检索结果-南通市图书馆

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed tayeb Ikhwan Yuda Kusuma Alaa A.M.Osman Renáta Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Education in Cambodia:Students’Perspectives toward Education and Active Learning Activities

Education in Cambodia:Students’Perspectives toward Educatio...

引用

2012 2nd International Conference on Humanities, Historical and Social Sciences (CHHSS 2012)

作者： Endear Van Kimsru Duth Phasy Res Ney Sométa samouy hour Sorya Seang Sreymom Eng Sreymom Pol Asian University for Women Bangladesh

This paper is a case-study report on the project Shaping New Ways to Approach Education in Cambodia,which surveyed over 1200 secondary students in 8 schools from 3 provinces and one capital city in Cambodia to find out students’ perspectives toward education,as well as implementing innovative activities to introduce active learning *** project has had an empirical component and an action research *** empirical component has been survey based to explore students’ attitudes towards *** conducted our first survey in 2010 and found that students value education;however,they had difficulties regarding low self-esteem,lack of inspiration,worst of all,they perceive that cheating during exam is *** verify the first survey’s findings,we re-conducted the survey in *** to the first survey results,the second survey showed that students valued education since 96% of students believe that education is important and more than 83% want to pursue higher education regardless of their social-economic *** findings also shows that family problems and poverty are the most common factors discouraging students to continue education and teachers are seen as the main actor encouraging students to continue *** the second survey,we also conducted educational workshops designed in response to the first survey *** this action-research component,we had 200 secondary students in two schools to join our workshops regarding improving their leadership,communication,and creativity skills through a range of active learning activities,including diary writing,presenting,creating cards,reading about the life stories of successful individuals as well as showing them *** found that students were enthusiastic to learn and participate in our workshops;they tried to share ideas in their dairies,demonstrated enormous creativity in the cards making,and applied their limited knowledge to solve their community ***

关键词： Cambodia Students’ perspective Education Leadership Active learning

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Voltage property analysis of piezoelectric floating mass actuator used in middle ear implant

引用

Journal of Southeast University(English Edition) 2009年第4期25卷 496-500页

作者：刘后广塔娜饶柱石上海交通大学机械系统与振动国家重点实验室上海200240

Aiming at a kind of middle ear implant（MEI）, the driving voltage of a piezoelectric floating mass actuator is analyzed using a 0. 7Pb （Mg1/3Nb2/3） O3-0. 3PbTiO3 （ PMN- 30% PT）stack as a new type of vibrator. For the purpose of facilitating the analysis, a simplified coupling model of the ossicular chain and the piezoelectric actuator is constructed. First, a finite element model of a human middle ear is constructed by reverse engineering technology, and the validity of this model is confirmed by comparing the simulated motion of the stapes footplate obtained by this model with experimental measurements. Then the displacement impedance of the incus long process is analyzed, and a single mass-spring-damper equivalent model of the ossicular chain attached with the clamp is derived. Finally, a simplified coupling model of the ossicular chain and the piezoelectric actuator is established and used to analyze the driving voltage property of the actuator. The results show that the required driving voltage decreases with the increase in the frequency, and the maximum required driving voltage is 20. 9 V in the voice frequencies. However, in the mid-high frequencies where most sensorineural hearing loss occurs, the maximum required driving voltage is 3.8 V, which meets the low-voltage and low-power requirements of the MEI.

关键词： middle ear implant piezoelectric actuator floating mass driving voltage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

(E)-2-Benzylidenecycloalkanones XII.*Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry

引用

Spectral Analysis Review 2015年第1期3卷 1-8页

作者： Beáta Veliká Vladimíra Tomecková Krisztina Fodor Ivan Kron Pál Perjési Department of medical Chemistry Biochemistry and Clinical BiochemistryFaculty of Medicine UPJSTrieda SNP 1KosiceSlovakia Institute of Pharmaceutical Chemistry University of PécsPécsHungary

UV-VIS spectroscopic investigations of interaction of bovine and human serum albumin with selected chalcones (1) and their cyclic chalcone analogues: (E)-2-(4’-X-benzylidene-1-tetralones (3), benzosuberones (4) with dimethylamino and methoxy substituents and (E)-2-(2’,4’-dimethox- ybenzylidene)-1-indanone (2) were performed in polar respiration medium. Absorption maxima of the tested compounds were investigated in the presence of bovine and human serum albumin at the 0, 10, 30 and 60 minute timepoints of the interaction. The absorbance of all studied compounds in the presence of proteins decreased after one hour of the reaction. Molecule 4a showed the strongest and fastest kinet initial interaction with both albumins.

关键词： Chalcones Cyclic Chalcone Analogues UV Spectra Kinetic Measurements Binding Constant Bovine Serum Albumin Human Serum Albumin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高分辨率超声Lamb波频散曲线测量与板厚估计

引用

数据采集与处理 2017年第2期32卷 286-292页

作者：许凯亮张正罡刘丹他得安胡波巴黎第六大学法国国家科学研究院国家卫生与医学研究院生物医学成像实验室(LIB) 法国巴黎75006 复旦大学电子工程系上海200433 上海市医学图像处理与计算机辅助手术重点实验室上海200032

超声Lamb波在工业无损检测与评价中具有广阔的应用前景。但受制于超声导波多模式频散与混叠的影响,如何实现高分辨率超声导波的模式分离与频散曲线提取,进而定量分析材料的健康状况一直是研究的热点与难点。本文旨在将现代信号处理中广... 详细信息

超声Lamb波在工业无损检测与评价中具有广阔的应用前景。但受制于超声导波多模式频散与混叠的影响,如何实现高分辨率超声导波的模式分离与频散曲线提取,进而定量分析材料的健康状况一直是研究的热点与难点。本文旨在将现代信号处理中广泛采用的谱估计技术应用于超声Lamb波阵列信号分析,并通过提取频散曲线定量测量板厚度。以经典参数谱估计法中的Yule-Walker法与Burg法为例,实验测量和分析了3mm,4mm和5mm厚铝板中的宽带多模式Lamb波信号,准确地提取了铝板中的宽带Lamb波频散曲线,并比较了两种经典谱估计方法与二维傅氏变换法的性能,最终实现了铝板厚度估计。

关键词：超声Lamb波经典谱估计法频散曲线厚度估计无损检测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adjudin attenuates lipopolysaccharide-induced neuroinflammation

Adjudin attenuates lipopolysaccharide-induced neuroinflammat...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia-Xiang SHAO,Qian Reuben XIE,Ye-Wei LIU,Wei-Liang XIA~* Neuroscience and Neuroengineering Center,School of Biomedical Engineering and med-X Research Institute, Shanghai Jiao Tong University,Shanghai 200030,China

＜正＞Neuroinflammation caused by microglial activation plays a key role in brain *** are activated in response to diverse stimuli and release multiple inflammatory *** seek for new drugs to modulate neuroinflammation,we recently found that Adjudin,a potential non-hormonal male contraceptive,exhibits additional function to reduce production of proinflammatory mediators in lipopolysaccharide（LPS）-stimulated microglial *** our present study,one-hour Adjudin pretreatment reduced IL-6 and IL-ip mRNA levels in BV2 microglial ***-6 secretion was also reduced with Adjudin *** determine whether Adjudin might have similar effects in vivo,mice were given Adjudin（100 mg/kg,i.p.） 3 h before and post LPS injection（2.5 mg/kg,i.p.）. The results showed that Adjudin decreased the induction of IL-6 and IL-1P mRNA by LPS in the ***,our data suggest that Adjudin might mitigate neuroinflammation.

关键词： Adjudin neuroinflammation IL-6 IL-1β BV2 microglial cells lipopolysaccharide

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

重组人生长激素对肠源性内毒素血症大鼠急性肝损伤的影响

引用

解放军医学杂志 2011年第2期36卷 158-160页

作者：林英朱曦么改琦阿拉塔杨燕琳北京大学第三医院SICU 北京100191 北京大学第三医院中心实验室北京100191

目的观察重组人缺血生长激素(rh-GH)对肠源性内毒素血症(IETM)大鼠急性肝损伤的影响。方法 SD大鼠60只,随机分为正常对照(NC)组、肠梗阻缺血(IOI)组和生长激素(GH)组,其中每组又按不同时间点分为2个亚组,每个亚组10只大鼠。结扎回肠和... 详细信息

目的观察重组人缺血生长激素(rh-GH)对肠源性内毒素血症(IETM)大鼠急性肝损伤的影响。方法 SD大鼠60只,随机分为正常对照(NC)组、肠梗阻缺血(IOI)组和生长激素(GH)组,其中每组又按不同时间点分为2个亚组,每个亚组10只大鼠。结扎回肠和肠系膜血管制备肠梗阻缺血大鼠模型,GH组另经肌肉注射2.25U/(kg·d)重组人生卡激素(rh-GH)。于制模后36h和72h分别测定各组大鼠的平均动脉压(MAP),血清丙氨酸氨基转移酶(ALT)和总胆红素(TBIL)水平;分别采用鲎试剂法和ELIsa法测定血浆内毒素、肿瘤坏死因子(TNF)α和白细胞介素(IL)-1β的浓度;观察各组大鼠肝脏的组织病理学改变。结果与NC组相比,IOI组大鼠MAP在各时间点均显著降低(P<0.05),而GH组无明显改变;IOI组血浆内毒素含量在各时间点均明显高于NC组,而GH组仅在36h有所增加(P<0.05);IOI组和GH组在各时间点血浆TNFαI、L-1β、ALT和TBIL的浓度均显著高于NC组,但GH组较IOI组明显降低(P<0.05)。GH组在各时间点的肝脏病理改变均较IOI组明显改善。结论 rh-GH能显著改善IETM大鼠肝功能及肝脏组织病理学改变,其作用机制可能与减轻感染性休克的严重程度,降低血浆内毒素含量及炎症细胞因子的浓度有关。

关键词：内毒素血症人生长激素细胞因子类肝损伤

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

脉搏指示连续心输出量监测在感染性休克患者早期液体复苏中的临床价值

引用

检验医学与临床 2015年第11期12卷 1508-1510页

作者：唐宇涛俞宁广西壮族自治区人民医院急诊科南宁530021

目的探讨根据脉搏指示连续心输出量(PICCO)监测中的容量指标对感染性休克患者的早期液体复苏,以及治疗效果和预后的影响。方法将该院急诊科重症监护病房收治的80例感染性休克患者随机分为根据中心静脉压(CVP)指导液体复苏治疗的对照组,... 详细信息

目的探讨根据脉搏指示连续心输出量(PICCO)监测中的容量指标对感染性休克患者的早期液体复苏,以及治疗效果和预后的影响。方法将该院急诊科重症监护病房收治的80例感染性休克患者随机分为根据中心静脉压(CVP)指导液体复苏治疗的对照组,和依据血管外肺水指数(EVWL)和全心舒张末期容积(GEDV)指导液体复苏治疗的实验组,每组各40例,2组患者经液体复苏治疗后的疗效与预后进行对比分析。结果实验组患者乳酸水平明显低于对照组,中心静脉血氧饱和度、氧合指数、尿量均明显高于对照组,差异均有统计学意义(P0.05)。结论依据EVWL和GEDV指导感染性休克患者早期液体复苏治疗,能够改善患者的预后、降低病死率,具有临床意义。

关键词：感染性休克血管外肺水指数液体复苏

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

张力促进瘢痕疙瘩纤维化的初步研究

引用

中华皮肤科杂志 2021年第3期54卷 196-200页

作者：宋海峰董高宏魏凯军胡新红张衍国刘涛空军军医大学唐都医院皮肤科西安710038

目的初步探讨张力刺激对瘢痕疙瘩成纤维细胞生物学活性及纤维化标志基因表达的影响。方法选取2017年1-3月于空军军医大学唐都医院皮肤科诊断为瘢痕疙瘩并接受手术治疗的3例患者,处理手术切除的瘢痕疙瘩组织,经原代培养获得人瘢痕疙瘩成... 详细信息

目的初步探讨张力刺激对瘢痕疙瘩成纤维细胞生物学活性及纤维化标志基因表达的影响。方法选取2017年1-3月于空军军医大学唐都医院皮肤科诊断为瘢痕疙瘩并接受手术治疗的3例患者,处理手术切除的瘢痕疙瘩组织,经原代培养获得人瘢痕疙瘩成纤维细胞(KD-Fbs),取3~6代KD-Fbs分别培养于张力刺激模型小室和对照小室中,分别接受张力刺激(张力组)和正常培养(对照组)。CCK8法检测培养1、2、3、4 d时KD-Fbs的增殖活性,划痕实验检测培养1、2 d时KD-Fbs的迁移能力;处理48 h后,实时定量PCR和Western印迹法分别检测KD-Fbs中纤维化标志物Ⅰ型胶原蛋白、纤连蛋白、α平滑肌肌动蛋白(α-SMA)mRNA和蛋白的表达。两组间比较采用两独立样本t检验。结果CCK8法显示,培养1、2、3、4 d时,张力组KD-Fbs增殖活性均高于对照组(t值分别为3.05、7.00、16.65、15.19,均P<0.05)。划痕实验显示,培养1、2 d时,张力组KD-Fbs迁移率(48.65%±3.96%、100.00%)均显著高于对照组(9.36%±1.14%、50.35%±4.23%;t值分别为16.53、20.35,均P<0.01)。实时定量PCR结果显示,张力组Ⅰ型胶原蛋白、纤连蛋白、α-SMA mRNA表达(3.04±0.20、2.16±0.10、3.76±0.24)均显著高于对照组(1.00),差异有统计学意义(t值分别为17.57、21.01、20.25,均P<0.01)。Western印迹法显示,3种纤维化标志物蛋白表达水平变化与其mRNA变化一致(均P<0.05)。结论张力可能通过促进纤维化标志基因的表达,增强KD-Fbs的增殖和迁移能力,进而参与瘢痕疙瘩的纤维化进程。

关键词：瘢痕疙瘩纤维化细胞增殖细胞迁移张力

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

经皮心肌内室间隔射频消融术治疗轻度室间隔肥厚的梗阻性肥厚型心肌病的随访研究

引用

中华超声影像学杂志 2023年第2期32卷 97-104页

作者：欧绪梅梁常婷李莹雷常慧王静拓胜军姚璐刘丽文空军军医大学第一附属医院(西京医院)超声医学科、空军军医大学第一附属医院(西京医院)肥厚型心肌病国际合作中心、陕西省肥厚型心肌病多学科会诊中心、西京医院肥厚型心肌病多学科诊治与遗传咨询中心西安710032

目的评价经皮心肌内室间隔射频消融术(PIMSRA)治疗轻度室间隔肥厚的梗阻性肥厚型心肌病患者的临床效果。方法纳入2016年11月至2021年2月在空军军医大学西京医院肥厚型心肌病诊治中心接受PIMSRA治疗的轻度室间隔肥厚(最大左室壁厚度15~19... 详细信息

目的评价经皮心肌内室间隔射频消融术(PIMSRA)治疗轻度室间隔肥厚的梗阻性肥厚型心肌病患者的临床效果。方法纳入2016年11月至2021年2月在空军军医大学西京医院肥厚型心肌病诊治中心接受PIMSRA治疗的轻度室间隔肥厚(最大左室壁厚度15~19 mm)的梗阻性肥厚型心肌病患者45例, 收集其临床资料, 评估术前、术后6个月及术后1年的临床症状、NYHA心功能分级等;采用经胸超声心动图评价术前、术后6个月及术后1年的室间隔厚度、左室流出道内径、左室流出道压差、二尖瓣反流、左室收缩及舒张功能等, 监测并记录术中并发症发生情况;采用常规12导联心电图和24 h动态心电图监测术后心律失常。结果所有患者均成功完成PIMSRA治疗, 术中及围术期内无死亡、出血和卒中等临床不良事件发生, 术后无左束支传导阻滞、完全性房室传导阻滞和恶性心律失常发生, 所有患者均无需永久起搏器植入。与术前相比, 术后6个月的NYHA心功能分级提高, 临床症状显著改善(均PsaM征分级降低(均P0.05)。结论 PIMSRA治疗轻度室间隔肥厚的梗阻性肥厚型心肌病的临床效果良好。

关键词：超声心动描记术心肌病肥厚型经皮心肌内室间隔射频消融术治疗结果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：