检索结果-南通市图书馆

董事会 2014年第6期 90-92页

作者： therese Kinal

长达一个世纪里,管理者一直在试图更好地控制人、流程和信息,而今转折点到来,公司需要认清过去起作用的思想和手段已经不再足以应付现在的新情况。如果公司想要的是顺从,那么传统的管理就很好;而如果想要创新和成长。

关键词：清单变革管理者控制人公司流程

Variability in Spatial Distribution of Precipitation Overall Rugged Topography of Lebanon, Using TRMM Images

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Atmospheric and Climate Sciences 2019年第3期9卷 369-380页

作者： Ihab Jomaa Marie therese Abi Saab Sleiman Skaf Nisrine El Haj Randa Massaad Lebanese Agricultural Research Institute Tal Amara Lebanon Lebanese Agricultural Research Institute Fanar Lebanon

Rain gages data represents limited spatial coverage, especially in rugged terrains like Lebanon. Other precipitation data sources are the developing satellite and radar technologies. In this study, Tropical Rain Measurement Mission (TRMM) monthly rainfall data of 18 years (1998-2014 and 2017) was used to understand monthly and yearly precipitation spatial distribution overall Lebanon. Topographic effect of rainfall spatial distribution was investigated in comparison to Plassard’s map of 1971. The annual precipitation over the country ranged between 850 mm and 200 mm that differs than the existing historical map. The maximum rainfall rate decreased by about 700 mm between the derived TRMM rainfall map and Plassard’s one. Spatial distribution of maximum precipitation rates does not coincide between maps. TRMM map of elevated terrains did not show similar trends of rainfall distribution as Plassard’s. Pixels (Lebanon was divided into 27 pixels) of lower rainfall rates was found toward the eastern side of Lebanon, in contrast to Plassard’s results. Anti-Lebanon did not show an increase in precipitation in accordance to altitude. Spatial variability of precipitation was about 50 mm between pixels which reveals the importance of considering topography while implemented rain gages as observation points. TRMM and satellite rainfall data aid in investigating complete spatial distribution of rainfall over continuous periods. Accumulating knowledge of spatial rainfall distribution on timely basis will lead to better future modelling on floods and drought conditions in Lebanon.

关键词： TRMM Data Rainfall Plassard’s Map Lebanon Topography

有针对性的代谢组学方法为个性化医疗提供新途径

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实验与分析 2017年第2期 36-38页

作者： therese Koal

如今，人类代谢物组学的研究为人们提供了利用代谢谱（代谢组）构成的代谢组全谱、利用最小量患者血液通过生物标记物标志确定各个患者健康状况的可能性——甚至可以在常规临床标准情况下确定患者健康状况。

关键词：代谢组学个性化医疗健康状况生物标记代谢物组学患者利用血液

Behavioral Evidence for Cognitive Dysfunctions in the(BALB/cByJ-Kv1.1mceph/mceph)Mouse Model for Epilepsy

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Journal of Behavioral and Brain Science 2011年第4期1卷 210-228页

作者： Sarah Holst Elin Aberg therese M.Eriksson Catharina Lavebratt Sven Ove Ogren Department of Neuroscience Karolinska InstituteStockholmSweden Department of Molecular Medicine and Surgery Karolinska University HospitalStockholmSweden Center of Molecular Medicine Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden Department of Clinical Neuroscience Karolinska InstituteStockholmSweden

The epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph (mceph/mceph) is homozygous for a spontaneous mutation truncating the Shaker-like voltage gated potassium channel, Kv1.1 (Kcna1). The mceph/mceph mice are asymptomatic at birth, but develop from 3 weeks of age epileptic seizures, overgrowth and neuronal hyperplasia of the hippocampus. Hippocampal cognitive function of the mice was examined by investigating emotional memory using the aversive Passive Avoidance (PA) task combined with studies of explorative behavior using the non-aversive Novel Cage test (NCT). The behavioural results were examined by multivariate analysis. Compared to wild type and heterozygous mice, the mceph/mceph mice displayed lower exploratory and safety assessment behavior in the NCT and impairment in PA retention 24 hours after training, indicating an impairment in cognitive functions. In conclusion, the epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph, with chronic epilepsy related to potassium-channelopathy, display a behavioural phenotype characterized by impairments in emotional memory and defensive motivational responses probably related to hippocampal dysfunctions.

关键词： Epilepsy Potassium Ion-Channelopathy Hippocampus Passive Avoidance Novel Cage Test Principal Component Analysis

Neonatal Outcome of Induced Prematurity for Severe Preeclampsia in Four Great Kinshasa Maternities

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Open Journal of Obstetrics and Gynecology 2020年第11期10卷 1637-1643页

作者： Olive Yalala Ambambula Andy Muela Mbangama therese Biselele Rashid Rahma Tozin Dieudonné Mushengezi Sengeyi Department of Obstetrics and Gynecology University Clinics of Kinshasa Kinshasa DR Congo Department of Pediatrics University Clinics of Kinshasa Kinshasa DR Congo

Severe preeclampsia (SPE) is associated with fetal complications including intrauterine growth retardation (IUGR), prematurity and in utero fetal death. Its treatment remains child birth that often is planned before term. However, this attitude can lead to fetal complications related to prematurity. Several studies on preeclampsia have already been studied in the DRC and several aspects have already been realized, but to date, the neonatal outcome has not yet been addressed. Methods: This is cross-sectional study performed in four public hospitals in Kinshasa (Democratic Republic of Congo). We included 400 cases of induced prematurity (IP) for SPE;the analysis compared pregnant women who gave birth before 34 weeks of amenorrhea (WA) and those after 34 WA. The comparison of the proportions was made by the Chi-square test and the calculation of Means by the Student’s test. The significance level was set at P Objective: To determine the frequency of induced prematurity for severe preeclampsia (SPE), to identify the indications and to evaluate neonatal outcome. Results: The IP frequency for SPE was 46.2%. The retro placental hematoma was the most indication in pregnancies before 34 WA 24.9%, while high blood pressure 54.5% in the after 34 WA group. In utero death was more common in pregnant women who gave birth before 34 weeks 25.4%;chroni

关键词： Preeclampsia Induced Prematurity Neonatal Outcome

Single nucleotide polymorphism(SNP)in genes of lupus:A Philippine study(SIGLA-PH)

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Rheumatology & Autoimmunity 2022年第1期2卷 22-30页

作者： Michael L.Tee Cherica A.Tee Jose B.Nevado Jr a.geline therese santiago Aedrian A.Abrilla Carlo M.Lapid Francis A.Tablizo Joshua A.Dizon El K.B.Morado Eva Maria Cutiongco-Dela Paz College of Medicine University of the Philippines ManilaManilaPhillipines Institute of Human Genetics National Institutes of HealthUniversity of the Philippines ManilaManilaPhillipines College of Medicine and Philippine General Hospital University of the Philippines ManilaManilaPhillipines Core Facility for Bioinformatics Philippine Genome CenterUniversity of the PhilippinesManilaPhillipines National Institutes of Health University of the Philippines ManilaManilaPhillipines

Background:Systemic lupus erythematosus(SLE)is a complex prototypic autoimmune disease,with a prevalence of 20–150 per 100,000,most commonly affecting women at child-bearing ***-wide association studies and fine mapping of candidate regions have paved the way for greater understanding of SLE as a disease of genetic–environmental susceptibility and the functions of the genes ***:This study was conducted to determine the association of selected single nucleotide polymorphisms(SNPs)from established genomic databases based on theoretical risk and protective odds ratios>2.5 or<0.40)to susceptibility of developing SLE among ***:We analyzed data from 310 SLE patients and 318 *** identified eight significant SNPs namely rs9271100,rs9271366,rs9272105,rs9275328,rs2647087,rs12734338,rs17885098,and rs3883013 to be associated with an increased risk of developing SLE among ***:Eight SNPs were found to be associated with the development of SLE among *** to previous genetic studies in lupus patients,majority of the SNPs were found in the major histocompatibilty complex genes in the HLA *** study identified two unique SNPs that will be validated as potential diagnostic markers for *** findings of this study may contribute to the development of a polygenic risk score in determining susceptibility to SLE among Filipinos.

关键词： genetics lupus SLE SNP susceptibility

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中国高龄老人健康状况和死亡率变动趋势

人口研究 2017年第4期41卷 22-32页

作者：曾毅冯秋石 therese Hesketh Kaare Christensen James W.Vaupel 北京大学国家发展研究院健康老龄与发展研究中心北京大学瑞意高等研究院美国杜克大学医学院老龄与人类发展研究中心美国杜克大学医学院老年医学部新加坡国立大学社会学系英国伦敦大学学院全球健康研究所浙江大学公共卫生学院全球健康研究所南丹麦大学公共健康研究所德国马普人口研究所

文章对"中国老年健康影响因素跟踪调查"近两万名80~105岁高龄老人的数据分析发现,社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被"救"存活率提高,使2008年高龄老... 详细信息

文章对"中国老年健康影响因素跟踪调查"近两万名80~105岁高龄老人的数据分析发现,社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被"救"存活率提高,使2008年高龄老人客观量测的躯体功能和认知功能比10年前显著下降;这给社会和亿万家庭带来严峻挑战。研究表明,经济社会发展和人类寿命提高带来效益的同时,也会产生一定成本;但它不是以往不少国际文献解释这一现象时所称的"胜利的失败",所以没有必要为此恐慌,而需要全社会积极应对,努力实现人口健康老龄化。

关键词：高龄老人生活自理能力躯体功能认知功能健康老龄化