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how to"pick up"colorectal serrated lesions and polyps in daily histopa.hology practice:From terminologies to diagnostic pitfalls

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World Journal of Clinical Oncology 2024年第9期15卷 1157-1167页

作者： Thai h Tran Vinh h nguyen Diem TN Vo Department of Pa.hology Da Nang HospitalDa Nang 50000Viet Nam Department of Pa.hology University Medical Center Ho Chi Minh CityHo Chi Minh 70000Viet Nam Department of histology-Embryology and Pa.hology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 70000Viet Nam

Over the last decade,our knowledge of colorectal serrated polyps and lesions has significantly improved due to numerous studies on this group of precursor *** lesions were misleading as benign before 2010,but they are currently reclassified as precancerous lesions that contribute to 30%of colorectal cancer through the serrated neoplasia *** World health Organization updated the classification for serrated lesions and polyps of the colon and rectum in 2019,which is more concise and applicable in daily *** responsible authors prescribe that“colorectal serrated lesions and polyps are characterized by a serrated(sawtooth or stellate)architecture of the epithelium.”From a clinical standpoint,sessile serrated lesion(SSL)and SSL with dysplasia(SSLD)are the two most significant *** these advancements,the precise diagnosis of SSL and SSLD based mainly on histopa.hology remains challenging due to various *** review describes the nomenclature and the terminology of colorectal serrated polyps and lesions and highlights the diagnostic criteria and obstacles encountered in the histopa.hological diagnosis of SSL and SSLD.

关键词： Sessile serrated lesions Sessile serrated lesions with dysplasia Serrated polyps Sessile serrated adenoma Benign hyperplastic polyps Serrated lesions/polyps

Clinical validation of the early embryo viability assessment system: Analysis for the blastocyst morphology and pregnancy outcomes

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Asian pacific Journal of Reproduction 2024年第5期13卷 219-227页

作者： Vu D hop An M Cuong Phi T T a.h nguyen T L huong Le hoang nguyen V ha.h Assisted Reproductive Technology Centre Tam Anh General HospitalHanoiVietnam Institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:To determine the relationship between the early embryo viability assessment(EEVA)and blastocyst morphological parameters and pregnancy ***:This retrospective cohort study was conducted on 291 intracytoplasmic sperm injection cycles including 2522 embryos with indications of prolonging embryo culture to the blastocyst stage in the Genea embryo review incubator,and 511 single vitrified-warmed blastocyst transfer cycles from January 2020 to June *** EEVA system produced an EEVA score from E1(best)to E5(worse)for the potential of blastocyst *** morphology was *** association between the EEVA score and ea.h type of blastocyst morphology,implantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estimating ***:The inner cell mass A(ICM A),trophectoderm A(TE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEVA *** adjusted odd ratio(aOR)(E5 vs E1)was 0.3 for ICM A,0.174 for TE A and 0.210 for BL3,4,5,6,7(all Phigher with lower the EEVA *** aOR of E5 vs E1 was 0.245 for implantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(Phere were associations between blastocyst morphology,pregnancy outcome and EEVA *** good blastocyst morphology and pregnancy outcomes are higher with lower the EEVA score.

关键词： Automated embryo assessment Blastocyst Early embryo viability assessment Genea embryo review incubator

One-loop contributions for h→ℓℓγ and e−e+→hγ in the U(1)_(B−L) extension of the standard model

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Chinese Physics C 2024年第5期48卷 23-49页

作者： Tran Dzung Tri Tha.h huy nguyen Khiem hong Phan Institute of Fundamental and Applied Sciences Duy Tan UniversityHo Chi Minh City 700000Vietnam Faculty of Natural Sciences Duy Tan UniversityDa Nang City 550000Vietnam VNUhCM-University of Science 227 Nguyen Van CuDistrict 5Ho Chi Minh CityVietnam

We present one-loop contributions for h→ℓℓγ with ℓ=νe,μ,τ,e,μ and e−e+→hγ in the U(1)_(B−L) extension of the standard model. In the phenomenological results, the signal strengths for h→ℓℓγ at the Large hadron Collider and for e−e+→hγ at future lepton colliders are analyzed in the physical parameter space for both the vector and chiral B−L models. We found that the contributions from the neutral gauge boson Z′ to the signal strengths are ra.her small. Consequently, the effects will be difficult to probe at future colliders. however, the impacts of charged higgs and CP-odd higgs in the chiral B−L model on the signal strengths are significant and can be measured with the help of the initial polarization beams at future lepton colliders.

关键词： higgs phenomenology one-loop Feynman integrals analytic methods for quantum field theory dimensional regularization future lepton colliders

honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh nguyen han Yu Xingzhi Li huiren Wang Tram Gia Bao nguyen Praka.h Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Ka.hman Bara Altartouri Guoqing Lu Sa.hish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(Na.h),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(h-VLNs)to naturally aged mice protects the liver from Na.h development.h-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,h-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in h-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of h-VLNs represents a promising new user-friendly modality to prevent the development of Na.h.

关键词： honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

One-loop contributions for h→?■γ and e-e+→hγ in the U（1）B-L extension of the standard model

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Chinese Physics C 2024年第5期 27-53页

作者： Tran Dzung Tri Tha.h huy nguyen Khiem hong Phan Institute of Fundamental and Applied Sciences Duy Tan University Faculty of Natural Sciences Duy Tan University VNUhCM-University of Science

We present one-loop contributions for h→?■γ with l=ve,μ,τ,e,μ and e-e+→ hγ in the U（1）B-Lextension of the standard *** the phenomenological results,the signal strengths for h→?■γ at the Large hadron Collider and for e-e+→hγ at future lepton colliders are analyzed in the physical parameter space for both the vector and chiral B-L *** found that the contributions from the neutral gauge boson Z' to the signal strengths are ra.her ***,the effects will be difficult to probe at future ***,the impacts of charged higgs and CP-odd higgs in the chiral B-L model on the signal strengths are significant and can be measured with the help of the initial polarization beams at future lepton colliders.

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Quantitative Mapping of Transient Thermodynamic States in Ultrafast Laser Nanostructuring of Quartz

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Ultrafast Science 2024年第2期4卷 9-18页

作者： h.D.nguyen A.Tsaturyan S.Sao Joao R.Dwivedi A.Melkonyan C.D’Amico E.Ka.han J.P.Colombier G.Kermouche R.Stoian Laboratoire hubert Curien UMR 5516 CNRSUniversite Jean Monnet42000 Saint EtienneFrance Laboratoire George Friedel UMR 5307 CNRSEcole des Mines de Saint Etienne42000 Saint EtienneFrance

Understanding material structural reaction to light is of utmost importance to advance processing resolution in ultrafast laser volume structuring into the *** thermodynamic pa.hways are required to quench energy transport in the most rapid manner and to confine the process to nanometer lengths,bypassing optical *** material dynamics under confinement,with in situ access to transient local temperature and density parameters,thus becomes key in understanding the *** report in situ reconstruction of thermodynamic states over the entire matter relaxation pa.h in bulkα-quartz irradiated by ultrafast nondiffractive laser beams using time-resolved qualitative and quantitative optical phase *** dynamics indicate rapid spatially confined crystalline-to-amorphous transition to a.hot dense fused silica *** exceeds 20%and the matrix temperature rises to more than 2,000 K in the first *** structural state relaxes in hundreds of *** dispersion and time design of the optical beam to picosecond durations increases the spatial confinement and triggers an extreme nanostructuring process based on nanocavitation that occurs within the amorphizing material,where the low-viscosity phase lowers the mechanical requirements for the *** feature scales of less than a tenth of the optical wavelength are obtained in the *** allows for structural and morphological nanoscale material features under 3D confinement that can engineer optical materials.

关键词： Quartz hundreds qualitative

high-temperature corrosion of sintered RE_(2)Si_(2)O_(7)(RE=Yb and ho)environmental barrier coating materials by volcanic a.h

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1628-1638页

作者： Ayahisa Okawa Son Tha.h nguyen Tada.hika Nakayama Thi-Mai-Dung Do hisayuki Suematsu Shu Yin Takuya.hasegawa Tsuneo Suzuki Taka.hi Goto Koichi Niihara Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan Department of Creative Engineering National Institute of TechnologyKushiro 084-0916Japan Extreme Energy-Density Research Institute Nagaoka University of TechnologyNagaoka 940-2188Japan Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversitySendai 980-8577Japan

Rare-earth silicates are promising environmental barrier coatings(EBCs)that can protect SiC_(f)/Si C_(m)substrates in next-genera tion gas turbine ***,RE_(2)Si_(2)O_(7)(RE=Yb and ho)shows potential as an EBC due to its coefficient of thermal expansion(CTE)compatible with substrates and high resistance to water vapor *** target operating temperature for next-generation tur bine blades is 1400°*** is inevitable during a.hesion to molten volcanic a.h,and thus,understanding the corrosion behavior o the material is crucial to its *** study investigates the high-temperature corrosion behavior of sintered RE_(2)Si_(2)O_(7)(RE=Yb and ho).Samples were prepared using a solid-state reaction and hot-press *** were then exposed to volcanic a.h at 1400°C for 224,and 48 *** 48 h of exposure,volcanic a.h did not react with Yb_(2)Si_(2)O_(7)but penetrated its interior,causing *** ho_(2)Si_(2)O_(7)was partially dissolved in the molten volcanic a.h,forming a reaction zone that prevented volcanic a.h melts from penetrating the *** increasing heat treatment time,the reaction zone expanded,and the thickness of the acicular apatite grains increased The Ca:Si ratios in the residual volcanic a.h were mostly unchanged for Yb_(2)Si_(2)O_(7)but decreased considerably over time for ho_(2)Si_(2)O_(7).Th Ca in volcanic a.h was consumed and formed apatite,indicating that RE^(3+)ions with large ionic radii(ho>Yb)easily precipitated apatit from the volcanic a.h.

关键词： environmental barrier coating volcanic a.h rare-earth disilicate corrosion

Sn nucleation and growth from Sn(II)dissolved in ethylene glycol:Electrochemical behavior and temperature effect

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2714-2732页

作者： Kiem Van DO hieu Van nguyen Tu Ma.h LE Faculty of Electrical and Electronic Engineering Phenikaa UniversityYen NghiaHa-DongHanoi 10000Vietnam Phenikaa Research and Technology Institute(PRATI) A&A Green Phoenix Group167 Hoang NganHanoi 10000Vietnam Faculty of Materials Science and Engineering Phenikaa Institute for Advanced Study(PIAS)Phenikaa UniversityHanoi 10000Vietnam

Thermodynamic and kinetic aspects of Sn nucleation and growth processes onto a glassy carbon electrode from SnCl2·2h2O dissolved in ethylene glycol solutions were *** reduction and oxidation peaks observed in voltammograms have demonstrated the capability of ethylene glycol solutions to electrodeposit *** temperature-dependence of diffusion coefficient values derived from potentiodynamic and potentiostatic studies helped to determine and validate estimations of the activation energy for Sn(II)bulk *** results have identified that,the suitable model to describe the early stage of Sn electrodeposition could be composed of Sn three-dimensional nucleation and diffusion-controlled growth and water reduction contributions,which was duly validated by theoretical and experimental *** the model,typical kinetic parameters such as the nucleation frequency of Sn(A),number density of Sn nuclei(N_(0)),and diffusion coefficient of Sn(II)ions(D),were *** presence of Sn nuclei with excellent quality and their structures were verified using SEM,EDX,and XRD techniques.

关键词： Sn nucleation growth ethylene glycol nucleation kinetics electrodeposition

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang howard h.W.Wong Leo C.h.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.h.Luk Jenson C.h.ho Wing Yan Li Amos M.T.Lee Jennifer h.Y.Lam Sau Man Chan Wilfred h.S.Wong Issan Y.S.tam Masa.hi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public health The University of Hong KongHong KongChina hKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine