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Projected Changes in the Climate Zoning of Côte d’Ivoire

Atmospheric and Climate Sciences 2024年第1期14卷 62-84页

作者： Mamadou Diarrassouba Adama Diawara Assi Louis Martial Yapo Benjamin Komenan Kouassi Fidèle Yoroba Kouakou Kouadio dro Touré Tiemoko Dianikoura Ibrahim Koné Arona Diedhiou Laboratory of Sciences Matter Environment and Solar Energy (LASMES) University Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire Geophysical Station of Lamto (GSL) N’douci C&#244te d’Ivoire Laboratory of Fundamental and Applied Physics University Nangui Abrogoua Abidjan C&#244te d’Ivoire Université Grenoble Alpes (UGA) Institut des Géosciences de l’Environnement (IGE) Institut de Recherche pour le Développement (IRD) Centre National de Recherche Scientifique (CNRS) Institut National Polytechnique (INP) Grenoble France African Centre of Excellence on Climate Change Biodiversity and Sustainable Agriculture (ACE-CCBAD)/University Felix Houphou&#235t-Boigny (UFHB) Abidjan C&#244te d’Ivoire

This study assesses the projected changes in the climate zoning of Côte d’Ivoire using the hierarchical classification of principal components (HCPC) method applied to the daily precipitation data of an ensemble of 14 CORDEX-AFRICA simulations under RCP4.5 and RCP8.5 scenarios. The results indicate the existence of three climate zones in Côte d’Ivoire (the coastal, the centre and the north) over the historical period (1981-2005). Moreover, CORDEX simulations project an extension of the surface area of drier climatic zones while a reduction of wetter zones, associated with the appearance of an intermediate climate zone with surface area varying from 77,560 km2 to 134,960 km2 depending on the period and the scenario. These results highlight the potential impacts of climate change on the delimitation of the climate zones of Côte d’Ivoire under the greenhouse gas emission scenarios. Thus, there is a reduction in the surface areas suitable for the production of cash crops such as cocoa and coffee. This could hinder the country’s economy and development, mainly based on these cash crops.

关键词： Climate Projection Climate Zone Principal Component Analysis Hierarchical Classification on Principal Components CORDEX Côte d’Ivoire

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Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1866-1886页

作者： Rania Awad Avi Avital a.eja.dro sosnik Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and EngineeringTechnion-Israel Institute of TechnologyHaifa 3200003Israel Behavioral Neurobiology Laboratory Department of Occupational TherapyFaculty of Social Welfare and Health SciencesUniversity of HaifaHaifa 3498838Israel

Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and *** disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental *** treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the *** nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS *** pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last *** nanoparticles have become key players in the field owing to the high design and synthetic *** review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome ***,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced.

关键词： Neurodegenerative diseases Neurodevelopmental disorders Central nervous system Blood—brain barrier Nano-drug delivery systems Nose-to-brain pathway Intranasal administration Polymeric nanoparticles Polymeric micelles Dendrimers

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Editorial of Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection

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药学学报:英文版 2023年第6期13卷 2296-2297页

作者： Wei He a.eja.dro sosnik Chenjie Xu School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and EngineeringTechnion-Israel Institute of TechnologyHaifa 3200003Israel Department of Biomedical Engineering City University of Hong KongHong Kong 999077China

Our immune system has a vital role,and any variation because of either heritable or non-heritable stimuli might cause health disorders such as cancer,diabetes,and cardiovascular *** addition,the complexity of the anatomical barriers,such as the blood brain barrier,challenges the therapy of central nervous system(CNS)*** goal of nano-dimensional drugs(nanomedicines)is to improve the efficacy of treatments while minimizing systemic toxicity and side effects.

关键词： drugs cardiovascular Immune

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Electrospun poly（vinylidene fluoride-trifluoroethylene）/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation

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Nano Research 2017年第10期10卷 3358-3376页

作者： Robin Augustine Pan Dan a.eja.dro sosnik Nandakumar Kalarikkal Nguyen Tran Brice Vincent Sabu Thomas Patrick Menu Didier Rouxel Laboratory of Pharmaceutical Nanomaterials Science Department of Materials Science and Engineering Technion-lsrael Institute of Technology De-Jur Building Technion City Haifa 3200003 Israel Intemationaland Inter University Centre for Nanoscience and Nanotechnology Mahatma Gandhi University Kottayam Kerala 686560 India Ingenierie Moleculaire et Physiopathologie Articulaire UMR 7365 CNRS-Universite de Lorraine Vandoeuvre-Ies Nancy F-54500 France School of Pure and Applied Physics Mahatma Gandhi University Kottayam Kerala 686560 India School of Surgery Faculty of Medicine Universite de Lorraine Vandoeuvre-Ies-Nancy F-54500 France Institut Jean Lamour UMR 7198 CNRS-Universite de Lorraine Vandoeuvre-Ies-Nancy F-54500 France School of Chemical Sciences Mahatma Gandhi University Kottayam Kerala 686560 India

Piezoelectric materials that generate electrical signals in response to mechanical strain can be used in tissue engineering to stimulate cell proliferation. Poly （vinylidene fluoride-trifluoroethylene）（P（VDF-TrFE））, a piezoelectric polymer, is widely used in biomaterial applications. We hypothesized that incorporation of zinc oxide （ZnO） nanoparticles into the P（VDF-TrFE） matrix could promote adhesion, migration, and proliferation of cells, as well as blood vessel formation （angiogenesis）. In this study, we fabricated and comprehensively characterized a novel electrospun P（VDF-TrFE）/ZnO nanocomposite tissue engineering scaffold. We analyzed the morphological features of the polymeric matrix by scanning electron microscopy, and utilized Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry to examine changes in the crystalline phases of the copolymer due to addition of the nanoparticles. We detected no or minimal adverse effects of the biomaterials with regard to blood compatibility in vitro, biocompatibility, and cytotoxicity, indicating that P（VDF-TrFE）/ZnO nanocomposite scaffolds are suitable for tissue engineering applications. Interestingly, human mesenchymal stem cells （hMSCs） and human umbilical vein endothelial cells cultured on the nanocomposite scaffolds exhibited higher cell viability, adhesion, and proliferation compared to cells cultured on tissue culture plates or neat P（VDF-TrFE） scaffolds. Nanocomposite scaffolds implanted into rats with or without hMSCs did not elicit immunological responses, as assessed by macroscopic analysis and histology. Importantly, nanocomposite scaffolds promoted angiogenesis, which was increased in scaffolds pre-seeded with hMSCs. Overall, our results highlight the potential of these novel P（VDF-TrFE）/ZnO nanocomposites for use in tissue engineering, due to their biocompatibility and ability to promote cell adhesion and angiogenesis.

关键词： scaffolds electrospinning poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) ZnO angiogenesis cell adhesion stem cells

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Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 570-579页

作者： Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka Department of Medical Chemistry Medical University of Lublin Chod?ki 4a Lublin 20-093 Poland Department of Gastrology Medical University of Lublin Jaczweskiego 8 Lublin 20-954 Poland 1st Department of Radiology University Hospital No. 4 Jaczewskiego 8 Lublin 20-954 Poland

BACKGROUND： There is a growing evidence that matrix metalloproteinase （MMP）-2 and MMP-9 （gelatinases） play an important role in the pathogenesis of numerous disorders, especially with inflammatory etiology and extracellular matrix （ECM） remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation. DATA SOURCES： We carried out a PubMed search of Englishlanguage articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases. RESULTS： The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however, reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation. CONCLUSION： The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases is observed, but the exact role of these enzymes demands further studies.

关键词： matrix metalloproteinase liver fibrosis chronic pancreatitis non-specific inflammatory bowel diseases

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Projected Changes in the Climate Zoning of Côte d’Ivoire

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Atmospheric and Climate Sciences（大气和气候科学） 2024年第1期

作者： Mamadou Diarrassouba Adama Diawara Assi Louis Martial Yapo Benjamin Komenan Kouassi Fidèle Yoroba Kouakou Kouadio dro Touré Tiemoko Dianikoura Ibrahim Koné Arona Diedhiou

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地球科学和城市和发展规划：改善资料传插的技术方法

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国外第四纪地质 1989年第3期 67-78页

作者： Loh.,eja ALWUEMC

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基于广义切削方法用多丸成形刀具加工的预断模型

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国外金属加工 2001年第3期22卷 32-39页

作者： Arm.,eja 姬鸿飞不详南阳天力变压器分司

在本文中，提出了预断力分量、切屑流和功率的模型。它适用于一次或多次走刀车削螺旋V型槽，以及用三角形成形刀具，在高和低进给量/切削深度下，一次走刀进行车削。该预断模型基本切削分析的广义力学。因单刃和多刃成形刀具加工，并使... 详细信息

在本文中，提出了预断力分量、切屑流和功率的模型。它适用于一次或多次走刀车削螺旋V型槽，以及用三角形成形刀具，在高和低进给量/切削深度下，一次走刀进行车削。该预断模型基本切削分析的广义力学。因单刃和多刃成形刀具加工，并使用满足基本切削参数的“通用”数据库，且刃品上作用的力系数由“经典”直角切削试验求出。当数据考虑到刀具/工件材料效应和刀具涂层时，该数学模型可适用于所有刀具和刀刃几何变量范围内得到证实，且用测量和预断力之间的百分差，估价了它们的预断能力，开发的模型可预断切向、进研究能将“切削方法的统一力学”进行的预断，扩展至用成形刀具机加工。

关键词：切削成形刀加工预断力模型

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Understanding the Local Carbon Fluxes Variations and Their Relationship to Climate Conditions in a Sub-Humid Savannah-Ecosystem during 2008-2015: Case of Lamto in Cote d’Ivoire

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Atmospheric and Climate Sciences 2020年第2期10卷 186-205页

作者： dro Touré Tiemoko Fidèle Yoroba Adama Diawara Kouakou Kouadio Benjamin Komenan Kouassi Assi Louis Martial Yapo Laboratory of Atmosphere Physic and Mechanic Fluids (LAPA-MF) University Felix Houphouet-Boigny UFR SSMT Abidjan Côte d’Ivoire Geophysical Station of Lamto (GSL) N’Douci Côte d’Ivoire

The temporal variations of the Gross Primary Productivity (GPP), the Total Ecosystem Respiration (TER) and the Net Ecosystem Exchange (NEE), and their responses to meteorological conditions (e.g. temperature, radiative flux and precipitation) at Lamto, in wet savannah region across C?te d’Ivoire are analyzed using GFED-CASA and daily meteorological data recorded over the 2008-2015 period. The study shows the links between these carbon fluxes and climate variability at Lamto that is subject to high anthropogenic pressures and seasonal bushfires. The correlative statistics from multiple regression methods were used to assess the different relationships and show how they change in time. The results show important seasonal variability in the Gross Primary Productivity and the Total Ecosystem Respiration mainly associated with the changes in temperature and radiative flux. In addition, the statistical analysis suggests a high correlation between meteorological conditions and the GPP and TER. These climatic conditions may explain 83% and 79% of the variances of GPP and TER respectively. Moreover, the interannual variability of the Net Ecosystem Exchange indicates that around Lamto, in the subhumid savannah, the ecosystem behaves as a carbon sink similar to other West African ecosystems. On the other hand, there is no clear link between the NEE and temperature, radiative flux and precipitation. This lack of connection may suggest a limited response of the NEE interannual dynamics related to the changes in climatic features.

关键词： Carbon Flux Ecosystem Subhumid Savannah Lamto Climatic Conditions Linear Models

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Quantitative Measurement of the Chemical Composition of Fatty Acid of Cocoa Butter and the Isotopic Content of Glycerol Contained in Cocoa Butter by the NMR ¹³C from the INEPT Sequence and Characterization of the Geographical Origin of the Cocoa

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American Journal of Analytical Chemistry 2022年第3期13卷 79-95页

作者： Didier Diomandé Tiemoko Touré dro Jacques Sagne Akpa Silvestre Virginie Illa Tea Gérald S. Remaud Laboratoire de Constitution et Réaction de la Matière de l’Université Félix Houphouë t-Boigny Abidjan C&ocirc te d’Ivoire Chimie et Interdisciplinarité Synthèse Analyse Modélisation (CEISAM) Nantes France Laboratoire des Sciences de la Matière de l’Environnement et de l’énergie Solaire Université Félix Houphou&euml t-Boigny Abidjan C&ocirc te d’Ivoire

The determination of the chemical composition of cocoa butter and the isotopic contents of the carbons (C-2, C-1 and C-3) of the glycerol contained in the cocoa butter were measured by the NMR-13C from the INEPT sequence. This technique has already been applied to triglycerides of animal origin. Thus, cocoa butter is made up of nearly 66% saturated fatty acid composed mainly of stearic acid and palmitic acid. Monounsaturated fatty acids represented by oleic acid have an average content of 31% and polyunsaturated fatty acids represent less than 4%. Likewise, the isotopic contents of the glycerol of the triglycerides of cocoa butter in 13C of the carbons C-2, C-1 and C-3 were measured directly and values vary from -11‰ to -19‰ for the C-2 and from -39‰ to -41‰ for all C-1 and C-3 because of the symmetry of glycerol.

关键词： Chemical Composition Cocoa Butter INEPT Isotopic Content

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