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The Impact of Black Sea Sand Treatment Effectively Reducing Different Type of Pain

Open Journal of Therapy and Rehabilitation 2024年第1期12卷 18-27页

作者： Mahmut Tokaç a.dulbari bener Fatma Nur Kesiktaş Bahar Dernek Semra Alkal Akkaya Zeynep Esra Akgün Department of Medicine and Education Unit School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Biostatistics & Medical Informatics School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences The University of Manchester Manchester UK Faculty of Medicine Health Sciences University Istanbul Physiotherapy Rehabilitation Training and Research Hospital Istanbul Türkiye Faculty of Medicine Health Sciences University Department of Physical Medicine and Rehabilitation Umraniye Training and Research Hospital Istanbul Türkiye Physical Medicine and Rehabilitation Vatan Clinics School of Medicine Istanbul Medipol University Istanbul Türkiye

Purpose: Low back pain (LBP), Gonarthrosis, knee, and Carpal Tunnel Syndrome have been regarded as affecting more than three-quarters’ of individuals in their lifetime. The aim of this study was conducted to determine and compare the effects of topical patients with sand compared with control related to Gonarthrosis, LBP, knee, and Carpal Tunnel Syndrome pain. Methods: This is a prospective case and control designed study based on 101 pain case with Sand and 101 control subjects. The interventional groups in addition either topical sand or without sand 2 months after the intervention were assessed. We assessed tolerability of an established pain perception scale by the Numeric Rating Scale (NRS). Categorical variables were compared using the chi-square (χ2) test. The paired t-test was used to compare the two groups before and after the intervention. One-way analysis of variance (ANOVA) was employed for comparison of several group means. Results: The study was based on 202 patients, 41 males (20.3%) and 161 females (79.7%). There were statistically significant differences between subjects with and without Sand in term of Gonarthrosis, Rheumatoid Arthritis LBP, knee, and Carpal Tunnel Syndrome pain (p = 0.033). Majority of patients were over age 55 years old (55%) and females 78 (77.2%). The mean score of total pain experience before and after the intervention was 7.41 ± 1.1 for black sand, and 4.24 ± 2.38 for without sand as control group. The mean scores of these 5 groups were highly significant before and after the intervention (p There was statistically highly significant in regarding subjects with Sand as compared with those before Sand after treatment mean score specifically with gonarthrosis before pain 7.23 ± 1.86 vs after treatment 4.54 ± 2.18 p < 0.001;rheumatoid arthritis before 8.28 ± 1.48 vs after treatment 4.80 ± 3.71 p < 0.001;Low Back Pain before 8.42 ± 1.83 vs after treatment 4.37 ± 1.52 p < 0.001;knee pain before 8.93 ± 0.89 vs after treat

关键词： Therapies Sand LBP Musculoskeletal Rheumatoid Arthritis Carpal Tunnel Syndrome

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Effect of nicotinamide on newly diagnosed type 1 diabetic children

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Acta Pharmacologica Sinica 2006年第6期27卷 724-727页

作者： Madeeha KAMAL Abdul-JabbarAlABBASY AhoodAlMUSLEMANI a.dulbari bener Department of Pediatrics Salmaniya Medical ComplexManamaBahrain School of Health Department of PediatricsHamad Medical CorporationDohaQatar Department of Pediatrics.Salmaniya Medical Complex ManamaBahrain Department of Medical Statistics and Epidemiology Hamad General HospitalHamad Medical CorporationDohaQatar Department of Evidence for Population Health Unit School of Epidemiology and Health SciencesUniversity of ManchesterManchester.UK

Aim:To determine whether a low dose of nicotinamide(NA)therapy for pediatricpatients with type 1 diabetes,initiated within the first 24 h of diagnosis,prolongsthe"honeymoon"period and lowers their insulin ***:Allchildren(n=66)with newly diagnosed type 1 diabetes admitted to Salmaniya MedicalComplex between 1998 and 2000,received NA 1-2 mg/kg per day,in addition tosc insulin *** patients were followed for 24 months(NA group).Findings inthis group were compared with records from a similarly diagnosed control group(n=37),who were admitted to the same hospital between 1995 and 1997 and did notreceive NA *** insulin dose per kg bodyweight required at baselineand at 3-monthly intervals up to 2 years after diagnosis was ***:At baseline,the two groups did not differ with respect to age,ethnic background,weight,insulin dose per kg bodyweight or glucose levels on ***,NA group had lower insulin requirements than control group at each 3-monthinterval up to 2 years after ***:Our study results suggest thateven low doses of oral NA given to children with newly diagnosed type 1 diabetesmay reduce insulin requirements and prolong the"honeymoon"period.

关键词： type 1 diabetes nicotinamide insulin therapy insulin dose glycated hemoglobin A

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Attosecond magnetization dynamics in non-magnetic materials driven by intense femtosecond lasers

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npj Computational Materials 2023年第1期9卷 1959-1968页

作者： Ofer Neufeld Nicolas Tancogne-Dejean Umberto De Giovannini Hannes Hübener Angel Rubio Max Planck Institute for the Structure and Dynamics of Matter and Center for Free-Electron Laser Science Hamburg 22761Germany Universitàdegli Studi di Palermo Dipartimento di Fisica e Chimica—Emilio SegrèPalermo I-90123Italy Center for Computational Quantum Physics(CCQ) The Flatiron InstituteNew YorkNY 10010USA

Irradiating solids with ultrashort laser pulses is known to initiate femtosecond timescale magnetization ***,sub-femtosecond spin dynamics have not yet been observed or ***,we explore ultrafast light-driven spin dynamics in a highly nonresonant strong-field *** state-of-the-art ab initio calculations,we predict that a nonmagnetic material can transiently transform into a magnetic one via dynamical extremely nonlinear spin-flipping processes,which occur on attosecond timescales and are mediated by cascaded multi-photon and spin–orbit *** are nonperturbative nonresonant analogs to the inverse Faraday effect,allowing the magnetization to evolve in very high harmonics of the laser frequency(*** up to the 42nd,oscillating at~100 attoseconds),and providing control over the speed of magnetization by tuning the laser power and ***,we show that even for linearly polarized driving,where one does not intuitively expect the onset of an induced magnetization,the magnetization transiently oscillates as the system interacts with *** response is enabled by transverse light-driven currents in the solid,and typically occurs on timescales of~500 attoseconds(with the slower femtosecond response suppressed).An experimental setup capable of measuring these dynamics through pump–probe transient absorption spectroscopy is *** results pave the way for attosecond regimes of manipulation of magnetism.

关键词： tuning transient dynamics

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Microalbuminuria in hepatitis C-genotype 4:Effect of pegylated interferon and ribavirin

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World Journal of Gastroenterology 2010年第10期16卷 1226-1231页

作者： Moutaz Derbala Fatma M Shebl Awad Rashid Aliaa Amer a.dulbari bener Department of Gastroenterology and Hepa-tology Hamad Medical Corporation Department of Medicine Weill Cornell Medical College in Qatar Infections & Immunoepidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer Institute Epidemiology Branch National Liver Institute Department of Nephrology Hamad Medical Corporation Department of Laboratory Medicine and Histo-pathology Hematology SectionHamad Medical Corporation Department of Medical Statistics and Epidemiology Hamad Medical Corporation

AIM:To study the relation between hepatitis C virus (HCV) genotype 4 and microalbuminuria and renal impairment in relation to hepatic histology, and viremia in the absence of cryoglobulinemia, and to examine the effect of treatment on ***: Three hundred subjects, including 233 HCV genotype-4 infected patients, were tested for cryoglobulinemia, microalbuminuria, albumin creatinine ratio (ACR), urea, creatinine, and estimated glomerular filtration rate (eGFR). The parameters were measured again in the HCV patients after 48 wk of treatment with pegylated interferon and ***: Significantly higher levels of microalbumin- uria were detected in HCV-positive patients compared to HCV-negative controls (median 9.5 vs 5.9, respectively, Kruskal-Wallis P=0.017). Log microalbuminuria was significantly correlated with hepatic inflammation (r=0.13, P=0.036) and f ibrosis (r=0.12, P=0.061), but not with viral load (r=-0.03, P=0.610), or alanine transaminase (r=-0.03, P=0.617). Diabetes mellitus neither significantly moderated (χ2=0.13, P=0.720), nor mediated (Sobel test P=0.49) the HCV effect. HCV status was signifi cantly associated with log microalbu-minuria (χ2=4.97, P=0.026), adjusting for age, gender, diabetes, cryoglobulinemia, urea and creatinine. A positive HCV status was not significantly associated with low eGFR (<60 mL/min every 1.73 m2) [odds ratio (OR): 0.5, 95% confidence interval (CI):0.2-1.4], nor with high ACR (OR: 1.7, 95% CI:0.7-4.1). End-of-treatment response (ETR) was achieved in 51.9% of patients. Individuals with ETR had significantly lower microalbuminuria post-treatment (χ2=8.19, P=0.004).CONCLUSION: HCV affected the development of microalbuminuria independent of diabetes or cryoglobulinemia. Combination therapy of pegylated interferon-ribavirin had a positive effect in reducing microalbuminuria.

关键词： Hepatitis C virus Genotype Kidney diseases Albuminuria Proteinuria Peginterferon α-2a Ribavirin

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Driver sleepiness,fatigue,careless behavior and risk of motor vehicle crash and injury:Population based case and control study

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第5期4卷 496-502页

作者： a.dulbari bener Erol Yildirim Turker Ozkan Timo Lajunen Department of Biostatistics and Medical Informatics Cerrahpasa Faculty of MedicineIstanbul UniversityIstanbulTurkey Department of Euidence for Population Health Unit School of Epidemiology and Health SciencesUniuersity of ManchesterManchesterUK International School of Medicine Istanbul Medipol UniversityIstanbulTurkey Department of Psychology Istanbul Medipol UniversityIstanbulTurkey Safety Research Unit Department of PsychologyMiddle East Technical UniversityAnkaraTurkey Department of Psychology Norwegian Uniuersity of Science and Technology(NTNU)TrondheimNorway

Background： A few studies have been conducted to determine the relationship between road motor vehicle crashes （MVC） and serious injuries related to tiredness, fatigues and sleeping. Aim： To determine the effects of aggressive behaviour, driver sleepiness and fatigue on MVC and related injuries among Turkish population. Design and setting： Population-based case and control study conducted at the accident emergency departments of hospitals and roads. Subjects： 515 car drivers involved in crashes with injury were admitted to hospital and 1030 car drivers involved while driving on public roads as control group during the study period. Methods： The Manchester driver behaviour questionnaire （DBQ） measured the aberrant driving behaviours leading to accidents. Participants completed a fatigue severity scale （FSS） and Stanford Sleeping questionnaire an epworth scale with items related to socio-demographic information, driving experiences, adherence to traffic laws （such as speed limits and seat belt）, and drivers＇ driving records. Results： In a representative sampling, participant＇s age ranged from 25 to 65 and the mean and standard deviation were 36.5 _＋ 7.8 for cases and 37.0 4- 8.0 for controls. There was a significant difference in both group of drivers regarding BMI, level of education, marital status, driving experience, seat belt use, excessive speed limits, physical activity number of sleeping hours, mobile phone use, and cigarette smoking habit （p = 0.017）. Also, there was a significant higher mean score on all the DBQ violation questions among case group in comparison with the control group （p 〈 0.001）. Further, cases had higher prevalence of Epworth sleeping disorders （p 〈 0.001） and fatigue severity （p - 0.003） compared to control drivers. Multivariate logistic regression revealed that excessive speed, fatigue, lapses, errors, Stanford sleepiness score, violations, mobile phone use and Epworth sleepiness scale were significantly associated with injury involvemen

关键词： Driver Stanford sleeping FatigueRisk Road traffic crash and injury

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Dynamical amplification of electric polarization through nonlinear phononics in 2D SnTe

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npj Computational Materials 2020年第1期6卷 155-162页

作者： Dongbin Shin Shunsuke A.Sato Hannes Hübener Umberto De Giovannini Noejung Park Angel Rubio Max Planck Institute for the Structure and Dynamics of Matter and Center for Free-Electron Laser Science Luruper Chaussee 149Hamburg 22761Germany Center for Computational Sciences University of TsukubaTsukuba 305-8577Japan Nano-Bio Spectroscopy Group Departamento de Fisica de MaterialesUniversidad del Pas VascoSan Sebastian 20018Spain Department of Physics Ulsan National Institute of Science and TechnologyUNIST-gil 50Ulsan 44919Korea Center for Computational Quantum Physics(CCQ) The Flatiron Institute162 Fifth AvenueNew YorkNY 10010USA

Ultrafast optical control of ferroelectricity using intense terahertz fields has attracted significant *** we show that the nonlinear interactions between two optical phonons in SnTe,a two-dimensional in-plane ferroelectric material,enables a dynamical amplification of the electric polarization within subpicoseconds time *** first-principles time-dependent simulations show that the infrared-active out-of-plane phonon mode,pumped to nonlinear regimes,spontaneously generates in-plane motions,leading to rectified oscillations in the in-plane electric *** suggest that this dynamical control of ferroelectric material,by nonlinear phonon excitation,can be utilized to achieve ultrafast control of the photovoltaic or other nonlinear optical responses.

关键词： nonlinear ferroelectric phonon

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Common microscopic origin of the phase transitions in Ta_(2)NiS_(5) and the excitonic insulator candidate Ta_(2)NiSe_(5)

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npj Computational Materials 2021年第1期7卷 1919-1932页

作者： Lukas Windgätter Malte Rösner Giacomo Mazza Hannes Hübener Antoine Georges Andrew J.Millis Simone Latini Angel Rubio Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGemany Radboud University Institute for Molecules and MaterialsHeijendaalseweg 1356525 AJ NijmegenNetherlands Department of Quantum Matter Physics University of GenevaQuai Ernest-Ansermet 241211 GenevaSwitzerland College de France 11 place Marcelin Berthelot75005 ParisFrance Center for Computational Quantum Physics Flatiron InstituteNew YorkNY 10010USA.CPHTCNRSEcole PolytechniqueIP Paris91128 PalaiseauFrance Department of Physics Columbia UniversityNew YorkNY 10027USA.Nano-Bio Spectroscopy Group Departamento de Fisica de Materiales Universidad del Pais Vasco20018 San SebastianSpain

The structural phase transition in Ta-NiSes has been envisioned as driven by the formation of an excitonic insulating ***,the role of structural and electronic instabilities on crystal symmetry breaking has yet to be ***,the phase transition in its complementary material Ta_(2)NiS_(5)does not show any experimental hints of an excitonic insulating *** present a microscopic investigation of the electronic and phononic effects involved in the structural phase transition in Ta_(2)NiSe_(5)and Ta-Niss using extensive first-principles *** both materials the crystal symmetries are broken by phonon instabilities,which in tum lead to changes in the electronic bandstructure also observed in the experiment.A total energy landscape analysis shows no tendency towards a purely electronic instability and we find that a sizeable lattice distortion is needed to open a *** conclude that an excitonic instability is not needed to explain the phase transition in both Ta_(2)NiSe_(5)and Ta_(2)NiS_(5).

关键词： phase structural transitions

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Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage

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World Journal of Gastroenterology 2006年第35期12卷 5692-5698页

作者： MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A bener Department of Gastroenterology and Hepatology Hamad Medical Corporation Doha Qatar Department of Immunology Hamad Medical Corporation Doha Qatar Department of Haematology Hamad Medical Corporation Doha Qatar Department of Histopathology Hamad Medical Corporation Doha Qatar Department of Medical Statistics and Epidemiology Hamad Medical Corporation Doha Qatar

AIM： To evaluate pegylated interferon alpha2a （PegIFN-α2a） in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS： A total of 73 nafve patients （61 with history of bilharziasis） with compensated chronic HCV genotype 4 were enrolled into： group A （38 patients） who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B （35 patients） received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS： Significant improvement in both end of treatment response （ETR）（P 〈 0.002） and sustained response （SR）（P 〈 0.05） was noted with pegylated interferon, where ETR was achieved in 29 （76.3%） and 14 patients （40%） in both groups respectively, and 25 patients in group A （65.8%） and 9 （25.7%） in group B could retain negative viraemia by the end of follow up period. Sustained virological response （SVR） showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR （P 〈 0.001）, but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis （grade 3 and 4） with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response between bilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect, both drugs were comparable. CONCLUSION： PegIFN-~2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation.

关键词： Hepatitis C virus Genotype 4 Pegasys Bilharziasis

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Automated Behavioral Phenotyping Reveals Presymptomatic Alterations in a SCA3 Genetrap Mouse Model

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Journal of Genetics and Genomics 2012年第6期39卷 287-299页

作者： Jeannette Hübener Nicolas Casadei Peter Teismann Mathias W. Seeliger Maria Bjrkqvist Stephan von Horsten Olaf Riess Huu Phuc Nguyen Department of Medical Genetics University of TubingenTubingen 72076Germany Institute of Medical Sciences University of AberdeenAB25 2ZDUK Division of Ocular Neurodegeneration Centre for OphthalmologyInstitute for Ophthalmic ResearchUniversity of TubingenTubingen 72076Germany Neuronal Survival Unit Department of Experimental Medical SciencesWallenberg Neuroscience CenterLund UniversityLund 221 84Sweden Experimental Therapy Franz-Penzoldt-CenterUniversity of Erlangen-NurnbergErlangen 91054Germany

Characterization of disease models of neurodegenerative disorders requires a systematic and comprehensive phenotyping in a highly standardized manner. Therefore, automated high-resolution behavior test systems such as the homecage based LabMaster system are of particular interest. We demonstrate the power of the automated LabMaster system by discovering previously unrecognized features of a recently characterized atxn3 mutant mouse model. This model provided neurological symptoms including gait ataxia, tremor, weight loss and premature death at the age of 12 months usually detectable just 2 weeks before the mice died. Moreover, using the LabMaster system we were able to detect hypoactivity in presymptomatic mutant mice in the dark as well as light phase. Additionally, we analyzed inflammation, immunological and hematological parameters, which indicated a reduced immune defense in phenotypic mice. Here we demonstrate that a detailed characterization even of organ systems that are usually not affected in SCA3 is important for further studies of pathogenesis and required for the preclinical therapeutic studies.

关键词： Automated homecage behavior Genetrap mouse model Spinocerebellar Ataxia Type 3

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Effects of family history and consanguinity in primary immunodeficiency diseases in children in Qatar

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Open Journal of Immunology 2013年第2期3卷 47-53页

作者： Mohammad Ehlayel a.dulbari bener Mohammad Abu Laban Department of Medical Statistics and Epidemiology Hamad Medical Corporation Department of Public Health Weill Cornell Medical College Doha Qatar Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences University of Manchester Manchester UK Section of Pediatrics Hematology-Oncology Hamad Medical Corporation Department of Pediatrics Doha Qatar Weill Cornell Medical College Doha Qatar Section of Pediatric Allergy-Immunology Department of Pediatrics Hamad Medical Corporation Doha Qatar

Background: The high consanguinity in Middle East increases the risk of genetic diseases, including primary immunodeficiency diseases (PID). Objectives: This study was aimed at determining the rate of positive family history of PID, the overall rate and type of consanguinity, and their effects on delay age during diagnosis of PID. Materials and methods: A retrospective analysis was conducted on 131 children with PID (aged 0 - 14 years) managed at Hamad General Hospital during 1998-2012. Results: Data on 131 patients (75 males & 56 females) of 82 families was analyzed. The most common phenotype of PID was predominantly antibody deficiency (23.7%). The onset age was 24.01 months and delay age 18.7 months. Family history of PID was 66.4% (38.7% in predominantly antibody deficiency and 100% in diseases of immune dysregulation). Positive family history significantly (p = 0.004) reduced the delay age of PID diagnosis by 52.9%. The consanguinity rate was 61.1% (32.3% in the predominantly antibody ID to 96% in the phagocyte defects group), where paternal cousin ranked the highest type (57.5%). Conclusions: This study indicates that family history is common in children with PID and helpful in reducing the delay age. Consanguinity among families of affected children is also high (higher than healthy population). Paternal parallel cousin marriages are the most common type of consanguinity. For a practicing physician, family history is a simple and useful tool when suspecting PID in children. Primary prevention of PID in Middle East communities should consider consanguinity reduction through public awareness and education and premarital counseling programs.

关键词： Pediatric Primary Immunodeficiency Diseases Family History Consanguinity

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