检索结果-南通市图书馆

UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第40期15卷 5058-5066页

作者： Christoph schulz Volker Heinemann Andreas Schalhorn Nikolas Moosmann Thomas Zwingers Stefan Boeck Clemens Giessen Hans-Joachim Stemmler Department of Haematology & Oncology Ludwig-Maximilians University of MunichCampus Grosshadern Estimate GmbH Konrad-Adenauer-Allee 1

AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy.

关键词： Irinotecan Colorectal cancer UGTIA1 Gene polymorphism Toxicity Efficacy Delayed diarrhoea Neutropenia

The orbital phase resolved spectroscopy of X-ray binary 4U 1822–371 with Suzaku

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2016年第4期16卷 37-46页

作者： Shu Niu Shu-Ping Yan Shi-Jun Lei Michael A.Nowak Norbert S.schulz Li Ji Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China MIT Kavli Institute for Astrophysics and Space Research CambridgeMA 02139USA

4U 1822-371 is a typical edge-on eclipsing low mass X-ray binary and the prototype of accre- tion disk coronal sources. We report on the results of a spectral analysis over the energy range 0.5-45 keV observed by Suzaku in 2006. We extract spectra from five orbital phases. The spectra can be equally well described by various previously proposed models： an optically thick model described by a partially cov- ered cutoff power law and an optically thin model described by a blackbody plus a cutoff power law. The optically thick model requires a covering fraction of about 55%, while the optically thin model requires a temperature of the central source of about 0.16 keV. The spectrum in the optically thick model also shows the previously detected cyclotron line feature at ~30 keV with the same Suzaku observation. This fea- ture confirms the presence of a strong magnetic field. The Fe Ks fluorescent line strengths as well as the detected Fe xxvI strengths are similar to previous Chandra and XMM-Newton detections in our phased spectral analysis; however, we also observe strong Fe xxvI during the eclipse, which indicates a slightly larger central corona.

关键词： accretion accretion disks -- binaries: eclipsing -- line: formation -- binaries: spectroscopic-- X-rays: binaries

BETWEEN WAR OF CONQUEST AND PRE-EMPTIVE ATTACK: NEW PERSPECTIVES ON THE BACKGROUND TO THE PERSIAN WARS

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Ancient Civilizations 2022年第2期37卷 193-224,275,276页

作者： Raimund schulz University of Biclefeld

*** The enduring fascinationwith the Persian Wars is matched onlyby its undisputed historical *** seeminglyfutile struggle of the Greeks to stem the tideof Persian *** loss of a fewto save somany,and thebid to defend both freedom and homeland from tyranny epitomize the time-honoured features ofa grand narrative that persists down to thepresent in the portrayals of popular literature and *** has over the years disclosed the myth behind this ***.

关键词： dispute matched struggle

GTR-Mediated Radial Import Directs Accumulation of Defensive Glucosinolates to Sulfur-Rich Cells in the Phloem Cap of Arabidopsis Inflorescence Stem

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2019年第11期12卷 1474-1484页

作者： Deyang Xu Pascal Hunziker Olga Koroleva Andreas Blennow Christoph Crocoll Alexander schulz Hussam Hassan Nour-Eldin Barbara Ann Halkier DynaMo Center Department of Plant and Environmental SciencesFaculty of ScienceUniversity of Copenhagen1871 Frederiksberg CDenmark Lonza Biologies Pic 228 Bath RoadSlough SL14DXUK Section for Plant Glycobiology Department of Plant and Environmental SciencesFaculty of ScienceUniversity of Copenhagen1871 Frederiksberg CDenmark

In the phloem cap region o i Arabidopsis plants,sulfur-rich cells(S-cells)accumulate>100 mM glucosinolates(GLS),but are biosynthetically *** source and route of S-cell-bound GLS remain *** this study,using single-cell sampling and scanning electron microscopy with energy-dispersive X-ray analysis we show that two GLS importers,NPF2.10/GTR1 and NPF2.11/GTR2,are critical for GLS accumulation in S-cells,although they are not localized in the *** of GLS levels in S-cells in multiple combinations of homo-and heterografts o lg t r l gtr2,biosynthetic null mutant and wild-type plants indicate that S-cells accumulate GLS via symplasmic connections either directly from neighboring biosynthetic cells or indirectly to non-neighboring cells expressing GTR1/*** sources and transport routes exist for different types of GLS,and vary depending on the position of S-cells in the inflorescence *** on these findings,we propose a model illustrating the GLS transport routes either directly from biosynthetic cells or via GTR-mediated import from apoplastic space radially into a symplasmic domain,wherein the S-cells are the ultimate ***,we observed accumulation of the cyanogenic glucoside defensive compounds in high-turgor cells in the phloem cap of Lotus japonicus,suggesting that storage of defensive compounds in high-turgor cells may be a general mechanism for chemical protection of the phloem cap.

关键词： Arabidopsis glucosinolate S-cell phloem cap xylem symplasmic transport

Artificial gauge field switching using orbital angular momentum modes in optical waveguides

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2020年第1期9卷 577-583页

作者： Christina Jorg Gerard Queralto Mark Kremer Gerard Pelegri Julian schulz Alexander Szameit Georg von Freymann Jordi Mompartand Veronica Ahufinger Physics Department and Research Center OPTIMAS Technische Universitat Kaiserslautern67663 KaiserslauternGermany Departament de Fisica Universitat Auto’noma de BarcelonaE-08193 BellaterraSpain Institut fur Physik Universitat RostockAlbert-Einstein-StraBe 2318059 RostockGermany Department of Physics and SUPA University of StrathclydeGlasgow G40NGUK Fraunhofer Institute for Industrial Mathematics ITWM 67663 KaiserslauternGermany

The discovery of artificial gauge fields controlling the dynamics of uncharged particles that otherwise elude the influence of standard electromagnetic fields has revolutionised the field of quantum ***,developing new techniques to induce these fields is essential to boost quantum simulation of photonic ***,we experimentally demonstrate the generation of an artificial gauge field in a photonic lattice by modifying the topological charge of a light beam,overcoming the need to modify the geometry along the evolution or impose external *** particular,we show that an effective magnetic flux naturally appears when a light beam carrying orbital angular momentum is injected into a waveguide lattice with a diamond chain *** demonstrate the existence of this flux,we measure an effect that derives solely from the presence of a magnetic flux,the Aharonov-Bohm caging effect,which is a localisation phenomenon of wavepackets due to destructive ***,we prove the possibility of switching on and off artificial gauge fields just by changing the topological charge of the input state,paving the way to accessing different topological regimes in a single structure,which represents an important step forward for optical quantum simulation.

关键词： gauge momentum orbital

SIRT and Its Unresolved Problems—Is Imaging the Solution? A Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2016年第7期7卷 505-518页

作者： Franziska schulz Michael Friebe Department of Medical Engineering Otto-von-Guericke University Magdeburg Germany

Selective Internal Radiation Therapy (SIRT) is used as a treatment option for unresectable liver tumors. In SIRT, microspheres, which have a radioactive substance as an integral component, are placed via image guided catheters into the hepatic artery. The ionizing radiation is directly delivered to the tumor. Currently used commercially available microspheres are based on Yttrium 90, a β-emitter, which has been shown to be safe and to produce good clinical results. The technical features of Y90, their applications and their limitations are presented. Image guidance and intraoperative depiction of Yttrium 90 microspheres are restricted, which is currently one of the main limitations in SIRT. Therapy planning and control is currently based on pre- and post-operative images to evaluate the placement of the microspheres respectively. Holmium 166, another possible nuclide integrated into the microspheres emits a higher amount of secondary γ-radiation (Bremsstrahlung) than Yttrium 90. This enables an improved depiction of the microspheres inside the patient during and immediately after application, but comes with other shortfalls. Imaging of delivery and verification of the microsphere placement could solve many of the identified problems with SIRT. The different technologies are reviewed and an outlook in future developments is given particularly on image guidance and therapy control.

关键词： Selective Internal Radiation Therapy (SIRT) Radioembolization Yttrium 90 Holmium 166 Liver Tumors

Tetranuclear yttrium and gadolinium 2-acetylcyclopentanoate clusters：Synthesis and their use as spin-coating precursors for metal oxide film formation for field-effect transistor fabrication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2018年第10期36卷 1098-1105页

作者： Elaheh Pousaneh Andrea Preuβ Khaybar Assim Tobias Rüffer Marcus Korb Jana Tittmann-Otto Sascha Hermann Stefan E.schulz Heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry D-09107 Chemnitz Germany Technische Universitiat Chemnitz Center for Mierotechnologies D-09107 Chemnitz Germany Fraunhofer Institute for Electronic Nano Systems ENAS Technologie-Campus 3 D-09126 Chemnitz Germany

Lanthanide clusters [Ln4（μ3-OH）2（η2-accp）4（（μ-O）-η2-accp）6]（Ln = Y（4）,Gd（5）; accp = 2-acetylcyclopentanoate） are accessible by treatment of [M（NO33·6 H2 O]（M = Y（1）,Gd（2）） with 3 equiv. of Haccp（3） in presence of NaOH. The molecular structures of 4 and 5） in the solid-state are discussed. The thermal behavior of 4 and 5 was studied by TG under Ar and O2, showing multistep decomposition processes. Additionally, DSC studies were carried out under an atmosphere of O2. PXRD measurements of the TG residues confirm the formation of Ln2 ***-coating experiments were carried out with 4 and 5 for Ln2 O3 film deposition on silicon substrates. The layers are smooth, close and are of thicknesses of 18.87±1.13 nm and 25.59 ± 4.55 nm for Ln = Y and Gd, which was evidenced by SEM and EDX studies. Field-effect transistors were successfully fabricated by deposition of carbon nanotubes on top of the Y2 O3 films and formation of palladium contacts by a lift-off procedure. An on/off ratio of more than 4 orders of magnitude is achieved without considerable leakage currents. These results demonstrate the potential use of spin-coated Y2 O3 as a gate dielectric in electronic devices.

关键词： β-Diketonates Yttrium Gadolinium Thermal analysis Spin coating CNT transistor

Eagles report:Developing cancer biomarkers from genomewide DNA methylation analyses

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2011年第1期2卷 1-7页

作者： Wolfgang A schulz Wolfgang Goering Department of Urology Medical FacultyHeinrich Heine University40225 DuesseldorfGermany

Analyses of DNA methylation in human cancers have identified hypermethylation of individual genes and diminished methylation at repeat elements as common alterations,and have thereby provided important mechanistic insights into cancer biology as well as biomarkers for cancer detection,prognosis and prediction of therapy *** techniques available in the past were best suited for investigations of individual candidate genes and sequences,whereas recently developed high-throughput techniques promise to generate unbiased and comprehensive surveys of DNA methylation states across entire *** this minireview we give a short overview of established and novel techniques and outline some major questions that can now be addressed to develop further cancer biomarkers and therapies based on DNA methylation.

关键词： Bisulfite CpG-island Deep sequencing DNA hypermethylation Hypomethylation Methylcytosine-binding domain

Early Paleozoic accretionary orogens along the Western Gondwana margin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2021年第1期12卷 109-130页

作者： Sebastián Oriolo Bernhard schulz Silvana Geuna Pablo DGonzález Juan E.Otamendi JiíSláma Elena Druguet Siegfried Siegesmund CONICET-Universidad de Buenos Aires Instituto de Geociencias BasicasAplicadas y Ambientales de Buenos Aires(IGEBA)Intendente Güiraldes 2160C1428EHABuenos AiresArgentina Institute of Mineralogy Division of Economic Geology and PetrologyTU Bergakademie FreibergBrennhausgasse 14D-09596FreibergSaxonyGermany Instituto de Investigacion en Paleobiología y Geología(UNRN-CONICET) Avenida Julio A.Roca 1242R8332EXZGeneral RocaArgentina CONICET Departamento de GeologíaUniversidad Nacional de Río CuartoCampus UniversitarioX5804BYARío CuartoArgentina Institute of Geology The Czech Academy of SciencesRozvojova 269CZ-16500Prague 6Czech Republic Departament de Geologia Universitat Autonoma de Barcelona08193BellaterraBarcelonaSpain Geoscience Centre Georg-August-Universit€at G€ottingenGoldschmidtstraße 337077GottingenGermany

Early Paleozoic accretionary orogens dominated the Western Gondwana margin and were characterized by nearly continuous subduction associated with crustal extension and back-arc basin *** southwestern margin is represented by Famatinian and Pampean basement realms exposed in South America,both related to the protracted Paleozoic evolution of the Terra Australis Orogen,whereas the northwestern margin is mainly recorded in Cadomian domains of Europe and adjacent ***,no clear relationships between these regions were so far *** on a compilation and reevaluation of geological,paleomagnetic,petrological,geochronological and isotopic evidence,this contribution focuses on crustal-scale tectonic and geodynamic processes occurring in Western Gondwana accretionary orogens,aiming at disentangling their common Early Paleozoic *** show that accretionary orogens were dominated by high-temperature/lowpressure metamorphism and relatively high geothermal gradients,resulting from the development of extended/hyperextended margins and bulk transtensional *** this sense,retreating-mode accretionary orogens characterized the Early Paleozoic Gondwana margin,though short-lived pulses of compression/transpression also *** existence of retreating subduction zones favoured mantle-derived magmatism and mixing with relatively young(meta)sedimentary sources in a thin continental *** reworking of previous forearc sequences due to trenchward arc migration thus took place through assimilation and anatexis in the arc/back-arc ***,retreating-mode accretionary orogens were the locus of Early Paleozoic crustal growth in Western Gondwana,intimately associated with major flare-up events,such as those related to the Cadomian and Famatian *** roll back,probably resulting from decreasing convergence rates and plate velocities after Gondwana assembly,was a key factor for orogen-scale geodynamic ***

关键词： Retreating accretionary orogen Lower Paleozoic Crustal growth Hf isotopic array Famatinian Cadomian