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Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective

World Journal of Hepatology 2015年第2期7卷 235-244页

作者： Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L frankel Dawn Owen Pranab M Barman University of Michigan and Veterans Administration Hospital

A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC.

关键词： Ablation Chemoembolization Radiation Hepatocellular carcinoma

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单克隆抗体用于生产乳腺癌选择性免疫毒素

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细胞与分子免疫学杂志 1985年第4期 92-92页

作者： frankel D. 王天骄

将人乳腺癌手术后的新鲜癌肿组织,应用多元匀浆法(Polytronhomogenization)及非连续蔗糖梯度离心沉淀法制备出细胞膜萃取物。用这些萃取物或人乳腺癌活细胞系对BALB/c小鼠进行免疫,经过追加免疫后,取免疫的脾细胞与SP2/0小鼠骨髓瘤细胞... 详细信息

将人乳腺癌手术后的新鲜癌肿组织,应用多元匀浆法(Polytronhomogenization)及非连续蔗糖梯度离心沉淀法制备出细胞膜萃取物。用这些萃取物或人乳腺癌活细胞系对BALB/c小鼠进行免疫,经过追加免疫后,取免疫的脾细胞与SP2/0小鼠骨髓瘤细胞融合,共进行52次融合,筛选出14,000个孔有乳腺癌选择性抗体的存在。95株杂交瘤产生的抗体对

关键词：乳腺癌萃取物小鼠反应乳腺肿瘤小家鼠抗毒素免疫毒素蓖麻毒素

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地震区划图有助于拯救生命和财产

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世界地震译丛 2002年第1期33卷 88-88,F003页

作者： W.M.BrownⅢ D.M.Perkins E.V.Leyendecker A.D.frankel J.W.HendleyⅡ P.H.Stauffer 杨一飞中国地震局地球物理研究所

美国地震区划图为编制和修订美国建筑物抗震规范设计提供了所需资料。为了能反映最新的认识水平,科学家经常修订地震区划图。满足现代抗震设计规范的建筑具有较好的抗震性能,不仅能减少人员伤亡,而且能使如生命线工程等正常运转。

关键词：地震区划图地震危险性抗震能力地震动水平人员伤亡经济损失

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综合多中心研究数据库评价依那西普治疗银屑病的有效性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 9-9页

作者： Gordon K. Korman N. frankel E. 朱国兴 Division of Dermatology Evanston Northwestern Healthcare 9977Woods Dr Skokie IL 60077 United States Dr.

Background: The tumor necrosis factor (TNF) inhibitor etanercept has been demonstrated to be safe and effective for treating chronic plaque psoriasis in 3 clinical trials. Objectives: To refine efficacy results for etanercept on the basis of a larger population size through the integration of the 3 studies, and to determine if the efficacy profile across all 3 studies is consistent with efficacy profiles observed for individual trials. Methods: In these integrated analyses, data for 1187 patients from 3 blinded treatment groups were pooled to compare efficacy at 12 weeks: etanercept 50 mg weekly (equivalent to 25 mg twice weekly) subcutaneously, etanercept 50 mg twice weekly subcutaneously, and placebo. The primary efficacy end point in all 3 studies was at least a 75% improvement in the Psoriasis Area and Severity Index (PASI 75). Other measurements included PASI 50, PASI 90, patient’ s and dermatologist’ s global assessments, and Dermatology Life Quality Index. Results: In the integrated analyses, statistically significant, dosede-pendent improvements in PASI 75 at 12weeks were observed in patients treated with etanercept 50 mg weekly (33% ) and 50 mg twice weekly (49% ), comparedwith the placebo group (3% ; P < .05). Significant improvements also were seen in all secondary end points (PASI 50 and PASI 90 responses, patient’ s and dermatologist’ s global assessments, and Dermatology Life Quality Index) at 12 weeks. Subgroup analyses of baseline patient characteristics demonstrated that there were no statistically significant treatment-by-covariate interactions. Limitations: A limitation of these integrated analyses is the relatively short (12-week) time frame. Conclusion: The efficacy profile of etanercept in patients with psoriasis was consistent across multiple studies as shown in the integrated analyses of the primary and secondary end points. Etanercept demonstrated rapid,dosedependent improvements in disease severity and quality of life consistently over all

关键词：银屑病依那西普研究数据库临床试验研究大样本量次要终点皮肤科医师严重度肿瘤坏死因子安

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新冠肺炎疫情会引发全球经济衰退吗

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中国房地产金融 2020年第1期 59-59页

作者：杰弗里·弗兰克尔美国哈佛大学肯尼迪政府管理学院

始于年初的新冠肺炎疫情,逐渐出现全球蔓延的趋势,美国哈佛大学肯尼迪政府管理学院经济学教授杰弗里·弗兰克尔撰文称,新冠肺炎Covid-19病毒正在改变全球经济复苏。弗兰克尔称,新冠肺炎早期发现时对经济影响的预测有点乐观,仅仅是对照2... 详细信息

始于年初的新冠肺炎疫情,逐渐出现全球蔓延的趋势,美国哈佛大学肯尼迪政府管理学院经济学教授杰弗里·弗兰克尔撰文称,新冠肺炎Covid-19病毒正在改变全球经济复苏。弗兰克尔称,新冠肺炎早期发现时对经济影响的预测有点乐观,仅仅是对照2003年SARS时期,对全球经济影响微乎其微,仅对中国经济造成了短期的影响,当疫情过后,中国经济很快反弹。

关键词：弗兰克尔经济学教授全球经济复苏杰弗里全球经济影响全球经济衰退全球蔓延政府管理学院

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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