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Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

Water Science and Engineering 2024年第2期17卷 177-186页

作者： er-feng Zhao Xin Li Chong-shi Gu The National Key laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China NationalEngineering Research Centerof Water Resources Eficient Utilization and Engineering Safety Hohai UniversityNanjing 20098China

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in *** control is essential to long-term operation of these *** study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in ***,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect *** findings revealed the governing mechanism of main ***,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch *** model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation ***,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam ***,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably *** of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan *** findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

关键词： Ultrahigh arch dam Structural performance Deformation behavior Diagnosis criterion Panel data model

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Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

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Science China(Life Sciences) 2024年第1期67卷 19-40页

作者： Jing Cai Xiaoding Xu Phei er Saw Guangdong Provincial Key laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineMedical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Nanhai Translational Innovation Center of Precision Immunology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityFoshan 528200China

A potential reason for the failure of tumor therapies is treatment *** to chemotherapy,radiotherapy,and immunotherapy continues to be a major obstacle in clinic,resulting in tumor recurrence and *** major mechanisms of therapy resistance are inhibitions of cell deaths,like apoptosis and necrosis,through drug inactivation and excretion,repair of DNA damage,tumor heterogeneity,or changes in tumor microenvironment,*** studies have shown that ferroptosis play a major role in therapies resistance by inducing phospholipid peroxidation and iron-dependent cell *** ferroptosis inducers in combination with clinical treatment techniques have been used to enhance the effect in tumor ***,versatile ferroptosis nanoinducers exhibit an extensive range of functions in reversing therapy resistance,including directly triggering ferroptosis and feedback ***,we provide a detailed description of the design,mechanism,and therapeutic application of ferroptosis-mediated synergistic tumor *** also discuss the prospect and challenge of nanomedicine in tumor therapy resistance by regulating ferroptosis and combination therapy.

关键词： ferroptosis cancer therapy therapy resistance nanoinducers

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Prospects of the Multi-channel Photometric Survey Telescope in the Cosmological Application of Type Ia Supernovae

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Research in Astronomy and Astrophysics 2024年第4期24卷 183-191页

作者： Zhenyu Wang Jujia Zhang Xinzhong er Jinming Bai Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China International Centre of Supernovae Yunnan Key LaboratoryKunming 650216China South-Western Institute for Astronomy Research Yunnan UniversityKunming 650500China

The Multi-channel Photometric Survey Telescope(Mephisto)is a real-time,three-color photometric system designed to capture the color evolution of stars and transients *** telescope system can be crucial in cosmological distance measurements of low-redshift(low-z,z■0.1)Type Ia supernovae(SNe Ia).To optimize the capabilities of this instrument,we perform a comprehensive simulation study before its official operation is scheduled to *** considering the impact of atmospheric extinction,weather conditions,and the lunar phase at the observing site involving the instrumental features,we simulate light curves of SNe Ia obtained by *** best strategy in the case of SN Ia cosmology is to take the image at an exposure time of 130 s with a cadence of 3 *** this condition,Mephisto can obtain hundreds of high-quality SNe Ia to achieve a distance measurement better than 4.5%.Given the on-time spectral classification and monitoring of the Lijiang 2.4 m Telescope at the same observatory,Mephisto,in the whole operation,can significantly enrich the well-calibrated sample of supernovae at low-z and improve the calibration accuracy of high-z SNe Ia.

关键词： (stars:)supernovae:general (cosmology:)cosmological parameters telescopes

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Stereotactic body radiotherapy in pancreatic adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 14-19页

作者： Carolina de la Pinta Radiation Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body radiotherapy(SBRT)in pancreatic cancer allows high delivery of radiation doses on tumors without affecting surrounding *** review aimed at the SBRT application in the treatment of pancreatic *** sources:We retrieved articles published in MEDLINE/PubMed from January 2017 to December *** used in the search included:“pancreatic adenocarcinoma”OR“pancreatic cancer”AND“stereotactic ablative radiotherapy(SABR)”OR“stereotactic body radiotherapy(SBRT)”OR“chemoradiotherapy(CRT)”.English language articles with information on technical characteristics,doses and fractionation,indications,recurrence patterns,local control and toxicities of SBRT in pancreatic tumors were *** articles were assessed for validity and relevant ***:Optimal doses and fractionation have not yet been ***,SBRT could be the standard treatment in patients with pancreatic adenocarcinoma in addition to ***,the combination of SBRT with chemotherapy may have additive or synergic effect on pancreatic ***:SBRT is an effective modality for patients with pancreatic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these patients,both in neoadjuvant treatment and with radical intent.

关键词： Chemoradiotherapy Pancreatic adenocarcinoma Radiotherapy Stereotactic body radiotherapy Stereotactic ablative radiotherapy

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A comparative study on characteristics of retracted publications across different open access levels

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Journal of Data and Information Science 2024年第2期9卷 22-40页

作者： er-Te Zheng Hui-Zhen Fu Department of Information Resources Management School of Public AffairsZhejiang UniversityHangzhou 310058China School of Information Resource Management Renmin University of ChinaBeijing 100872China

Purpose:Recently,global science has shown an increasing open trend,however,the characteristics of research integrity of open access(OA)publications have rarely been *** aim of this study is to compare the characteristics of retracted articles across different OA levels and discover whether OA level influences the characteristics of retracted ***/methodology/approach:The research conducted an analysis of 6,005 retracted publications between 2001 and 2020 from the Web of Science and Retraction Watch *** publications were categorized based on their OA levels,including Gold OA,Green OA,and *** study explored retraction rates,time lags and reasons within these ***:The findings of this research revealed distinct patterns in retraction rates among different OA *** with Gold OA demonstrated the highest retraction rate,followed by Green OA and non-OA.A comparison of retraction reasons between Gold OA and non-OA categories indicated similar proportions,while Green OA exhibited a higher proportion due to falsification and manipulation issues,along with a lower occurrence of plagiarism and authorship *** retraction time lag was shortest for Gold OA,followed by non-OA,and longest for Green *** prolonged retraction time for Green OA could be attributed to an atypical distribution of retraction reasons.A comparative study on characteristics of retracted publications across different open access levels Research limitations:There is no exploration of a wider range of OA levels,such as Hybrid OA and Bronze *** implications:The outcomes of this study suggest the need for increased attention to research integrity within the OA *** occurrences offalsification,manipulation,and ethical concerns within Green OA publications warrant attention from the scientific ***/value:This study contributes to the understanding of research integrity in the realm of OA publications,she

关键词： Open access Retracted publications Reasons for retraction Retraction time lag Bibliometrics

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Etiological Agent, Pathogenesis, Diagnosis, Treatment, Measures for Prevention and Control of Caseous Lymphadenitis Disease in the Small Ruminants with Special Reference to Sheep

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Journal of Biosciences and Medicines 2024年第5期12卷 154-170页

作者： eréndira de la Fuente Mancera Abel Ciprian Carrasco Susana Mendoza Elvira Facultad de Estudios Superiores Cuautitlá n Universidad Nacional Aut&#243noma de M&#233xico M&#233xico City M&#233xico

Caseous lymphadenitis (CL) is a chronic infectious disease caused by Corynebacterium pseudotuberculosis (C. pseudotuberculosis) that is transmitted mainly by contact with contaminated exudate wounds. Caseous lymphadenitis affects different species of animals and is considered an occupational zoonotic disease. CL is responsible for important economic losses in the small ruminant industry, which include decreased production, damaged quality of milk and wool, reproductive disorders, total or partial confiscation of carcasses, and depreciation of the skin. Caseous lymphadenitis disease can present in two clinical pictures: a skin or superficial picture and a visceral or deep picture. The presumptive diagnosis of CL in the skin is based on the exploration of superficial lymph nodes. These have little value in diagnosing visceral CL, where the main sign is emaciation. The prevention and control of CL involve identifying the skin condition and debriding the abscesses. In addition to the treatment of superficial lesions, the animal facilities must be repaired and adapted. To avoid exposure of negative herds to CL, new animals must be subjected to observation to identify any of the clinical manifestations. Another form of control is vaccination, though only some countries have commercial vaccines. General information on the etiological agent and its characteristics can be used to improve the understanding of this disease.

关键词： Abscess CMNR Corynebacterium pseudotuberculosis Goat CL Lymph Nodes Pseudotuberculosis Sheep

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Self-assembly Induced by Complexation of Diblock Copolyelectrolytes and Oppositely Charged Homopolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1321-1332,I0006页

作者： Ling Zhao Zhi-Yuan Yin Jia-Di Jiang er-Qiang Chen Shuang Yang Beijing National laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Mater Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Beijing National laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

We investigate the solution self-assembly of a mixture of positively charged homopolymers and AB diblock copolymers,in which the A blocks are negatively charged,and the B blocks are *** electrostatic complexation between oppositely charged polymers drives the formation of many ordered *** microstructures and phase diagrams are calculated using self-consistent field theory(SCFT)based on an ion-pair model with an equilibrium constant K to characterize the strength of binding between positively and negatively charged *** effects of the charge ratio,representing the ratio of charges from the homopolymer over all charges from polymers in the system,on the ordered structure are systematically studied,both for hydrophobic and hydrophilic A *** charge ratio plays an important role in determining the phase boundaries in the phase diagram of salt concentration versus polymer *** also provide information about the varying tendency of the domain spacing and core size of the spherical phase when the charge ratio is changed,and the results are in good agreement with *** studies provide a deep understanding of the self-assembled microstructures of oppositely charged diblock copolymer-homopolymer systems.

关键词： Self-assembly Polyelectrolyte complexation Self-consistent field theory Ion-pair

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Truly optimal semi-active damping to control free vibration of a single degree of freedom system

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 142-145页

作者： Viet Duc la Ngoc Tuan Nguyen Institute of Mechanics Vietnam Academy of Science and TechnologyHanoi 10000Vietnam Graduate University of Science and Technology Vietnam Academy of Science and TechnologyHanoi 10000Vietnam

This paper studies a single degree of freedom system under free vibration and controlled by a general semiactive damping.A general integral of squared error is considered as the performance index.A one-time switching damping controller is proposed and *** pontryagin maximum principle is used to prove that no other form of semi-active damping can provide the better performance than the proposed one-time switching damping.

关键词： Analytical optimization Quadratic integral Lyapunov equation Pontryagin maximum principle

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World Journal of Emergency Medicine 2024年第4期15卷 256-262页

作者： Jie er Janice Soo Yuan Helen Zhang Gek Hsiang Lim Fatimah lateef Department of Emergency Medicine Singapore General HospitalSingapore 168753Singapore Health Services Research Unit Singapore General HospitalSingapore168753Singapore

BACKGROUND:This study aimed to review bicycle-related injuries during the COVID-19 pandemic to assist with reinforcement or implementation of new policies for injury ***:This is a retrospective descriptive analysis of injuries sustained during cycling for patients 18 years old and above who presented to Singapore General Hospital from January to June *** records were reviewed and *** analyses were used to summarize patient characteristics,and differences in characteristics subgrouped by triage acuity and discharge status were ***:The study included 272 patients with a mean age of 43 years and a male predominance(71.7%).Most presented without referrals(88.2%)and were not conveyed by ambulances(70.6%).Based on acuity category,there were 24(8.8%)Priority 1(P1)patients with 7 trauma activations,174(64.0%)and 74(27.2%)P2 and P3 patients *** most common injuries were fractures(34.2%),followed by superficial abrasion/contusion(29.4%)and la.eration/wound(19.1%).Thirteen(4.8%)patients experienced head injury and 85 patients(31.3%)were documented to be wearing a *** majority occurred on the roads as traffic accidents(32.7%).Forty-two patients(15.4%)were admitted with a mean length of stay of 4.1 d and 17(6.3%)undergone surgical *** of 214(78.7%)discharged patients,no re-attendances or mortality were *** the subgroup analysis,higher acuity patients were generally older,with higher proportions of head injuries leading to ***:Our study highlights significant morbidities in bicycle-related *** is also a high proportion of fractures in the young healthy male *** prevention is paramount and we propose emphasizing helmet use and road user safety.

关键词： Cycling Injuries Emergency department

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Investigation of Microstructure, Microhardness and Thermal Properties of Ag-In Intermetallic Alloys Prepared by Vacuum Arc Meltings

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 182-187页

作者： ÇELİK erçevik ATA ESENer Pınar ÖZTÜRK Esra AKSÖZ Sezen Nevşehir HacıBektaşVeli University Department of Physics50300NevşehirTurkey erciyes University Graduate School of Natural and Applied Sciences38039KayseriTurkey Kocaeli University Department of Physics41380KocaeliTurkey

Ag-In intermetallic alloys were produced by using vacuum arc furnace. Differential Scanning Calorimetry(DSC) and Energy Dispersive X-Ray Spectrometry(EDX) were used to determine the thermal properties and chemical composition of the phases respectively. Microhardness values of Ag-In intermetallics were calculated with Vickers hardness measurement method. According to the experimental results, Ag-34 wt%In intermetallic system generated the best results of energy saving and storage compared to other intermetallic systems. Also from the microhardness results, it was observed that intermetallic alloys were harder than pure silver and Ag-26 wt%In system had the highest microhardness value with 143.45 kg/mm^(2).

关键词： thermal properties microstructure characterization microhardness alloys material characterization

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