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Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats

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Bioactive Materials 2022年第12期7卷 339-353页

作者： Justin C.Burrell Suradip Das Franco A.Laimo Kritika S.Katiyar Kevin D.Browne Robert B.Shultz Vishal J.Tien Phuong T.Vu Dmitriy petrov Zarina SAli Joseph M.Rosen D.Kacy Cullen Center for Brain Injury&Repair Department of NeurosurgeryPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Bioengineering School of Engineering&Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Center for Neurotrauma Neurodegeneration&RestorationCorporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA19104USA Axonova Medical LLCPhiladelphiaPAUSA Dartmouth-Hitchcock Medical Center Division of Plastic SurgeryDartmouth CollegeLebanonNHUSA

Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle. While surgeons can re-route local axon fascicles to the target muscle, there are no technologies to provide an exogenous source of axons without sacrificing healthy nerves. Accordingly, we have developed tissue engineered neuromuscular interfaces (TE-NMIs) as the first injectable microtissue containing motor and sensory neurons in an anatomically-inspired architecture. TE-NMIs provide axon tracts that are intended to integrate with denervated distal structures and preserve regenerative capacity during prolonged periods without host innervation. Following implant, we found that TE-NMI axons promoted Schwann cell maintenance, integrated with distal muscle, and preserved an evoked muscle response out to 20-weeks post nerve transection in absence of innervation from host axons. By repopulating the distal sheath with exogenous axons, TE-NMIs also enabled putative delayed fusion with proximal host axons, a phenomenon previously not achievable in delayed repair scenarios due to distal axon degeneration. Here, we found immediate electrophysiological recovery after fusion with proximal host axons and improved axon maturation and muscle reinnervation at 24-weeks post-transection (4-weeks following delayed nerve fusion). These findings show that TE-NMIs provide the potential to improve functional recovery following delayed nerve repair.

关键词： Nerve regeneration Neuromuscular injury Muscle preservation Tissue engineering Microtissue Axon fusion

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Dynamic failure of dry and fully saturated limestone samples based on incubation time concept

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 125-134页

作者： Yuri V. petrov Ivan V. Smirnov Grigory A. Volkov Andrei K. Abramian Anatoliy M. Bragov Stanislav N. Verichev Saint Petersburg University Universitetskaya nab. 7-9 Saint Petersburg 199034 Russia Institute of Problems of Mechanical Engineering Russian Academy of Sciences Bolshoj pr. 61 V.O. Saint Petersburg 199178 Russia Lobachevsky State University of Nizhni Novgorod Prospekt Gagarina 23 Nizhny Novgorod 603950 Russia Allseas Engineering B.V. Poortweg 12 Delft 2612 PA The Netherlands

This paper outlines the results of experimental study of the dynamic rock failure based on the comparison of dry and saturated limestone samples obtained during the dynamic compression and split tests. The tests were performed using the Kolsky method and its modifications for dynamic splitting. The mechanical data(e.g. strength, time and energy characteristics) of this material at high strain rates are obtained. It is shown that these characteristics are sensitive to the strain rate. A unified interpretation of these rate effects, based on the structuraletemporal approach, is hereby presented. It is demonstrated that the temporal dependence of the dynamic compressive and split tensile strengths of dry and saturated limestone samples can be predicted by the incubation time criterion. Previously discovered possibilities to optimize(minimize) the energy input for the failure process is discussed in connection with industrial rock failure processes. It is shown that the optimal energy input value associated with critical load, which is required to initialize failure in the rock media, strongly depends on the incubation time and the impact duration. The optimal load shapes, which minimize the momentum for a single failure impact, are demonstrated. Through this investigation, a possible approach to reduce the specific energy required for rock cutting by means of high-frequency vibrations is also discussed.

关键词： Dynamic strength Incubation time criterion Split Hopkinson pressure bar(SHPB) test Tensile strength Compressive strength Water-saturated limestone Vibration-assisted rock cutting

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The Study of Different Structuring Techniques for Creation of Non-Evaporable Getters

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Materials Sciences and Applications 2013年第8期4卷 57-61页

作者： Anton Boyko Dahir Gaev Sergei Timoshenkov Yuri Chaplygin Vladimir petrov Kabardino-Balkarian State University Moscow Russia National Research University of Electronic Technology Moscow Russia Research Institute of Advanced Materials and Technology Moscow Russia

The results of observation of different structuring techniques of thin metal layers applied in micro system technologies are presented. The Ti V getter films formed by magnetron sputtering have been explored using scanning electron and atomic-force microscopy, Brunauer-Emmett-Teller method, thermogravimetric analysis and fractal geometry. The film sorption capacity for hydrogen given by thermogravimetry was of 7.7 m3·pa·g-1. To estimate the effective surface area, the fractal geometry tools were used and the calculated value of the specific surface area was about 155 m2/m3. The second object under investigation was a structure composed of micro- and mesoporous silicon and copper layer deposited electrochemically on the pore walls. Porous silicon when coupled with a reactive metal or alloy is expected to be an effective getter for micro system techniques. The use of porous silicon and specific conditions of depositions allows to form the structure of complex fractal type with a specific surface area of 167 m2/cm3.

关键词： Non-Evaporable Getters MEMS Structuring Magnetron Sputtering Electrodeposition Porous Silicon

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淋巴管内介入疗法预防下肢骨折术后感染的前瞻性研究

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中华创伤杂志 2007年第9期23卷 686-688页

作者：刘永轶 ПeTpoB Cepгeй　BиKTOPOBич 刘尚礼宋卫东黄东生崔力扬中山大学附属第二医院骨外科广州510120 PoCCия CaHKT-ПeTepбyprкaфeдpa Xиpypгии　MeдициHCKOгO ФakyлbTeTa CaHKT-ПeTepбypгCKOгO ГocyдapCTBehhOгO УHиBePCиTeTa199406

目的观察淋巴管内介入疗法预防下肢骨折术后感染的临床疗效。方法前瞻性研究接受手术治疗的严重下肢骨折住院患者160例。随机分为研究组和对照组，每组各80例。研究组采用淋巴管内介入疗法，对照组采用传统的抗生素静脉注射法。结果通... 详细信息

目的观察淋巴管内介入疗法预防下肢骨折术后感染的临床疗效。方法前瞻性研究接受手术治疗的严重下肢骨折住院患者160例。随机分为研究组和对照组，每组各80例。研究组采用淋巴管内介入疗法，对照组采用传统的抗生素静脉注射法。结果通过对淋巴小管收缩活性的评价证明，创伤和术后下肢大部分淋巴床的改变是功能性的、可逆的。研究组并发局部伤口感染5例（6．3％）、化脓性骨关节感染1例（1．3％），相应的对照组为16例（20．0％）和7例（8．8％）。研究组和对照组的住院时间分别为（15．6±0．6）d和（21．5±0．5）d。研究组使用头孢唑啉（5．0±0．54）g或林可霉素（1．5±0．14）g，而对照组使用相应抗生素（20．64±1．23）g或（6．19±0．15）g。结论淋巴管内介入疗法较传统的抗生素静脉注射疗法能更有效地预防下肢创伤及手术后感染。

关键词：淋巴管内介入疗法骨折外科伤口感染前瞻性研究

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