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How we can improve patients’comfort after Milligan- Morgan open haemorrhoidectomy

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World Journal of Gastroenterology 2011年第11期17卷 1448-1456页

作者： Ma-Mu-Ti-Jiang A ba-bai-ke-re Hong-Guo Huang Wen-Ni Re Kai Fan Hui Chu Er-ha-Ti Ai Mai-Mai-Ti-Tu-Er-Xun KE Li-Mu Yi-Rui Wang hao Wen Department of Anorectal Surgical First Affiliated Hospital of Xinjiang Medical University Urumqi 830011 Xinjiang Uygur Autonomous Region China Department of Otolaryngeological Urumqi General Hospital Lanzhou Military Command Urumqi 830011 Xinjiang Uygur Autonomous Region China Department of Pharmocological First Affiliated Hospital of Xinjiang Medi- cal University Ururnqi 830011 Xinjiang Uygur Autonomous Region China Digestive and Vascular Surgical Center First Affili. ated Hospital Xinjiang Medical University Urumqi 830011 Xinjiang Uygur Autonomous Region China

AiM:To demonstrate the value of Diosmin(flavonidic fraction)in the management of post-haemorhoidectomic ***:Eighty-six consecutive patients with grades ⅢandⅣacute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital,Xinjiang Medical University from April 2009 to April 2010,were enrolled in this *** observerblinded,randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs ***-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk(n=43)or placebo(n=43).The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision ***,bleeding,heaviness,pruritus,wound edema and mucosal discharge were observed after *** postoperative symptoms and hospitalization time were ***:The mean age of the Diosmin group and controls was 53.2 and 51.3 years,*** Diosmin group,haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10;and in the control group,29 were of the third degree and 14 were of the fourth *** was no statistically significance in age,gender distribution,degree and number of excised haemorrhoid piles,and the mean duration of haemorrhoidal disease between the two *** was a statistically significant improvement in pain,heaviness,bleeding,pruritus from baseline to the 8th week after operation(Pients taking Diosmin had a shorter hospitalization stay after surgery(Pignificant improvement on the proctoscopic appearance(Pistical difference between the two groups in terms of wound mucosal *** patients experienced minor bleeding at the 8th week in Diosmin group,and underwent ***:Diosmin is effective in alleviating postoperational symptoms of ***,it should be considered for the initial treatment afte

关键词： Flavonidic fraction Postoperative complication haemorrhoids

OPTiCAL ChaRACTERizATiON OF TiO_2 THiN FiLM ON SiLiCON SUBSTRATE DEPOSiTED BY DC REACTiVE MAGNETRON SPUTTERiNG

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 194-198页

作者： H.Q.Wang H.Shen D.C.ba B.W.Wang L.S.Wen D.Chen SchoolofMechanismandAutomobile ShenyangInstituteofAeronauticalEngineeringShenyang110034Ghina／／MechanismandAeronauticalCollegeNortheasternUniversityShenyang110004China TheSchoolofPhysicsandEngineering ZhongshanUniversityGuangzhou510275Ghina MechanismandAeronauticalCollege NortheasternUniversityShenyang110004China GuangzhouinstimdeofEnergyConversion Guangzhou510070China instituteofMetalResearch TheChineseAcademyofSciencesShenyang110016China MaterialandScienceEngineeringAcademy SouthChinaUniversityofTechnologyGuangzhou510641China

TiO2 thin film has attracted considerable attention in recent years, due to its different refractive index and transparency with amorphous and different crysta ls in the visible and near-infrared wavelength region, high dielectric constant, wide band gap, high wear resistance and stability, etc, for which make it being used in many fields. This paper aims to investigate the optical characterizatio n of thin film TiO2 on silicon wafer. The TiO2 thin films were prepared by DC re active magnetron sputtering process from Ti target. The reflectivity of the film s was measured by UV-3101PC, and the index of refraction (n) and extinction coef ficient (k) were measured by n & k Analyzer 1200.

关键词： optical characterization TiO2 thin film DC reactive magnetron sputtering n & k

Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins

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Journal of Pharmaceutical Analysis 2023年第3期13卷 305-314页

作者： Chi Soo Park Minju Kang Ahyeon Kim Chulmin Moon Mirae Kim Jieun Kim Subin Yang Leeseul Jang Ji Yeon Jang ha Hyung Kim Department of Global innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974Republic of Korea

Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to ***-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte-associated antigen-4-immunoglobulin(CTLA4-ig),were produced in Chinese hamster ovary cell lines;however,their linkage isomers have not been *** this study,N-glycans of CTLA4-igs were released,labeled with procainamide,and analyzed by liquid chromatography-tandem mass spectrometry(MS/MS)to identify and quantify sialylated N-glycan linkage *** linkage isomers were distinguished by comparison of 1)intensity of the N-acetylglucosamine ion to the sialic acid ion(Ln/Nn)using different fragmentation stability in MS/MS spectra and 2)retention time-shift for a selective m/z value in the extracted ion *** isomer was distinctively identified,and each quantity(>0.1%)was obtained relative to the total N-glycans(100%)for all observed ionization *** sialylated N-glycan isomers with onlyα2-3 linkage(s)in WT were identified,and each isomer's sum of quantities was 50.4%.Furthermore,39 sialylated N-glycan isomers(58.8%)in mono-(3 N-glycans;0.9%),bi-(18;48.3%),tri-(14;8.9%),and tetra-(4;0.7%)antennary structures of mutant were obtained,which comprised mono-(15 N-glycans;25.4%),di-(15;28.4%),tri-(8;4.8%),and tetra-(1;0.2%)sialylation,respectively,with onlyα2-3(10 N-glycans;4.8%),bothα2-3 andα2-6(14;18.4%),and onlyα2-6(15;35.6%)linkage(s).These results are consistent with those forα2-3 neuraminidase-treated *** study generated a novel plot of Ln/Nn versus retention time to distinguish sialylated N-glycan linkage isomers in glycoprotein.

关键词： Therapeutic glycoprotein Sialylation Linkage isomer LC-MS/MS

脉搏氧饱和度检测在高原地区先天性心脏病筛查中的意义

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实用儿科临床杂志 2012年第14期27卷 1098-1099页

作者：边巴卓嘎卓嘎扇敏娜张婉西藏自治区人民医院儿科拉萨850000

目的探讨脉搏氧饱和度(SPO2)检测在高原地区先天性心脏病(CHD)新生儿早期筛查中的意义。方法在本院妇产科因高危妊娠、窒息、黄疸、早产等原因会诊的新生儿386例,通过临床查体和SPO2测定,将SPO2≤90%的新生儿进一步行超声心动图、胸片检... 详细信息

目的探讨脉搏氧饱和度(SPO2)检测在高原地区先天性心脏病(CHD)新生儿早期筛查中的意义。方法在本院妇产科因高危妊娠、窒息、黄疸、早产等原因会诊的新生儿386例,通过临床查体和SPO2测定,将SPO2≤90%的新生儿进一步行超声心动图、胸片检查,做出补充诊断和治疗。将SPO2≤90%的171例患儿分为轻度缺氧组(SPO2≥86%～90%)和重度缺氧组(SPO2≤85%),比较分析2组CHD患儿的检出率。结果 386例中SPO2≤90%者171例。其中胸片、超声心动图正常者35例,占20%(其SPO2均>86%);诊断肺炎77例,占45%;诊断CHD 59例,占34%,其中PDA 28例,ASD 16例,VSD 5例,法洛四联症、ASD并PDA各3例,肺动脉狭窄2例,完全性大动脉转位、主动脉弓断离各1例。轻度缺氧组48例中诊断CHD 8例,其检出率为16.6%;重度缺氧组123例中诊断CHD 51例,其检出率41.4%,重度缺氧组CHD检出率明显高于轻度缺氧组(P=0.001)。结论 SPO2检测在高原地区新生儿CHD筛查中可作为除体格检查以外的一项重要简便筛查项目,可提高高原地区新生儿CHD的早期诊断率。

关键词：脉搏氧饱和度先天性心脏病高原婴儿新生

CT纹理分析在区分非小细胞肺癌组织学亚型中的应用价值

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肿瘤学杂志 2023年第2期29卷 123-128页

作者：陈亮巴哈提新疆医科大学第一附属医院新疆乌鲁木齐830054

[目的]探讨CT纹理分析在区分肺鳞状细胞癌(squamous cell carcinoma,SCC)和腺癌(adenocarcinoma,AD)中的应用价值。[方法 ] 2020年3月至2022年3月从新疆医科大学第一附属医院共收集70例术后确诊的NSCLC患者资料。将患者随机分配到训练队... 详细信息

[目的]探讨CT纹理分析在区分肺鳞状细胞癌(squamous cell carcinoma,SCC)和腺癌(adenocarcinoma,AD)中的应用价值。[方法 ] 2020年3月至2022年3月从新疆医科大学第一附属医院共收集70例术后确诊的NSCLC患者资料。将患者随机分配到训练队列(n=50)和测试队列(n=20)。从每例患者CT数据的瘤内和瘤周区域中提取了7类放射组学特征,共涉及2 055个指标。采用基于线性SVM的递归特征消除(SVM-RFE)特征选择算法确定最佳特征。使用具有这些最佳特征的5个常见机器学习分类器(QDA、SVCrbf、SVCsigmoid、RFC和Xgboost)开发了一个集成分类器。通过受试者工作特征曲线(ROC)在训练队列和测试队列评估集成分类器区分SCC和AD的性能。[结果]经过基于统计分析的特征选择,最终获得了来自瘤内和瘤周区域选择的9个最佳特征,包括2个firstorder特征,2个glrcm特征和5个glszm特征。从瘤内和瘤周区域确定的分类模型在预测SCC和AD方面整体性能较好,与5个独立分类器开发的模型相比,集成分类器开发的模型在训练集和测试集中显示了较好的性能。集成分类器在训练集中的AUC为0.87(灵敏度为0.80,特异度为0.84),在测试集中的AUC为0.78(灵敏度为0.72,特异度为0.75)。[结论]基于CT的放射组学策略从瘤内和瘤周区域提取纹理特征,采用SVM-RFE进行最佳特征选择,并利用集成学习进行分类模型开发,在术前预测区分不同非小细胞肺癌组织学亚型时具有良好的精度和稳定性。

关键词： CT 纹理分析非小细胞肺癌组织学亚型集成学习

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论混合血清法筛检HiV抗体的可行性

中国输血杂志 1992年第1期5卷 5-8页

作者：季阳瞿德敏 Chyang T. Fang Ellen Lam ba The ha 中国医学科学院输血研究所美国红十字会国家传染病参比实验室

本实验论证了用10份血清标本混合检测HiV抗体的可行性。应用美国Organon Teknika公司的ELiSA法HiV-1抗体检测试剂进行试验,在只变动血清标本量与标本稀释液量比例,但两者总量不变的情况下进行测定。10份血清混合后血清量由5μl扩大到50... 详细信息

本实验论证了用10份血清标本混合检测HiV抗体的可行性。应用美国Organon Teknika公司的ELiSA法HiV-1抗体检测试剂进行试验,在只变动血清标本量与标本稀释液量比例,但两者总量不变的情况下进行测定。10份血清混合后血清量由5μl扩大到50μl,而标本稀释液量相应减少后标本的光密度(吸光值)略为增加,但均低于界限值,说明试验的特异性尚未受到影响。此外,将已经确证为HiV抗体阳性的血清标本1份同9份正常献血者血清混合后,经多次配对试验,均能正确反映出含有HiV抗体的标本,说明试验的敏感性不受影响,能保持原法的水平。由于混合血清法检测HiV抗体可节约开支10倍,同时节省人力、物力和工时等众多优点,故容易推广应用。

关键词：献血员艾滋病毒抗体混合血清法

PARAMAGNETiC MEiSSNER EFFECTS iN MELT-TEXTURED Y_(0.99)Nd_(0.01)ba_2Cu_3O_(7-y)SUPERCONDUCTOR

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Acta Metallurgica Sinica(English Letters) 2002年第3期15卷 295-298页

作者： Xing Y.T. Wang Y.z. Qiao G.W. inst. of Metal Res. Chinese Acad. of Sci. Shenyang 110016 China

The paramagnetic Meissner effect (PME) was observed on the field-cooled M-T curves of melt-textured Y0.99Nd0.01ba2Cu3O7-y in applied magnetic fields from 1kOe to 40kOe. in the magnetic field below 1kOe, the sample undergoes the typical transition from the normal state to the superconducting state when it was cooled down. The applied magnetic fields in which the PME occurs, are very high compared with the fields reported in literatures. We propose that the occurrence of the PME may be due to a phase transition of flux vortices in the superconductors.

关键词： YBCO superconductor paramagnetic Meissner effect (PME)

Severe Acute Malnutrition among Hospitalized Children, Aden, Yemen

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Open Journal of Epidemiology 2016年第2期6卷 121-127页

作者： Mohammed Ali badi iman Ali ba-Saddik Pediatric Department Faculty of Medicine and Health Sciences University of Aden Aden Yemen

Objective: Severe acute malnutrition (SAM) is one of the most common causes of morbidity and mortality among children under 5 years of age worldwide. The aim of this study was to find out the prevalence of SAM among hospitalized children at Al-Wahda teaching hospital in Aden, Yemen. Methods: This descriptive cross-sectional hospital based study was conducted on 622 hospitalized children (336 males and 286 females) below 6 years of age during 2012-2013. SAM was defined as a very low weight for height (below-3 z scores of the median WHO growth standards). Results: SAM was diagnosed in 622 children with prevalence rate of 5.2% from total 11,941 admissions during 24 months period. A higher proportion of patients were marasmus 586 (94.2%) and only 36 (5.8%) were kwashiorkor. Marasmus was common in in 347 (59.2%) while kwashiorkor between 1 - 5 years in 22 (61.1%) patients. Males (54%) predominated females (46%) with a male to female ratio of 1.18:1 in SAM but with no significant difference in sex. The highest comorbidities with SAM were gastroenteritis 442 (71.1%) and 103 pneumonia (16.6%) with a total cure of 492 (79.1%) patients. Conclusion: This high prevalence of SAM among males who were ith high risk of gastroenteritis and pneumonia added weight to the urgent need to improve the nutritional status of children.

关键词： Severe Acute Malnutrition Marasmus Kwashiorkor

Polygonatum kingianum rhizome extract alleviates collagen antibody-induced arthritis by modulating proinflammatory cytokine production in mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第11期10卷 490-495页

作者： Huyen Do Thi Thanh Phuong Ngo Thi Hien Nguyen Thi Thu Nga Nguyen Thi Hung Le Ngoc Thao DoThi ha Le Minh Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam institute of Natural Products Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam hanoi Open University101 Nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Laboratory of Bioassay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Project Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

Objective: To evaluate the anti-arthritic effects of Polygonatum kingianum rhizome extract using both in vitro and in vivo ***: Lipopolysaccharide-induced RAW 264.7 macrophages were treated with an ethanol extract of Polygonatum kingianum rhizomes at different concentrations to determine nitric oxide and prostaglandin E2(PGE2) production. For in vivo study, Polygonatum kingianum ethanol extract was further investigated for its antiinflammatory effect in a mouse model with collagen antibodyinduced arthritis. Phytochemical study of Polygonatum kingianum ethanol extract was also ***: Saponins(142 mg/g total yield) was the main component in the Polygonatum kingianum ethanol extract. 5α,8α-ergosterol peroxide,(E,E)-9-oxooctadeca-10,12-dienoic acid and 3-(2?-hydroxy-4?-methoxy-benzyl)-5,7-dihydroxy-8-methyl-chroman-4-one were isolated from the extract. Polygonatum kingianum ethanol extract exhibited potential anti-inflammatory effects by inhibiting nitric oxide and PGE2 production in RAW 264.7 cells in a dosedependent manner. The level of arthritis in mice with collagen antibody-induced arthritis was significantly reduced(Pith Polygonatum kingianum ethanol extract, particularly at a dose of 1 000 mg/kg body weight. Besides, the extract demonstrated the regulatory effects on serum tumor necrosis factoralpha, interleukin-6, and interleukin-10 in treated ***: Polygonatum kingianum ethanol extract has beneficial effects on inflammatory cytokine regulation and PGE2 inhibition in an experimental mouse model with collagen antibody-induced arthritis. The phytochemical screening reveals that the saponin, as the main component, and sterols(daucosterol and 5α,8α-ergosterol peroxide) from Polygonatum kingianum ethanol extract may contribute to its promising in vitro and in vivo anti-inflammatory activities.

关键词： inflammatory cytokine PGE2