉瘤血管介入术麻醉的临床研究

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中国临床药理学杂志 2024年第13期40卷 1860-1864页

作者：郑德利王巨增陈欢李慧利史记孟莉河北医科大学第一医院麻醉科河北石家庄050000 河北医科大学第一医院介入治疗科河北石家庄050000 河北医科大学第一医院神经内科河北石家庄050000

目的探究不同剂量瑞马唑仑全麻在颅内动脉瘤血管介入术麻醉中的应用效果及安全性分析。方法以颅内动脉瘤患者为研究对象,按照随机数字表法分为高、中和低剂量组。患者入室后开放静脉通路,密切监测生命体征,低、中、高剂量组分别静脉注... 详细信息

目的探究不同剂量瑞马唑仑全麻在颅内动脉瘤血管介入术麻醉中的应用效果及安全性分析。方法以颅内动脉瘤患者为研究对象,按照随机数字表法分为高、中和低剂量组。患者入室后开放静脉通路,密切监测生命体征,低、中、高剂量组分别静脉注射注射用瑞马唑仑0.25、0.30和0.35 mg·kg^(-1),待意识消失后均给予阿芬太尼、米库氯铵进行麻醉诱导。比较3组麻醉效果、苏醒质量及麻醉诱导前(T0)、置入喉罩时(T1)、栓塞时(T2)、术毕5 min(T3)和术毕30 min(T4)血流动力学指标、脑血流动力学指标、神经功能指标,并统计患者术后脑血管痉挛(CVS)、迟发性缺血性神经功能障碍(DIND)发生率及麻醉相关药物不良反应发生率。结果高、中和低剂量组的麻醉起效时间分别为(5.03±1.28)、(5.17±1.09)和(7.21±1.15)min,麻醉补救次数分别为(0.12±0.02)、(0.21±0.06)和(1.51±0.23)次,高、中剂量组上述指标与低剂量组比较,在统计学上差异有统计学意义(均P6%,T2时的平均动脉压(MAP)分别为(87.06±6.02)、(86.85±5.61)和(81.09±5.37)mmHg,T4时的MAP分别为(92.05±5.13)、(87.57±6.29)和(84.42±5.16)mmHg,高剂量上述指标与低剂量组比较,在统计学上差异有统计学意义(均Phr)、血氧饱和度(SpO_(2))及左侧大脑中动脉峰值血流速度(Vp-MCA)、左侧大脑中动脉平均血流速度(Vm-MCA)及搏动指数(PI)、各时间段特异性蛋白100β(S100β蛋白)、神经元特异性烯醇化酶(NSE)水平比较,在统计学上差异均无统计学意义(均P>0.05)。3组CVS、DIND发生率及麻醉相关药物不良反应发生率比较,在统计学上差异均无统计学意义(均P>0.05)。结论不同剂量瑞马唑仑全麻在颅内动脉瘤血管介入治疗麻醉的安全性均较高,且对脑血流动力学及神经功能的影响相当,但高剂量瑞马唑仑全麻诱导时间较短、术中麻醉补救次数较少,而高剂量瑞马唑仑术后氟马西尼拮抗治疗率较高。

关键词：瑞马唑仑用药剂量麻醉氟马西尼拮抗治疗颅内动脉瘤脑血流动力学神经功能安全性

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高频振荡通气联合西地那非治疗新生儿持续性肺动脉高压的有效性及不良反应分析

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当代医学 2024年第4期30卷 74-77页

作者：李晓琳李举郭磊平邑县人民医院新生儿科山东临沂273300

目的探讨高频振荡通气联合西地那非治疗新生儿持续性肺动脉高压(PPHN)的效果。方法选取2020年1月至2021年12月平邑县人民医院收治的80例PPHN新生儿作为研究对象,采用奇偶数法分为研究组与对照组,每组40例。对照组采用高频振荡通气治疗,... 详细信息

目的探讨高频振荡通气联合西地那非治疗新生儿持续性肺动脉高压(PPHN)的效果。方法选取2020年1月至2021年12月平邑县人民医院收治的80例PPHN新生儿作为研究对象,采用奇偶数法分为研究组与对照组,每组40例。对照组采用高频振荡通气治疗,研究组采用高频振荡通气联合西地那非治疗。比较两组临床疗效、血气指标及不良反应发生率。结果研究组治疗总有效率为92.50%,高于对照组的72.50%,差异有统计学意义(Phr)均慢于治疗前,且研究组PAP低于对照组,hr慢于对照组,差异有统计学意义(P<0.05),而两组治疗前后体循环血压(SBP)组内及组间比较差异无统计学意义。两组不良反应发生率比较差异无统计学意义。结论高频振荡通气联合西地那非治疗PPHN效果佳,可改善血气指标,且不增加不良反应发生风险。

关键词：新生儿持续性肺动脉高压高频振荡通气西地那非疗效不良反应

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