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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping Fu Can-xu Zhou Guo-fa mi Yuan Liu School of materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 mPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration

radioisotope production using lasers:From basic science to applications

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matter and radiation at Extremes 2024年第3期9卷 31-44页

作者： m.r.D.rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur D.Singappuli D.molloy D.raffestin m.Alonzo G.G.rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.La Cognata S.Palmerini T.Carriere m.Cipriani G.Di Giorgio G.Cristofari r.De Angelis G.A.P.Cirrone D.margarone L.Giuffrida D.Batani P.Nicolai K.Batani r.Lera L.Volpe D.Giulietti S.Agarwal m.Krupka S.Singh fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

Knowledge Graph Enhanced Transformers for Diagnosis Generation of Chinese medicine

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Chinese Journal of Integrative medicine 2024年第3期30卷 267-276页

作者： WANG Xin-yu YANG Tao GAO Xiao-yuan HU Kong-fa School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing210023China School of Information management Nanjing UniversityNanjing210023China Jiangsu Collaborative Innovation Center of Traditional Chinese medicine in Prevention and Treatment of Tumor Nanjing210023China Jiangsu Province Engineering research Center of TCm Intelligence Health Service Nanjing210023China

Chinese medicine(Cm)diagnosis intellectualization is one of the hotspots in the research of Cm *** traditional Cm intelligent diagnosis models transform the Cm diagnosis issues into classification issues,however,it is difficult to solve the problems such as excessive or similar *** the development of natural language processing techniques,text generation technique has become increasingly *** this study,we aimed to establish the Cm diagnosis generation model by transforming the Cm diagnosis issues into text generation *** semantic context characteristic learning capacity was enhanced referring to Bidirectional Long Short-Term memory(BILSTm)with Transformer as the backbone ***,the Cm diagnosis generation model Knowledge Graph Enhanced Transformer(KGET)was established by introducing the knowledge in medical field to enhance the inferential *** KGET model was established based on 566 Cm case texts,and was compared with the classic text generation models including Long Short-Term memory sequence-to-sequence(LSTm-seq2seq),Bidirectional and Auto-regression Transformer(BArT),and Chinese Pre-trained Unbalanced Transformer(CPT),so as to analyze the model ***,the ablation experiments were performed to explore the influence of the optimized part on the KGET *** results of Bilingual Evaluation Understudy(BLEU),recall-Oriented Understudy for Gisting Evaluation 1(rOUGE1),rOUGE2 and Edit distance of KGET model were 45.85,73.93,54.59 and 7.12,respectively in this *** with LSTm-seq2seq,BArT and CPT models,the KGET model was higher in BLEU,rOUGE1 and rOUGE2 by 6.00–17.09,1.65–9.39 and 0.51–17.62,respectively,and lower in Edit distance by 0.47–*** ablation experiment results revealed that introduction of BILSTm model and prior knowledge could significantly increase the model ***,the manual assessment indicated that the Cm diagnosis results of the KGET model used

关键词： Chinese medicine diagnosis knowledge graph enhanced transformer text generation

Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo Pan-Pan ma Xiao-Long Ye ming-Lin Pan Bo Hang Jian-Hua mao Antoine m Snijders Yi-Bing Lu Da-fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGrOUND The understanding of bile acid(BA)and unsaturated fatty acid(Ufa)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2Dm)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2Dm without NAFLD,and 152 individuals with T2Dm and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2Dm and NAFLD groups exhibited diminished levels of specific *** Ufas,particular acids exhibited a positive correlation with NAFLD risk in T2Dm,while theω-6:ω-3 Ufa ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2Dm *** This study underscores the connection between altered BA and Ufa profiles and the presence of NAFLD in individuals with T2Dm,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

Calibration and experimental verification of discrete element parameters of Panax notoginseng root

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 13-23页

作者： Kaiting Xie Zhaoguo Zhang fa’an Wang Xiaolan Yu Chenglin Wang Shifei Jiang faculty of mechanical and Electrical Engineering Kunming University of Science and TechnologyKunming 650500China faculty of modern Agricultural Engineering Kunming University of Science and TechnologyKunming 650500China Guizhou Agricultural machinery Technology Promotion Station Guiyang 550003China Yunnan Tobacco machinery Co. LtdKunming 650100China

Existing discrete element method-based simulation analysis of Panax notoginseng root soil separation still has the challenge to get the accurate and reliable basic parameters,which are necessary for discrete element *** this paper,the *** roots suitable for harvesting period were taken as the experimental *** using 3D scanning reverse modeling technology and EDEm software to establish the discrete element model of ***,based on which,the physical and virtual tests were carried out to calibrate the simulation ***,the basic physical parameters(density,triaxial geometric size,moisture content,shear modulus,and elastic modulus)and contact coefficients(static friction coefficient,rolling friction coefficient,and crash recovery coefficient between *** roots and 65mn steel)were measured by physical ***,treating the contact coefficients of *** roots as the influence factor,the steepest uphill test,and four factors combing five levels of rotational virtual simulation are *** measured relative error accumulation angle and simulation accumulation angle are set as the performance *** results show that the static friction coefficient,rolling friction coefficient,crash recovery coefficient,and surface energy coefficient of *** roots are 0.55,0.35,0.16,and 19.5 J/m2,*** calibration results as parameters of the vibration separation simulation test of *** soil,the Box-Behnken vibration separation simulation tests were carried out,in which the vibration frequency,inclination angle,and vibration amplitude of separation device as factors,screening rate and damage rate of *** soil complex are regarded as *** results show that the optimal operating parameters of the separation device are the vibration frequency of 10 Hz,the inclination angle of 5°,and the amplitude of 6 *** on the optimal operation parameters,the discrete element

关键词： Panax notoginseng root EDEm parameter calibration separation test

Spatial construction of ultrasmall Pt-decorated 3D spinel oxidemodified N-doped graphene nanoarchitectures as high-efficiency methanol oxidation electrocatalysts

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rare metals 2024年第1期43卷 186-197页

作者： Qi Zhang min-min Yan Wen-fa Du Chen-Yu Yin Jian Zhang Lu Yang Yun-Qing Kang Hai-Yan He Hua-Jie Huang College of mechanics and materials Hohai UniversityNanjing 210098China New Energy Technology Engineering Lab of Jiangsu Province College of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China International Center for materials Nanoarchitectonics(WPImANA) National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan

Direct methanol fuel cell technology recently becomes the focus of both academic and engineering circles,which stimulates the exploitation and utilization of advanced electrode catalysts with high activity and long ***,we demonstrate a robust bottom-up approach to the spatial construction of three-dimensional(3D) spinel manganese-cobalt oxide-modified N-doped graphene nanoarchitectures decorated with ultrasmall Pt nanoparticles(Pt/mnCo_(2)O_(4)-NG) via a controllable selfassembly *** incorporation of mnCo_(2)O_(4)nanocrystals provides abundant hydroxyl sources to promote the oxidative removal of CO-like byproducts on Pt sites,while the existence of 3D porous N-doped graphene networks facilitates the transportation of both ions and electrons in the hybrid system,thus giving rise to remarkable synergetic coupling effects during the methanol oxidation ***,the optimized Pt/mnCo_(2)O_(4)-NG nano architecture expres ses exceptional electrocatalytic properties with a large electrochemically active surface area of 99.5 m^(2)·g^(-1),a high mass activity of1508.3 mA·mg^(-1),strong toxicity resistance and reliable long-term durability,which have obvious competitive advantages over those of conventional Pt/carbon black,Pt/carbon nano tube,Pt/graphene,and Pt/N-doped graphene catalysts with the same Pt usage.

关键词： Platinum mnCo_(2)O_(4) 3D graphene Electrocatalysts methanol oxidation

Urban Electric Vehicle Charging Station Placement Optimization with Graylag Goose Optimization Voting Classifier

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Computers, materials & Continua 2024年第7期80卷 1163-1177页

作者： Amel Ali Alhussan Doaa Sami Khafaga El-Sayed m.El-kenawy marwa m.Eid Abdelhameed Ibrahim Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Communications and Electronics Delta Higher Institute for Engineering and TechnologyMansoura35511Egypt faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt

To reduce the negative effects that conventional modes of transportation have on the environment,researchers are working to increase the use of electric *** demand for environmentally friendly transportation may be hampered by obstacles such as a restricted range and extended rates of *** establishment of urban charging infrastructure that includes both fast and ultra-fast terminals is essential to address this ***,the powering of these terminals presents challenges because of the high energy requirements,whichmay influence the quality of *** the maximum hourly capacity of each station based on its geographic location is necessary to arrive at an accurate estimation of the resources required for charging *** is vital to do an analysis of specific regional traffic patterns,such as road networks,route details,junction density,and economic zones,rather than making arbitrary conclusions about traffic *** vehicle traffic is simulated using this data and other variables,it is possible to detect limits in the design of the current traffic engineering ***,the binary graylag goose optimization(bGGO)algorithm is utilized for the purpose of feature ***,the graylag goose optimization(GGO)algorithm is utilized as a voting classifier as a decision algorithm to allocate demand to charging stations while taking into consideration the cost variable of traffic *** on the results of the analysis of variance(ANOVA),a comprehensive summary of the components that contribute to the observed variability in the dataset is *** results of the Wilcoxon Signed rank Test compare the actual median accuracy values of several different algorithms,such as the voting GGO algorithm,the voting grey wolf optimization algorithm(GWO),the voting whale optimization algorithm(WOA),the voting particle swarm optimization(PSO),the voting firefly algorithm(fa),and the voting genetic algori

关键词： Electric vehicle graylag goose optimization metaheuristics optimization machine learning

Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress

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World Journal of Gastroenterology 2024年第19期30卷 2564-2574页

作者： Yan-Fei Li fang-Yuan Zheng Xin-Yu miao Hai-Long Liu Yao-Yao Zhang Nai-Xia Chao fa-rong mo School of Basic medical Sciences Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Biological molecular medicine research(Guangxi medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Development and Disease research(Guangxi medical University) Education Department of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGrOUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the m *** research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely *** To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC *** Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shrNA interference sequences(LV-CDC25C shrNA)to knock down ***,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in *** proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,*** expression of endoplasmic reticulum(Er)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCr(qrT-PCr)and western ***,apoptosis was investigated using flow cytometry,qrT-PCr,and western *** CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shrNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in ***25C knockdown not only inhibited cell proliferation and migration but also significantly increased the Er stress response,ultimately promoting Er stress-induced apoptosis in HCC *** The regulatory mechanism of CDC25C in HCC development may involve the activation of Er stress and the Er stress-induced apoptosis signali

关键词： Cell division cyclin 25C Hepatocellular carcinoma Endoplasmic reticulum stress Proliferation Apoptosis

mercury Levels Assessment in the Population of Aby and Frambo Villages in the Vinicity of Aby Lagoon in Côte d’Ivoire (West Africa)

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Journal of Water resource and Protection 2024年第3期16卷 219-232页

作者： Stéphane Jean Claon Serge Kouakou Kouassi Nina Laurette Ahouéfa Laurent Kipré Seri Arsène m’bassidjé Seka Joseph Allico Djaman Luc Kouakou Kouadio Analytical Sciences and Public Health Department University of Félix Houphou&eumlt-Boigny Abidjan C&ocircte d'Ivoire Water Quality Control and Analysis Laboratory (LACQUE) Office National de l’Eau Potable (ONEP) Abidjan C&ocircte d’Ivoire Biology and Health Laboratory University of Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Laboratory of Nutrition and Food Safety Department of Science and Food Technology Nangui Abrogoua University Abidjan C&ocircte d'Ivoire Department of medical and Fundamental Biochemistry Institut Pasteur of C&ocircte d'Ivoire Abidjan C&ocircte d’Ivoire Laboratory of Environmental Sciences (LSE) University of Nangui Abrogoua Abidjan C&ocircte d’Ivoire

The minamata Convention in the aim to protect human life and the environment, seeks to reduce mercury (Hg) by monitoring it concentrations in the environment. Artisanal and Small-scale Gold mining (ASGm) has been identified as the most important anthropogenic source of human exposure to Hg. In this context, the main goal of this study was to assess the level of mercury in hair of two (2) populations living along two lagoons respectively Aby and Tendo, in Ivory Coast. To reach this goal, hair samples of 138 residents were collected and analyzed by using Cold Vapor Atomic Fluorescence Spectrophotometry (CV-AFS) technique for mercury concentration. results showed that for the entire population the Hg mean was 2.34 μg/g. Also, they were ranged between 0.15 to 8.53 μg/g and presented substantial differences amongst the villages. In Aby village, we observed the highest Hg concentrations (mean = 2.62 μg/g). Our findings showed that almost the entire sample group (82%) exceed the USEPA recommended limit, furthermore 56% of them exceed the normal level of WHO and 2% of the respondent has the unhealthy levels of mercury (≥6 μg Hg/g) of hair by WHO standards. Gender differences in hair mercury varies greatly among reports. Lower levels in women’s hair compared to men were reported in the both village. Considering age, the lowest concentrations were observed with children. However, when we take in account the age groups, data suggested that the most exposed sub-population of [18-29] years old is from Aby village in opposite at Frambo village, the same case those who were ≥ 40 years old. It’s convenient to note that, the proportion of mercury levels would not to be neglected among studied population especially with the resident from Aby village. So, some measures need to be taken at the political level to control mercury contamination.

关键词： mercury Hair ASGm Population Exposure Côte d’Ivoire

mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing Joshua m.Little Haochen Yang Tsai-Chun Chung Po-Yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA maryland robotics Center University of MarylandCollege ParkMD 20742USA School of materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2Dms)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2Dm microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2Dm microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2Dm microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2Dm nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2Dm aerogels,and(4)wrinkle skin of an elephant that influences the development of 2Dm protective skin for soft ***,challenges and future opportunities of adopting 2Dm nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality