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Tr.-axial acceler.metr. allows to deter.ine par.ntal food pr.visioning behaviour.in a mar.ne bir.

Avian r.sear.h 2024年第3期15卷 345-351页

作者： Monser.at Del caño Flavio Quintana Giacomo Dell’omo Agustina Gómez-Laich Instituto de Biología de or.anismos Mar.nos(IBIoMAr. CONICETBoulevard Brown 2915U9120ACDPuerto MadrynChubutArgentina or.is Italica Piazza Crati 1500199RomeItaly Depar.amento de Ecología Genética y Evolución(EGE)and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)CONICETFacultad de CienciasExactas y NaturalesUniversidad de Buenos AiresPabellón II Ciudad UniversitariaC1428EGACiudad Autónoma de Buenos AiresArgentina

The study of par.ntal food pr.visioning is essential for.understanding the br.eding ecology of *** conducted the fir.t study using acceler.metr. to detect food pr.visioning in bir.s,using Suppor. Vector.Machine(SVM)models to identify when adults feed chicks of thr.e differ.nt age *** wer. attached to the head of adult female Imper.al Shags(Leucocar.o atr.ceps),and var.ous attr.butes derived fr.m the acceler.tion signals wer. used to tr.in SVM models for.each chick age *** per.or.ance impr.ved with chick age class,with SVM models achieving high over.ll accur.cy(>88%)and highest sensitivity in older chick categor.es(>91%).However.pr.cision values,especially for.younger.chicks,r.mained r.latively low(between 26%and 45%).The application of a time filter.based on the minimum dur.tion of the obser.ed food pr.visioning behaviour. for.each chick age categor.,impr.ved model per.or.ance by r.ducing false pr.visioning behaviour.,par.icular.y in the model for.older chicks,which showed the highest pr.cision(72.4%).This study highlights the effectiveness of acceler.metr. and machine lear.ing in studying par.ntal food pr.visioning in bir.s,pr.viding a r.pid and accur.te data collection method to complement tr.ditional *** descr.bed methodology can be applied to any bir. species that exhibits distinctive movements while feeding its offspr.ng and has suitable char.cter.stics for.attaching an acceler.meter.to the body par. that best captur.s this ***,it is hoped that the r.sults of this study will contr.bute to futur. r.sear.h on key questions in par.ntal investment theor. and r.pr.ductive str.tegies in bir.s.

关键词： Acceler.metr. Food pr.visioning Imper.al shag Leucocar.o atr.ceps Seabir. Suppor. vector.machine

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Assimilation of GoES-r.Geostationar. Lightning Mapper.Flash Extent Density Data in GSI 3Dvar. EnKF, and Hybr.d En3Dvar.for.the Analysis and Shor.-Ter. For.cast of a Super.ell Stor. case

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Advances in Atmospher.c Sciences 2024年第2期41卷 263-277页

作者： r.ng KoNG Ming XUE Edwar. r.MANSELL Chengsi LIU Alexandr. o.FIEr.o Center.for.Analysis and Pr.diction of Stor.s Norman Oklahoma 73072U.S.A Univer.ity of oklahoma Norman Oklahoma 73072U.S.A NoAA/National Sever. Stor.s Labor.tor. NormanOklahoma 73072U.S A.4Zentr.lanstalt für.Meteor.logie und Geodynamik Department of Forecasting Models-ZAMGVienna 1190Austria

capabilities to assimilate Geostationar. oper.tional Envir.nmental Satellite “r.ser.es ”(GoES-r. Geostationar. Lightning Mapper.GLM) flash extent density(FED) data within the oper.tional Gr.dpoint Statistical Inter.olation ensemble Kalman filter.GSI-EnKF) fr.mewor. wer. pr.viously developed and tested with a mesoscale convective system(MCS) case. In this study, such capabilities ar. fur.her.developed to assimilate GoES GLM FED data within the GSI ensemble-var.ational(Envar. hybr.d data assimilation(DA) fr.mewor.. The r.sults of assimilating the GLM FED data using 3Dvar. and pur. En3Dvar.PEn3Dvar. using 100% ensemble covar.ance and no static covar.ance) ar. compar.d with those of EnKF/DfEnKF for.a super.ell stor. case. The focus of this study is to validate the cor.ectness and evaluate the per.or.ance of the new implementation r.ther.than compar.ng the per.or.ance of FED DA among differ.nt DA schemes. only the r.sults of 3Dvar.and pEn3Dvar.ar. examined and compar.d with EnKF/DfEnKF. Assimilation of a single FED obser.ation shows that the magnitude and hor.zontal extent of the analysis incr.ments fr.m PEn3Dvar.ar. gener.lly lar.er.than fr.m EnKF, which is mainly caused by using differ.nt localization str.tegies in EnFK/DfEnKF and PEn3Dvar.as well as the integr.tion limits of the gr.upel mass in the obser.ation oper.tor. over.ll, the for.cast per.or.ance of PEn3Dvar.is compar.ble to EnKF/DfEnKF, suggesting cor.ect implementation.

关键词： GoES-r lightning data assimilation EnKF Envar

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r.dent biology and ecologically based r.dent management(EBr.)-25 year. of pr.gr.ss thr.ugh pr.moting multidisciplinar. r.sear.h

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Integr.tive Zoology 2024年第1期19卷 2-7页

作者： Gr.nt r. SINGLEToN Lyn A. HINDS r.odes MAKUNDI Steven r. BELMAIN Natur.l r.sour.es Institute University of Greenwich Kent UK CSIr. Health and Biosecur.ty Canberra ACT Australia Afr.can Centr. of Excellence for.Innovative r.dent Pest Management and Biosensor.Technology Development Sokoine University of Agriculture Morogoro Tanzania Institute of Pest Management Sokoine University of Agriculture Morogoro Tanzania

“Dur.ng r.dent outbr.ak year. in easter. Afr.ca,lo-cally,mor. than 80%of the potential har.est may be lost,but even in non-outbr.ak per.ods,r.dents cause chr.nic damage to cr.ps….The pest r.dent stor. in Afr.ca in-volves sever.l species embedded in a br.ad and var.able landscape with highly var.able densities.”(Leir. et al.2010).

关键词： damage cr.ps

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Fast pr.diction of r.in er.sion in wind tur.ine blades using a data-based computational tool

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Jour.al of Hydr.dynamics 2024年第3期36卷 504-518页

作者： Juan M.Gimenez Ser.io r.Idelsohn Eugenio oñate Centr. Inter.acional de Mètodes Numèr.cs en Enginyer.a(CIMNE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind tur.ines(WTs)face a high r.sk of failur. due to envir.nmental factor. like er.sion,par.icular.y in high-pr.cipitation ar.as and offshor. *** this paper.we intr.duce a novel computational tool for.the fast pr.diction of r.in er.sion damage on WT blades that is useful in oper.tion and maintenance decision making *** appr.ach is as follows:Pseudo-Dir.ct Numer.cal Simulation(P-DNS)simulations of the dr.plet-laden flow ar.und the blade section pr.file ar. employed to build a high-fidelity data set of impact statistics for.potential oper.ting *** this database as tr.ining data,a machine lear.ing-based sur.ogate model pr.vides the featur. of the impact patter. over.the 2-D section for.given wind and r.in *** this infor.ation,a fatigue-based model estimates the r.maining lifetime and er.sion damage for.both homogeneous and coating-substr.te blade *** pr.diction is done by quantifying the accumulated dr.plet impact ener.y and evaluating oper.tive conditions over.time per.ods for.which the weather.at the installation site is *** this wor.,we descr.be the modules that compose the pr.diction method,namely the database cr.ation,the tr.ining of the sur.ogate model and their.coupling to build the pr.diction ***,the method is applied to pr.dict the r.maining lifetime and er.sion damage to the blade sections of a r.fer.nce *** evaluate the r.liability of the tool,sever.l site locations(offshor.,coastal,and inland),the coating mater.al and the coating thickness of the blade ar. *** few minutes we ar. able to estimate er.sion after.many year. of *** r.sults ar. in good agr.ement with field obser.ations,showing the pr.mise of the new r.in er.sion pr.diction appr.ach.

关键词： Wind tur.ine blades leading edge er.sion fatigue Pseudo-Dir.ct Numer.cal Simulation(P-DNS) machine lear.ing eblader

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Assessment of pr.gr.mmed death-ligand 1 expr.ssion in pr.mar. tumor. and pair.d lymph node metastases of gastr.c adenocar.inoma

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Wor.d Jour.al of Gastr.intestinal oncology 2024年第3期16卷 883-893页

作者： Br.ndha cação Coimbr. Mar.na Alessandr. Per.ir. Leonar.o car.ili Venancio Avancini Fer.eir. Alves Evandr. Sobr.za de Mello Ulysses r.beir. Jr.Mar.us Fer.ando Kodama Per.ille r.mos Depar.ment of Gastr.enter.logy Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Depar.ment of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGr.UND Anti-pr.gr.mmed death-1/pr.gr.mmed death-ligand 1(PD-1/PD-L1)immuno-ther.py has demonstr.ted pr.mising r.sults on gastr.c cancer.GC).However.PD-L1 can expr.ss differ.ntly between metastatic sites and pr.mar. tumor.(PT).AIM To compar. PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to deter.ine the cor.elation between the PD-L1 status and clinicopathological *** We r.tr.spectively r.viewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistr.(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+wer. also tested for.PD-L1 expr.ssion in their.***-L1(-)GC with pN+ser.ed as the compar.son *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For.compar.son,44 PD-L1(-)cases with pN+wer. included(sample loss of 4 cases).of the PD-L1+PT,54.2%(13/24 cases)wer. also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agr.ement between PT and LNM had a kappa value of *** tumor.size and moderate/sever. per.tumor.l inflammator. r.sponse wer. associated with PD-L1 positivity in both *** was no statistical differ.nce in over.ll sur.ival for.PT and LNM accor.ing to the PD-L1 status(P=0.166 and P=0.837,r.spectively).CoNCLUSIoN Intr.-patient heter.geneity in PD-L1 expr.ssion was obser.ed between the PT and matched *** disagr.ement in PD-L1 status may emphasize the impor.ance of considering differ.nt tumor.sites for.analyses to select patients for.immunother.py.

关键词： Gastr.c cancer Lymph node Pr.gr.mmed death ligand 1 Stomach neoplasms Immunohistochemistr. Metastasis

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Per.pectives for.deliver. of ther.peutics by extr.vasation of biodegr.dable micr.spher.s in the br.in

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Neur.l r.gener.tion r.sear.h 2024年第5期19卷 969-970页

作者： Anne-Eva van der Wijk Ed vanBavel Amster.am UMC location Univer.ity of Amster.am Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amster.am Neur.science Neurovascular Disorders ProgramAmsterdamThe Netherlands Amster.am car.iovascular.Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of ther.peutics for.br.in diseases has r.mained challenging,in par.icular.due to the difficulty of passing the blood-br.in *** a r.sult,the cur.ent ar.enal of ther.peutics tar.eting the br.in is limited to small,lipid-soluble dr.gs and ther. is a lack of options for.tr.ating neur.blastomas,Alzheimer.s disease,and many other.devastating *** the advances in str.tegies for.cr.ssing the blood-br.in bar.ier.such as the use of nanopar.icles(Her.h et al.,2022;Duan et al.,2023),such deliver. systems have not yet r.ached clinical ***,novel platfor.s for.the tr.nspor. of ther.peutics acr.ss the blood-br.in bar.ier.r.main highly *** specifically holds for.lar.e molecules such as monoclonal antibodies and r.combinant pr.teins,as well as nucleotide-based ther.peutics and cell *** effor.s in this field ar. incr.asing exponentially,with thousands of publications in the last few year..

关键词： ther.peutics holds spite

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New insights into pr.tein–polysacchar.de complex coacer.ation:Dynamics,molecular.par.meter.,and applications

Aggregate

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Aggr.gate 2024年第1期5卷 148-166页

作者： Jiabao Zheng Paul van der Meer.n Weizheng Sun School of Food Science and Engineer.ng South China University of TechnologyGuangzhouChina Depar.ment of Gr.en Chemistr. and Technology Faculty of Bioscience EngineeringGhent UniversityGhentBelgium over.eas Exper.ise Intr.duction Center.for.Discipline Innovation of Food Nutr.tion and Human Health(111 Center. GuangzhouChina

For.mor. than a decade,the discover. of liquid–liquid phase separ.tion within living or.anisms has pr.mpted colloid scientists to understand the connection between coacer.ate functionality,phase behavior.and dynamics at a multidisciplinar. *** the pr.tein–polysacchar.de was the fir.t system in which the coacer.ation phenomenon was discover.d and is widely used in food systems,the phase state and r.laxation dynamics of pr.tein–polysacchar.de complex coacer.ates(PPCC)have r.r.ly been discussed ***,this r.view aims to unr.vel the r.lationship between PPCC dynamics,ther.odynamics,molecular.ar.hitectur.,applications,and phase states in past *** ahead,solving the way molecular.ar.hitectur. spr.ads to macr.-functionality,that is,establishing the r.lationship between molecular.ar.hitectur.–dynamics–application,will catalyze novel advancements in PPCC r.sear.h within the field of foods and biomater.als.

关键词： dynamics encapsulation liquid coacer.ate pr.tein-polysacchar.de complex coacer.ation solid pr.cipitate

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optimal pr.vatisation,and optimum-welfar. and maximum-r.venue tar.ffs

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Economic and Political Studies 2024年第2期12卷 220-234页

作者： Tien-der Han r.ochen Li Loughbor.ugh Business School Loughborough UniversityLoughboroughUK Centr. for.Economic r.sear.h Shandong UniversityJinanChina

We examine the effect of pr.vatisation on the pr.or.ty of the maximum-r.venue tar.ff and the optimum-welfar. tar.ff in an inter.ational mixed oligopoly with for.ign competition and optimal *** demonstr.te that when the mar.inal cost of the domestic pr.vatised fir. is high enough,the optimumwelfar. tar.ff will exceed the maximum-r.venue ***,due to the higher.tar.ff r.te that leads to the high degr.e of pr.vatisation,the optimum-welfar. tar.ff gener.tes gr.ater.optimal pr.vatisation than the maximum-r.venue tar.ff ***,when the gap between the number.of domestic pr.vate fir.s and that of their.for.ign counter.ar.s becomes lar.er.the optimum-welfar. tar.ff will exceed the maximum-r.venue tar.ff.

关键词： Mixed oligopoly par.ial pr.vatisation tar.ff r.nking

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Game changer.How Janus kinase inhibitor. ar. r.shaping the landscape of ulcer.tive colitis mana

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Wor.d Jour.al of Gastr.enter.logy 2024年第35期30卷 3942-3953页

作者： Antonio M caballer.-Mateos Guiller.o Ar.ur. cañadas-de la Fuente Depar.ment of Gastr.enter.logy and Hepatology San Cecilio University HospitalGranada 18014Spain Depar.ment of Nur.ing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

r.cent advancements in the tr.atment landscape of ulcer.tive colitis(UC)have usher.d in a new er. of possibilities,par.icular.y with the intr.duction of Janus kinase(JAK)-signal tr.nsducer.and activator.of tr.nscr.ption *** novel agents offer.a par.digm shift in UC management by tar.eting key signaling pathways involved in inflammator. *** appr.ved JAK inhibitor.(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have power.ul tools to modulate immune r.sponses and gene expr.ssion,potentially r.volutionizing the tr.atment algor.thm for.*** tr.als have demonstr.ted the efficacy of JAKis in inducing and maintaining r.mission,pr.senting viable options for.patients who have failed conventional ***-wor.d data suppor. the use of JAKis not only as fir.t-line tr.atments but also in subsequent lines of ther.py,par.icular.y in patients with aggr.ssive disease phenotypes or.r.fr.ctor. to biologic *** r.pid onset of action and potency of JAKis have br.adened the possibilities in the management str.tegies of UC,offer.ng timely r.lief for.patients with active disease and facilitating per.onalized tr.atment *** safety concer.s,including car.iovascular.r.sks and infections,ongoing r.sear.h and post-mar.eting sur.eillance will continue to r.fine our.understanding of the r.sk-benefit pr.file of JAKis in UC management.

关键词： Ulcer.tive colitis Janus kinase inhibitor. Filgotinib Tofacitinib Upadacitinib

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Fr.eze-thaw cycles and associated geomor.hology in a post-glacial envir.nment:cur.ent glacial,par.glacial,per.glacial and pr.glacial scenar.os at Pico de or.zaba volcano,Mexico

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Jour.al of Mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor.SoTo car.os M.WELSH r. Kenji YoSHIKAWA Hugo DELGADo Gr.NADoS Centr. de Ciencias de la Tier.a Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water.and Envir.nmental r.sear.h Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Depar.ment of Ear.h and Envir.nmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial histor. of Pico de or.zaba indicates that dur.ng the Last Glacial Maximum,its icecap cover.d up to~3000 m asl;due to the air.temper.tur. incr.asing,its main glacier.has r.tr.ated to 5050 m *** r.tr.ction of the glacier.has left behind an intense climatic instability that causes a high fr.quency of fr.eze-thaw cycles of gr.at intensity;the r.sulting geomor.hological pr.cesses ar. r.pr.sented by the fr.gmentation of the bedr.ck that occupies the upper.par.s of the *** is a notable lack of studies r.gar.ing the fr.gmentation and er.sion occur.ing in tr.pical high mountains,and the associated geomor.hological r.sks;for.this r.ason,as a fir.t stage of futur. continuous r.sear.h,this study analyzes the fr.ezing and thawing cycles that occur.above 4000 m asl,thr.ugh continuous monitor.ng of sur.ace gr.und *** r.sults allow us to identify and char.cter.ze four.zones:glacial,par.glacial,per.glacial and *** was found that the par.glacial zone pr.sents an intense dr.p of temper.tur.,of up to~9℃ in only sixty *** r.ck fatigue and intense fr.eze-thaw cycles that occur.in this ar.a ar. r.sponsible for.the high r.te of r.ck disintegr.tion and r.pr.sent the main factor.of the constant slope dynamics that occur.at the *** activity decr.ases,both in fr.quency and intensity,accor.ing to the distance to the glacier.which is wher. the temper.tur. pr.sents a cer.ain degr.e of stability,until r.aching the pr.glacial zone,wher. cycles ar. almost non-existent,and ther.for. ther. is no gelifr.ction *** geomor.hological pr.cesses have r.sulted in significant alter.tions to the mountain slopes,which can have sever. consequences in ter.s of r.sk and water.

关键词： Fr.eze-Thaw Gelifr.ction Mountain mechanical er.sion Per.glacial geomor.hology Postglacial scenar.os

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