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Wilson disease and psychiatric symptoms: A brief case report

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General Psychiatry 2019年第3期32卷 155-158页

作者： Margarita Guerrero-Jimenez Carmen Maura Carrillo de Albornoz Calahorro Luis gutierrez Rojas Department of Psychiatry Hospital Universitario Virgen de las Nieves Granada Spain Department of Psychiatry University of Granada Granada Spain Department of Psychiatry Hospital Universitario San Cecilio Granada Spain

Wilson disease (WD) is an uncommon recessive genetic disorder affecti叩 copper metabolism. Cardiac, neurological, hepatic and renal manifestations are well defined, nevertheless approximately 30% of patients debut with neuropsychiatric symptoms. These psychiatric alterations resulting from the accumulation of this heavy metal in the basal ganglia are some how less specific. We present a short review of psychiatric symptoms of WD and describe a case of a 37-year-old woman diagnosed with WD who presented neuropsychiatric symptoms and had a consequent delay in diagnosis and causal treatment. Patients who develop WD starti叩 with a predominance of neuropsychiatric symptoms tend to manifest hepatic symptoms later, therefore have a longer delay of diagnosis and a poorer outcome than patients with hepatic symptoms. An early diagnosis ofWD can avoid irreversible neurological damage.

关键词： Wilson disease psychiatric symptoms A brief case report

Phylogenetic endemism of the orchids of Megamexico reveals complementary areas for conservation

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Plant Diversity 2022年第4期44卷 351-359页

作者： Brandon E.gutierrez-Rodríguez Marilyn Vasquez-Cruz Victoria Sosa Instituto de Ecología AC Carretera Antigua a Coatepec 351El Haya91073 XalapaVeracruzMexico Unidad de Genomica Avanzada Laboratorio Nacional de Genomica para La BiodiversidadCentro de Investigaciony Estudios Avanzados IrapuatoLibramiento Norte Carretera Leon Km.9.636821 IrapuatoGuanajuatoMexico

Orchid diversity provides a unique opportunity to further our understanding of biotic and abiotic factors linked to patterns of richness,endemism,and phylogenetic endemism in many ***,orchid diversity is consistently threatened by illegal trade and habitat ***,we identified areas critical for orchid conservation in the biogeographic province of *** this purpose,we evaluated orchid endemism,phylogenetic diversity,and phylogenetic endemism within Megamexico and characterized orchid life *** results indicate that the majority of the regions with the highest estimates of endemism and phylogenetic endemism are in southern Mexico and northern Central America,mostly located on the Pacific side of *** the most important orchid lineages,several belong to epiphytic lineages such as Pleurothallidinae,Laeliinae and *** also found that species from diverse and distantly related lineages converge in montane forests where suitable substrates for epiphytes ***,the southernmost areas of phylogenetic diversity and endemism of Megamexico are in unprotected ***,we conclude that the most critical areas for orchid conservation in Megamexico are located in southern Mexico and northern Central *** recommend that these areas should be given priority by the Mexican system of natural protected areas as complementary conservation areas.

关键词： Epiphytes Geophytes Orchids Phylogenetic endemism Weighted endemism

Caseous calcification of mitral annulus in the setting of multivessel disease

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Journal of Geriatric Cardiology 2022年第3期19卷 238-240页

作者： Swetha R Nuthulaganti Bijal R Patel Carly A Rabinowitz Maria gutierrez Khadeeja Esmail Reeba Omman Department of Medicine Division of CardiologyUF Health JacksonvileJacksonville FlUnited States

Caseous calcification of the mitral annulus(CCMA)is a chronic degenerative process affecting the mitral valve fibrous *** is a rare variant of mitral annular calcification(MAC)that is frequently misdiagnosed as endocarditis,cardiac tumor,or *** can present with palpitations and dyspnea;however,CCMA does not have a specific clinical presentation and diagnosis is typically made incidentally by presence of an intracardiac mass on cardiac imaging.

关键词： mitral cardiac diagnosis

iPlant Systems Biology (iPSB): An International Network Hub in the Plant Community

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Molecular Plant 2019年第6期12卷 727-730页

作者： Pascal Falter-Braun Siobhan Brady Rodrigo A.gutierrez Gloria M.Coruzzi Gabriel Krouk Institute of Network Biology (INET) Helmholtz Zentrum Munchen (HMGU) 85764 Munchen-Neuherberg Germany Microbe-Host Interactions Faculty of Biology. Ludwig-Maximilians-University (LMU) Munich 82152 Planegg-Martinsried Germany Department of Plant Biology and the Genome Center University of California Davis CA 95616 USA Departamento de Genetica Molecular y Microbiologia FONDAP Center for Genome Regulation Millennium Institute for Integrative Biology Pontificia Universidad Catolica de Chile Santiago 8331150 Chile Center for Genomics and Systems Biology Department of Biology New York University New York NY 10003 USA B&PMP Univ Montpellier CNRS INRA SupAgro Montpellier France

sequenced genome of a multicellular organism (Arabidopsis Genome, 2000) completed just after those of the nematode Caenorhabditis elegans (C. elegans Sequencing Consortium, 1998) and the fruit fly drosophila melanogaster (Adams et al., 2000). Availability of a full whole-genome sequence for the reference plant opened to plant biologists what is commonly called the post-genomic era.

关键词： Systems Biology International Network Hub Plant Community

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库奥皮奥城市剧院芬兰库奥皮奥

世界建筑导报 2024年第2期39卷 110-113页

作者： Juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Heikki Riitahuhta Toni Laurila Pekka Sivula Jyri Tartia Auvo Lindroos Harri Ahokas Petra Grisova Vladimir Ilic Lotta Kindberg Santtu Hyvärinen Gerard gutierrez Tuomas Uusheimo(摄影) ALA建筑师事务所不详

现在的库奥皮奥城市剧院是建筑师赫尔默•斯丹露丝和Risto-Veikko Luukkonen在20世纪60年代的现代主义建筑。扩建包括一个新的200座演播舞台,具有灵活的座位和舞台机械。新的空间还提供装载和物流、服装生产和存储,以及新舞台的支持功能... 详细信息

现在的库奥皮奥城市剧院是建筑师赫尔默•斯丹露丝和Risto-Veikko Luukkonen在20世纪60年代的现代主义建筑。扩建包括一个新的200座演播舞台,具有灵活的座位和舞台机械。新的空间还提供装载和物流、服装生产和存储,以及新舞台的支持功能。从市中心接近剧院时,唯一可见的变化是4米高的剧院塔楼。主舞台的舞台技术将全面更新,因此必须增加当前塔楼的高度。附加组件可形成一个发光的玻璃灯箱,使旧塔的独特形状易于辨认。

关键词：现代主义建筑主舞台舞台机械服装生产塔楼剧院

Diagnosis of Leukemia Disease Based on Enhanced Virtual Neural Network

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Computers, Materials & Continua 2021年第11期69卷 2031-2044页

作者： K.Muthumayil S.Manikandan S.Srinivasan JoséEscorcia-gutierrez Margarita Gamarra Romany F.Mansour Department of Information Technology PSNA College of Engineering and TechnologyDindigul624622India Department of Information Technology K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Biomedical Engineering Saveetha School of EngineeringSIMATSChennai602105India Electronic and Telecommunicacions Program Universidad Autónoma del CaribeBarranquilla08001Colombia Department of Computational Science and Electronic Universidad de la CostaCUCBarranquilla08001Colombia Department of Mathematics Faculty of ScienceNew Valley UniversityEl-Kharga72511Egypt

White Blood Cell(WBC)cancer or leukemia is one of the serious cancers that threaten the existence of human *** spite of its prevalence and serious consequences,it is mostly diagnosed through manual *** risks of inappropriate,sub-standard and wrong or biased diagnosis are high in manual ***,there is a need exists for automatic diagnosis and classification method that can replace the manual *** is mainly classified into acute and chronic *** current research work proposed a computer-based application to classify the *** the feature extraction stage,we use excellent physical properties to improve the diagnostic system’s accuracy,based on Enhanced Color Co-Occurrence *** study is aimed at identification and classification of chronic lymphocytic leukemia using microscopic images of WBCs based on Enhanced Virtual Neural Network(EVNN)*** proposed method achieved optimum accuracy in detection and classification of leukemia from WBC ***,the study results establish the superiority of the proposed method in automated diagnosis of *** values achieved by the proposed method in terms of sensitivity,specificity,accuracy,and error rate were 97.8%,89.9%,76.6%,and 2.2%,***,the system could predict the disease in prior through images,and the probabilities of disease detection are also highly optimistic.

关键词： White blood cells enhanced virtual neural networking segmentation feature extraction chronic lymphocytic leukemia

Meteorological indicators of dengue epidemics in non-endemic Northwest Argentina

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Infectious Disease Modelling 2022年第4期7卷 823-834页

作者： Javier Armando gutierrez Karina Laneri Juan Pablo Aparicio Gustavo Javier Sibona Departamento de Física-FCE-Universidad Nacional de Salta SaltaArgentina Grupo de Física Estadística e Interdisciplinaria CONICETCentro Atòmico Bariloche-CNEASan Carlos de BarilocheRío NegroArgentina Instituto de Investigaciones en Energía no Convencional(INENCO)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional de Salta Av.Bolivia 51004400SaltaArgentina Simon A.Levin Mathematical Computational and Modeling Sciences Center Arizona State UniversityPO Box 871904TempeAZ85287-1904USA IFEG-CONICET and Fa.M.A.F.-Universidad Nacional de Cordoba CordobaArgentina

In the last two decades dengue cases increased significantly throughout the world,giving place to more frequent outbreaks in Latin *** the non-endemic city of San Ramòn de la Nueva Orán,located in Northwest Argentina,large dengue outbreaks alternate with several years of smaller *** pattern,as well as the understanding of the underlying mechanisms,could be essential to design proper strategies to reduce epidemic *** develop a stochastic model that includes climate variables,social structure,and mobility between a non-endemic city and an endemic *** variables were input of a mosquito population ecological model,which in turn was coupled to a meta-population,spatially explicit,epidemiological *** mobility was included into the model given the high border crossing to the northern country of Bolivia,where dengue transmission is sustained during the whole *** tested different hypotheses regarding people mobility as well as climate variability by fitting numerical simulations to weekly clinical data reported from 2009 to *** assessing the number of imported cases that triggered the observed outbreaks,our model allows to explain the observed epidemic *** found that the number of vectors per host and the effective reproductive number are proxies for large *** proxies are related with climate variability such as rainfall and temperature,opening the possibility to test these meteorological variables for forecast purposes.

关键词： Mathematical modelling Dengue Outbreak Mosquitoes population

Europeanization and Multilevel Governance： Trying to Make Sense of International Activities of European Local Governments

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International Relations and Diplomacy 2014年第2期2卷 85-101页

作者： Amau gutierrez-Camps Pompeu Fabra University Barcelona SpainInternational Relations of Province of Barcelona Barcelona Spain

This paper analyzes the links among Europeanization, multilevel governance, and international activities of local governments. To do so, a revision of the literature on these three areas is provided, with a special emphasis on the effects that the Europeanization process （hierarchical and horizontal） and multilevel governance （type I and type II） have had over the internationalization of local governments. Thus, local governments＇ international activities have evolved and adapted to a complex system of governance. Furthermore, the paper offers a reflection on current trends such as European Union （EU） and national programmes aimed at fostering International initiatives of local governments, and the impact of the economic crisis on these activities.

关键词： multilevel governance Europeanization local governments

The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA

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Molecular Plant 2022年第5期15卷 840-856页

作者： Thomas Roulé Aurelie Christ Nosheen Hussain Ying Huang Caroline Hartmann Moussa Benhamed Jose gutierrez-Marcos Federico Ariel Martin Crespi Thomas Blein UniversitéParis-Saclay CNRSINRAEUniversitéEvryInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Universitéde Paris Institute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Instituto de Agrobiotecnología del Litoral CONICETFBCBUniversidad Nacional del LitoralColectora Ruta Nacional 168 km 03000 Santa FeArgentina School of Life Sciences University of WarwickCoventry CV47ALUK

Clustered organization of biosynthetic non-homologous genes is emerging as a characteristic feature of plant *** co-regulation of clustered genes seems to largely depend on epigenetic reprogram-ming and three-dimensional chromatin *** this study,we identified the long non-coding RNA(lncRNA)MARneral Silencing(MARS),localized inside the Arabidopsis marneral cluster,which con-trols the local epigenetic activation of its surrounding region in response to abscisic acid(ABA).MARS modulates the POLYCOMB REPRESSIVE COMPLEX 1(PRC1)component LIKE HETEROCHROMATIN PROTEIN 1(LHP1)binding throughout the cluster in a dose-dependent manner,determining H3K27me3 deposition and chromatin *** response to ABA,MARS decoys LHP1 away from the cluster and promotes the formation of a chromatin loop bringing together the MARNERAL SYNTHASE 1(MRN1)locus and a distal ABA-responsive *** enrichment of co-regulated lncRNAs in clustered meta-bolic genes in Arabidopsis suggests that the acquisition of novel non-coding transcriptional units may constitute an additional regulatory layer driving the evolution of biosynthetic pathways.

关键词： lncRNA enhancer cluster chromatin conformation LHP1 ABA seed germination epigenetics marneral