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随机两体耗散诱导的非厄米多体局域化

物理学报 2024年第7期73卷 300-306页

作者：刘敬鹄徐志浩山西大学理论物理研究所量子光学与光量子器件国家重点实验室太原030006 山西大学极端光学协同创新中心太原030006

本文数值研究了在一维非厄米的硬核玻色模型中由随机两体耗散诱导的非厄米多体局域化现象.随着无序强度的增强,系统的能谱统计分布从AI■对称类向二维泊松系综过渡,多体本征态的归一化参与率展示了从有限值到接近零的转变,半链纠缠熵服... 详细信息

本文数值研究了在一维非厄米的硬核玻色模型中由随机两体耗散诱导的非厄米多体局域化现象.随着无序强度的增强,系统的能谱统计分布从AI■对称类向二维泊松系综过渡,多体本征态的归一化参与率展示了从有限值到接近零的转变,半链纠缠熵服从体积律到面积律的转变,动力学半链纠缠熵表现为从线性增长到对数增长的转变.数值结果表明,在该模型中由随机两体耗散诱导的非厄米多体局域化现象的鲁棒性.该研究结果为非厄米系统中多体局域化的研究提供了新的视角.

关键词：无序非厄米随机矩阵理论多体局域化

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数字经济赋能消费升级:微观机制和关联效应

技术经济与管理研究 2024年第7期 56-63页

作者：金晶董敬畏中共绍兴市委党校浙江绍兴312000 中共浙江省委党校浙江杭州311100

数字经济发展是高质量建设共同富裕示范区的重要动力。居民消费升级是实现共同富裕目标的重要成果之一。供需双侧在数字化转型的过程中产生新的增量,推动供需双侧实现更高水平的平衡。通过逻辑推演,阐释消费升级是高质量发展实现共同富... 详细信息

数字经济发展是高质量建设共同富裕示范区的重要动力。居民消费升级是实现共同富裕目标的重要成果之一。供需双侧在数字化转型的过程中产生新的增量,推动供需双侧实现更高水平的平衡。通过逻辑推演,阐释消费升级是高质量发展实现共同富裕的逻辑终点,是共同富裕实现程度的重要参照;分析数字经济对深化供给侧结构性改革和增加有效需求的驱动作用。通过理论分析,以市场经济一般均衡理论为基础,阐释数字经济在创造新的供需动态平衡,追求市场最优的过程中实现消费升级的微观机制。同时,以浙江省为例进行有限的实证分析,通过灰色关联度分析和中介效应分析验证数字经济赋能下,供需双侧驱动消费升级的路径有效性和存在的阻滞点。

关键词：数字经济消费升级供需平衡高质量建设

Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World journal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren Li-Chao Qian Xiao-jing Lv Ying-Ying Cao Marcus j Daniels Zhong-Qiu Wang Li-Na Song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

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机械工业应对“双碳”的机遇与挑战

科学通报 2024年第8期69卷 997-1004页

作者：侯睿祁卓娅王婧机械工业技术发展基金会北京100045 机械工业节能与资源利用中心北京100045

为应对全球气候变化,我国积极行动,逐步构建了碳达峰碳中和(简称“双碳”)的政策体系,对我国工业绿色低碳发展提出了更高要求^([1~6]).机械工业是我国国民经济发展的基础性产业,为国民经济各行业提供技术装备,所提供技术装备的节能低碳... 详细信息

为应对全球气候变化,我国积极行动,逐步构建了碳达峰碳中和(简称“双碳”)的政策体系,对我国工业绿色低碳发展提出了更高要求^([1~6]).机械工业是我国国民经济发展的基础性产业,为国民经济各行业提供技术装备,所提供技术装备的节能低碳化是各行业实现节能降碳目标的重要保障^([7,8]).在“双碳”目标约束下,机械工业面临诸多机遇与挑战.

关键词：机械工业基础性产业节能低碳碳中和目标约束绿色低碳发展机遇与挑战技术装备

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long jIANG Li-ying FENG jie ZHA jing-wei YAO Yin LI Xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： Pan Zheng Xue-Yang Li Xiao-Yu Yang Huan Wang Ling Ding Cong He jian-Hua Wan Hua-jing Ke Nong-Hua Lu Nian-Shuang Li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6j-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways

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一种精量播种机的可视化模块优化研究

农机化研究 2024年第6期46卷 214-217页

作者：刘静晋中信息学院山西晋中030800

以精量播种机监测显示系统为研究对象,基于播种机主控制器和传感器,以CAN网络总线通讯的方式进行数据交互,设计了一种便于人机交互的可视化功能模块,以保证播种过程作业参数实时采集和数据传输。应用结果表明:精量播种机监测显示系统以... 详细信息

以精量播种机监测显示系统为研究对象,基于播种机主控制器和传感器,以CAN网络总线通讯的方式进行数据交互,设计了一种便于人机交互的可视化功能模块,以保证播种过程作业参数实时采集和数据传输。应用结果表明:精量播种机监测显示系统以传感器和硬件电路为基础,利用传感器对运行参数进行采集,经主控制器分析计算后在可视化模块进行显示,使操作人员能够实时掌握运行状态信息,提高了精量播种机的使用工作效率和智能化水平。

关键词：精量播种机可视化模块数据交互优化

The transgenerational effects of maternal low-protein diet during lactation on offspring

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journal of Genetics and Genomics 2024年第8期51卷 824-835页

作者： Lin-jian Gu Li Li Qian-Nan Li Ke Xu Wei Yue jing-Yi Qiao Tie-Gang Meng Ming-Zhe Dong Wen-Long Lei jia-Ni Guo Zhen-Bo Wang Qing-Yuan Sun State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute of Laboratory Animal Sciences CAMS&PUMCBeijing 100021China Guangzhou Key Laboratory of Metabolic Diseases and Reproductive Health Guangdong-Hong Kong Metabolism&Reproduction Joint LaboratoryReproductive Medicine CenterGuangdong Second Provincial General HospitalGuangzhouGuangdong 510317China

Environmental factors such as diet and lifestyle can influence the health of both mothers and ***,its transgenerational transmission and underlying mechanisms remain largely ***,using a maternal lactation-period low-protein diet(LPD)mouse model,we show that maternal LPD during lactation causes decreased survival and stunted growth,significantly reduces ovulation and litter size,and alters the gut microbiome in the female LPD-F1 *** transcriptome of LPD-F1 metaphase II(MII)oocytes shows that differentially expressed genes are enriched in female pregnancy and multiple metabolic ***,maternal LPD causes early stunted growth and impairs metabolic health,which is transmitted over two *** methylome alteration of LPD-F1 oocytes can be partly transmitted to the F2 ***,our results reveal that LPD during lactation transgenerationally affects offspring health,probably via oocyte epigenetic changes.

关键词： Lactationdiet Maternal low-proteindiet DNAmethylation Transgenerational effect Oocyte

Abnormal function of EPHA2/p.R957P mutant in congenital cataract

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International journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： jing-jin Zhang Zong-Fu Cao Bi-Ting Zhou ju-Hua Yang Zhong Li Shuang Lin Xiao-Le Chen Nan-Wen Zhang Qin Ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis