检索结果-南通市图书馆

Egyptian male breast carcinoma:patients' hormonal profile,management and outcome

The Chinese-German Journal of Clinical Oncology 2012年第2期11卷 89-98页

作者： Manal el-Baradie Asmaa Salama Ola Khorshid Hoda.ismail Gerges Attia Abeer A.Bahnassy Department of Radiation Oncology&Nuclear Medicine National Cancer InstituteCairo UniversityCairoEgypt Department of Pathology National Cancer InstituteCairo UniversityCairoEgypt Department of Medical Oncology National Cancer InstituteCairo UniversityCairoEgypt

Objective:Male breast cancer(MBC) represents < 1% of all breast *** receptors and Her-2/neu status are established prognostic factors in female breast cancer but not yet studied enough in male breast *** aim of the study was to verify the clinico-pathologic profile of male patients with breast cancer including analysis of hormone receptors and Her-2/neu state and its impact on survival ***:This is a retrospective study carried on a total of 123 male patients presented to the National Cancer Institute(NCI),Cairo University,Egypt-with breast carcinoma from January 1999 to December ***:The patients had a median age of 58(ranged from 29-92) *** 39.8% of the patients presented with T4 *** presentation,12.2% of the cases had metastasis with bone represented 86.7% of metastatic *** 92.7% of patients were subjected to modified radical mastectomy and radical *** duct carcinoma reported in 91.1%,and 76.4% of the patients had grade II *** profile was reported in 74% of the patients with 71.4% positive ER and 69.2% positive *** 57 cases tested for Her-2/neu,10.5% were *** A was the most common subtype detected in male breast carcinoma patients constituting 66.7%.Comparison with female patients with breast carcinoma revealed some differences regarding stage,hormone profile,Her-2/neu status and breast cancer *** as adjuvant,neo-adjuvant and metastatic was given for 73.1%,17.3% and 9.6% of the cases,with 83% of them had an anthracyclin-containing ***-nine patients received radiation treatment,65.2% and 34.8% of them with adjuvant and palliative aim,*** of adjuvant radiotherapy had a median value of 4410(3400-5000) *** hormonal treatment(Tamoxafin) was given for 47 patients all of them with ER and/or PR positive for a median period of 33.5(4-60) *** 5-year overall survival(OS),loco-regional control(LRC),metastasis-free

关键词： male breast carcinoma(MBC) hormonal profile outcome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of Convective Heat Exchanges and Fluid Dynamics in the Air Gap of a Discoid Technology Rotary Machine

引用

Frontiers in Heat and Mass Transfer 2024年第3期22卷 733-746页

作者： Abdellatif el Hannaoui Rachid Boutarfa Chadia Haidar Mechanical Engineering Industrial Management and Innovation LaboratoryFaculty of Science and TechniquesHassan 1st UniversitySettatMorocco Department of Energy Laboratory University Moulay IsmailENSAMMeknèsMorocco

The proposedwork focuses on the in-depth study of convective heat transfer in the unconfined air gap of a discoidal rotor-stator *** rotary cooling mechanism is achieved by the injection of two air jets,while the cavity geometry is characterized by a dimensionless parameter *** numerical analysis primarily concentrated on the effect of flow velocity and rotation on the heat exchange *** precisely,the range of analysis extends from the rotational Reynolds number Re_(ω)=2.35×10^(5)to Re_(ω)=5.04×10^(5),while varying the Reynolds value of the jet in a range from 16×10^(3)to 55.46×10^(3).To carry out this analysis,a numerical simulation was conducted with Ansys-Fluent software,using the RSM turbulence *** results of the study significantly reveal the impact of rotation on heat exchange transfer within the cavity,identifying two distinct zones of fluid *** zones exhibit remarkable heat transfer characteristics,contributing to a better understanding of the complexmechanisms governing heat transfer in this particular technological ***,the analysis of radial mean velocity distributions,as well as local and mean Nusselt numbers,provides further insight into the heat transfer performance of this unique configuration.

关键词： Heat transfer rotor-stator impacting jets RSM turbulence model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

阿特拉津和林丹对紫贻贝生长与繁殖净能的影响(英文)

引用

动物学报 2006年第4期52卷 712-723页

作者： Nahla S.el-SHENAWY Richard GREENWOOD ismail M.ABDel-NABI Zohour I.NABIL Department of Zoology Faculty of ScienceSuez Canal UniversityEgypt School of Biological Sciences University of PortsmouthUK

本研究评估了亚致死浓度的林丹(1/2的60dLC50,0.935mg/L)和阿特拉津(1/2的60dLC50,3.585mg/L)对海洋性贝类影响的生理学反应。林丹和阿特拉津是已被公认的环境污染物质。56d的实验表明,这两种农药在贝类体内具有积累作用,而且在体内各... 详细信息

本研究评估了亚致死浓度的林丹(1/2的60dLC50,0.935mg/L)和阿特拉津(1/2的60dLC50,3.585mg/L)对海洋性贝类影响的生理学反应。林丹和阿特拉津是已被公认的环境污染物质。56d的实验表明,这两种农药在贝类体内具有积累作用,而且在体内各器官的积累程度与其作用的靶器官相一致。林丹在体内的积累浓度(每克干重372μg)比阿特拉津(每克干重137μg)更高。该贝类在林丹中暴露56d,其氧的消耗比对照组降低10%,而在阿特拉津中则比对照组提高了29%。经林丹和阿特拉津暴露后,增加了氨排泄物。但是,两种农药均使贝类的取食率和吸收率下降。林丹会降低贝类的取食率、氧消耗、氨排泄、食物吸收率以及生长范围。在形式上,阿特拉津对贝类的影响与林丹的影响有不同之处,它会降低贝类的取食率和食物吸收率,但与林丹不同的是,它会提高贝类的氧消耗和氨排泄。总之,阿特拉津会明显地减小贝类繁殖净能。因此,阿特拉津暴露与林丹暴露的毒性症状是一致的。结合组织化学分析,贝类的生理学反应可作为一种理想的环境监测工具。研究结果表明,在二分之一的半致死浓度下暴露两个月,不仅能有效地证明林丹和阿特拉津在贝类组织内具有积累作用,而且对这些积累能产生生理反应。

关键词：林丹阿特拉津生长与繁殖净能生物积累

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relation between serum progranulin, inflammatory markers and visceral fat in childhood obesity

引用

Advances in Bioscience and Biotechnology 2013年第12期4卷 1030-1038页

作者： Nagwa Abdallah ismail Shadia Ragab Abeer Nour eldin Abd el Baky Mona Hamed Dina F. Ayoub Department of Clinical Pathology National Research Center Cairo Egypt Pediatrics’ Department National Research Center Cairo Egypt

Aim: To study serum progranulin (PGRN) level in children with obesity and its relationship to inflamamatory markers and visceral fat. Methods: Fifty obese children and 50 controls aged 10-18 years were recruited. Demographic, anthropometric and biochemical features were collected according to a standard protocol. Serum progranulin levels, serum IL-6 and hsCRP were measured using elISA. Insulin resistance was calculated by the homeostasis model (HOMA-IR) using the following formula: HOMA-IR = fasting insulin (mU/L) × fasting glucose (mmoL/L)/ 22.5. The maximum visceral fat thickness (VFT) and the minimum subcutaneous fat thickness (SFT) were measured by ultrasonography. Results: In the obese group, a significant increase was found in serum PGRN (48.87 ± 42.33 ng/mL) compared to control group (30.18 ± 23.82 ng/mL). Progranulin correlated significantly with VFT (r = 0.475), IL6 (r = 0.368), Insulin(r = 0.440) and HOMA-IR (r = 0.379). The mean serum progranulin in the high tertile VFT group was significantly higher than those in the low tertile and middle tertile groups (P = 0.030 and P = 0.039 respectively). VFT was highly positively correlated to progranulin, SFT, IL6, insulin, HOMA-IR and hsCRP (P = 0.001, 0.000, 0.001, 0.001, 0.003 and 0.003). However, the correlation coefficient between SFT and progranulin was insignificant. Summary: we demonstrated for the first time that serum PGRN concentrations increased in Egyptian obese children. The concentrations of serum PGRN correlated closely with visceral fat and IL6. Conclusion: PGRN may contribute to the pathogenesis of chronic inflammation in obesity. It could be a novel marker of visceral fat in obesity. Thus PGRN could be a potential therapeutic target for management of chronic inflammation in obesity.

关键词： Progranulin Obesity Visceral Fat Insulin Resistance IL6

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proposition and design of a new Micro-Architected Domes family:A biomimicry-based approach

引用

Frontiers of Architectural Research 2024年第3期13卷 650-667页

作者： Nadir Rihani Iatimad Akhrif Mostapha.el Jai Euromed Polytechnic School Euromed Center of ResearchEuromed University of FesFesMorocco Mechanic Mechatronic and Command LaboratoryENSAM-MeknesMoulay Ismail UniversityMeknesMorocco

In the last decade,micro-architected structures have gained significant attention in academia and industry for their lightweight,strong,and thermally efficient *** by biomimicry design,this paper presents a novel ribbed family of additively manufactured Micro-Architected Domes(MAD).The design incorporates tetrapod pyramid unit cells,golden ratio-based fractal patterns,Schoen’s Minimal Gyroid,and spherical *** study focuses on dome radius,height,and azimuth/elevation partitioning as input variables,with the main output being ribbed micro-cell *** relationships between unit-cells’diameter and input variables were established through problem-solving and numerical computations:linear dependency with the dome radius and hyperbolic dependency with the azimuth and elevation *** proposed design successfully adhered to the Surface-to-Volume ratio of Schoen’s Minimal Gyroid,achieving an average volume relative density of 2.5%,confirming its lightweight *** feasibility of the design was further supported by fabricating three specimens using Filament Fused *** research showcases the potential of biomimicry-inspired micro-architected structures,paving the way for innovative applications in various fields.

关键词： Micro-architected structures Domes Biomimicry Mathematical design Optimization Fractal decomposition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the gradient tracking problem for a bilinear reaction–diffusion equation excited by distributed bounded controls

引用

Journal of Control and Decision 2023年第3期10卷 365-373页

作者： el Hassan Zerrik Abderrahman Ait Aadi Mohamed Ouhafsaa MACS Laboratory Faculty of SciencesMoulay Ismail UniversityMeknesMorocco Department of Sciences Ecole Normale SupérieureMoulay Ismail UniversityMeknesMorocco

This paper addresses a gradient tracking problem of a bilinear reaction–diffusion equation evolvingin a spatial domainΩ ⊂ Rn, n ≤ 3. Such an equation is excited with distributed and boundedcontrols. The problem is formulated by the minimisation of a functional constituted of the deviationbetween the desired gradient and the current one all over a time interval and the energyterm. Then we prove the existence of an optimal control that we characterise by an optimalitysystem. Moreover, we discuss two sets of particular controls: the set of time dependent controlsand the space dependent ones. A computational approach and illustrative simulations are alsogiven.

关键词： Infinite dimensional systems bilinear systems reaction–diffusion equation controllability optimal control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

可食用文蛤中氧化性胁迫的生物标记物与甲基毒死蜱和草甘膦的生物富集(英文)

引用

动物学报 2007年第5期53卷 910-920页

作者： ismail M.ABDel-NABI Nahla S.el-SHENAWY Inas A.TAHA Tarak S.MOAWAD Department of Zoology Faculty of ScienceSuez Canal University Toxicological and Microanalytical Research Unit Faculty of ScienceSuez Canal University

近几十年期间,在种群和个体受干扰后,对作为早期指示剂的生物标记物的研究受到越来越多的关注。我们用对水生生态系统污染敏感的生物标记物双壳类软体动物(文蛤)来评估两种有机磷杀虫剂(甲基毒死蜱、草甘膦)的影响。文蛤是水生生态系统... 详细信息

近几十年期间,在种群和个体受干扰后,对作为早期指示剂的生物标记物的研究受到越来越多的关注。我们用对水生生态系统污染敏感的生物标记物双壳类软体动物(文蛤)来评估两种有机磷杀虫剂(甲基毒死蜱、草甘膦)的影响。文蛤是水生生态系统污染的一种敏感的指示物种。在不同时间段测定文蛤中不同组织的非酶的(谷胱苷肽)和酶的(过氧化氢酶)抗氧化剂,作为文蛤中生物标记物的反应。在实验室条件下,测定了脂质过氧化作用、蛋白羰基含量、总蛋白含量、总脂质含量以及胆碱酯酶的活性。对不同的生物标记与杀虫剂的生物体内积累的相互关系进行了研究。甲基毒死蜱在文蛤组织中具有最大的诱导氧化胁迫的潜能,导致脂质过氧化反应增加并抑制抗氧化剂。而且,鳃是对该反应最敏感的器官。文蛤是一种极好的甲基毒死蜱的积聚者,因为暴露60天后,可以测定到其组织中浓度为824.0 mg/kg w.w的甲基毒死蜱。随着在草甘膦中暴露时间的增加,与背景水平相比,组织中草甘膦的浓度增加大约8×103mg/kg w.w。可以得出这样的结论:在一种生物中测定几种生物标记物是有用的。在双壳类中,蛋白质的羰基诱导可用于双壳类中化学污染物诱导的氧化胁迫的生物指示剂。抗氧化剂的防御成分是敏感的参数,是评估污染的水生生态系统的有用的生物标记物。辅以蛤组织的化学分析,生物标记参数能够提供一种有力的监测工具。

关键词：文蛤还原性谷胱甘肽脂质过氧化反应蛋白羰基含量过氧化氢酶胆碱脂酶鳃外套膜残留量毒死蜱草甘膦有机磷杀虫剂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antihyperglycemic effect of Juniperus phoenicea *** alloxan-induced diabetic rats and diterpenoids isolated from the fruits

引用

Journal of Coastal Life Medicine 2015年第11期 906-909页

作者： Salma Ahmed el-Sawi Hemaia Mohamed Motawae Abdel-Rahman Omar el-Shabrawy Mohamed Aboul-Fotouh Sleem Amani Ameen Sleem Maii Abdel Naby ismail Maamoun Pharmacognosy Department National Research CentreCairoEgypt Pharmacognosy Department Faculty of PharmacyCairo UniversityCairoEgypt Pharmacology Department National Research CentreCairoEgypt

Objective:To explore the traditional use of Juniperus phoenicea L.(***)growing in Egypt as antidiabetic ***:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves and fruits of the plant were investigated in alloxan-induced diabetic rats after collecting blood samples through retro-orbital puncture *** a consequence of the biological results,phytochemical investigation of the chloroform fraction of fruits was carried out by column chromatography and thin layer ***:Results revealed the reduction in blood glucose levels in rats,which were significantly different from control at 4 and 8 weeks(Pely,after 8 weeks,comparing to metformin drug(100%potency).Chloroform fractions of leaves and fruits were the most potent fractions(potencies were 70.3%,71.4%),respectively,along with ethyl acetate fraction of fruits(71.4%).Phytochemical investigating of the chloroform fraction of fruits resulted in the isolation and identification of 5 abietane ***,7-dehydroabietanone,sugiol,6-α-hydroxy-7-oxoferruginol,totarolone and a labdane diterpenoid,varodiol were isolated for the first time from the fruits of *** growing in *** identification of these compounds was based on spectroscopic analysis:1hydrogen-nuclear magnetic resonance and electron impact mass spectrometry,comparing the results with the ***:It has become clear that leaves and fruits of the Egyptian *** provide effective antihyperglycemic action in diabetic rats as was reported in folk *** high contents of terpenoids in the non-polar fractions may attribute to the antidiabetic effect of the plant.

关键词： Juniperus phoenicea Antihyperglycemic Abietane Labdane Diterpenoid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Machine Learning Based Framework for a Stage-Wise Classification of Date Palm White Scale Disease

引用

Big Data Mining and Analytics 2023年第3期6卷 263-272页

作者： Abdelaaziz Hessane Ahmed el Youssefi Yousef Farhaoui Badraddine Aghoutane Fatima Amounas STI Laboratory IDMSFaculty of Sciences and TechniquesMoulay Ismail University of MeknesErrachidia 52000Morocco. IA Laboratory Department of Computer ScienceFaculty of SciencesMoulay Ismail University of MeknesMeknes 50070Morocco. RO.AL&I Group Computer Sciences DepartmentFaculty of Sciences and TechniquesMoulay Ismail University of MeknesErrachidia 52000Morocco.

Date palm production is critical to oasis agriculture,owing to its economic importance and nutritional *** diseases endanger this precious tree,putting a strain on the economy and *** scale Parlatoria blanchardi is a damaging bug that degrades the quality of *** an infestation reaches a specific degree,it might result in the tree’s *** counter this threat,precise detection of infected leaves and its infestation degree is important to decide if chemical treatment is *** decision is crucial for farmers who wish to minimize yield losses while preserving production *** this purpose,we propose a feature extraction and machine learning(ML)technique based framework for classifying the stages of infestation by white scale disease(WSD)in date palm trees by investigating their leaflets images.80 gray level co-occurrence matrix(GLCM)texture features and 9 hue,saturation,and value(HSV)color moments features are extracted from both grayscale and color images of the used *** classify the WSD into its four classes(healthy,low infestation degree,medium infestation degree,and high infestation degree),two types of ML algorithms were tested;classical machine learning methods,na.ely,support vector machine(SVM)and k-nearest neighbors(KNN),and ensemble learning methods such as random forest(RF)and light gradient boosting machine(LightGBM).The ML models were trained and evaluated using two datasets:the first is composed of the extracted GLCM features only,and the second combines GLCM and HSV *** results indicate that SVM classifier outperformed on combined GLCM and HSV features with an accuracy of 98.29%.The proposed framework could be beneficial to the oasis agricultural community in terms of early detection of date palm white scale disease(DPWSD)and assisting in the adoption of preventive measures to protect both date palm trees and crop yield.

关键词： machine learning feature extraction ensemble learning diseases precision agriculture date palm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of vitamin A and E on carbohydrate and lipid metabolism in diet-induced obese wistar rats

引用

Advances in Bioscience and Biotechnology 2014年第1期5卷 4-11页

作者： Mohamed Mohamed Soliman Mohamed Mohamed Ahmed Samir Ahmed el-Shazly Tamer Ahmed ismail Hossam Fouad Attia Ahmed Farag elkirdasy Department of Biochemistry College of Veterinary Medicine University of Sadat City Sadat City Egypt Department of Biomedical Sciences Shaqraa University College of Pharmacy Shaqraa Saudi Arabia Department of Biotechnology College of Science Taif University Taif Saudi Arabia Department of Biochemistry College of Veterinary Medicine Kaferel-sheikh University Kafer El-Sheikh Egypt Department of Biotechnology College of Science Taif University Taif Saudi Arabia Department of Biochemistry College of Veterinary Medicine University of Sadat City Sadat City Egypt Medical Laboratory Department College of Applied Medical Sciences Taif University Turabah Saudi Arabia Department of Biochemistry College of Veterinary Medicine Benha University Banha Egypt Medical Laboratory Department College of Applied Medical Sciences Taif University Turabah Saudi Arabia Department of Histology College of Veterinary Medicine Benha Uni-versity Banha Egypt Medical Laboratory Department College of Applied Medical Sciences Taif University Turabah Saudi Arabia Department of Physiology College of Veterinary Medicine Zagazig University Zagazig Egypt

In the present study, we investigated the biochemical alterations and gene expression of carbohydrate and lipid metabolism after oral administration of vitamin A and E for 2 months in diet-induced obese Wistar rats. Vitamin A and E administration reduced significantly the increase in body weight and food intake and normalized the alterations in lipid profiles in obese rats compared to normal rats. Moreover, both vitamins decreased the fat accumulation in liver tissues of obese rats. Finally, they up-regulated mRNA expression of Pyruvate Kinase (PK) and Glucose Transporter-2 (GLUT-2), and increased lipolysis and cholesterol metabolism through up-regulation of lipoprotein lipase (LPL), Sterol Responsible element Binding Protein-1a (STREBP-1a) and STREBP-1c mRNA expression. In conclusion, vitamin A and E regulate gene expression of carbohydrate and lipid metabolism, and also a.eliorate changes associated with obesity induced by high fat diet in Wistar rats.

关键词： Vitamin A and E Lipid Metabolism Carbohydrate Metabolism Gene Regulation Wistar Rats

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：