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Outcomes of External-Beam Radiation Therapy Boost with Conventional Fractionation in Cervical Cancer: A Retrospective Analysis about 133 Cases

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Journal of Cancer Therapy 2020年第9期11卷 547-560页

作者： Evrard Narcisse Séka Bertrand Ghislain Compaoré Bassané Alain Wilfried Mossé Siham Jaba Kouadio Davy N’chiépo Maroua Benlemlih Hasnae Bouhia Mohammed Adnane Tazi Sanae el Majjaoui Noureddine Benjaafar Department of Radiotherapy National Institute of Oncology Rabat Morocco Department of Radiotherapy Mohammed V Military Hospital Rabat Morocco National School of Public Health Rabat Morocco Mohammed V University in Rabat Rabat Morocco

Introduction: External-beam radiation therapy boost is a treatment option in cervical cancer when brachytherapy is not feasible. Though less effective than brachytherapy, some encouraging results have been reported from some institutions experiences. We conducted this study to assess outcomes of EBRT boost for our patients at National Institute of Oncology in Rabat. Patients and Methods: We collected data from patients treated for cervical cancer between January 2012 and December 2015. Patients, tumor and treatment characteristics were collected. Overall survival (OS), disease-free survival (DFS) and prognostic factors influencing DFS were assessed. Results: One hundred and thirty-three patients were enrolled. Median age was 52 years. Patient haemoglobin level ranged from 3.9 to 15.5 g/dl [mean: 11.2 g/dl]. Most tumors were classified stage III/IVA (63.2%) according to the FIGO classification. Regional lymph node metastases (pelvic and or para-aortic) were observed in 45.1%. Median total dose to tumor was 69.6 Gy (ranging from 66 to 70 Gy). Overall treatment time was protracted, with a median of 60 days. Most of patients received concurrent chemotherapy (94.7%) and the number of cycle ranged from 2 to 7 (median = 5). The follow-up median was 31.3 months, ranging from 6.2 to 96.8 months. At the first visit, most patients achieved complete response (80.5%). Five years OS and DFS were 47% and 44% respectively. In univariate and multivariate analysis, regional lymph nodes metasta

关键词： Cervical Cancer External Beam Radiation Therapy Boost Survival Prognostic Factors

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Inventory of Radiation Protection in Hospitals of Level III in Senegal

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Open Journal of Biophysics 2021年第4期11卷 397-406页

作者： Boucar Ndong Sidi Ahmed Dia Mamadou Salif Djigo Herbert Fachinan el Hadji Lamine Bathily ousseynou Diop kanta ka Gérard Léra Kelvin Akpo el Hadji Fallou Diouf Louis Auguinstin Diaga Diouf Pape Mady Sy Alphonse Djiboune Gora Mbaye Maguette Diagne Omar Ndoye Mamadou Mbodji Laboratoire de Biophysique Médecine Nucléaire Universite Cheikh Anta Diop Dakar Senegal Service de Médecine du Travail Universite Cheikh Anta Diop Dakar Senegal Faculté de Médecine Université de Parakou Parakou Benin Service de Radiothérapie de Dalal Jamm Dakar Senegal Service de Radiologie de l’Hô pital Aristide Le Dantec Dakar Senegal Laboratoire de Physique Pharmaceutique Universite Cheikh Anta Diop Dakar Senegal Service de Radiothérapie de l’Hô pital Aristide Le Dantec Dakar Senegal

The aim of this study was to evaluate the level of protection of employees who are exposed to radiation in a level III hospital establishment. It was a descriptive cross-sectional survey of six months’ duration, involving eight level III Hospitals (Aristide Le Dantec, Fann, Hoggy, Hear, Abass Ndao, Pikine, Touba, and Thiès) in Senegal. Sixty-one of the one hundred questionnaires were recovered (overall response rate of 61%). The population of the study was mainly female (54.1%). The average age was 38.57 with extremes ranging from 23 to 65 years old. In the places where ionizing radiation sources are handled, only at the Aristide Le Dantec Hospital did we find a “competent person in radiation protection”. This explained the lack of a classification of employees and work areas. Forty out of sixty-one (73.77%) had no knowledge of the basic principles of radiation protection (justification, optimisation, dose limitation) and had not ever taken radiation holidays. For radiovigilance, exposure time limits to ionizing radiation concerned only 29/61 or 47.54% of the study population. The inverse square law of distance was known by only 40 workers, of whom 15 had no compliance. We found the presence of dosifilms in only 7/61 or 11.47% of the workers. On the other hand, the use of lead aprons was well established and concerned 57/61 workers, i.e., 93.44%. In sum, ionizing radiation causes adverse health effects. The absence of a good radiation protection culture in Senegal requires the presence of at least 4 to 5 competent persons in radiation protection for quality training of workers in radiobiology, radiopathology and radiation protection.

关键词： Ionizing Radiation Radiation Protection Workers Senegal

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Wideband Reconfigurable Millimeter-Wave Linear Array Antenna Using Liquid Crystal for 5G Networks

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Wireless Engineering and Technology 2021年第1期12卷 1-14页

作者： Ali el Hajj Hassan Najib Fadlallah Mohammad Rammal Georges Zakka.el Nashef elias Rachid Ecole Doctorale des Sciences et de la Technologie (EDST) Lebanese University (LU) Beirut Lebanon Ecole Supérieure d’Ingénieurs de Beyrouth (ESIB) Université Saint-Joseph (USJ) Beirut Lebanon

The advanced design of a 10 × 1 linear antenna array system with the capa-bility of frequency tunability using GT3-23001 liquid crystal (LC) is pro-posed. The design for this reconfigurable wideband antenna array for 5G ap-plications at ka-band millimeter-wave (mmw) consists of a double layer of stacked patch antenna with aperture coupled feeding. The bias voltage over LC varies from 0 V to 10.6 V to achieve a frequency tunability of 1.18 GHz. The array operates from 25.3 GHz to 33.8 GHz with a peak gain of 19.2 dB and a beamwidth of 5.2° at 30 GHz. The proposed reconfigurable antenna ar-ray represents a real and efficient solution for the recent and future mmw 5G networks. The proposed antenna is suitable for 5G base stations in stadiums, malls and convention centers. It is proper for sa.ellite communications and radars at mmw.

关键词： 5G Networks Liquid Antenna Liquid Crystal Frequency Reconfigurability Antenna Array Millimeter-Wave

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儿童重症监护医师对血糖控制认识的临床一致性调查

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中国小儿急救医学 2013年第1期 95-95页

作者： Hirshberg el Sward ka Faustino EV 武洁首都医科大学附属北京儿童医院

目的评估儿童重症监护医师对开展儿童血糖控制临床试验的意愿,以及自我报告的儿科临床实践在过去4年里是否受到了成人相关研究数据的影响。这是我们2005年调查基础上的后续研究。设计包括30项问题的电子问卷调查。场所北美96家PICU(儿... 详细信息

目的评估儿童重症监护医师对开展儿童血糖控制临床试验的意愿,以及自我报告的儿科临床实践在过去4年里是否受到了成人相关研究数据的影响。这是我们2005年调查基础上的后续研究。设计包括30项问题的电子问卷调查。场所北美96家PICU(儿童急性肺损伤和败血症研究网络成员或相关单位)。对象209位北美儿童重症监护医师。干预无方法采用网络问卷对北美PICU进行调查,发送邀请至37个州的96家机构。结果调查反馈率为68%(141/209)。高血糖(150 mg/d1)与低血糖(≤60 mg/d1)中位数的定义与我们2005年的调查结果类似。自我报告的临床实践仍然存在差异。虽然75%的被调查者称依据文献未改变临床实践,但更被接受的血糖控制目标已经由2005年的80～110 mg/dl增加至2009年的90～140 mg/dl。2005年接受80～110 mg/dl血糖控制目标的重症监护医师由43%降至2009年的6%(P<0.001)。45%的被调查者表示一项血糖控制方案所定义的严重低血糖率(患者比率)≤2.5%是可接受的。93%的被调查者表示他们愿意在血糖控制的儿科试验中纳入患者。结论儿童重症监护医师自我报告他们在治疗重症患儿时会采用胰岛素控制血糖,但没有必要采用成人数据或者采取统一的血糖控制目标。已发表的文献并未引起PICU医生的充分关注。临床未解决的问题及持续存在的实践差异提示有必要针对危重症患儿血糖控制开展一项多中心临床研究。

关键词：血糖控制高血糖低血糖胰岛素治疗重症监护儿科临床实践诊疗常规调查

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Plasma Coaxial Discharge for Thin Film Deposition

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中国核科技报告 1999年第S4期 386-386页

作者： H.a.el-Gamal,H.a.el-Taeb,M.abd-elmonim Plasma Physics and Nuclear Fusion Department Nuclear Material Divsion N.R.C.Atomic Energy Authority Egypt Plasma Physics and Nuclear Fusion Department Nuclear Material Divsion N.R.C.Atomic Energy Authority Egypt Plasma Physics and Nuclear Fusion Department Nuclear Material Divsion N.R.C.Atomic Energy Authority Egypt

A coaxial discharge, of 6 capacitors each with 7.71 μF, is used to explore plasma thin film coating by insert a graphite powder at the breach of the coaxial head. Plasma current sheath reached 25 ka, after 10 μs fro... 详细信息

关键词： Plasma Coaxial Discharge for Thin Film Deposition

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Multiple Myeloma Secondary to HIV Infection, Revealed by Renal Failure: About a Case

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Open Journal of Nephrology 2019年第1期9卷 20-25页

作者： Mbengue Mansour Cissé Mouhamadou Moustapha Faye Maria Lemrabott Tall Ahmed Fall Khodia Keita Alex Faye Moustapha Ba Bakary Diagne Seynabou Keita Niakhaleen Ba Mamadou Aw Dieng Ameth Niang Abdou Ka.el Hadji Fary Diouf Boucar Department of Nephrology Regional Hospital Thies Senegal Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal

Multiple myeloma is on the list of neoplasia that may be associated with human immunodeficiency virus infection. It is an affection that aggravates the prognosis in these particular patients. We present the case of a patient with multiple myeloma and HIV infection, revealed by renal failure. This was a 59-year-old patient who was received to the Department of nephrology for renal failure associated with severe aregenerative pancytopenia. In etiological investigations, multiple myeloma associated with HIV1 infection was found. The evolution was unfavorable, marked by the death of the patient caused by digestive haemorrhage before the start of antiretroviral treatment and chemotherapy.

关键词： Multiple Myeloma HIV Renal Failure

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Secondary Hypertension in Sub-Saharan African Populations: A Retrospective Study between 2011 and 2016 at Regional Hospital of Saint-Louis, Senegal

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Open Journal of Nephrology 2016年第3期6卷 93-97页

作者： Yaya kane Joel Simon Manga Diatou Gueye Dia Maiga Moussa Zeinabou Tondi Ahmed Tall Lemrabott Maria Faye Sidy Mouhamed Seck Mouhamadou Moustapha Cisse Alex Ismael Keita kalilou Diallo el Hadj Fary ka Abdou Niang Boucar Diouf Nephrology-Cardiology and Internal Medicine Department Assane Seck University Ziguinchor Sénégal Nephrology and Internal Medicine Department Gaston Berger University Saint-Louis Sénégal Nephrology Department Abdou Moumouni University Niamey Niger Nephrology Department Teaching Hospital Aristide Le Dantec Dakar Senegal

Introduction: High blood pressure (HBP) is a worldwide health issue responsible of high cardiovascular morbidity and mortality. Even though essential HBP is far the most frequently reported in patients, secondary causes must be known because of their severity and the possibility of aetiological treatment. No recent epidemiological data are available about secondary causes of HBP in black African populations. The aim of this study was to describe aetiological patterns of secondary HBP in patients followed at Saint-Louis Hospital. Patients and Method: We conducted a retrospective and descriptive study in regional hospital of Saint-Louis. All patients aged ≥15 years old admitted from January 1st 2011 to January 31st 2015 in internal medicine, nephrology, emergency and cardiology departments were included. Clinical, paraclinical data and patients outcomes were collected from medical records. Hypertension was defined according to JNC8 criteria. Secondary HBP was considered if explorations identified a clear aetiology to hypertension. Statistical analysis was done with Excel 2010 and STATA 12.0. Results: We included 9253 patients with mean age of 35 ± 12 years (15 - 83 years) and sex-ratio of 1.6. Overall 67.5% of patients had hypertension and secondary causes were found in 10.5% of them. The majority of patients presented clinical symptoms suggesting a secondary cause of HBP and first-line laboratory explorations were normal in half of cases. Renal diseases were responsible for 79.1% of secondary HBP cases mainly dominated by glomerulonephritis (22.6%), vascular nephropathies (18.7%) and autosomal dominant polycystic kidney disease (5.8%). They were followed by preeclampsia (13.6%) and endocrinal aetiologies such as hyperthyroidism (5.8%), hypercorticism (0.5%), pheochromcytoma (0.5%), primary hyperparathyroidism (0.4%) and Conn’s adenoma (0.1%). Combination of ≥3 antihypertensive drugs was necessary in 71.5% of cases and surgical treatment was performed in three patient

关键词： Secondary High Blood Pressure Internal Medicine Black Africans

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Miniature Coaxial Plasma Injector for Diagnostics by Beam Plasma Interaction

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中国核科技报告 1999年第S4期 387-387页

作者： H.A.M.el-Tayeb N.R.C.Atomic Energy Aythority Plasma Physics and Nuclear Fusion Department Nuclear Material Division Egypt

A miniature coaxial gun has been used to study the interaction between plasma beam and low density plasma formed in glow discharge. The peak discharge current flow between the coaxial electrodes was 5.25 ka as a singl... 详细信息

关键词： cm Miniature Coaxial Plasma Injector for Diagnostics by Beam Plasma Interaction

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Renal Disease among HIV Positive Patients in Senegal

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Open Journal of Nephrology 2017年第4期7卷 101-106页

作者： Khodia Fall Mouhamadou Moustapha Cissé Ahmed Tall Lemrabott Maria Faye Mouhamed Cherif Dial Atoumane Faye Seynabou Fall Moustapha Faye Alex Keita Mansour Mbengue Seynabou Diagne Niakhaleen Keita Bacary Ba Abdou Niang Boucar Diouf el Hadji Fary ka Nephrology and Hemodialysis Department CHU Aristide Le Dantec Dakar Senegal Cytology and Histopathology Department Grand-Yoff General Hospital Dakar Senegal Internal Medicine Department CHU Aristide Le Dantec Dakar Sénégal

Introduction: Renal disease (RD) in human immunodeficiency virus (HIV) infection is a decisive turning point in the development and prognosis of this disease. In Africa, the prevalence varies between 2.5% and 48.6%. In Senegal, little data are available in the literature. The objective of our study was to describe the epidemiological, clinical, paraclinical, therapeutic and progressional aspects in patients living with HIV (PLWHIV). Patients and methods: This was a retrospective, descriptive and analytical study carried out over a 10-year period in the Department of Internal Medicine and Nephrology at the Aristide Le Dantec Hospital in Dakar, Senegal. We included all 15-year old and above PLHIV with available CD4 count and viral load. Results: Out of 248 PLHIV, 32 had kidney disease (KD), which means a hospital prevalence of 12.9%. The mean age was 51.22 ± 10 years (extremes of 36 and 77 years) with a sex ratio (male/female) of 1.28. Renal signs were dominated by glomerular nephropathy syndrome. It was present at 80%. Tubulo-interstitial nephropathy syndrome and chronic uremic syndrome accounted for 6.25% and 3.1% of cases, respectively. Renal function Impairment was present in 21 patients with 18 cases of acute kidney injury (85.7%) and 3 cases of chronic renal failure (14.3%), including 2 in stage 5 of chronic kidney disease. Renal biopsy (RB) was indicated and performed in 20 (62.5%) patients with glomerular signs in 12 patients (60%). Glomerular lesions were dominated by focal and segmental glomerulosclerosis (FSGS) in 6 cases, membraneous nephropathy (MN) in 4 cases and minimal change disease (MCD) in 2 cases. Tubulo-interstitial and vascular lesions were present in 45% and 12.5% of cases, respectively. In highly active antiretroviral therapy (HAART), 12 (37.5%) patients had total remission, 9 (28.12%) had partial remission. One (3.12%) death from severe metabolic acidosis on chronic renal failure was deplored. Conclusion: This study illustrates the high preval

关键词： Kidney Disease HIV HIVAN Senegal

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Prognostic Aspects of Lupus Nephritis at Aristide Le Dantec University Hospital in Dakar

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Open Journal of Nephrology 2018年第4期8卷 124-132页

作者： Mbengue Mansour Faye Maria Cissé Mouhamadou Moustapha Lemrabott Tall Ahmed Fall Khodia Keita Alex Faye Moustapha Ba Bakary Diagne Seynabou Keita Niakhaleen Ba Mamadou Aw Dieng Ameth Motula Latou Lot Niang Abdou Diouf Boucar Ka.el Hadji Fary Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal

Introduction: Kidney injury is common in the course of lupus and affects the functional and vital prognosis. The risk of progression to end-stage renal failure can reach 40% to 60%. Thus we carried out this work for the purpose of an evaluation of the renal and vital prognosis and to deduce the factors of poor prognosis. Patients and method: This was a retrospective, descriptive and analytical study conducted over a period of 10 years from January 1, 2007 to December 31, 2016, performed in the Nephrology Department of Aristide Le Dantec Hospital in Dakar. Patients with lupus nephritis were included. The studied parameters were epidemiological, clinical, paraclinical and progression. We had done a crossover of the patients to look for the factors of poor renal and vital prognosis. Results: Out of 93 cases of lupus patients, 64 were included, a prevalence of 69%. The mean age of the patients was 31.97 ± 10.44 years old. There were 81% women and 19% men, a sex ratio of 0.23. Class III was found in 24 cases (37.5%), Class IV in 20 cases (31.25%), Class V in 15 cases (23.4%), Class II in 4 cases (6.25%) and Class I in 1 case (1.6%). The combination of corticosteroids and immunosuppressants was used in 56.25% of cases. After a follow-up of six months, 19 patients were in complete remission, 21 had resistance and 9 had partial remission. Of the 21 patients who had resistance, 8 were in chronic renal failure. Death was observed in 5 patients and the causes were in 3 patients: pulmonary embolism, bacterial meningitis and pulmonary tuberculosis. The cause of death was unknown in 2 patients. The factors of poor renal prognosis were lymphopenia, the presence of anti-native DNA antibodies, nephrotic syndrome, microscopic hematuria, tubular atrophy and interstitial fibrosis. Risk factors affecting renal survival were the presence of native anti-DNA antibodies, microscopic hematuria, leukocyturia and the presence of a proliferative class. The factors of poor prognosis were renal f

关键词： Remission Resistance Chronic Renal Failure Lupus Nephritis

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