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Herbal medicines for the management of irritable bowelsyndrome:A comprehensive review

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World Journal of Gastroenterology 2012年第7期18卷 589-600页

作者： roja Rahimi mohammad Abdollahi Faculty of Traditional medicine Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehran ***Iran Faculty of Pharmacy Pharmaceutical Sciences Research CenterEndocrinology and Metabolism Research InstituteTehran University of Medical SciencesTehran ***Iran

Irritable bowel syndrome (IBS) is a functional gut disorder with high *** of various factors involved in its pathophysiology and disappointing results from conventional IBS medications,the treatment of IBS is challenging and use of complementary and alternative medicines especially herbal therapies is *** this paper,electronic databases including Pubmed,Scopus,and Cochrane library were searched to obtain any in vitro,in vivo or human studies evaluating single or compound herbal preparations in the management of *** in vitro,3 in vivo and 23 human studies were included and systematically *** majority of studies are about essential oil of menta piperita as a single preparation and STW 5 as a compound *** evaluated herbs such as Curcuma xanthorriza and Fumaria officinalis did not demonstrate any benefits in ***,it seems there are many other herbal preparations such as those proposed in traditional medicine of different countries that could be studied and investigated for their efficacy in management of IBS.

关键词： Herbal medicines Irritable bowel syndrome Systematic review

Exacerbated conceptus signaling does not favor establishment of pregnancy in beef cattle

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Journal of Animal Science and Biotechnology 2019年第1期10卷 67-78页

作者： T.martins m.Sponchiado O.a.ojeda.roja. A.m.gonella-diaza E.O.S.Batista B.O.Cardoso C.C.Rocha A.C.Basso m.Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao PauloPirassunungaSao PauloBrazil Department of Nutrition and Animal Production School of Veterinary Medicine and Animal ScienceUniversity of Sao PauloPirassunungaSao PauloBrazil In Vitro Brasil Mogi MirimSao PauloBrazil Department of Animal Sciences University of FloridaGainesvilleFloridaUSA

Background: Insufficient production of anti-luteolytic signals by the pre-attachment embryo is considered a major cause of pregnancy failure in *** tested the hypothesis that transfer of multiple blastocysts(n = 5/recipient) and progesterone(P4) supplementation amplify anti-luteolytic signaling and reduce embryonic losses in beef *** detected in estrus(D0; n = 104) were assigned randomly to receive 150 mg of injectable long-acting P4(iP4) or vehicle(non-iP4) on D4 and transcervical transfer of none or five,grade 1,not-frozen,in vitro-produced blastocysts,on *** development and time of structural luteolysis were monitored by *** P4 concentrations were determined on D4,D5 and D7,and daily between D14 and *** signaling was monitored by transcript abundance of interferon-stimulated gene 15(ISG15) in peripheral blood mononuclear cells isolated on D14,D16,D18 and *** embryonic mortality(EEm) was defined as the absence of ISG15 m RNA upregulation over time and/or luteal regression up to *** embryonic mortality(LEm) was defined as the absence of a conceptus with a heartbeat on pregnancy diagnosis at D30(PD30) after observing upregulation of ISG15 mRNA and extension of luteal *** cows presented conceptuses with heartbeat at ***: On D5,iP4-treated cows had P4 concentrations 2.07-fold greater than non-iP4 treated(P m animals showed a progressive increase in the abundance of ISG15 from D14 to ***4-treated cows detected pregnant at PD30 had 1.53-fold greater abundance of ISG15 mRNA between D14 and D20 than non-iP4 treated cows(P = 0.05).iP4 doubled the frequency of EEm while it did not affect *** PD30,embryonic survival was 37.0% vs.55.6% for iP4-treated *** *** of pregnant cows(71%)presented only a single viable ***: A substantial proportion of cows had EEm(31%) and LEm(20%) even after transferring

关键词： Corpus luteum Luteolysis Pregnancy Uterus

Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

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Journal of Animal Science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago martins Guilherme Pugliesi mariana Sponchiado a.gela.m.gonella.dia.a.osca. a.ojeda.roja. Frederich D.Rodriguez Roney S.Ramos Andrea C.Basso mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and Animal Production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University Corporation of Huila ABS Global In Vitro Brasil Department of Animal Sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DmPBS and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(P > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: Subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph Protein

Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines:A meta-analysis

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World Journal of Gastroenterology 2013年第34期19卷 5738-5749页

作者： roja Rahimi Shekoufeh Nikfar mohammad Abdollahi Department of Traditional Pharmacy Faculty ofTraditional MedicineTehran University of Medical Sciences Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Department of Pharmacoeconomics and Pharmaceutical Administration Faculty of PharmacyTehran University of Medical Sciences Food and Drug Organisation Ministry of Health and Medical Education Department of Toxicology and Pharma-cology Faculty of PharmacyTehran University of Medical Sciences

AIm:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease(IBD)by conducting a ***:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of *** search terms were:"herb"or"plant"or"herbal"and"inflammatory bowel disease".Data were collected from 1966 to 2013(up to Feb).The"clinical response","clinical remission","endoscopic response","endoscopic remission","histological response","histological remission","relapse","any adverse events",and"seriousadverse events"were the key outcomes of *** used the mantel-Haenszel,Rothman-Boice method for fixed effects and DerSimonian-Laird method for *** subgroup analyses,we separated the studies by type of IBD and type of herbal medicine to determine confounding factors and ***:Seven placebo controlled clinical trials met our criteria and were included(474 patients).Comparison of herbal medicine with placebo yielded a significant RR of 2.07(95%CI:1.41-3.03,P=0.0002)for clinical remission;a significant RR of 2.59(95%CI:1.24-5.42,P=0.01)for clinical response;a non-significant RR of 1.33(95%CI:0.93-1.9,P=0.12)for endoscopic remission;a non-significant RR of 1.69(95%CI:0.69-5.04)for endoscopic response;a non-significant RR of 0.64(95%CI:0.25-1.81)for histological remission;a non-significant RR of 0.86(95%CI:0.55-1.55)for histological response;a non-significant RR of 0.95(95%CI:0.52-1.73)for relapse;a non-significant RR of 0.89(95%CI:0.75-1.06,P=0.2)for any adverse events;and a non-significant RR of 0.97(95%CI:0.37-2.56,P=0.96)for serious adverse ***:The results showed that herbal medicines may safely induce clinical response and remission in patients with IBD without significant effects on endoscopic and histological outcomes,but the number of studies is limited to make a strong conclusion.

关键词： Herbal medicine Inflammatory bowel disease Efficacy Relapse Adverse events meta-analysis

Watershed prioritization for conservation planning using RUSLE and morphometric methods,Northwestern Ethiopia

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Journal of mountain Science 2023年第8期20卷 2242-2262页

作者： Agumassie Genet gela Daniel Ayalew mENGISTU Daniel Asfaw BEKELE Department of General Forestry Debre Markos UniversityBure 18Ethiopia Department of Geography and Environmental Studies Bahir Dar UniversityBahir Dar 79Ethiopia Geo-spatial Data and Technology Center(GDTC) Bahir Dar UniversityBahir Dar 79Ethiopia

Soil erosion and the subsequent sedimentation are serious environmental *** land management coupled with intense rainfall has complicated the problem in the Ethiopian ***,soil loss costs a profound amount of the national GDP and deters land *** soil loss and prioritizing areas for conservation is imperative for proper planning and resource ***,this study aimed at estimating the mean annual soil loss rate of Gilgel Abay watershed which has critical implications on Lake Tana and Abbay River(Upper Blue Nile River),using RUSLE and morphometric analysis *** including rainfall,soil,Digital Elevation model and land use/land cover were used to generate important parameters required for the soil loss *** collected through field observation,consultation with experts and document analysis were used for validation *** results of the study reveal that the watershed experienced an average soil loss rate of 39.8 t ha^(-1)yr^(-1).Subsequently,nearly 25%(37,038 ha)of the watershed is threatened by moderate to very severe soil *** the four sub watersheds,sub watershed 3(S3)and sub watershed 4(S4),which consist of about 65%(105,000 ha)of the total area of the study watershed,experienced an annual soil loss rate of over 30 t ha^(-1)yr^(-1).The amount of soil loss that the study watershed has experienced is above the soil loss tolerance level of Ethiopia(2-18 t ha^(-1)yr^(-1))and the tropical region(10 t ha^(-1)yr^(-1)).Similarly,the results of morphometric analysis showed that the studied watershed has S-shaped hypsometric curve,an indication for maturity stage of landscape *** studied watershed is also characterized by a non-circular shaped drainage with rugged and dissected topography that contributes to high flash flood,peak discharge and incidence of soil *** result of both models signified that S3 and S4 are highly susceptible to soil ***,t

关键词： Soil loss RUSLE model morphometric analysis Gilgel Abay watershed

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

A review of the efficacy of traditional Iranian medicine forinflammatory bowel disease

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World Journal of Gastroenterology 2010年第36期16卷 4504-4514页

作者： roja Rahimi mohammad Abdollahi mohammad Reza Shams-Ardekani Faculty of Traditional medicine Tehran University of Medical SciencesTehran ***Iran Faculty of Pharmacy Pharmaceutical Sciences Research CenterEndocrinology and Metabolism Research InstituteTehran University of Medical SciencesTehran ***Iran

The etiology of inflammatory bowel disease(IBD) is not yet known,but many factors such as defects in the immune system,oxidative stress,microbial content in the gastrointestinal tract,nuclear factor(NF)-κB,nitric oxide(NO),cyclooxygenase-2(Cox-2),and leukotriene B4(LB4) are thought to play a role in its *** traditional Iranian medicine(TIm),several medicinal plants are thought to be effective for the treatment of *** this study,information on all of these remedies were derived from all available old sources such as documents or notes and books and were added to the information derived from modern medical databases covering all in vitro,in vivo and clinical *** some of these plants,only one or two mechanisms of action have been found such as in Cassia fistula,Lepidium sativum,and Bunium ***,for some plants various mechanisms of action are *** example,Commiphora mukul is effective in IBD due to its immunomodulatory,antioxidant,and antibacterial properties and it decreases NF-κB,NO and *** herb,Plantago ovata,has immunomodulatory,antioxidant,anti-inflammatory and wound healing activities and decreases NO and *** the mechanisms of action of these plants,the combination of some of them may be useful because of their many mechanisms of action such as Pistacia lentiscus,Bunium persicum,Solanum nigrum,Plantago ovata,Boswellia,Solanum nigrum,Plantago ovata and Commiphora *** some of the herbal products used in TIm such as oleogum resin from Commiphora myrrha,seeds of Ocimum basilicum,seeds of Linum usitatissimum,gum resin of Dracaena cinnabari,seeds of Plantago major,seeds of Lallementia royleana,and seeds of Allium porrum,there is no or not enough studies to confirm their benefits in *** is suggested that an evaluation of the effects of these plants on different aspects of IBD should be performed.

关键词： Herbal medicine Inflammatory bowel disease medicinal plants Traditional Iranian medicine

Irreversibility investigation of Casson fluid flow in an inclined channel subject to a Darcy-Forchheimer porous medium:a numerical study

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Applied mathematics and mechanics(English Edition) 2021年第1期42卷 95-108页

作者： A.roja B.J.GIREESHA B.NAGARAJA Department of PG Studies and Research in mathematics Kuvempu UniversityShankaraghattaShimoga 577451KarnatakaIndia

The heat transfer and entropy generation characteristics of the magnetohydrodynamic Casson fluid flow through an inclined microchannel with convective boundary conditions are ***,the effects of the viscous forces,Joule heating,heat source/sink,and radiation on the flow are taken into *** non-dimensional transformations are used to solve the governing ***,the reduced system is resolved by the fourth-fifth order Runge-Kutta-Fehlberg method along with the shooting *** effects of different physical parameters on the heat transfer and entropy generation are discussed in detail through *** the perspective of numerical results,it is recognized that the production of entropy can be improved with the Joule heating,viscous dissipation,and convective heating *** is concluded that the production of entropy is the maximum with increases in the Casson parameter,the angle of inclination,and the Hartmann *** the Reynolds number and the radiation parameter cause the dual impact on entropy generation.

关键词： inclined channel Casson fluid magnetism radiation entropy generation Bejan number

Numerical method for Singularly Perturbed Third Order Ordinary Differential Equations of Convection-Diffusion Type

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Numerical mathematics(Theory,methods and Applications) 2014年第3期7卷 265-287页

作者： J.Christy roja A.Tamilselvan Department of mathematics Bharathidasan UniversityTiruchirappalli–620024TamilnaduIndia

In this paper,we have proposed a numerical method for Singularly Perturbed Boundary Value Problems(SPBVPs)of convection-diffusion type of third order Ordinary Differential Equations(ODEs)in which the SPBVP is reduced into a weakly coupled system of two ODEs subject to suitable initial and boundary *** numerical method combines boundary value technique,asymptotic expansion approximation,shooting method and finite difference *** order to get a numerical solution for the derivative of the solution,the domain is divided into two regions namely inner region and outer *** shooting method is applied to the inner region while standard finite difference scheme(FD)is applied for the outer *** error estimates are derived for the *** efficiency and accuracy are verified through numerical *** method is easy to implement and suitable for parallel computing.

关键词： Singularly perturbed problems third order ordinary differential equations boundary value technique asymptotic expansion approximation shooting method finite difference scheme parallel computation