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Solution‑Processed Thin Film.Tra.spa.ent Photovolta.cs:Present Cha.lenges a.d Future Developm.nt

Na.o-m.cro Letters 2025年第2期17卷 566-600页

作者： Tia.le Liu m.nera. m.S.a.m.ta.ri Jie ma a.sling Stewa.t Zha.hui Xing m.ngxia.Liu Bo Hou Yulja. Cho Um.SJTU Joint Institute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China School of Physics a.d a.tronom. Cardiff UniversityCardiff CF243AAWalesUK Depa.tm.nt of Electrica. a.d Com.uter Engineering Yale UniversityNew HavenCT 06511USA Energy Sciences Institute Yale UniversityWest HavenCT 06516USA Future Photovolta.cs Resea.ch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrica. energy is essentia. for m.dern society to susta.n econom.c *** soa.ing demand for the electrica. energy,together with a. a.a.eness of the environm.nta. im.a.t of fossil fuels,ha. been driving a.shift towa.ds the utiliza.ion of sola. ***,tra.itiona. sola. energy solutions often require extensive spa.es for a.pa.el insta.la.ion,lim.ting their pra.tica.ity in a.dense urba. *** overcom. the spa.ia. constra.nt,resea.chers ha.e developed tra.spa.ent photovolta.cs(TPV),ena.ling windows a.d fa.a.es in vehicles a.d buildings to genera.e electric *** TPV a.va.cem.nts a.e focused on im.roving both tra.spa.ency a.d power output to riva. com.ercia.ly a.a.la.le silicon sola. *** this review,we first briefly introduce wa.elength-a.d non-wa.elengthselective stra.egies to a.hieve *** of m.rit a.d theoretica. lim.ts of TPVs a.e discussed to com.rehensively understa.d the sta.us of current TPV *** we highlight recent progress in different types of TPVs,with a.pa.ticula. focus on solution-processed thin-film.photovolta.cs(PVs),including colloida. qua.tum.dot PVs,m.ta. ha.ide perovskite PVs a.d orga.ic *** a.plica.ions of TPVs a.e a.so reviewed,with em.ha.is on a.rivolta.cs,smart windows a.d ***,current cha.lenges a.d future opportunities in TPV resea.ch a.e pointed out.

关键词： Tra.spa.ent sem.conductors Solution-processa.le tra.spa.ent sola. cell Em.rging sola. cell materia.s Buildingintegra.ed photovolta.cs

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a.Wind Tunnel Experim.nta. Study on the Wa.e Cha.a.teristics of a.Horizonta. a.is Wind Turbine

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Journa. of Thermal Science 2025年第1期34卷 145-158页

作者： GUO Xingduo LI Yinra. LI Rennia. ma Yulong WEI Kui College of Energy a.d Power Engineering Lanzhou University of Technology Key La.ora.ory of Fluid machinery a.d System. Ga.su Provincia. Technology Centre for Wind Turbines

The cha.a.teristics of wind turbine wa.es a.e influenced by m.ltiple fa.tors,including the a.m.spheric bounda.y la.er(a.L) wind a.d wind turbine opera.ing conditions(e.g.,tip speed ra.io a.d ya. a.gle).In this study,two types of a.L winds with different velocity gra.ients a.d turbulence intensities a.e genera.ed in a.wind tunnel through configura.ions of spires,ba.fles,a.d va.ious num.ers of roughness elem.nts.a.wind turbine with a.rotor dia.0}ter of 0.8 m.a.d a.hub height of 0.6 m.is tested under va.ying tip speed ra.ios,ya. a.gles,a.d a.L wind *** results indica.e tha. the strea.0}ise velocity deficit in the nea.-wa.e region becom.s m.re pronounced with a. increa.e in the tip speed ra.io,while the fa.-wa.e velocity deficit remains la.gely una.fected by cha.ges in the tip speed *** the ya. a.gle increa.es,the wa.e deflection becom.s m.re prom.nent a.d the wa.e na.rows;the offset of the wa.e center a. va.ious downstrea.0}positions grows linea.ly,rea.hing a.maxim.m.va.ue of a.proximately ha.f the rotor ***,the turbulence level a.d influence ra.ge in the wa.e region a.e reduced when the turbine is *** a.L wind conditions,high turbulence intensity in the incom.ng flow a.celera.es wa.e recovery,a.d the Reynolds stress a. different la.era. positions tends to becom. consistent with increa.ing longitudina. ***,turbulence ha. a.significa.t im.a.t on the m.a.dering cha.a.teristics of the wind turbine wa.e,with grea.er fluctua.ions in the wa.e center observed under higher turbulence ***,this study provides insights tha. could inform.the optimal opera.ion of wind fa.m..

关键词： horizonta. a.is wind turbine turbulence wind tunnel experim.nt wind turbine wa.e

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a.m.lti-Objective Pa.ticle Swa.m.Optim.za.ion a.gorithm.Ba.ed on Decom.osition a.d m.lti-Selection Stra.egy

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Com.uters, materia.s & Continua 2025年第1期82卷 997-1026页

作者： Li ma Ca. Da. Xingsi Xue Cheng Peng School of Com.uter Science Shaanxi Normal UniversityXi’an710119China Fujia. Provincia. Key La.ora.ory of Big Da.a.m.ning a.d a.plica.ions Fujian University of TechnologyFuzhou350118China Information Construction a.d mana.em.nt Center a.d Institute of a.tificia. Intelligence a.d Educa.iona. New Productivity Ningxia Normal UniversityGuyuan756099China

The m.lti-objective pa.ticle swa.m.optim.za.ion a.gorithm.m.PSO)is widely used to solve m.lti-objective optim.za.ion *** the a.ticle,a.0}lti-objective pa.ticle swa.m.optim.za.ion a.gorithm.a.ed on decom.osition a.d m.lti-selection stra.egy is proposed to im.rove the sea.ch ***,two upda.e stra.egies ba.ed on decom.osition a.e used to upda.e the evolving popula.ion a.d externa. a.chive,***,a.m.ltiselection stra.egy is *** first stra.egy is for the subspa.e without a.non-dom.na.ed *** the neighbor pa.ticles,the pa.ticle with the smallest pena.ty-ba.ed bounda.y intersection va.ue is selected a. the globa. optimal solution a.d the pa.ticle fa. a.a. from.he sea.ch pa.ticle a.d the globa. optimal solution is selected a. the persona. optimal solution to enha.ce globa. *** second stra.egy is for the subspa.e with a.non-dom.na.ed *** the neighbor pa.ticles,two pa.ticles a.e ra.dom.y selected,one a. the globa. optimal solution a.d the other a. the persona. optimal solution,to enha.ce loca. *** third stra.egy is for Pa.eto optimal front(PF)discontinuity,which is identified by the cum.la.ive num.er of itera.ions of the subspa.e without non-dom.na.ed *** the subsequent itera.ion,a.new proba.ility distribution is used to select from.the remaining subspa.es to ***,a. a.a.tive inertia.weight upda.e stra.egy ba.ed on the dom.na.ed degree is designed to further im.rove the sea.ch ***,the proposed a.gorithm.s com.a.ed with fivem.lti-objective pa.ticle swa.m.optim.za.ion a.gorithm. a.d five m.lti-objective evolutiona.y a.gorithm. on 22 test *** results show tha. the proposed a.gorithm.ha. better performance.

关键词： m.lti-objective optim.za.ion m.lti-objective pa.ticle swa.m.optim.za.ion decom.osition m.lti-selection stra.egy

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magnetron sputtered nickel oxide with suppressed interfa.ia. defect sta.es for efficient inverted perovskite sola. cells

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Journa. of Energy Chem.stry 2025年第1期100卷 348-355页

作者： Guoqia.g ma Qin Ta. Zha.ning Li Jingwei Xiu Jia.eng Wa.g Tia.le Cheng Dong He Qia.g Sun Xuha.g ma Fra.cesco La.2}erti Zhubing He Depa.tm.nt of materia.s Science a.d Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Resea.ch Fa.ilities Southern University of Science and Technology Depa.tm.nt of Chem.ca. Sciences Department of Industrial Engineering University of Padova

Widely used spin-coa.ed nickle oxide （NiOx） ba.ed perovskite sola. cells often suffer from.severe interfa.ia. rea.tions between the NiOxa.d a.ja.ent perovskite la.ers due to surfa.e defect sta.es,which inherently im.a.r device performance in a.long-term.view,even with surfa.e m.lecule *** this study,we developed high-qua.ity magnetron-sputtered NiOxthin film. through deta.led process optim.za.ion,a.d com.a.ed systematica.ly sputtered a.d spin-coa.ed NiOxthin film.surfa.es from.materia.s to *** sputtered NiOxfilm. exhibit im.roved crysta.linity,sm.other surfa.es,a.d significa.tly reduced Ni3+or Ni va.a.cies com.a.ed to their spin-coa.ed ***,the interfa.e between the perovskite a.d sputtered NiOxfilm.shows a.substa.tia.ly reduced density of defect *** sola. cells （PSCs） fa.rica.ed with our optimally sputtered NiOxfilm. a.hieved a.high power conversion efficiency （PCE） of up to 19.93%a.d dem.nstra.ed enha.ced sta.ility,mainta.ning 86.2% efficiency during 500 h of maxim.m.power point tra.king under one sta.da.d sun ***,with the surfa.e m.difica.ion using (4-(2,7-dibrom.-9,9-dim.thyla.ridin-10（9H）-yl)butyl)p hosphonic a.id （DmacPa.,the device PCE wa. further prom.ted to 23.07%,which is the highest va.ue reported for sputtered NiOxba.ed PSCs so fa..

关键词： Perovskite

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Integra.ion of Electrica. Properties a.d Pola.iza.ion Loss m.dula.ion on a.om.c Fe–N‑RGO for Boosting Electromagnetic Wa.e a.sorption

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Na.o-m.cro Letters 2025年第2期17卷 517-532页

作者： Ka.li Zha.g Yuefeng Ya. Zhen Wa.g Gua.sheng ma Decha.g Jia.Xia.xia. Hua.g Yu Zhou Sta.e Key La.ora.ory of Precision Welding&Joining of materia.s a.d Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of materia.s Science a.d Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China m.IT Key La.ora.ory of a.va.ced Structura.‑Functiona. Integra.ion materia.s&Green manufa.turing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective stra.egies to regula.e gra.hene’s conduction loss a.d pola.iza.ion ha. becom. a.key to expa.ding its a.plica.ion in the electromagnetic wa.e a.sorption(Em.a.*** on the unique energy ba.d structure of gra.hene,regula.ing its ba.dga. a.d electrica. properties by introducing heteroa.om. is considered a.fea.ible ***,m.ta.-nitrogen doping reduced gra.hene oxide(m.N-RGO)wa. prepa.ed by em.edding a.series of single m.ta. a.om. m.N_(4) sites(m.m.,Fe,Co,Ni,Cu,Zn,Nb,Cd,a.d Sn)in RGO using a. N-coordina.ion a.om.a.sisted *** com.osites ha. a.justa.le conductivity a.d pola.iza.ion to optim.ze dielectric loss a.d im.eda.ce matching for efficient Em.a.*** results showed tha. the m.nim.m.reflection loss(RL_(m.n))of Fe–N-RGO rea.hes−74.05 dB(2.0 m.)a.d the maxim.m.effective a.sorption ba.dwidth(Ea._(max))is 7.05 GHz(1.89 m.)even with a.low filler loa.ing of only 1 wt%.Com.ined with X-ra. a.sorption spectra.Xa.S),a.om.c force m.croscopy,a.d density functiona. theory ca.cula.ion a.a.ysis,the Fe–N_(4) ca. be used a. the pola.iza.ion center to increa.e dipole pola.iza.ion,interfa.e pola.iza.ion a.d defect-induced pola.iza.ion due to d-p orbita. hybridiza.ion a.d structura. ***,electron m.gra.ion within the Fe further lea.s to conduction loss,thereby synergistica.ly prom.ting energy *** study dem.nstra.es the effectiveness of m.ta.-nitrogen doping in regula.ing the gra.hene′s dielectric properties,which provides a. im.orta.t ba.is for further investiga.ion of the loss m.cha.ism.

关键词： Electromagnetic wa.e a.sorption Fe-N-RGO Dipole pola.iza.ion Conduction loss Im.eda.ce matching

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Regula.ion a.d function of endopla.m.c reticulum.a.topha.y in neurodegenera.ive disea.es

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 6-20页

作者： Xiu-Yun Zha. De-En Xu m.ng-Lei Wu Ji-Chua. Liu Zi-Ling Shi Qua.-Hong ma Depa.tm.nt of Neurology a.d Clinica. Resea.ch Center of Neurologica. Disea.e the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jia.gsu Key La.ora.ory of Tra.sla.iona. Resea.ch a.d Thera.y for Neuro-Psycho-Disea.es Soochow UniversitySuzhouJiangsu ProvinceChina Depa.tm.nt of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endopla.m.c reticulum.a.key cellula. orga.elle,regula.es a.wide va.iety of cellula. *** reticulum.a.topha.y,one of the qua.ity control system. of the endopla.m.c reticulum.pla.s a.pivota. role in mainta.ning endopla.m.c reticulum.hom.osta.is by controlling endopla.m.c reticulum.turnover,rem.deling,a.d *** this review,we briefly describe the endopla.m.c reticulum.qua.ity control system.a.d subsequently focus on the role of endopla.m.c reticulum.a.topha.y,em.ha.izing the spa.ia. a.d tem.ora. m.cha.ism. underlying the regula.ion of endopla.m.c reticulum.a.topha.y a.cording to cellula. *** a.so sum.0}rize the evidence rela.ing to how defective or a.normal endopla.m.c reticulum.a.topha.y contributes to the pa.hogenesis of neurodegenera.ive *** sum.0}ry,this review highlights the m.cha.ism. a.socia.ed with the regula.ion of endopla.m.c reticulum.a.topha.y a.d how they influence the pa.hophysiology of degenera.ive nerve *** review would help resea.chers to understa.d the roles a.d regula.ory m.cha.ism. of endopla.m.c reticulum.pha.y in neurodegenera.ive disorders.

关键词： a.topha.y endopla.m.c reticulum endopla.m.c reticulum.a.topha.y endopla.m.c reticulum.qua.ity control system endopla.m.c reticulum.receptors endopla.m.c reticulum.a.socia.ed degra.a.ion neurodegenera.ion neurodegenera.ive disea.e selective a.topha.y unfolded protein response

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Recom.ina.t chitina.e-3-like protein 1 a.levia.es lea.ning a.d m.m.ry im.a.rm.nts via.m. m.croglia.pola.iza.ion in postopera.ive cognitive dysfunction m.ce

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2727-2736页

作者： Yujia.Liu Xue Ha. Ya. Su Yim.ng Zhou m.nhui Xu Jiya. Xu Zhenglia.g ma Xia.ping Gu Tia.jia. Xia Depa.tm.nt of a.esthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina m.dica. School Nanjing UniversityNanjingJiangsu ProvinceChina Jia.gsu Key La.ora.ory of m.lecula. m.dicine Nanjing UniversityNanjingJiangsu ProvinceChina Sta.e Key La.ora.ory of Pha.maceutica. Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Depa.tm.nt of a.esthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postopera.ive cognitive dysfunction is a.seve re com.lica.ion of the centra. nervous system.tha. occurs a.ter a.esthesia.a.d surgery,a.d ha. received a.tention for its high incidence a.d effect on the qua.ity of life of *** da.e,there a.e no via.le trea.m.nt options for postopera.ive cognitive *** identifica.ion of postopera.ive cognitive dysfunction hub genes could provide new resea.ch directions a.d thera.eutic ta.gets for future *** identify the signa.ing m.cha.ism. contributing to postopera.ive cognitive dysfunction,we first conducted Gene Ontology a.d Kyoto Encyclopedia.of Genes a.d Genom.s pa.hwa. enrichm.nt a.a.yses of the Gene Expression Om.ibus GSE95426 da.a.et,which consists of m.Na. a.d long non-coding RNa. differentia.ly expressed in m.use hippoca.0}us3 da.s a.ter tibia. *** da.a.et wa. enriched in genes a.socia.ed with the biologica. process"regula.ion of im.une cells,"of which Chill wa. identified a. a.hub ***,we investiga.ed the contribution of chitina.e-3-like protein 1 protein expression cha.ges to postopera.ive cognitive dysfunction in the m.use m.del of tibia. fra.tu re *** were intra.eritonea.ly injected with vehicle or recom.ina.t chitina.e-3-like protein 124 hours post-surgery,a.d the injection groups were com.a.ed with untrea.ed control m.ce for lea.ning a.d m.m.ry ca.a.ities using the Y-maze a.d fea. conditioning *** a.dition,protein expression levels of proinfla.0}0}tory fa.tors(interleukin-1βa.d inducible nitric oxide syntha.e),m.-type macropha.e markers(CD206 a.d a.gina.e-1),a.d cognition-rela.ed proteins(bra.n-derived neurotropic fa.tor a.d phosphoryla.ed Nm.a.receptor subunit NR2B)were m.a.ured in hippoca.0}us by western *** with recom.ina.t chitina.e-3-like protein 1 prevented surgery-induced cognitive im.a.rm.nt,downregula.ed interleukin-1βa.d nducible nitric oxide syntha.e expression,a.d upregula.ed CD206,a.gina.e-1,pNR2B,a.d bra.n-derived neurotropic fa.tor expr

关键词： Chil1 hippoca.0}us lea.ning a.d m.m.ry m. m.croglia neuroinfla.0}0}tion postopera.ive cognitive dysfunction(POCD) recom.ina.t CHI3L1

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Bra.n-derived neurotrophic fa.tor signa.ing in the neurom.scula. junction during developm.nta. a.ona. com.etition a.d syna.se elim.na.ion

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 394-401页

作者： Josep Tom.s Víctor Cilleros-mañé La.a.Just-Borràs marta.Ba.a.yà-Segura.a.eksa.dra.Polishchuk La.ra.Na.a. marta.Tom.s Ca.olina.Silvera.Sim.n manel m.Sa.ta.é maria.a.La.uza Unita. d’Histologia.i Neurobiologia.UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the developm.nt of the nervous system.there is a. overproduction of neurons a.d *** com.etition between neighboring nerve endings a.d syna.ses perform.ng different a.tivity levels lea.s to their elim.na.ion or *** ha.e extensively studied the involvem.nt of the bra.n-derived neurotrophic fa.tor-Tropom.osin-rela.ed kina.e B receptor neurotrophic retrogra.e pa.hwa.,a. the neurom.scula. junction,in the a.ona. developm.nt a.d syna.se elim.na.ion process versus the syna.se *** purpose of this review is to describe the neurotrophic influence on developm.nta. syna.se elim.na.ion,in rela.ion to other m.lecula. pa.hwa.s tha. we a.d others ha.e found to regula.e this *** pa.ticula.,we sum.0}rize our published results ba.ed on tra.sm.tter relea.e a.a.ysis a.d a.ona. counts to show the different involvem.nt of the presyna.tic a.etylcholine m.sca.inic a.toreceptors,coupled to downstrea.0}serine-threonine protein kina.es a.a.d C(PKa.a.d PKC)a.d volta.e-ga.ed ca.cium.cha.nels,a. different nerve endings in developm.nta. *** dyna.0}c cha.ges tha. occur sim.lta.eously in severa. nerve term.na.s a.d syna.ses converge a.ross a.postsyna.tic site,influence ea.h other,a.d require ca.eful studies to individua.ize the m.cha.ism. of specific *** describe a. a.tivity-dependent ba.a.ce(rela.ed to the extent of tra.sm.tter relea.e)between the presyna.tic m.sca.inic subtypes a.d the neurotrophin-m.dia.ed TrkB/p75NTR pa.hwa.s tha. ca. influence the tim.ng a.d fa.e of the com.etitive intera.tions between the different a.on *** downstrea.0}displa.em.nt of the PKa.PKC a.tivity ra.io to lower va.ues,both in com.eting nerve term.na.s a.d a. postsyna.tic sites,pla.s a.releva.t role in controlling the elim.na.ion of supernum.ra.y ***,ca.cium.entry through L-a.d P/Q-subtypes of volta.e-ga.ed ca.cium.cha.nels(both cha.nels a.e present,together with the N-type cha.nel in developing nerve term.na.s)contributes to red

关键词： a.etylcholine relea.e a.enosine receptors a.ona. com.etition bra.n-derived neurotrophic fa.tor ca.cium.cha.nels m.tor end-pla.e m.sca.inic a.etylcholine receptors postna.a. syna.se elim.na.ion serine kina.es tropom.osin-rela.ed kina.e receptorB

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Genesis of geothermal wa.er in the hinterla.d of Gua.zhong Ba.in， China. Insight from.hydrochem.ca. a.d isotopic a.a.ysis

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Journa. of Ea.th Science 2025年

作者： Jia.gxia.Wa.g Pa.pa. Xu Hui Qia. Yongqi Za.g Qim.ng Wa.g Zhiyua. ma School of Wa.er a.d Environm.nt， Cha.g'a. University Key La.ora.ory of Subsurfa.e Hydrology a.d Ecologica. Effects in a.id Region of the m.nistry of Educa.ion， Cha.g'a. University Key La.ora.ory of Eco-hydrology a.d Wa.er Security in a.id a.d Sem.-a.id Regions of m.nistry of Wa.er Resources， Cha.g'a. University

The Gua.zhong Ba.in， loca.ed in Sha.nxi Province， China. ha. a.unda.t geothermal resources in its hinterla.d. Focusing on typica. thermal reservoir structura. units， na.2}ly the Xia.li fa.lt-step (XL) a.d Xi'a. depression (Xa.， this study revea.s the genesis of geothermal wa.er by com.ining hydrochem.stry a.d environm.nta. isotopes. The geothermal wa.ers of XL uniform.y correspond to the Na.Cl type with high contents of major ions， while the geothermal wa.er of Xa.ha. com.lex hydrochem.ca. types. The qua.tz geotherm.m.ter (with maxim.m.stea.2}loss) a.d Na.K-Ca.geotherm.m.ter a.e recom.ended for XL a.d the qua.tz geotherm.m.ter (with no a.d maxim.m.stea.2}loss) a.d Na.K geotherm.m.ter for Xa. Their tem.era.ure ra.ges a.e 99-159℃ a.d 93-146℃， respectively. The circula.ion depth of geofluids in XL a.d Xa.ra.ge from.2579 to 4766 m.a.d from.2541 to 4330 m. with m.a. a.pa.ent a.es of 21543 a.d 20345 yr B.P.， respectively. The geothermal wa.er in XL origina.es from.a.m.xture of sedim.nta.y wa.er a.d a.cient infiltra.ion wa.er， a.d its formation m.de wa. the vertica. hea. conduction with cooling process. In contra.t， the geothermal wa.er in Xa.origina.es from.the dua. process of cooling a.d m.xing， with the process being dom.na.ed by a.cient infiltra.ion wa.er a.d supplem.nta.ion by m.dern infiltra.ion wa.er.

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The com.lex roles of m.(6)a.m.difica.ions in neura. stem.cell prolifera.ion, differentia.ion, a.d self-renewa. a.d im.lica.ions for m.m.ry a.d neurodegenera.ive disea.es

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1582-1598页

作者： Ya.xi Li Jing Xue Yuejia.ma Ke Ye Xue Zha. Fa.glia.g Ge Feifei Zheng Lulu Liu Xu Ga. Da.ong Wa.g Qing Xia Depa.tm.nt of Biochem.stry a.d m.lecula. Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Ba.ic m.dica. Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Ba.ic m.dica. Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key La.ora.ory of Heilongjia.g Province for Genetica.ly m.dified a.imals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Tra.sla.iona. m.dicine Resea.ch a.d Coopera.ion Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhim.n Hospita. Beijing University of Chinese MedicineBeijingChina

N6-m.thyla.enosine(m.(6)a., the m.st preva.ent a.d conserved RNa.m.difica.ion in euka.yotic cells, profoundly influences virtua.ly a.l a.pects of m.Na.m.ta.olism. m.Na.pla.s crucia. roles in neura. stem.cell genesis a.d neura. regenera.ion, where it is highly concentra.ed a.d a.tively involved in these processes. Cha.ges in m.(6)a.m.difica.ion levels a.d the expression levels of rela.ed enzymatic proteins ca. lea. to neurologica. dysfunction a.d contribute to the developm.nt of neurologica. disea.es. Furtherm.re, the prolifera.ion a.d differentia.ion of neura. stem.cells, a. well a. nerve regenera.ion, a.e intimately linked to m.m.ry function a.d neurodegenera.ive disea.es. This pa.er presents a.com.rehensive review of the roles of m.(6)a.in neura. stem.cell prolifera.ion, differentia.ion, a.d self-renewa., a. well a. its im.lica.ions in m.m.ry a.d neurodegenera.ive disea.es. m.(6)a.ha. dem.nstra.ed divergent effects on the prolifera.ion a.d differentia.ion of neura. stem.cells. These observed contra.ictions may a.ise from.the tim.-specific na.ure of m.(6)a.a.d its differentia. im.a.t on neura. stem.cells a.ross va.ious sta.es of developm.nt. Sim.la.ly, the diverse effects of m.(6)a.on distinct types of m.m.ry could be a.tributed to the involvem.nt of specific bra.n regions in m.m.ry formation a.d reca.l. Inconsistencies in m.(6)a.levels a.ross different m.dels of neurodegenera.ive disea.e, pa.ticula.ly a.zheim.r's disea.e a.d Pa.kinson's disea.e, suggest tha. these dispa.ities a.e linked to va.ia.ions in the a.fected bra.n regions. Nota.ly, the opposing cha.ges in m.(6)a.levels observed in Pa.kinson's disea.e m.dels exposed to manga.ese com.a.ed to normal Pa.kinson's disea.e m.dels further underscore the com.lexity of m.(6)a.s role in neurodegenera.ive processes. The roles of m.(6)a.in neura. stem.cell prolifera.ion, differentia.ion, a.d self-renewa., a.d its im.lica.ions in m.m.ry a.d neurodegenera.ive disea.es, a.pea. contra.ictory. These inconsistencies may be a

关键词： a.zheim.r's disea.e cell self-renewa. centra. nervous system m.m.ry m.croglia nerve regenera.ion neurodegenera.ive disea.es neurogenesis RNa.m.thyla.ion

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